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Protein

AMP phosphorylase

Gene

Hbut_0381

Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168AMP; via amide nitrogenUniRule annotation1
Binding sitei204AMP; via amide nitrogenUniRule annotation1
Active sitei257Proton donorUniRule annotation1
Binding sitei265AMPUniRule annotation1
Binding sitei289AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 200AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciHBUT415426:GC56-381-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Hbut_0381
OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Taxonomic identifieri415426 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
Proteomesi
  • UP000002593 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147191 – 502AMP phosphorylaseAdd BLAST502

Interactioni

Protein-protein interaction databases

STRINGi415426.Hbut_0381.

Structurei

3D structure databases

ProteinModelPortaliA2BJU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013. Archaea.
COG0213. LUCA.
HOGENOMiHOG000252767.
KOiK18931.
OMAiYVEVAIT.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase. 1 hit.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BJU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKGLKVEA ASIDPGHDAV ILNPRDAEHL GVVAGLRASV VCRGRGVGAV
60 70 80 90 100
VIVDPRVPER VAQLTKGLVE RLGDCDTVDV HPIDVPPSFD AFKKRLSGAR
110 120 130 140 150
LSAAEYKMLI ADIVAGYYDD AQIASFLVSQ LYSKLADEEL EHLIRAMVET
160 170 180 190 200
GEVVKFGEPV YDVHSIGGVP GNSKVALLVV PIVASRGLLI PKTSSRAITS
210 220 230 240 250
PAGTADTMEV LAKVAFKPQE LHDMALRARG LIVWGGALNL APADDIFVRV
260 270 280 290 300
ERRIGVDPPT QMVASILAKK LAMSVSRLVI DLPTGRGAKV QDESEAELLA
310 320 330 340 350
SMFLAQAGRL NIAMRVAITF GGEPIGFSVG PALEAREALQ TLMKGDGASS
360 370 380 390 400
LVEKACSLAG LVFELGGVVP RGRGYSLACE ILRSGAAYRK FREIIEVQEG
410 420 430 440 450
DPDIKPEDIK LAPKQFTLEA PRDGIVTMID NRAISLAARA AGAPEDKGAG
460 470 480 490 500
IQLHVKTGYR VRKGDPLLTI YASSDTRLHE AVRLLDEYNA VLIEGVVVKV

LP
Length:502
Mass (Da):53,499
Last modified:February 20, 2007 - v1
Checksum:i124DF85BC940F955
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000493 Genomic DNA. Translation: ABM80251.1.
RefSeqiWP_011821569.1. NC_008818.1.

Genome annotation databases

EnsemblBacteriaiABM80251; ABM80251; Hbut_0381.
GeneIDi4782885.
KEGGihbu:Hbut_0381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000493 Genomic DNA. Translation: ABM80251.1.
RefSeqiWP_011821569.1. NC_008818.1.

3D structure databases

ProteinModelPortaliA2BJU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi415426.Hbut_0381.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM80251; ABM80251; Hbut_0381.
GeneIDi4782885.
KEGGihbu:Hbut_0381.

Phylogenomic databases

eggNOGiarCOG02013. Archaea.
COG0213. LUCA.
HOGENOMiHOG000252767.
KOiK18931.
OMAiYVEVAIT.

Enzyme and pathway databases

BioCyciHBUT415426:GC56-381-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase. 1 hit.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMPPA_HYPBU
AccessioniPrimary (citable) accession number: A2BJU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: November 11, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.