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A2BGT0

- UBP30_DANRE

UniProt

A2BGT0 - UBP30_DANRE

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Protein

Ubiquitin carboxyl-terminal hydrolase 30

Gene

usp30

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park2).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731NucleophilePROSITE-ProRule annotation
Active sitei432 – 4321Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. mitochondrial fusion Source: UniProtKB
  2. mitochondrion degradation Source: UniProtKB
  3. protein deubiquitination Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 30 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 30
Ubiquitin thioesterase 30
Ubiquitin-specific-processing protease 30
Short name:
Ub-specific protease 30
Gene namesi
Name:usp30
ORF Names:si:dkey-72n1.2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Ubiquitin carboxyl-terminal hydrolase 30PRO_0000377538Add
BLAST

Expressioni

Gene expression databases

BgeeiA2BGT0.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073858.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini53 – 491439CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 482419USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259866.
GeneTreeiENSGT00550000075075.
HOGENOMiHOG000065744.
InParanoidiA2BGT0.
KOiK11851.
OMAiNQPGGPK.
OrthoDBiEOG7P8P7N.
PhylomeDBiA2BGT0.
TreeFamiTF105781.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BGT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPWCKQGTTD KLVREFLRTG AAARNKMMKN WGVIGGIAAA MAAGVYVLWG
60 70 80 90 100
PISDRRKKRK GMVPGLLNLG NTCFMNSLLQ GLAACPSFIR WLEDFTSQNS
110 120 130 140 150
ADRERTERET QLSRSLMQLL KALSSHDPGE DDVLDAGGLL EALRLYRWHI
160 170 180 190 200
SSFEEQDAHE LFHVLTSSLE EEQERQPRVA HLFDMQTLEK SVESKEKNIS
210 220 230 240 250
CRSGGPLHPI PSLWRTRHPF HGRLTSYMAC KRCEQQSPVH YDSFDSLSLS
260 270 280 290 300
IPSIQWGRPV TLDQCLQHFI SSETIKEVEC ENCTKQQAGE LVNGEVLESQ
310 320 330 340 350
RTTFVKQLKL GKRLTWSKEG SPIKRQEHVQ FTEYLSLDRY KHCSAAQSQQ
360 370 380 390 400
KTSRTNKAKA SADPKDKAIA NGVDSEHCNN NKPQSNGTFP SVFLHSPGLS
410 420 430 440 450
SQLNLTYDYS TSEYLFRLTA VLVHHGDMHS GHFITYRRCP AAPRGTSPFS
460 470 480 490
SQWLWVSDDS VRKASLQEVL SSSAYLLFYE RMQRPGLRVE E
Length:491
Mass (Da):55,643
Last modified:February 20, 2007 - v1
Checksum:i8F3FF87F855E4CC9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX511005 Genomic DNA. Translation: CAM16313.1.
RefSeqiNP_001155956.1. NM_001162484.1.
UniGeneiDr.103783.

Genome annotation databases

EnsembliENSDART00000079402; ENSDARP00000073858; ENSDARG00000056842.
GeneIDi559099.
KEGGidre:559099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX511005 Genomic DNA. Translation: CAM16313.1 .
RefSeqi NP_001155956.1. NM_001162484.1.
UniGenei Dr.103783.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000073858.

Protein family/group databases

MEROPSi C19.060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000079402 ; ENSDARP00000073858 ; ENSDARG00000056842 .
GeneIDi 559099.
KEGGi dre:559099.

Organism-specific databases

CTDi 84749.

Phylogenomic databases

eggNOGi NOG259866.
GeneTreei ENSGT00550000075075.
HOGENOMi HOG000065744.
InParanoidi A2BGT0.
KOi K11851.
OMAi NQPGGPK.
OrthoDBi EOG7P8P7N.
PhylomeDBi A2BGT0.
TreeFami TF105781.

Miscellaneous databases

NextBioi 20882786.
PROi A2BGT0.

Gene expression databases

Bgeei A2BGT0.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiUBP30_DANRE
AccessioniPrimary (citable) accession number: A2BGT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3