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A2BFH1

- PAL4G_HUMAN

UniProt

A2BFH1 - PAL4G_HUMAN

Protein

Peptidyl-prolyl cis-trans isomerase A-like 4G

Gene

PPIAL4G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4G (EC:5.2.1.8)
    Short name:
    PPIase A-like 4G
    Alternative name(s):
    Peptidylprolyl cis-trans isomerase A-like 4
    Gene namesi
    Name:PPIAL4G
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:33996. PPIAL4G.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164724931.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Peptidyl-prolyl cis-trans isomerase A-like 4GPRO_0000324639Add
    BLAST

    Proteomic databases

    PaxDbiA2BFH1.
    PRIDEiA2BFH1.

    PTM databases

    PhosphoSiteiA2BFH1.

    Expressioni

    Gene expression databases

    BgeeiA2BFH1.
    CleanExiHS_PPIAL4A.
    GenevestigatoriA2BFH1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000393845.

    Structurei

    3D structure databases

    ProteinModelPortaliA2BFH1.
    SMRiA2BFH1. Positions 2-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 163157PPIase cyclophilin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0652.
    HOGENOMiHOG000065981.
    HOVERGENiHBG001065.
    InParanoidiA2BFH1.
    KOiK12738.
    OrthoDBiEOG79GT7W.
    PhylomeDBiA2BFH1.
    TreeFamiTF316719.

    Family and domain databases

    Gene3Di2.40.100.10. 1 hit.
    InterProiIPR029000. Cyclophilin-like_dom.
    IPR024936. Cyclophilin-type_PPIase.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view]
    PfamiPF00160. Pro_isomerase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
    PRINTSiPR00153. CSAPPISMRASE.
    SUPFAMiSSF50891. SSF50891. 1 hit.
    PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2BFH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNSVIFFDI TVDGKPLGRI SIKQFADKIP KTAENFRALS TGEKGFRYKG    50
    SCFHRIIPGF MCQGGDFTHP NGTGDKSIYG EKFDDENLIR KHTGSGILSM 100
    ANAGPNTNGS QFFICTAKTE WLDGKHVAFG KVKERVNIVE AMEHFGYRNS 150
    KTSKKITIAD CGQF 164
    Length:164
    Mass (Da):18,166
    Last modified:February 20, 2007 - v1
    Checksum:iCEAFE5FE3D858213
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61I → V in AAI30379. (PubMed:15489334)Curated
    Sequence conflicti6 – 61I → V in AAI30377. (PubMed:15489334)Curated
    Sequence conflicti24 – 241Q → L in AAI30379. (PubMed:15489334)Curated
    Sequence conflicti24 – 241Q → L in AAI30377. (PubMed:15489334)Curated
    Sequence conflicti69 – 691H → R in AAI30379. (PubMed:15489334)Curated
    Sequence conflicti69 – 691H → R in AAI30377. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX284650 Genomic DNA. Translation: CAM26887.1.
    BC130376 mRNA. Translation: AAI30377.1.
    BC130378 mRNA. Translation: AAI30379.1.
    CCDSiCCDS41375.1.
    RefSeqiNP_001116540.1. NM_001123068.1.
    NP_001129261.2. NM_001135789.3.
    UniGeneiHs.534674.

    Genome annotation databases

    EnsembliENST00000419275; ENSP00000393845; ENSG00000236334.
    GeneIDi644591.
    653598.
    KEGGihsa:644591.
    hsa:653598.
    UCSCiuc001ejt.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX284650 Genomic DNA. Translation: CAM26887.1 .
    BC130376 mRNA. Translation: AAI30377.1 .
    BC130378 mRNA. Translation: AAI30379.1 .
    CCDSi CCDS41375.1.
    RefSeqi NP_001116540.1. NM_001123068.1.
    NP_001129261.2. NM_001135789.3.
    UniGenei Hs.534674.

    3D structure databases

    ProteinModelPortali A2BFH1.
    SMRi A2BFH1. Positions 2-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000393845.

    PTM databases

    PhosphoSitei A2BFH1.

    Proteomic databases

    PaxDbi A2BFH1.
    PRIDEi A2BFH1.

    Protocols and materials databases

    DNASUi 644591.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000419275 ; ENSP00000393845 ; ENSG00000236334 .
    GeneIDi 644591.
    653598.
    KEGGi hsa:644591.
    hsa:653598.
    UCSCi uc001ejt.3. human.

    Organism-specific databases

    CTDi 644591.
    653598.
    GeneCardsi GC01M143767.
    HGNCi HGNC:33996. PPIAL4G.
    neXtProti NX_A2BFH1.
    PharmGKBi PA164724931.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0652.
    HOGENOMi HOG000065981.
    HOVERGENi HBG001065.
    InParanoidi A2BFH1.
    KOi K12738.
    OrthoDBi EOG79GT7W.
    PhylomeDBi A2BFH1.
    TreeFami TF316719.

    Miscellaneous databases

    GenomeRNAii 644591.
    NextBioi 116407.
    PROi A2BFH1.

    Gene expression databases

    Bgeei A2BFH1.
    CleanExi HS_PPIAL4A.
    Genevestigatori A2BFH1.

    Family and domain databases

    Gene3Di 2.40.100.10. 1 hit.
    InterProi IPR029000. Cyclophilin-like_dom.
    IPR024936. Cyclophilin-type_PPIase.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view ]
    Pfami PF00160. Pro_isomerase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001467. Peptidylpro_ismrse. 1 hit.
    PRINTSi PR00153. CSAPPISMRASE.
    SUPFAMi SSF50891. SSF50891. 1 hit.
    PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiPAL4G_HUMAN
    AccessioniPrimary (citable) accession number: A2BFH1
    Secondary accession number(s): A1L431
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3