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A2BH40

- ARI1A_MOUSE

UniProt

A2BH40 - ARI1A_MOUSE

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Protein

AT-rich interactive domain-containing protein 1A

Gene

Arid1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.By similarity1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. androgen receptor signaling pathway Source: UniProtKB
  2. ATP-dependent chromatin remodeling Source: MGI
  3. cardiac chamber development Source: MGI
  4. chromatin organization Source: MGI
  5. forebrain development Source: MGI
  6. intracellular estrogen receptor signaling pathway Source: UniProtKB
  7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  8. neural tube closure Source: MGI
  9. optic cup formation involved in camera-type eye development Source: MGI
  10. placenta blood vessel development Source: MGI
  11. positive regulation of transcription, DNA-templated Source: UniProtKB
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_244207. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 1A
Short name:
ARID domain-containing protein 1A
Alternative name(s):
BRG1-associated factor 250
Short name:
BAF250
BRG1-associated factor 250a
Short name:
BAF250A
Osa homolog 1
SWI-like protein
SWI/SNF complex protein p270
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
Gene namesi
Name:Arid1a
Synonyms:Baf250, Baf250a, Osa1, Smarcf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1935147. Arid1a.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. BAF-type complex Source: MGI
  2. nBAF complex Source: UniProtKB
  3. npBAF complex Source: UniProtKB
  4. nuclear chromatin Source: MGI
  5. SWI/SNF complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 22832282AT-rich interactive domain-containing protein 1APRO_0000391619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei287 – 2871PhosphothreonineBy similarity
Modified residuei302 – 3021PhosphoserineBy similarity
Modified residuei365 – 3651Phosphoserine1 Publication
Modified residuei605 – 6051PhosphoserineBy similarity
Modified residuei697 – 6971Phosphoserine1 Publication
Modified residuei699 – 6991PhosphoserineBy similarity
Modified residuei703 – 7031PhosphoserineBy similarity
Modified residuei765 – 7651PhosphoserineBy similarity
Modified residuei773 – 7731PhosphoserineBy similarity
Modified residuei1185 – 11851PhosphoserineBy similarity
Modified residuei1605 – 16051PhosphoserineBy similarity
Modified residuei1613 – 16131N6-acetyllysineBy similarity
Modified residuei1903 – 19031N6-acetyllysineBy similarity
Modified residuei1942 – 19421PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiA2BH40.
PaxDbiA2BH40.
PRIDEiA2BH40.

PTM databases

PhosphoSiteiA2BH40.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high levels in the testis.1 Publication

Developmental stagei

Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5. In the earlier stages at E9.5 and E10.5, is fairly ubiquitous though with clearly elevated expression in the progress zone and lateral mesoderm of limb buds, optic and otic vesicle, neural tube, and brain. Later on at E11.5 and E12.5, expression becomes more restricted and is confined to the interdigital area of limbs, dorsal mes/metencephalon, neocortex, and neural tube. Expression is seen in the eye lens from E10.5 until E12.5.2 Publications

Gene expression databases

BgeeiA2BH40.
ExpressionAtlasiA2BH40. baseline and differential.
GenevestigatoriA2BH40.

Interactioni

Subunit structurei

Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the SWI/SNF-B (PBAF) complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Component of the SWI/SNF Brm complex, at least composed of SMARCA2/BRM/BAF190B, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, HDAC1, HDAC2, and RBAP4. Component of the SWI/SNF complex Brg1(I), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, and probably HDAC2 and RBAP4. Component of the SWI/SNF Brg1(II), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A and probably HDAC2 and RBAP4. Component of a SWI/SNF-like EPAFa complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL. Component of a SWI/SNF-like complex containing ARID1A/BAF250A and ARID1B/BAF250B. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with SMARCC1/BAF155 (By similarity). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Smarca4O358452EBI-371499,EBI-371515

Protein-protein interaction databases

BioGridi220298. 17 interactions.
DIPiDIP-58952N.
IntActiA2BH40. 21 interactions.
MINTiMINT-4123278.
STRINGi10090.ENSMUSP00000101517.

Structurei

3D structure databases

ProteinModelPortaliA2BH40.
SMRiA2BH40. Positions 1001-1120, 1673-1700, 2146-2196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1018 – 110992ARIDPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi296 – 3005LXXLL
Motifi1710 – 17145LXXLL
Motifi1965 – 19695LXXLL
Motifi2083 – 20875LXXLL

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 205Poly-Pro
Compositional biasi38 – 436Poly-Ala
Compositional biasi53 – 425373Gly-richAdd
BLAST
Compositional biasi331 – 35020Ala-richAdd
BLAST
Compositional biasi405 – 612208Gln-richAdd
BLAST
Compositional biasi999 – 10024Poly-Ser
Compositional biasi1328 – 1500173Gln-richAdd
BLAST
Compositional biasi1545 – 1644100Pro-richAdd
BLAST
Compositional biasi1761 – 17666Poly-Glu
Compositional biasi1773 – 17786Poly-Glu

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00550000074575.
HOGENOMiHOG000232161.
HOVERGENiHBG058196.
InParanoidiA2BH40.
KOiK11653.
PhylomeDBiA2BH40.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR001606. ARID/BRIGHT_DNA-bd.
IPR016024. ARM-type_fold.
IPR021906. DUF3518.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
PF12031. DUF3518. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
SSF48371. SSF48371. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2BH40-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQVAPAAA SSLGNPPPPP SELKKAEQQQ REEAGGEAAA AAAERGEMKA
60 70 80 90 100
AAGQESEGPA VGPPQPLGKE LQDGAESNGG GGGGGAGSGG GPGAEPDLKN
110 120 130 140 150
SNGNAGPRPA LNNNLPEPPG GGGGGGSSSS DGVGAPPHSA AAALPPPAYG
160 170 180 190 200
FGQAYGRSPS AVAAAAAAVF HQQHGGQQSP GLAALQSGGG GGLEPYAGPQ
210 220 230 240 250
QNSHDHGFPN HQYNSYYPNR SAYPPPPQAY ALSSPRGGTP GSGAAAAAGS
260 270 280 290 300
KPPPSSSASA SSSSSSFAQQ RFGAMGGGGP SAAGGGTPQP TATPTLNQLL
310 320 330 340 350
TSPSSARGYQ GYPGGDYGGG PQDGGAGKGP ADMASQCWGA AAAAAAAAAA
360 370 380 390 400
VSGGAQQRSH HAPMSPGSSG GGGQPLARTP QSSSPMDQMG KMRPQPYGGT
410 420 430 440 450
NPYSQQQGPP SGPQQGHGYP GQPYGSQTPQ RYPMTMQGRA QSAMGSLSYA
460 470 480 490 500
QQIPPYGQQG PSAYGQQGQT PYYNQQSPHP QQQPPYAQQP PSQTPHAQPS
510 520 530 540 550
YQQQPQTQQP QLQSSQPPYS QQPSQPPHQQ SPTPYPSQQS TTQQHPQSQP
560 570 580 590 600
PYSQPQAQSP YQQQQPQQPA SSSLSQQAAY PQPQPQQSQQ TAYSQQRFPP
610 620 630 640 650
PQELSQDSFG SQASSAPSMT SSKGGQEDMN LSLQSRPSSL PDLSGSIDDL
660 670 680 690 700
PMGTEGALSP GVSTSGISSS QGEQSNPAQS PFSPHTSPHL PGIRGPSPSP
710 720 730 740 750
VGSPASVAQS RSGPLSPAAV PGNQMPPRPP SGQSDSIMHP SMNQSSIAQD
760 770 780 790 800
RGYMQRNPQM PQYTSPQPGS ALSPRQPSGG QMHSGVGSYQ QNSMGSYGPQ
810 820 830 840 850
GSQYGPQGGY PRQPNYNALP NANYPNAGMA GSMNPMGAGG QMHGQPGIPP
860 870 880 890 900
YGTLPPGRMA HASMGNRPYG PNMANMPPQV GSGMCPPPGG MNRKTQESAV
910 920 930 940 950
AMHVAANSIQ NRPPGYPNMN QGGMMGTGPP YGQGINSMAG MINPQGPPYP
960 970 980 990 1000
MGGTMANNSA GMAASPEMMG LGDVKLTPAT KMNNKADGTP KTESKSKKSS
1010 1020 1030 1040 1050
SSTTTNEKIT KLYELGGEPE RKMWVDRYLA FTEEKAMGMT NLPAVGRKPL
1060 1070 1080 1090 1100
DLYRLYVSVK EIGGLTQVNK NKKWRELATN LNVGTSSSAA SSLKKQYIQC
1110 1120 1130 1140 1150
LYAFECKIER GEDPPPDIFA AADSKKSQPK IQPPSPAGSG SMQGPQTPQS
1160 1170 1180 1190 1200
TSSSMAEGGD LKPPTPASTP HSQIPPLPGM SRSNSVGIQD AFPDGSDPTF
1210 1220 1230 1240 1250
QKRNSMTPNP GYQPSMNTSD MMGRMSYEPN KDPYGSMRKA PGSDPFMSSG
1260 1270 1280 1290 1300
QGPNGGMGDP YSRAAGPGLG SVAMGPRQHY PYGGPYDRVR TEPGIGPEGN
1310 1320 1330 1340 1350
MGTGAPQPNL MPSTPDSGMY SPSRYPPQQQ QQQQQQHDSY GNQFSTQGTP
1360 1370 1380 1390 1400
SSSPFPSQQT TMYQQQQQNY KRPMDGTYGP PAKRHEGEMY SVPYSAGQGQ
1410 1420 1430 1440 1450
PQQQQLPAAQ SQPASQPQAA QPSPQQDVYN QYSNAYPASA TAATDRRPAG
1460 1470 1480 1490 1500
GPQNQFPFQF GRDRVSAPPG SSAQQNMPPQ MMGGPIQASA EVAQQGTMWQ
1510 1520 1530 1540 1550
GRNDMTYNYA NRQNTGSATQ GPAYHGVNRT DEMLHTDQRA NHEGPWPSHG
1560 1570 1580 1590 1600
TRQPPYGPSA PVPPMTRPPP SNYQPPPSMP NHIPQVSSPA PLPRPMENRT
1610 1620 1630 1640 1650
SPSKSPFLHS GMKMQKAGPP VPASHIAPTP VQPPMIRRDI TFPPGSVEAT
1660 1670 1680 1690 1700
QPVLKQRRRL TMKDIGTPEA WRVMMSLKSG LLAESTWALD TINILLYDDN
1710 1720 1730 1740 1750
SIMTFNLSQL PGLLELLVEY FRRCLIEIFG ILKEYEVGDP GQRTLLDPGR
1760 1770 1780 1790 1800
FTKVYSPAHT EEEEEEHLDP KLEEEEEEGV GNDEEMAFLG KDKPSSENNE
1810 1820 1830 1840 1850
EKLVSKFDKL PVKIVQRNDP FVVDCSDKLG RVQEFDSGLL HWRIGGGDTT
1860 1870 1880 1890 1900
EHIQTHFESK IELLPSRPYV PCPTPPRKHL TTVEGTPGTT EQEGPPPDGL
1910 1920 1930 1940 1950
PEKRITATMD DMLSTRSSTL TDEGAKSAEA TKESSKFPFG ISPAQSHRNI
1960 1970 1980 1990 2000
KILEDEPHSK DETPLCTLLD WQDSLAKRCV CVSNTIRSLS FVPGNDFEMS
2010 2020 2030 2040 2050
KHPGLLLILG KLILLHHKHP ERKQAPLTYE KEEEQDQGVS CDKVEWWWDC
2060 2070 2080 2090 2100
LEMLRENTLV TLANISGQLD LSPYPESICL PVLDGLLHWA VCPSAEAQDP
2110 2120 2130 2140 2150
FSTLGPNAVL SPQRLVLETL SKLSIQDNNV DLILATPPFS RLEKLYSTMV
2160 2170 2180 2190 2200
RFLSDRKNPV CREMAVVLLA NLAQGDSLAA RAIAVQKGSI GNLLGFLEDS
2210 2220 2230 2240 2250
LAATQFQQSQ ASLLHMQNPP FEPTSVDMMR RAARALLALA KVDENHSEFT
2260 2270 2280
LYESRLLDIS VSPLMNSLVS QVICDVLFLI GQS
Length:2,283
Mass (Da):242,092
Last modified:February 20, 2007 - v1
Checksum:i0F14BB1372CC4268
GO
Isoform 2 (identifier: A2BH40-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-385: Missing.
     1336-1336: Q → QQQQQR

Show »
Length:1,903
Mass (Da):206,488
Checksum:i0080AA3C078CE09C
GO
Isoform 3 (identifier: A2BH40-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1367-1583: Missing.

Show »
Length:2,066
Mass (Da):218,477
Checksum:i4532D4C3766E31D5
GO
Isoform 4 (identifier: A2BH40-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-385: Missing.
     1181-1181: Missing.
     1336-1336: Q → QQQQQR

Show »
Length:1,902
Mass (Da):206,400
Checksum:i2CEFFA889AE68DC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti697 – 6971S → F in AAK54504. (PubMed:11318604)Curated
Sequence conflicti750 – 7501D → E in AAK54504. (PubMed:11318604)Curated
Sequence conflicti758 – 7581P → S in AAK54504. (PubMed:11318604)Curated
Sequence conflicti833 – 8331M → I in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1011 – 10111K → Q in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1148 – 11481P → H in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1181 – 11822SR → G in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1635 – 16351M → I in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1755 – 17551Y → S in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1795 – 17951S → P in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1799 – 17991N → S in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1929 – 19291E → D in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1956 – 19561E → D in AAK54504. (PubMed:11318604)Curated
Sequence conflicti1974 – 19741S → P in AAK54504. (PubMed:11318604)Curated
Sequence conflicti2233 – 22331A → P in AAK54504. (PubMed:11318604)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 385385Missing in isoform 2 and isoform 4. 2 PublicationsVSP_038737Add
BLAST
Alternative sequencei1181 – 11811Missing in isoform 4. 1 PublicationVSP_038738
Alternative sequencei1336 – 13361Q → QQQQQR in isoform 2 and isoform 4. 2 PublicationsVSP_038739
Alternative sequencei1367 – 1583217Missing in isoform 3. CuratedVSP_038740Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268912 mRNA. Translation: AAK54504.1.
CR751606, BX537327, CR925752 Genomic DNA. Translation: CAM20580.1.
BX537327, CR751606, CR925752 Genomic DNA. Translation: CAM25151.1.
CR925752, BX537327, CR751606 Genomic DNA. Translation: CAM27607.1.
BC082554 mRNA. Translation: AAH82554.1.
CCDSiCCDS38908.1. [A2BH40-1]
RefSeqiNP_001074288.1. NM_001080819.1. [A2BH40-1]
UniGeneiMm.22478.

Genome annotation databases

EnsembliENSMUST00000008024; ENSMUSP00000008024; ENSMUSG00000007880.
ENSMUST00000105897; ENSMUSP00000101517; ENSMUSG00000007880. [A2BH40-1]
GeneIDi93760.
KEGGimmu:93760.
UCSCiuc008vdh.1. mouse. [A2BH40-1]
uc008vdj.1. mouse. [A2BH40-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268912 mRNA. Translation: AAK54504.1 .
CR751606 , BX537327 , CR925752 Genomic DNA. Translation: CAM20580.1 .
BX537327 , CR751606 , CR925752 Genomic DNA. Translation: CAM25151.1 .
CR925752 , BX537327 , CR751606 Genomic DNA. Translation: CAM27607.1 .
BC082554 mRNA. Translation: AAH82554.1 .
CCDSi CCDS38908.1. [A2BH40-1 ]
RefSeqi NP_001074288.1. NM_001080819.1. [A2BH40-1 ]
UniGenei Mm.22478.

3D structure databases

ProteinModelPortali A2BH40.
SMRi A2BH40. Positions 1001-1120, 1673-1700, 2146-2196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 220298. 17 interactions.
DIPi DIP-58952N.
IntActi A2BH40. 21 interactions.
MINTi MINT-4123278.
STRINGi 10090.ENSMUSP00000101517.

PTM databases

PhosphoSitei A2BH40.

Proteomic databases

MaxQBi A2BH40.
PaxDbi A2BH40.
PRIDEi A2BH40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000008024 ; ENSMUSP00000008024 ; ENSMUSG00000007880 .
ENSMUST00000105897 ; ENSMUSP00000101517 ; ENSMUSG00000007880 . [A2BH40-1 ]
GeneIDi 93760.
KEGGi mmu:93760.
UCSCi uc008vdh.1. mouse. [A2BH40-1 ]
uc008vdj.1. mouse. [A2BH40-4 ]

Organism-specific databases

CTDi 8289.
MGIi MGI:1935147. Arid1a.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00550000074575.
HOGENOMi HOG000232161.
HOVERGENi HBG058196.
InParanoidi A2BH40.
KOi K11653.
PhylomeDBi A2BH40.

Enzyme and pathway databases

Reactomei REACT_244207. RMTs methylate histone arginines.

Miscellaneous databases

ChiTaRSi Arid1a. mouse.
NextBioi 351643.
PROi A2BH40.
SOURCEi Search...

Gene expression databases

Bgeei A2BH40.
ExpressionAtlasi A2BH40. baseline and differential.
Genevestigatori A2BH40.

Family and domain databases

Gene3Di 1.10.150.60. 1 hit.
InterProi IPR001606. ARID/BRIGHT_DNA-bd.
IPR016024. ARM-type_fold.
IPR021906. DUF3518.
[Graphical view ]
Pfami PF01388. ARID. 1 hit.
PF12031. DUF3518. 1 hit.
[Graphical view ]
SMARTi SM00501. BRIGHT. 1 hit.
[Graphical view ]
SUPFAMi SSF46774. SSF46774. 1 hit.
SSF48371. SSF48371. 1 hit.
PROSITEi PS51011. ARID. 1 hit.
[Graphical view ]
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Publicationsi

« Hide 'large scale' publications
  1. "Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex."
    Kozmik Z., Machon O., Kralova J., Kreslova J., Paces J., Vlcek C.
    Genomics 73:140-148(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "An essential switch in subunit composition of a chromatin remodeling complex during neural development."
    Lessard J., Wu J.I., Ranish J.A., Wan M., Winslow M.M., Staahl B.T., Wu H., Aebersold R., Graef I.A., Crabtree G.R.
    Neuron 55:201-215(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NBAF AND NPBAF COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NBAF AND NPBAF COMPLEXES, DEVELOPMENTAL STAGE.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-697, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARI1A_MOUSE
AccessioniPrimary (citable) accession number: A2BH40
Secondary accession number(s): Q640Q1, Q925Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3