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A2BGT0

- UBP30_DANRE

UniProt

A2BGT0 - UBP30_DANRE

Protein

Ubiquitin carboxyl-terminal hydrolase 30

Gene

usp30

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park2).By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731NucleophilePROSITE-ProRule annotation
    Active sitei432 – 4321Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. mitochondrial fusion Source: UniProtKB
    2. mitochondrion degradation Source: UniProtKB
    3. protein deubiquitination Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 30 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 30
    Ubiquitin thioesterase 30
    Ubiquitin-specific-processing protease 30
    Short name:
    Ub-specific protease 30
    Gene namesi
    Name:usp30
    ORF Names:si:dkey-72n1.2
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB
    3. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Ubiquitin carboxyl-terminal hydrolase 30PRO_0000377538Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA2BGT0.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000073858.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini53 – 491439CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 482419USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259866.
    GeneTreeiENSGT00550000075075.
    HOGENOMiHOG000065744.
    InParanoidiA2BGT0.
    KOiK11851.
    OMAiNQPGGPK.
    OrthoDBiEOG7P8P7N.
    PhylomeDBiA2BGT0.
    TreeFamiTF105781.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2BGT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPWCKQGTTD KLVREFLRTG AAARNKMMKN WGVIGGIAAA MAAGVYVLWG    50
    PISDRRKKRK GMVPGLLNLG NTCFMNSLLQ GLAACPSFIR WLEDFTSQNS 100
    ADRERTERET QLSRSLMQLL KALSSHDPGE DDVLDAGGLL EALRLYRWHI 150
    SSFEEQDAHE LFHVLTSSLE EEQERQPRVA HLFDMQTLEK SVESKEKNIS 200
    CRSGGPLHPI PSLWRTRHPF HGRLTSYMAC KRCEQQSPVH YDSFDSLSLS 250
    IPSIQWGRPV TLDQCLQHFI SSETIKEVEC ENCTKQQAGE LVNGEVLESQ 300
    RTTFVKQLKL GKRLTWSKEG SPIKRQEHVQ FTEYLSLDRY KHCSAAQSQQ 350
    KTSRTNKAKA SADPKDKAIA NGVDSEHCNN NKPQSNGTFP SVFLHSPGLS 400
    SQLNLTYDYS TSEYLFRLTA VLVHHGDMHS GHFITYRRCP AAPRGTSPFS 450
    SQWLWVSDDS VRKASLQEVL SSSAYLLFYE RMQRPGLRVE E 491
    Length:491
    Mass (Da):55,643
    Last modified:February 20, 2007 - v1
    Checksum:i8F3FF87F855E4CC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX511005 Genomic DNA. Translation: CAM16313.1.
    RefSeqiNP_001155956.1. NM_001162484.1.
    UniGeneiDr.103783.

    Genome annotation databases

    EnsembliENSDART00000079402; ENSDARP00000073858; ENSDARG00000056842.
    GeneIDi559099.
    KEGGidre:559099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX511005 Genomic DNA. Translation: CAM16313.1 .
    RefSeqi NP_001155956.1. NM_001162484.1.
    UniGenei Dr.103783.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000073858.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000079402 ; ENSDARP00000073858 ; ENSDARG00000056842 .
    GeneIDi 559099.
    KEGGi dre:559099.

    Organism-specific databases

    CTDi 84749.

    Phylogenomic databases

    eggNOGi NOG259866.
    GeneTreei ENSGT00550000075075.
    HOGENOMi HOG000065744.
    InParanoidi A2BGT0.
    KOi K11851.
    OMAi NQPGGPK.
    OrthoDBi EOG7P8P7N.
    PhylomeDBi A2BGT0.
    TreeFami TF105781.

    Miscellaneous databases

    NextBioi 20882786.
    PROi A2BGT0.

    Gene expression databases

    Bgeei A2BGT0.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.

    Entry informationi

    Entry nameiUBP30_DANRE
    AccessioniPrimary (citable) accession number: A2BGT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3