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A2BIU4

- MTAP_HYPBU

UniProt

A2BIU4 - MTAP_HYPBU

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201PhosphateUniRule annotation
    Sitei175 – 1751Important for substrate specificityUniRule annotation
    Binding sitei194 – 1941Substrate; via amide nitrogenUniRule annotation
    Binding sitei195 – 1951PhosphateUniRule annotation
    Sitei229 – 2291Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciHBUT415426:GC56-22-MONOMER.
    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Gene namesi
    Name:mtnPUniRule annotation
    Ordered Locus Names:Hbut_0022
    OrganismiHyperthermus butylicus (strain DSM 5456 / JCM 9403)
    Taxonomic identifieri415426 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesPyrodictiaceaeHyperthermus
    ProteomesiUP000002593: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274S-methyl-5'-thioadenosine phosphorylasePRO_0000415104Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. Dimer of a homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi415426.Hbut_0022.

    Structurei

    3D structure databases

    ProteinModelPortaliA2BIU4.
    SMRiA2BIU4. Positions 7-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 632Phosphate bindingUniRule annotation
    Regioni95 – 962Phosphate bindingUniRule annotation
    Regioni218 – 2203Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000228987.
    KOiK00772.
    OMAiCEAQLCY.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2BIU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDFPPKPSV KADIAIIGGS GLYDPGVLEN AKEYKIYTPY GEPSDYIIVG    50
    ELGGKRVAFL PRHGRGHRIP PHKINYRANI WALKMLGVKW VIAVSAVGSL 100
    REDYKPGDIV VPDQFIDMTK SRVYTFFDEG IVAHVSMADP FCEHLRQEII 150
    STARELGYRV HPRGTYICIE GPRFSTRAES RVWREVFKAD IIGMTLVPEV 200
    NLACEAQLCY ATIALVTDYD VWAERPVTAE EVARVMKENT EKAKKILYKL 250
    IPRLPPEPDK ARCSCCSSLE TALL 274
    Length:274
    Mass (Da):30,784
    Last modified:February 20, 2007 - v1
    Checksum:i305ED09C45DDCE01
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000493 Genomic DNA. Translation: ABM79900.1.
    RefSeqiYP_001012245.1. NC_008818.1.

    Genome annotation databases

    EnsemblBacteriaiABM79900; ABM79900; Hbut_0022.
    GeneIDi4782054.
    KEGGihbu:Hbut_0022.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000493 Genomic DNA. Translation: ABM79900.1 .
    RefSeqi YP_001012245.1. NC_008818.1.

    3D structure databases

    ProteinModelPortali A2BIU4.
    SMRi A2BIU4. Positions 7-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 415426.Hbut_0022.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM79900 ; ABM79900 ; Hbut_0022 .
    GeneIDi 4782054.
    KEGGi hbu:Hbut_0022.

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000228987.
    KOi K00772.
    OMAi CEAQLCY.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .
    BioCyci HBUT415426:GC56-22-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C."
      Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M., She Q., Garrett R.A., Klenk H.-P.
      Archaea 2:127-135(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 5456 / JCM 9403.

    Entry informationi

    Entry nameiMTAP_HYPBU
    AccessioniPrimary (citable) accession number: A2BIU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3