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A2BH40 (ARI1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
AT-rich interactive domain-containing protein 1A

Short name=ARID domain-containing protein 1A
Alternative name(s):
BRG1-associated factor 250
Short name=BAF250
BRG1-associated factor 250a
Short name=BAF250A
Osa homolog 1
SWI-like protein
SWI/SNF complex protein p270
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
Gene names
Name:Arid1a
Synonyms:Baf250, Baf250a, Osa1, Smarcf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2283 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene By similarity. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Ref.4

Subunit structure

Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the SWI/SNF-B (PBAF) complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Component of the SWI/SNF Brm complex, at least composed of SMARCA2/BRM/BAF190B, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, HDAC1, HDAC2, and RBAP4. Component of the SWI/SNF complex Brg1(I), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, and probably HDAC2 and RBAP4. Component of the SWI/SNF Brg1(II), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A and probably HDAC2 and RBAP4. Component of a SWI/SNF-like EPAFa complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL. Component of a SWI/SNF-like complex containing ARID1A/BAF250A and ARID1B/BAF250B. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with SMARCC1/BAF155 By similarity. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Ref.4

Subcellular location

Nucleus By similarity.

Tissue specificity

Widely expressed. Expressed at high levels in the testis. Ref.1

Developmental stage

Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5. In the earlier stages at E9.5 and E10.5, is fairly ubiquitous though with clearly elevated expression in the progress zone and lateral mesoderm of limb buds, optic and otic vesicle, neural tube, and brain. Later on at E11.5 and E12.5, expression becomes more restricted and is confined to the interdigital area of limbs, dorsal mes/metencephalon, neocortex, and neural tube. Expression is seen in the eye lens from E10.5 until E12.5. Ref.1 Ref.4

Sequence similarities

Contains 1 ARID domain.

Ontologies

Keywords
   Biological processNeurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandDNA-binding
   Molecular functionChromatin regulator
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processATP-dependent chromatin remodeling

Inferred from direct assay PubMed 23129809. Source: MGI

androgen receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

cardiac chamber development

Inferred from mutant phenotype PubMed 23129809. Source: MGI

chromatin organization

Inferred from physical interaction Ref.1. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 23129809. Source: MGI

glucocorticoid receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

intracellular estrogen receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 23129809. Source: MGI

neural tube closure

Inferred from mutant phenotype PubMed 23129809. Source: MGI

nucleosome disassembly

Inferred from electronic annotation. Source: Ensembl

optic cup formation involved in camera-type eye development

Inferred from mutant phenotype PubMed 23129809. Source: MGI

placenta blood vessel development

Inferred from mutant phenotype PubMed 23129809. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentBAF-type complex

Inferred from direct assay PubMed 23129809. Source: MGI

SWI/SNF complex

Inferred from sequence or structural similarity. Source: UniProtKB

nBAF complex

Inferred from direct assay Ref.4. Source: UniProtKB

npBAF complex

Inferred from direct assay Ref.4. Source: UniProtKB

nuclear chromatin

Inferred from direct assay PubMed 23129809. Source: MGI

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 11988099. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Smarca4O358452EBI-371499,EBI-371515

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A2BH40-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A2BH40-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-385: Missing.
     1336-1336: Q → QQQQQR
Isoform 3 (identifier: A2BH40-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1367-1583: Missing.
Isoform 4 (identifier: A2BH40-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2-385: Missing.
     1181-1181: Missing.
     1336-1336: Q → QQQQQR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 22832282AT-rich interactive domain-containing protein 1A
PRO_0000391619

Regions

Domain1018 – 110992ARID
Motif296 – 3005LXXLL
Motif1710 – 17145LXXLL
Motif1965 – 19695LXXLL
Motif2083 – 20875LXXLL
Compositional bias16 – 205Poly-Pro
Compositional bias38 – 436Poly-Ala
Compositional bias53 – 425373Gly-rich
Compositional bias331 – 35020Ala-rich
Compositional bias405 – 612208Gln-rich
Compositional bias999 – 10024Poly-Ser
Compositional bias1328 – 1500173Gln-rich
Compositional bias1545 – 1644100Pro-rich
Compositional bias1761 – 17666Poly-Glu
Compositional bias1773 – 17786Poly-Glu

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue771Phosphoserine By similarity
Modified residue2871Phosphothreonine By similarity
Modified residue3021Phosphoserine By similarity
Modified residue3651Phosphoserine Ref.6
Modified residue6051Phosphoserine By similarity
Modified residue6971Phosphoserine Ref.5
Modified residue6991Phosphoserine By similarity
Modified residue7031Phosphoserine By similarity
Modified residue7651Phosphoserine By similarity
Modified residue7731Phosphoserine By similarity
Modified residue11851Phosphoserine By similarity
Modified residue16051Phosphoserine By similarity
Modified residue16131N6-acetyllysine By similarity
Modified residue19031N6-acetyllysine By similarity
Modified residue19421Phosphoserine By similarity

Natural variations

Alternative sequence2 – 385384Missing in isoform 2 and isoform 4.
VSP_038737
Alternative sequence11811Missing in isoform 4.
VSP_038738
Alternative sequence13361Q → QQQQQR in isoform 2 and isoform 4.
VSP_038739
Alternative sequence1367 – 1583217Missing in isoform 3.
VSP_038740

Experimental info

Sequence conflict6971S → F in AAK54504. Ref.1
Sequence conflict7501D → E in AAK54504. Ref.1
Sequence conflict7581P → S in AAK54504. Ref.1
Sequence conflict8331M → I in AAK54504. Ref.1
Sequence conflict10111K → Q in AAK54504. Ref.1
Sequence conflict11481P → H in AAK54504. Ref.1
Sequence conflict1181 – 11822SR → G in AAK54504. Ref.1
Sequence conflict16351M → I in AAK54504. Ref.1
Sequence conflict17551Y → S in AAK54504. Ref.1
Sequence conflict17951S → P in AAK54504. Ref.1
Sequence conflict17991N → S in AAK54504. Ref.1
Sequence conflict19291E → D in AAK54504. Ref.1
Sequence conflict19561E → D in AAK54504. Ref.1
Sequence conflict19741S → P in AAK54504. Ref.1
Sequence conflict22331A → P in AAK54504. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 0F14BB1372CC4268

FASTA2,283242,092
        10         20         30         40         50         60 
MAAQVAPAAA SSLGNPPPPP SELKKAEQQQ REEAGGEAAA AAAERGEMKA AAGQESEGPA 

        70         80         90        100        110        120 
VGPPQPLGKE LQDGAESNGG GGGGGAGSGG GPGAEPDLKN SNGNAGPRPA LNNNLPEPPG 

       130        140        150        160        170        180 
GGGGGGSSSS DGVGAPPHSA AAALPPPAYG FGQAYGRSPS AVAAAAAAVF HQQHGGQQSP 

       190        200        210        220        230        240 
GLAALQSGGG GGLEPYAGPQ QNSHDHGFPN HQYNSYYPNR SAYPPPPQAY ALSSPRGGTP 

       250        260        270        280        290        300 
GSGAAAAAGS KPPPSSSASA SSSSSSFAQQ RFGAMGGGGP SAAGGGTPQP TATPTLNQLL 

       310        320        330        340        350        360 
TSPSSARGYQ GYPGGDYGGG PQDGGAGKGP ADMASQCWGA AAAAAAAAAA VSGGAQQRSH 

       370        380        390        400        410        420 
HAPMSPGSSG GGGQPLARTP QSSSPMDQMG KMRPQPYGGT NPYSQQQGPP SGPQQGHGYP 

       430        440        450        460        470        480 
GQPYGSQTPQ RYPMTMQGRA QSAMGSLSYA QQIPPYGQQG PSAYGQQGQT PYYNQQSPHP 

       490        500        510        520        530        540 
QQQPPYAQQP PSQTPHAQPS YQQQPQTQQP QLQSSQPPYS QQPSQPPHQQ SPTPYPSQQS 

       550        560        570        580        590        600 
TTQQHPQSQP PYSQPQAQSP YQQQQPQQPA SSSLSQQAAY PQPQPQQSQQ TAYSQQRFPP 

       610        620        630        640        650        660 
PQELSQDSFG SQASSAPSMT SSKGGQEDMN LSLQSRPSSL PDLSGSIDDL PMGTEGALSP 

       670        680        690        700        710        720 
GVSTSGISSS QGEQSNPAQS PFSPHTSPHL PGIRGPSPSP VGSPASVAQS RSGPLSPAAV 

       730        740        750        760        770        780 
PGNQMPPRPP SGQSDSIMHP SMNQSSIAQD RGYMQRNPQM PQYTSPQPGS ALSPRQPSGG 

       790        800        810        820        830        840 
QMHSGVGSYQ QNSMGSYGPQ GSQYGPQGGY PRQPNYNALP NANYPNAGMA GSMNPMGAGG 

       850        860        870        880        890        900 
QMHGQPGIPP YGTLPPGRMA HASMGNRPYG PNMANMPPQV GSGMCPPPGG MNRKTQESAV 

       910        920        930        940        950        960 
AMHVAANSIQ NRPPGYPNMN QGGMMGTGPP YGQGINSMAG MINPQGPPYP MGGTMANNSA 

       970        980        990       1000       1010       1020 
GMAASPEMMG LGDVKLTPAT KMNNKADGTP KTESKSKKSS SSTTTNEKIT KLYELGGEPE 

      1030       1040       1050       1060       1070       1080 
RKMWVDRYLA FTEEKAMGMT NLPAVGRKPL DLYRLYVSVK EIGGLTQVNK NKKWRELATN 

      1090       1100       1110       1120       1130       1140 
LNVGTSSSAA SSLKKQYIQC LYAFECKIER GEDPPPDIFA AADSKKSQPK IQPPSPAGSG 

      1150       1160       1170       1180       1190       1200 
SMQGPQTPQS TSSSMAEGGD LKPPTPASTP HSQIPPLPGM SRSNSVGIQD AFPDGSDPTF 

      1210       1220       1230       1240       1250       1260 
QKRNSMTPNP GYQPSMNTSD MMGRMSYEPN KDPYGSMRKA PGSDPFMSSG QGPNGGMGDP 

      1270       1280       1290       1300       1310       1320 
YSRAAGPGLG SVAMGPRQHY PYGGPYDRVR TEPGIGPEGN MGTGAPQPNL MPSTPDSGMY 

      1330       1340       1350       1360       1370       1380 
SPSRYPPQQQ QQQQQQHDSY GNQFSTQGTP SSSPFPSQQT TMYQQQQQNY KRPMDGTYGP 

      1390       1400       1410       1420       1430       1440 
PAKRHEGEMY SVPYSAGQGQ PQQQQLPAAQ SQPASQPQAA QPSPQQDVYN QYSNAYPASA 

      1450       1460       1470       1480       1490       1500 
TAATDRRPAG GPQNQFPFQF GRDRVSAPPG SSAQQNMPPQ MMGGPIQASA EVAQQGTMWQ 

      1510       1520       1530       1540       1550       1560 
GRNDMTYNYA NRQNTGSATQ GPAYHGVNRT DEMLHTDQRA NHEGPWPSHG TRQPPYGPSA 

      1570       1580       1590       1600       1610       1620 
PVPPMTRPPP SNYQPPPSMP NHIPQVSSPA PLPRPMENRT SPSKSPFLHS GMKMQKAGPP 

      1630       1640       1650       1660       1670       1680 
VPASHIAPTP VQPPMIRRDI TFPPGSVEAT QPVLKQRRRL TMKDIGTPEA WRVMMSLKSG 

      1690       1700       1710       1720       1730       1740 
LLAESTWALD TINILLYDDN SIMTFNLSQL PGLLELLVEY FRRCLIEIFG ILKEYEVGDP 

      1750       1760       1770       1780       1790       1800 
GQRTLLDPGR FTKVYSPAHT EEEEEEHLDP KLEEEEEEGV GNDEEMAFLG KDKPSSENNE 

      1810       1820       1830       1840       1850       1860 
EKLVSKFDKL PVKIVQRNDP FVVDCSDKLG RVQEFDSGLL HWRIGGGDTT EHIQTHFESK 

      1870       1880       1890       1900       1910       1920 
IELLPSRPYV PCPTPPRKHL TTVEGTPGTT EQEGPPPDGL PEKRITATMD DMLSTRSSTL 

      1930       1940       1950       1960       1970       1980 
TDEGAKSAEA TKESSKFPFG ISPAQSHRNI KILEDEPHSK DETPLCTLLD WQDSLAKRCV 

      1990       2000       2010       2020       2030       2040 
CVSNTIRSLS FVPGNDFEMS KHPGLLLILG KLILLHHKHP ERKQAPLTYE KEEEQDQGVS 

      2050       2060       2070       2080       2090       2100 
CDKVEWWWDC LEMLRENTLV TLANISGQLD LSPYPESICL PVLDGLLHWA VCPSAEAQDP 

      2110       2120       2130       2140       2150       2160 
FSTLGPNAVL SPQRLVLETL SKLSIQDNNV DLILATPPFS RLEKLYSTMV RFLSDRKNPV 

      2170       2180       2190       2200       2210       2220 
CREMAVVLLA NLAQGDSLAA RAIAVQKGSI GNLLGFLEDS LAATQFQQSQ ASLLHMQNPP 

      2230       2240       2250       2260       2270       2280 
FEPTSVDMMR RAARALLALA KVDENHSEFT LYESRLLDIS VSPLMNSLVS QVICDVLFLI 


GQS 

« Hide

Isoform 2 [UniParc].

Checksum: DE732A3D63CFFC0F
Show »

FASTA1,904206,619
Isoform 3 [UniParc].

Checksum: 4532D4C3766E31D5
Show »

FASTA2,066218,477
Isoform 4 [UniParc].

Checksum: 1F6FFBECD9FA1E46
Show »

FASTA1,903206,532

References

« Hide 'large scale' references
[1]"Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex."
Kozmik Z., Machon O., Kralova J., Kreslova J., Paces J., Vlcek C.
Genomics 73:140-148(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Strain: C57BL/6.
Tissue: Brain.
[4]"An essential switch in subunit composition of a chromatin remodeling complex during neural development."
Lessard J., Wu J.I., Ranish J.A., Wan M., Winslow M.M., Staahl B.T., Wu H., Aebersold R., Graef I.A., Crabtree G.R.
Neuron 55:201-215(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF THE NBAF AND NPBAF COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NBAF AND NPBAF COMPLEXES, DEVELOPMENTAL STAGE.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-697, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF268912 mRNA. Translation: AAK54504.1.
CR751606, BX537327, CR925752 Genomic DNA. Translation: CAM20580.1.
BX537327, CR751606, CR925752 Genomic DNA. Translation: CAM25151.1.
CR925752, BX537327, CR751606 Genomic DNA. Translation: CAM27607.1.
BC082554 mRNA. Translation: AAH82554.1.
CCDSCCDS38908.1. [A2BH40-1]
RefSeqNP_001074288.1. NM_001080819.1. [A2BH40-1]
UniGeneMm.22478.

3D structure databases

ProteinModelPortalA2BH40.
SMRA2BH40. Positions 1001-1120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid220298. 17 interactions.
DIPDIP-58952N.
IntActA2BH40. 20 interactions.
MINTMINT-4123278.
STRING10090.ENSMUSP00000101517.

PTM databases

PhosphoSiteA2BH40.

Proteomic databases

MaxQBA2BH40.
PaxDbA2BH40.
PRIDEA2BH40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000008024; ENSMUSP00000008024; ENSMUSG00000007880.
ENSMUST00000105897; ENSMUSP00000101517; ENSMUSG00000007880. [A2BH40-1]
GeneID93760.
KEGGmmu:93760.
UCSCuc008vdh.1. mouse. [A2BH40-1]
uc008vdj.1. mouse. [A2BH40-4]

Organism-specific databases

CTD8289.
MGIMGI:1935147. Arid1a.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00550000074575.
HOGENOMHOG000232161.
HOVERGENHBG058196.
InParanoidA2BH40.
KOK11653.
PhylomeDBA2BH40.

Gene expression databases

ArrayExpressA2BH40.
BgeeA2BH40.
GenevestigatorA2BH40.

Family and domain databases

Gene3D1.10.150.60. 1 hit.
InterProIPR001606. ARID/BRIGHT_DNA-bd.
IPR016024. ARM-type_fold.
IPR021906. DUF3518.
[Graphical view]
PfamPF01388. ARID. 1 hit.
PF12031. DUF3518. 1 hit.
[Graphical view]
SMARTSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMSSF46774. SSF46774. 1 hit.
SSF48371. SSF48371. 1 hit.
PROSITEPS51011. ARID. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSARID1A. mouse.
NextBio351643.
PROA2BH40.
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Entry information

Entry nameARI1A_MOUSE
AccessionPrimary (citable) accession number: A2BH40
Secondary accession number(s): Q640Q1, Q925Q1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot