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A2BGT0 (UBP30_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 30

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 30
Ubiquitin thioesterase 30
Ubiquitin-specific-processing protease 30
Short name=Ub-specific protease 30
Gene names
Name:usp30
ORF Names:si:dkey-72n1.2
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May participate in the maintenance of mitochondrial morphology By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Mitochondrion outer membrane By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Ubiquitin carboxyl-terminal hydrolase 30
PRO_0000377538

Regions

Topological domain1 – 3131Mitochondrial intermembrane Potential
Transmembrane32 – 5221Helical; Potential
Topological domain53 – 491439Cytoplasmic Potential
Domain64 – 482419USP

Sites

Active site731Nucleophile By similarity
Active site4321Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A2BGT0 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 8F3FF87F855E4CC9

FASTA49155,643
        10         20         30         40         50         60 
MPWCKQGTTD KLVREFLRTG AAARNKMMKN WGVIGGIAAA MAAGVYVLWG PISDRRKKRK 

        70         80         90        100        110        120 
GMVPGLLNLG NTCFMNSLLQ GLAACPSFIR WLEDFTSQNS ADRERTERET QLSRSLMQLL 

       130        140        150        160        170        180 
KALSSHDPGE DDVLDAGGLL EALRLYRWHI SSFEEQDAHE LFHVLTSSLE EEQERQPRVA 

       190        200        210        220        230        240 
HLFDMQTLEK SVESKEKNIS CRSGGPLHPI PSLWRTRHPF HGRLTSYMAC KRCEQQSPVH 

       250        260        270        280        290        300 
YDSFDSLSLS IPSIQWGRPV TLDQCLQHFI SSETIKEVEC ENCTKQQAGE LVNGEVLESQ 

       310        320        330        340        350        360 
RTTFVKQLKL GKRLTWSKEG SPIKRQEHVQ FTEYLSLDRY KHCSAAQSQQ KTSRTNKAKA 

       370        380        390        400        410        420 
SADPKDKAIA NGVDSEHCNN NKPQSNGTFP SVFLHSPGLS SQLNLTYDYS TSEYLFRLTA 

       430        440        450        460        470        480 
VLVHHGDMHS GHFITYRRCP AAPRGTSPFS SQWLWVSDDS VRKASLQEVL SSSAYLLFYE 

       490 
RMQRPGLRVE E 

« Hide

References

[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX511005 Genomic DNA. Translation: CAM16313.1.
RefSeqNP_001155956.1. NM_001162484.1.
UniGeneDr.103783.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000073858.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000079402; ENSDARP00000073858; ENSDARG00000056842.
GeneID559099.
KEGGdre:559099.

Organism-specific databases

CTD84749.

Phylogenomic databases

eggNOGNOG259866.
GeneTreeENSGT00550000075075.
HOGENOMHOG000065744.
InParanoidA2BGT0.
KOK11851.
OMANQPGGPK.
OrthoDBEOG7P8P7N.
PhylomeDBA2BGT0.
TreeFamTF105781.

Gene expression databases

BgeeA2BGT0.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20882786.
PROA2BGT0.

Entry information

Entry nameUBP30_DANRE
AccessionPrimary (citable) accession number: A2BGT0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries