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A2BIU4

- MTAP_HYPBU

UniProt

A2BIU4 - MTAP_HYPBU

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
mtnP, Hbut_0022
Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Phosphate By similarity
Sitei175 – 1751Important for substrate specificity By similarity
Binding sitei194 – 1941Substrate; via amide nitrogen By similarity
Binding sitei195 – 1951Phosphate By similarity
Sitei229 – 2291Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciHBUT415426:GC56-22-MONOMER.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Gene namesi
Name:mtnP
Ordered Locus Names:Hbut_0022
OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403)
Taxonomic identifieri415426 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
ProteomesiUP000002593: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000415104Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi415426.Hbut_0022.

Structurei

3D structure databases

ProteinModelPortaliA2BIU4.
SMRiA2BIU4. Positions 7-274.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 632Phosphate binding By similarity
Regioni95 – 962Phosphate binding By similarity
Regioni218 – 2203Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0005.
HOGENOMiHOG000228987.
KOiK00772.
OMAiCEAQLCY.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BIU4-1 [UniParc]FASTAAdd to Basket

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MPDFPPKPSV KADIAIIGGS GLYDPGVLEN AKEYKIYTPY GEPSDYIIVG    50
ELGGKRVAFL PRHGRGHRIP PHKINYRANI WALKMLGVKW VIAVSAVGSL 100
REDYKPGDIV VPDQFIDMTK SRVYTFFDEG IVAHVSMADP FCEHLRQEII 150
STARELGYRV HPRGTYICIE GPRFSTRAES RVWREVFKAD IIGMTLVPEV 200
NLACEAQLCY ATIALVTDYD VWAERPVTAE EVARVMKENT EKAKKILYKL 250
IPRLPPEPDK ARCSCCSSLE TALL 274
Length:274
Mass (Da):30,784
Last modified:February 20, 2007 - v1
Checksum:i305ED09C45DDCE01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000493 Genomic DNA. Translation: ABM79900.1.
RefSeqiYP_001012245.1. NC_008818.1.

Genome annotation databases

EnsemblBacteriaiABM79900; ABM79900; Hbut_0022.
GeneIDi4782054.
KEGGihbu:Hbut_0022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000493 Genomic DNA. Translation: ABM79900.1 .
RefSeqi YP_001012245.1. NC_008818.1.

3D structure databases

ProteinModelPortali A2BIU4.
SMRi A2BIU4. Positions 7-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 415426.Hbut_0022.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM79900 ; ABM79900 ; Hbut_0022 .
GeneIDi 4782054.
KEGGi hbu:Hbut_0022.

Phylogenomic databases

eggNOGi COG0005.
HOGENOMi HOG000228987.
KOi K00772.
OMAi CEAQLCY.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
BioCyci HBUT415426:GC56-22-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C."
    Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P.
    Archaea 2:127-135(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5456 / JCM 9403.

Entry informationi

Entry nameiMTAP_HYPBU
AccessioniPrimary (citable) accession number: A2BIU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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