A2BJU0 (TYPH_HYPBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Hbut_0381

Organism

Hyperthermus butylicus (strain DSM 5456 / JCM 9403) [Reference proteome] [HAMAP]

Taxonomic identifier

415426 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Pyrodictiaceae › Hyperthermus › Hyperthermus butylicus

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314719

Sequences

	Sequence		Length	Mass (Da)
	A2BJU0 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 124DF85BC940F955	FASTA	502	53,499
	10 20 30 40 50 60 MPVKGLKVEA ASIDPGHDAV ILNPRDAEHL GVVAGLRASV VCRGRGVGAV VIVDPRVPER 70 80 90 100 110 120 VAQLTKGLVE RLGDCDTVDV HPIDVPPSFD AFKKRLSGAR LSAAEYKMLI ADIVAGYYDD 130 140 150 160 170 180 AQIASFLVSQ LYSKLADEEL EHLIRAMVET GEVVKFGEPV YDVHSIGGVP GNSKVALLVV 190 200 210 220 230 240 PIVASRGLLI PKTSSRAITS PAGTADTMEV LAKVAFKPQE LHDMALRARG LIVWGGALNL 250 260 270 280 290 300 APADDIFVRV ERRIGVDPPT QMVASILAKK LAMSVSRLVI DLPTGRGAKV QDESEAELLA 310 320 330 340 350 360 SMFLAQAGRL NIAMRVAITF GGEPIGFSVG PALEAREALQ TLMKGDGASS LVEKACSLAG 370 380 390 400 410 420 LVFELGGVVP RGRGYSLACE ILRSGAAYRK FREIIEVQEG DPDIKPEDIK LAPKQFTLEA 430 440 450 460 470 480 PRDGIVTMID NRAISLAARA AGAPEDKGAG IQLHVKTGYR VRKGDPLLTI YASSDTRLHE 490 500 AVRLLDEYNA VLIEGVVVKV LP

References

[1]

"The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C." Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P. Archaea 2:127-135(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 5456 / JCM 9403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000493 Genomic DNA. Translation: ABM80251.1.
RefSeq	YP_001012596.1. NC_008818.1.
3D structure databases
ProteinModelPortal	A2BJU0.
ModBase	Search...
Protein-protein interaction databases
STRING	415426.Hbut_0381.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABM80251; ABM80251; Hbut_0381.
GeneID	4782885.
KEGG	hbu:Hbut_0381.
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	CLSK2399321.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_HYPBU

Accession

Primary (citable) accession number: A2BJU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program