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Protein
Submitted name:

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b

Gene

grin2bb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-DRE-3928662 EPHB-mediated forward signaling
R-DRE-438066 Unblocking of NMDA receptor, glutamate binding and activation
R-DRE-442729 CREB phosphorylation through the activation of CaMKII
R-DRE-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-8849932 Synaptic adhesion-like molecules

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate bImported
Gene namesi
Name:grin2bbImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-061207-27 grin2bb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei637 – 659HelicalSequence analysisAdd BLAST23
Transmembranei709 – 731HelicalSequence analysisAdd BLAST23
Transmembranei900 – 923HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Proteomic databases

PaxDbiA2BH14

Expressioni

Gene expression databases

BgeeiENSDARG00000030376

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000113415

Structurei

3D structure databases

ProteinModelPortaliA2BH14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini510 – 878PBPeInterPro annotationAdd BLAST369
Domaini528 – 582Lig_chan-Glu_bdInterPro annotationAdd BLAST55

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000113802
HOVERGENiHBG052635
InParanoidiA2BH14
KOiK05210
OMAiGKWERGS
OrthoDBiEOG091G09KH
PhylomeDBiA2BH14
TreeFamiTF314731

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR018884 NMDAR2_C
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PF10565 NMDAR2_C, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

A2BH14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVGLAMFKG LYLHSSAMLV SLHLSSSPFS DCRVLSFVSL VSSFKLPLYI
60 70 80 90 100
SLLLLSLFFF PTCESRRGGG IGTPTGGMNS QSIISPPHYP PPGVSPVGPP
110 120 130 140 150
MSPKFAQGLS IAVILVGNSS EVSLSEGLEK EDFLHVPLPP KVELVTMNET
160 170 180 190 200
DPKSIINRIC ALMSRNWLQG VVFGDDTDQE AIAQILDFIS AQTHIPILGI
210 220 230 240 250
RGGSSMIMAA KDDHSMFFQF GPSIEQQASV MLNIMEEYDW YIFSIVTTYY
260 270 280 290 300
PGHQDFVNRI RSTVDNSFVG WELEEVLLLD MSVDDGDSKI QNQMKKLQSP
310 320 330 340 350
VILLYCTKEE ATTIFEVAHS VGLTGYGYTW IVPSLVAGDT DNVPNVFPTG
360 370 380 390 400
LISVSYDEWD YGLEARVRDA VAIIAMATST MMLDRGPHTL LKSGCHGAPD
410 420 430 440 450
KKGSKSGNPN EVLRYLMNVT FEGRNLSFSE DGFQMHPKLV IILLNKERQY
460 470 480 490 500
ERVGKWENGS LAMKYHVWPR FELYSDAEER EDDHLSIVTL EEAPFVIVED
510 520 530 540 550
VDPLSGTCMR NTVPCRKQLK LQNLTGDSGI YIKRCCKGFC IDILKKIAKS
560 570 580 590 600
VKFTYDLYLV TNGKHGKKIN GTWNGMVGEV VLKNAHMAVG SLTINEERSE
610 620 630 640 650
VIDFSVPFIE TGISVMVSRS NGTVSPSAFL EPFSADVWVM MFVMLLIVSA
660 670 680 690 700
VAVFVFEYFS PVGYNRCLAD GREPGGPSFT IGKAIWLLWG LVFNNSVPVQ
710 720 730 740 750
NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEYVD QVTGLSDKKF
760 770 780 790 800
QHPNDFSPPF RFGTVPNGST ERNIRNNYKE MHSYMTSFHQ KNVNEALHSL
810 820 830 840 850
KSGKLDAFIY DAAVLNYMAG RDEGCKLVTI GSGYIFATTG YGIAIQKDSG
860 870 880 890 900
WKRAVDLAIL QLFGDGEMEE LEALWLTGIC HNEKNEVMSS QLDVDNMAGV
910 920 930 940 950
FYMLGAAMAL SLITFIAEHL FYWQLRFCFM GVCSGKPGMT FSISRGIYSC
960 970 980 990 1000
IHGVQIEENK SALNSPSATM KMNMNNTHSN ILRLLRTAKN MTSVPGVNGS
1010 1020 1030 1040 1050
PHSALDYSHR ESAVYDISEH RRSLAGHSDC KPPPYLPEDN MFSDYVSEVE
1060 1070 1080 1090 1100
RTFGNLHLKD SNLYQDHYLH HHGGSELALG MSGPLPNRPR SLGSASSLEG
1110 1120 1130 1140 1150
GYDCDSLGGG VAPIFTTQPR QSLTHRNREK FDLIAGHPTQ SSFKSGLPDL
1160 1170 1180 1190 1200
YGKFSFKGGA SSSGFIAGHD RYCGGGGVGS GGDDGNIRSD VSDISTHTVT
1210 1220 1230 1240 1250
YGNLEGHSKR RKQYRDSLKK RPASAKSRRE QDEIELGFRR RPHHTIHHHH
1260 1270 1280 1290 1300
HHHPATQAHR SATPPVERKS QRGGNCTSYL FRDKENLRDF YVDQFRAKEG
1310 1320 1330 1340 1350
ASPWDLDLSD APGMGGGVGL GGGSCGGVVS SGGAGGACTS LVPMEDFLKG
1360 1370 1380 1390 1400
KSKKTECKGG MGGGSPGQQG HACWEKGIGG VGGLAGGDWE CRSCHSGGVG
1410 1420 1430 1440 1450
SGGSKPVCMH GGGGAGGYPA AGGVGGSSGG SGQISSRPSS ATCKRCDSCK
1460 1470 1480 1490 1500
KPGNLYDISE DNLLLDQIAG KHPLESGKGG GGTGAQTQVQ RRKFGPGGKV
1510 1520 1530 1540 1550
LRRQHSYDTF VELQKEGAGR MGGFGGGGGA SMLPPPRSVS LKDKDRYMEG
1560 1570 1580 1590 1600
ASPYAQMFEQ YAGGERETSY FGDRGKGGGS SFSLFRGGEG GLHRRSVGER
1610 1620 1630 1640 1650
DMRDRDRGMM GGGVGGTRGV GTYSLSKSLY PDKVNQNPFI PTFGDDQCLL
1660 1670 1680 1690 1700
HGAKSYYIKK QQAQPQQQQT PQQQQQQLLN NSRADFRGSM GVTSYLPASA
1710 1720 1730 1740 1750
TSGVLSNVAP RFPKELCLGG PLGNHHGGGP SNNKLLSARD GLGMGQGQRP
1760 1770
FNGSSNGHVY EKLSSIESDV
Length:1,770
Mass (Da):192,129
Last modified:February 20, 2007 - v1
Checksum:iDE7F857CB0FD0D9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537268 Genomic DNA No translation available.
BX901927 Genomic DNA No translation available.
BX901961 Genomic DNA No translation available.
RefSeqiNP_001121809.1, NM_001128337.2
XP_017210497.1, XM_017355008.1
XP_017210500.1, XM_017355011.1

Genome annotation databases

EnsembliENSDART00000143664; ENSDARP00000113415; ENSDARG00000030376
GeneIDi559976
KEGGidre:559976

Similar proteinsi

Entry informationi

Entry nameiA2BH14_DANRE
AccessioniPrimary (citable) accession number: A2BH14
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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