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A2BJH2 (A2BJH2_HYPBU) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224
Gene names
Name:pyrD HAMAP MF_00224
Ordered Locus Names:Hbut_0261
OrganismHyperthermus butylicus (strain DSM 5456 / JCM 9403)
Taxonomic identifier415426 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Pyrodictiaceae › Hyperthermus

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224

Catalytic activity

(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224

Cofactor

Binds 1 FMN per subunit By similarity. HAMAP MF_00224

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224

Subcellular location

Cytoplasm By similarity HAMAP MF_00224.

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1281Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

Sequence LengthMass (Da)Tools
A2BJH2 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 78A2E78F56605BA7

FASTA30231,395
        10         20         30         40         50         60 
MAGLAVRVAG LTLRHPVMNA SGILGSHPEG VKLLVDAGVS AVVTKSFTVE PREGYPTPIA 

        70         80         90        100        110        120 
VPLPYGLLNA VGLSNPGIDG ISVVVEEARR AGLPVVVSIA GSSEDEFSRL ASAAEEAGAD 

       130        140        150        160        170        180 
AIEVNLSCPH AKGMGREIGI EPRLVYSVVS ATASVTRIPV IAKLGYVDRL VEAVGKALEA 

       190        200        210        220        230        240 
GARAVTLINT LPAMMIDVYA MKPVLGNLVG GLSGPAIHPV AVRAIYEVYR EYRIDIIGAG 

       250        260        270        280        290        300 
GVEDWRTAAE LVLAGARAVQ VGTALVTRGL RVIGEIVQGL ERYMEEVGVE SIEELVGAAH 


RD

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References

[1]"The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C."
Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P.
Archaea 2:127-135(2007) [PubMed: 17350933] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 5456 / JCM 9403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000493 Genomic DNA. Translation: ABM80133.1.
RefSeqYP_001012478.1. NC_008818.1.

3D structure databases

ProteinModelPortalA2BJH2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2BJH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4781695.
GenomeReviewsGene locus Hbut_0261 in contig CP000493_GR.
KEGGhbu:Hbut_0261.

Phylogenomic databases

eggNOGarNOG04551.
HOGENOMHBG472415.
OMAVALRMVW.
PhylomeDBA2BJH2.
ProtClustDBPRK07259.

Family and domain databases

HAMAPMF_00224. DHO_dh_type1.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00226.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsTIGR01037. PyrD_sub1_fam. 1 hit.
PROSITEPS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2BJH2_HYPBU
AccessionPrimary (citable) accession number: A2BJH2
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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