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A2BH40

- ARI1A_MOUSE

UniProt

A2BH40 - ARI1A_MOUSE

Protein

AT-rich interactive domain-containing protein 1A

Gene

Arid1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene By similarity. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.By similarity1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. androgen receptor signaling pathway Source: UniProtKB
    2. ATP-dependent chromatin remodeling Source: MGI
    3. cardiac chamber development Source: MGI
    4. chromatin organization Source: MGI
    5. forebrain development Source: MGI
    6. glucocorticoid receptor signaling pathway Source: Ensembl
    7. intracellular estrogen receptor signaling pathway Source: UniProtKB
    8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    9. neural tube closure Source: MGI
    10. nucleosome disassembly Source: Ensembl
    11. optic cup formation involved in camera-type eye development Source: MGI
    12. placenta blood vessel development Source: MGI
    13. positive regulation of transcription, DNA-templated Source: UniProtKB
    14. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AT-rich interactive domain-containing protein 1A
    Short name:
    ARID domain-containing protein 1A
    Alternative name(s):
    BRG1-associated factor 250
    Short name:
    BAF250
    BRG1-associated factor 250a
    Short name:
    BAF250A
    Osa homolog 1
    SWI-like protein
    SWI/SNF complex protein p270
    SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
    Gene namesi
    Name:Arid1a
    Synonyms:Baf250, Baf250a, Osa1, Smarcf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1935147. Arid1a.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. BAF-type complex Source: MGI
    2. nBAF complex Source: UniProtKB
    3. npBAF complex Source: UniProtKB
    4. nuclear chromatin Source: MGI
    5. SWI/SNF complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 22832282AT-rich interactive domain-containing protein 1APRO_0000391619Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei77 – 771PhosphoserineBy similarity
    Modified residuei287 – 2871PhosphothreonineBy similarity
    Modified residuei302 – 3021PhosphoserineBy similarity
    Modified residuei365 – 3651Phosphoserine1 Publication
    Modified residuei605 – 6051PhosphoserineBy similarity
    Modified residuei697 – 6971Phosphoserine1 Publication
    Modified residuei699 – 6991PhosphoserineBy similarity
    Modified residuei703 – 7031PhosphoserineBy similarity
    Modified residuei765 – 7651PhosphoserineBy similarity
    Modified residuei773 – 7731PhosphoserineBy similarity
    Modified residuei1185 – 11851PhosphoserineBy similarity
    Modified residuei1605 – 16051PhosphoserineBy similarity
    Modified residuei1613 – 16131N6-acetyllysineBy similarity
    Modified residuei1903 – 19031N6-acetyllysineBy similarity
    Modified residuei1942 – 19421PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiA2BH40.
    PaxDbiA2BH40.
    PRIDEiA2BH40.

    PTM databases

    PhosphoSiteiA2BH40.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed at high levels in the testis.1 Publication

    Developmental stagei

    Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5. In the earlier stages at E9.5 and E10.5, is fairly ubiquitous though with clearly elevated expression in the progress zone and lateral mesoderm of limb buds, optic and otic vesicle, neural tube, and brain. Later on at E11.5 and E12.5, expression becomes more restricted and is confined to the interdigital area of limbs, dorsal mes/metencephalon, neocortex, and neural tube. Expression is seen in the eye lens from E10.5 until E12.5.2 Publications

    Gene expression databases

    ArrayExpressiA2BH40.
    BgeeiA2BH40.
    GenevestigatoriA2BH40.

    Interactioni

    Subunit structurei

    Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the SWI/SNF-B (PBAF) complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Component of the SWI/SNF Brm complex, at least composed of SMARCA2/BRM/BAF190B, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, HDAC1, HDAC2, and RBAP4. Component of the SWI/SNF complex Brg1(I), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, and probably HDAC2 and RBAP4. Component of the SWI/SNF Brg1(II), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A and probably HDAC2 and RBAP4. Component of a SWI/SNF-like EPAFa complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL. Component of a SWI/SNF-like complex containing ARID1A/BAF250A and ARID1B/BAF250B. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with SMARCC1/BAF155 By similarity. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Smarca4O358452EBI-371499,EBI-371515

    Protein-protein interaction databases

    BioGridi220298. 17 interactions.
    DIPiDIP-58952N.
    IntActiA2BH40. 20 interactions.
    MINTiMINT-4123278.
    STRINGi10090.ENSMUSP00000101517.

    Structurei

    3D structure databases

    ProteinModelPortaliA2BH40.
    SMRiA2BH40. Positions 1001-1120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1018 – 110992ARIDPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi296 – 3005LXXLL
    Motifi1710 – 17145LXXLL
    Motifi1965 – 19695LXXLL
    Motifi2083 – 20875LXXLL

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi16 – 205Poly-Pro
    Compositional biasi38 – 436Poly-Ala
    Compositional biasi53 – 425373Gly-richAdd
    BLAST
    Compositional biasi331 – 35020Ala-richAdd
    BLAST
    Compositional biasi405 – 612208Gln-richAdd
    BLAST
    Compositional biasi999 – 10024Poly-Ser
    Compositional biasi1328 – 1500173Gln-richAdd
    BLAST
    Compositional biasi1545 – 1644100Pro-richAdd
    BLAST
    Compositional biasi1761 – 17666Poly-Glu
    Compositional biasi1773 – 17786Poly-Glu

    Sequence similaritiesi

    Contains 1 ARID domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00550000074575.
    HOGENOMiHOG000232161.
    HOVERGENiHBG058196.
    InParanoidiA2BH40.
    KOiK11653.
    PhylomeDBiA2BH40.

    Family and domain databases

    Gene3Di1.10.150.60. 1 hit.
    InterProiIPR001606. ARID/BRIGHT_DNA-bd.
    IPR016024. ARM-type_fold.
    IPR021906. DUF3518.
    [Graphical view]
    PfamiPF01388. ARID. 1 hit.
    PF12031. DUF3518. 1 hit.
    [Graphical view]
    SMARTiSM00501. BRIGHT. 1 hit.
    [Graphical view]
    SUPFAMiSSF46774. SSF46774. 1 hit.
    SSF48371. SSF48371. 1 hit.
    PROSITEiPS51011. ARID. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2BH40-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAQVAPAAA SSLGNPPPPP SELKKAEQQQ REEAGGEAAA AAAERGEMKA     50
    AAGQESEGPA VGPPQPLGKE LQDGAESNGG GGGGGAGSGG GPGAEPDLKN 100
    SNGNAGPRPA LNNNLPEPPG GGGGGGSSSS DGVGAPPHSA AAALPPPAYG 150
    FGQAYGRSPS AVAAAAAAVF HQQHGGQQSP GLAALQSGGG GGLEPYAGPQ 200
    QNSHDHGFPN HQYNSYYPNR SAYPPPPQAY ALSSPRGGTP GSGAAAAAGS 250
    KPPPSSSASA SSSSSSFAQQ RFGAMGGGGP SAAGGGTPQP TATPTLNQLL 300
    TSPSSARGYQ GYPGGDYGGG PQDGGAGKGP ADMASQCWGA AAAAAAAAAA 350
    VSGGAQQRSH HAPMSPGSSG GGGQPLARTP QSSSPMDQMG KMRPQPYGGT 400
    NPYSQQQGPP SGPQQGHGYP GQPYGSQTPQ RYPMTMQGRA QSAMGSLSYA 450
    QQIPPYGQQG PSAYGQQGQT PYYNQQSPHP QQQPPYAQQP PSQTPHAQPS 500
    YQQQPQTQQP QLQSSQPPYS QQPSQPPHQQ SPTPYPSQQS TTQQHPQSQP 550
    PYSQPQAQSP YQQQQPQQPA SSSLSQQAAY PQPQPQQSQQ TAYSQQRFPP 600
    PQELSQDSFG SQASSAPSMT SSKGGQEDMN LSLQSRPSSL PDLSGSIDDL 650
    PMGTEGALSP GVSTSGISSS QGEQSNPAQS PFSPHTSPHL PGIRGPSPSP 700
    VGSPASVAQS RSGPLSPAAV PGNQMPPRPP SGQSDSIMHP SMNQSSIAQD 750
    RGYMQRNPQM PQYTSPQPGS ALSPRQPSGG QMHSGVGSYQ QNSMGSYGPQ 800
    GSQYGPQGGY PRQPNYNALP NANYPNAGMA GSMNPMGAGG QMHGQPGIPP 850
    YGTLPPGRMA HASMGNRPYG PNMANMPPQV GSGMCPPPGG MNRKTQESAV 900
    AMHVAANSIQ NRPPGYPNMN QGGMMGTGPP YGQGINSMAG MINPQGPPYP 950
    MGGTMANNSA GMAASPEMMG LGDVKLTPAT KMNNKADGTP KTESKSKKSS 1000
    SSTTTNEKIT KLYELGGEPE RKMWVDRYLA FTEEKAMGMT NLPAVGRKPL 1050
    DLYRLYVSVK EIGGLTQVNK NKKWRELATN LNVGTSSSAA SSLKKQYIQC 1100
    LYAFECKIER GEDPPPDIFA AADSKKSQPK IQPPSPAGSG SMQGPQTPQS 1150
    TSSSMAEGGD LKPPTPASTP HSQIPPLPGM SRSNSVGIQD AFPDGSDPTF 1200
    QKRNSMTPNP GYQPSMNTSD MMGRMSYEPN KDPYGSMRKA PGSDPFMSSG 1250
    QGPNGGMGDP YSRAAGPGLG SVAMGPRQHY PYGGPYDRVR TEPGIGPEGN 1300
    MGTGAPQPNL MPSTPDSGMY SPSRYPPQQQ QQQQQQHDSY GNQFSTQGTP 1350
    SSSPFPSQQT TMYQQQQQNY KRPMDGTYGP PAKRHEGEMY SVPYSAGQGQ 1400
    PQQQQLPAAQ SQPASQPQAA QPSPQQDVYN QYSNAYPASA TAATDRRPAG 1450
    GPQNQFPFQF GRDRVSAPPG SSAQQNMPPQ MMGGPIQASA EVAQQGTMWQ 1500
    GRNDMTYNYA NRQNTGSATQ GPAYHGVNRT DEMLHTDQRA NHEGPWPSHG 1550
    TRQPPYGPSA PVPPMTRPPP SNYQPPPSMP NHIPQVSSPA PLPRPMENRT 1600
    SPSKSPFLHS GMKMQKAGPP VPASHIAPTP VQPPMIRRDI TFPPGSVEAT 1650
    QPVLKQRRRL TMKDIGTPEA WRVMMSLKSG LLAESTWALD TINILLYDDN 1700
    SIMTFNLSQL PGLLELLVEY FRRCLIEIFG ILKEYEVGDP GQRTLLDPGR 1750
    FTKVYSPAHT EEEEEEHLDP KLEEEEEEGV GNDEEMAFLG KDKPSSENNE 1800
    EKLVSKFDKL PVKIVQRNDP FVVDCSDKLG RVQEFDSGLL HWRIGGGDTT 1850
    EHIQTHFESK IELLPSRPYV PCPTPPRKHL TTVEGTPGTT EQEGPPPDGL 1900
    PEKRITATMD DMLSTRSSTL TDEGAKSAEA TKESSKFPFG ISPAQSHRNI 1950
    KILEDEPHSK DETPLCTLLD WQDSLAKRCV CVSNTIRSLS FVPGNDFEMS 2000
    KHPGLLLILG KLILLHHKHP ERKQAPLTYE KEEEQDQGVS CDKVEWWWDC 2050
    LEMLRENTLV TLANISGQLD LSPYPESICL PVLDGLLHWA VCPSAEAQDP 2100
    FSTLGPNAVL SPQRLVLETL SKLSIQDNNV DLILATPPFS RLEKLYSTMV 2150
    RFLSDRKNPV CREMAVVLLA NLAQGDSLAA RAIAVQKGSI GNLLGFLEDS 2200
    LAATQFQQSQ ASLLHMQNPP FEPTSVDMMR RAARALLALA KVDENHSEFT 2250
    LYESRLLDIS VSPLMNSLVS QVICDVLFLI GQS 2283
    Length:2,283
    Mass (Da):242,092
    Last modified:February 20, 2007 - v1
    Checksum:i0F14BB1372CC4268
    GO
    Isoform 2 (identifier: A2BH40-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-385: Missing.
         1336-1336: Q → QQQQQR

    Show »
    Length:1,904
    Mass (Da):206,619
    Checksum:iDE732A3D63CFFC0F
    GO
    Isoform 3 (identifier: A2BH40-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1367-1583: Missing.

    Show »
    Length:2,066
    Mass (Da):218,477
    Checksum:i4532D4C3766E31D5
    GO
    Isoform 4 (identifier: A2BH40-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-385: Missing.
         1181-1181: Missing.
         1336-1336: Q → QQQQQR

    Show »
    Length:1,903
    Mass (Da):206,532
    Checksum:i1F6FFBECD9FA1E46
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti697 – 6971S → F in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti750 – 7501D → E in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti758 – 7581P → S in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti833 – 8331M → I in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1011 – 10111K → Q in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1148 – 11481P → H in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1181 – 11822SR → G in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1635 – 16351M → I in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1755 – 17551Y → S in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1795 – 17951S → P in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1799 – 17991N → S in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1929 – 19291E → D in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1956 – 19561E → D in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti1974 – 19741S → P in AAK54504. (PubMed:11318604)Curated
    Sequence conflicti2233 – 22331A → P in AAK54504. (PubMed:11318604)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 385384Missing in isoform 2 and isoform 4. 2 PublicationsVSP_038737Add
    BLAST
    Alternative sequencei1181 – 11811Missing in isoform 4. 1 PublicationVSP_038738
    Alternative sequencei1336 – 13361Q → QQQQQR in isoform 2 and isoform 4. 2 PublicationsVSP_038739
    Alternative sequencei1367 – 1583217Missing in isoform 3. CuratedVSP_038740Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268912 mRNA. Translation: AAK54504.1.
    CR751606, BX537327, CR925752 Genomic DNA. Translation: CAM20580.1.
    BX537327, CR751606, CR925752 Genomic DNA. Translation: CAM25151.1.
    CR925752, BX537327, CR751606 Genomic DNA. Translation: CAM27607.1.
    BC082554 mRNA. Translation: AAH82554.1.
    CCDSiCCDS38908.1. [A2BH40-1]
    RefSeqiNP_001074288.1. NM_001080819.1. [A2BH40-1]
    UniGeneiMm.22478.

    Genome annotation databases

    EnsembliENSMUST00000008024; ENSMUSP00000008024; ENSMUSG00000007880.
    ENSMUST00000105897; ENSMUSP00000101517; ENSMUSG00000007880. [A2BH40-1]
    GeneIDi93760.
    KEGGimmu:93760.
    UCSCiuc008vdh.1. mouse. [A2BH40-1]
    uc008vdj.1. mouse. [A2BH40-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268912 mRNA. Translation: AAK54504.1 .
    CR751606 , BX537327 , CR925752 Genomic DNA. Translation: CAM20580.1 .
    BX537327 , CR751606 , CR925752 Genomic DNA. Translation: CAM25151.1 .
    CR925752 , BX537327 , CR751606 Genomic DNA. Translation: CAM27607.1 .
    BC082554 mRNA. Translation: AAH82554.1 .
    CCDSi CCDS38908.1. [A2BH40-1 ]
    RefSeqi NP_001074288.1. NM_001080819.1. [A2BH40-1 ]
    UniGenei Mm.22478.

    3D structure databases

    ProteinModelPortali A2BH40.
    SMRi A2BH40. Positions 1001-1120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 220298. 17 interactions.
    DIPi DIP-58952N.
    IntActi A2BH40. 20 interactions.
    MINTi MINT-4123278.
    STRINGi 10090.ENSMUSP00000101517.

    PTM databases

    PhosphoSitei A2BH40.

    Proteomic databases

    MaxQBi A2BH40.
    PaxDbi A2BH40.
    PRIDEi A2BH40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000008024 ; ENSMUSP00000008024 ; ENSMUSG00000007880 .
    ENSMUST00000105897 ; ENSMUSP00000101517 ; ENSMUSG00000007880 . [A2BH40-1 ]
    GeneIDi 93760.
    KEGGi mmu:93760.
    UCSCi uc008vdh.1. mouse. [A2BH40-1 ]
    uc008vdj.1. mouse. [A2BH40-4 ]

    Organism-specific databases

    CTDi 8289.
    MGIi MGI:1935147. Arid1a.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00550000074575.
    HOGENOMi HOG000232161.
    HOVERGENi HBG058196.
    InParanoidi A2BH40.
    KOi K11653.
    PhylomeDBi A2BH40.

    Miscellaneous databases

    ChiTaRSi ARID1A. mouse.
    NextBioi 351643.
    PROi A2BH40.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2BH40.
    Bgeei A2BH40.
    Genevestigatori A2BH40.

    Family and domain databases

    Gene3Di 1.10.150.60. 1 hit.
    InterProi IPR001606. ARID/BRIGHT_DNA-bd.
    IPR016024. ARM-type_fold.
    IPR021906. DUF3518.
    [Graphical view ]
    Pfami PF01388. ARID. 1 hit.
    PF12031. DUF3518. 1 hit.
    [Graphical view ]
    SMARTi SM00501. BRIGHT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46774. SSF46774. 1 hit.
    SSF48371. SSF48371. 1 hit.
    PROSITEi PS51011. ARID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex."
      Kozmik Z., Machon O., Kralova J., Kreslova J., Paces J., Vlcek C.
      Genomics 73:140-148(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Strain: C57BL/6.
      Tissue: Brain.
    4. "An essential switch in subunit composition of a chromatin remodeling complex during neural development."
      Lessard J., Wu J.I., Ranish J.A., Wan M., Winslow M.M., Staahl B.T., Wu H., Aebersold R., Graef I.A., Crabtree G.R.
      Neuron 55:201-215(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE NBAF AND NPBAF COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NBAF AND NPBAF COMPLEXES, DEVELOPMENTAL STAGE.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-697, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiARI1A_MOUSE
    AccessioniPrimary (citable) accession number: A2BH40
    Secondary accession number(s): Q640Q1, Q925Q1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3