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Protein
Submitted name:

MCL1, BCL2 family apoptosis regulator b

Gene

mcl1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

  • protein heterodimerization activity Source: ZFIN
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

  • chordate embryonic development Source: ZFIN
  • extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
  • negative regulation of apoptotic process Source: ZFIN
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ZFIN
  • negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
  • negative regulation of mitotic nuclear division Source: ZFIN
  • regulation of apoptotic process Source: ZFIN
  • regulation of mitotic nuclear division Source: ZFIN

Names & Taxonomyi

Protein namesi
Submitted name:
MCL1, BCL2 family apoptosis regulator bImported
Gene namesi
Name:mcl1bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-030825-1 mcl1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSDARG00000008363
ExpressionAtlasiA2BF68 baseline and differential

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: ZFIN
  • protein homodimerization activity Source: GO_Central

Structurei

3D structure databases

ProteinModelPortaliA2BF68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00510000048923
HOGENOMiHOG000232116
HOVERGENiHBG003527
OMAiNNSWEGF
OrthoDBiEOG091G0E6Q
TreeFamiTF315834

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR013281 Apop_reg_Mc1
IPR002475 Bcl2-like
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF46 PTHR11256:SF46, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PRINTSiPR01866 APOPREGMCL1
PR01862 BCL2FAMILY
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

Sequencei

Sequence statusi: Complete.

A2BF68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAGRNNDNG FWPCTGLQSK PLVIPELKAH NQFAVDSLQG SVPSSPSDET
60 70 80 90 100
GDYPPTALDM DTREIIDTFL KIFTGLPHSK SGRKQVLSTM RRVVDNLAVK
110 120 130 140 150
HELAYKGMIA RLNLEQKGED VSFIKQVATE LFSDGTTNWG RIASLLTFGA
160 170 180 190 200
MLCKYQNDRG HSKYVRLVGE EISSYLLTEQ RDWILRNKAW DGFVEFFHVP
210 220
DTEAAVRNTL LTIGGVATLS AALAYWIR
Length:228
Mass (Da):25,501
Last modified:February 20, 2007 - v1
Checksum:i09927BFC89B02004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248517 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSDART00000149520; ENSDARP00000124404; ENSDARG00000008363

Similar proteinsi

Entry informationi

Entry nameiA2BF68_DANRE
AccessioniPrimary (citable) accession number: A2BF68
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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