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A2BJL6

- ASSY_HYPBU

UniProt

A2BJL6 - ASSY_HYPBU

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Protein
Argininosuccinate synthase
Gene
argG, Hbut_0305
Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831Citrulline By similarity
Binding sitei113 – 1131ATP; via amide nitrogen By similarity
Binding sitei115 – 1151Aspartate By similarity
Binding sitei119 – 1191Aspartate By similarity
Binding sitei119 – 1191Citrulline By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei123 – 1231Citrulline By similarity
Binding sitei171 – 1711Citrulline By similarity
Binding sitei180 – 1801Citrulline By similarity
Binding sitei256 – 2561Citrulline By similarity
Binding sitei268 – 2681Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 149ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHBUT415426:GC56-305-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Hbut_0305
OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403)
Taxonomic identifieri415426 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
ProteomesiUP000002593: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Argininosuccinate synthaseUniRule annotation
PRO_1000000399Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi415426.Hbut_0305.

Structurei

3D structure databases

ProteinModelPortaliA2BJL6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BJL6-1 [UniParc]FASTAAdd to Basket

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MKVVLAYSGG LDTSAILVLL REQGHEVVTV TVSVGQEEDL EEVEERAYKL    50
GASKHYTVNA VEEFAEKYIS MAIKANALYE DKYPLGTALA RPLIAEKVAE 100
IARKESADAV AHGCTSKGND QVRFDTMLKY YLGDDIKIIA PVRELRLTRA 150
KAAEILRRNG FQPPGLHKTY SIDENLWSRS IEGGPLDDPM AEPPEDAFAW 200
TVAPEKAPDQ PLYLEIGFEK GIPVSINGEK MHLAKIVSLL NRLVGAYGYG 250
RIDHIENRVV GLKSREVYEA PAALTLIEAH RDLEKTVYTP RELRFKRILD 300
QEWSDLVYQG LWVEPLRATL EKAIDELNRW VTGTVRVKVY KGSLMVVGRW 350
SPYSGYSREA IDYNHGWYPS DEEARGFITI WSLHSLAAAK ARSLWG 396
Length:396
Mass (Da):44,521
Last modified:February 20, 2007 - v1
Checksum:i6DE1CD0EAB61DDB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000493 Genomic DNA. Translation: ABM80177.1.
RefSeqiYP_001012522.1. NC_008818.1.

Genome annotation databases

EnsemblBacteriaiABM80177; ABM80177; Hbut_0305.
GeneIDi4782292.
KEGGihbu:Hbut_0305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000493 Genomic DNA. Translation: ABM80177.1 .
RefSeqi YP_001012522.1. NC_008818.1.

3D structure databases

ProteinModelPortali A2BJL6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 415426.Hbut_0305.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM80177 ; ABM80177 ; Hbut_0305 .
GeneIDi 4782292.
KEGGi hbu:Hbut_0305.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci HBUT415426:GC56-305-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C."
    Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P.
    Archaea 2:127-135(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5456 / JCM 9403.

Entry informationi

Entry nameiASSY_HYPBU
AccessioniPrimary (citable) accession number: A2BJL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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