Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AMP phosphorylase

Gene

Hbut_0381

Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168AMP; via amide nitrogenUniRule annotation1
Binding sitei204AMP; via amide nitrogenUniRule annotation1
Active sitei257Proton donorUniRule annotation1
Binding sitei265AMPUniRule annotation1
Binding sitei289AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 200AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciHBUT415426:GC56-381-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Hbut_0381
OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Taxonomic identifieri415426 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
Proteomesi
  • UP000002593 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147191 – 502AMP phosphorylaseAdd BLAST502

Interactioni

Protein-protein interaction databases

STRINGi415426.Hbut_0381

Structurei

3D structure databases

ProteinModelPortaliA2BJU0
SMRiA2BJU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A2BJU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKGLKVEA ASIDPGHDAV ILNPRDAEHL GVVAGLRASV VCRGRGVGAV
60 70 80 90 100
VIVDPRVPER VAQLTKGLVE RLGDCDTVDV HPIDVPPSFD AFKKRLSGAR
110 120 130 140 150
LSAAEYKMLI ADIVAGYYDD AQIASFLVSQ LYSKLADEEL EHLIRAMVET
160 170 180 190 200
GEVVKFGEPV YDVHSIGGVP GNSKVALLVV PIVASRGLLI PKTSSRAITS
210 220 230 240 250
PAGTADTMEV LAKVAFKPQE LHDMALRARG LIVWGGALNL APADDIFVRV
260 270 280 290 300
ERRIGVDPPT QMVASILAKK LAMSVSRLVI DLPTGRGAKV QDESEAELLA
310 320 330 340 350
SMFLAQAGRL NIAMRVAITF GGEPIGFSVG PALEAREALQ TLMKGDGASS
360 370 380 390 400
LVEKACSLAG LVFELGGVVP RGRGYSLACE ILRSGAAYRK FREIIEVQEG
410 420 430 440 450
DPDIKPEDIK LAPKQFTLEA PRDGIVTMID NRAISLAARA AGAPEDKGAG
460 470 480 490 500
IQLHVKTGYR VRKGDPLLTI YASSDTRLHE AVRLLDEYNA VLIEGVVVKV

LP
Length:502
Mass (Da):53,499
Last modified:February 20, 2007 - v1
Checksum:i124DF85BC940F955
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000493 Genomic DNA Translation: ABM80251.1
RefSeqiWP_011821569.1, NC_008818.1

Genome annotation databases

EnsemblBacteriaiABM80251; ABM80251; Hbut_0381
GeneIDi4782885
KEGGihbu:Hbut_0381

Similar proteinsi

Entry informationi

Entry nameiAMPPA_HYPBU
AccessioniPrimary (citable) accession number: A2BJU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health