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A2BE28

- LAS1L_MOUSE

UniProt

A2BE28 - LAS1L_MOUSE

Protein

Ribosomal biogenesis protein LAS1L

Gene

Las1l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA By similarity. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.By similarity1 Publication

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Biological processi

    rRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal biogenesis protein LAS1L
    Alternative name(s):
    Protein LAS1 homolog
    Gene namesi
    Name:Las1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1923380. Las1l.

    Subcellular locationi

    Nucleusnucleolus By similarity. Nucleusnucleoplasm 1 Publication. Cytoplasm 1 Publication
    Note: Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export By similarity. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. MLL1 complex Source: UniProtKB
    3. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 776776Ribosomal biogenesis protein LAS1LPRO_0000390998Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei509 – 5091PhosphoserineBy similarity
    Modified residuei658 – 6581PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiA2BE28.
    PaxDbiA2BE28.
    PRIDEiA2BE28.

    Expressioni

    Gene expression databases

    ArrayExpressiA2BE28.
    BgeeiA2BE28.
    GenevestigatoriA2BE28.

    Interactioni

    Subunit structurei

    Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 By similarity. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi217980. 3 interactions.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LAS1 family.Curated

    Phylogenomic databases

    eggNOGiNOG323169.
    GeneTreeiENSGT00390000014785.
    HOGENOMiHOG000232090.
    HOVERGENiHBG080556.
    InParanoidiQ6KAR5.
    KOiK16912.
    OMAiPFSQFWQ.
    OrthoDBiEOG7G7KPC.
    TreeFamiTF314042.

    Family and domain databases

    InterProiIPR007174. Las1.
    [Graphical view]
    PANTHERiPTHR15002. PTHR15002. 1 hit.
    PfamiPF04031. Las1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2BE28-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDRVWRAWDG QSFKENQPES PSARGIVVSW LSRAEWEQVT VYLFCDDHKL    50
    QQYALNRITV WRSRLGNELP LAVASTADLV RCKLIDAAGT LGTDELRLLY 100
    GMALVRFVNL ISERKTKCSN LPLKYLAQEV NIPDWIVELR HNLTHKKMPH 150
    INECRRGCYF VLNWLQKTYW SRQLEGSLKE TWELDEDQLD AEDPEEEERE 200
    IIADDVLEEI PEPQDDDKDE ELAVEDDANT KGNEEVASHP EPSSRHKELY 250
    EKARELLVSY EEEQFKVLEK HRHLLQAIKV WNNLSPRVQC ILEELKSISW 300
    ENRDAVLDAF LDDGFLIPTF EQLAALQIEY EDGQTEVQKG EVTEPNSHKN 350
    IDLNEVLVPK PFSQFWQPLL RGLHSQTFTQ ALLERMFSEL STVGSTGIRP 400
    TYILRWTVEL IVANTKTGRN ARRFSASQWE ARKSWRLFNC SATLDWPQVI 450
    ESCLGSPCWA SPQLLQVVFK AMGQVLPDEE QEKLLRVCSI YTQNGENGLA 500
    KAIEGSSSSS TGKAPYTLDT LHEDLQPPGT NCESEESIQQ KEQGNLKDVK 550
    QEEKKENEEE EKEEEEMEEE EEEEEEEKEE EEEEQEQEEH QEEEQEEEEE 600
    EENQKVFQDQ MEADVEESDD VEEEEEVDDE EEDEDDDYDD DEEEDRMEVG 650
    AFSLAQGSSV FENTRTTSRK REALQGSAWQ VSSEDVRWGT FPLGRLPGQT 700
    EDPAELMLDN YDTMYLLDQP VIEHRLEPQK SKSSTLSLCC GGSNTNSSSS 750
    SSSGNMEGLL WNQGQMHGLK AGLQLF 776
    Length:776
    Mass (Da):89,414
    Last modified:February 20, 2007 - v1
    Checksum:i6855167CD37D57EC
    GO
    Isoform 2 (identifier: A2BE28-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         332-349: DGQTEVQKGEVTEPNSHK → E

    Show »
    Length:759
    Mass (Da):87,578
    Checksum:i93701CFEE32B2326
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei332 – 34918DGQTE…PNSHK → E in isoform 2. 1 PublicationVSP_038670Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX005184 Genomic DNA. Translation: CAM25407.1.
    BX005184 Genomic DNA. Translation: CAM25408.1.
    BC141155 mRNA. Translation: AAI41156.1.
    AK052578 mRNA. Translation: BAC35047.1.
    AK131142 mRNA. Translation: BAD21392.1.
    CCDSiCCDS30287.1. [A2BE28-2]
    RefSeqiNP_690035.2. NM_152822.3. [A2BE28-2]
    XP_006528397.1. XM_006528334.1. [A2BE28-1]
    UniGeneiMm.274318.

    Genome annotation databases

    EnsembliENSMUST00000079987; ENSMUSP00000078901; ENSMUSG00000057421. [A2BE28-2]
    ENSMUST00000113864; ENSMUSP00000109495; ENSMUSG00000057421. [A2BE28-1]
    GeneIDi76130.
    KEGGimmu:76130.
    UCSCiuc009tud.1. mouse. [A2BE28-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX005184 Genomic DNA. Translation: CAM25407.1 .
    BX005184 Genomic DNA. Translation: CAM25408.1 .
    BC141155 mRNA. Translation: AAI41156.1 .
    AK052578 mRNA. Translation: BAC35047.1 .
    AK131142 mRNA. Translation: BAD21392.1 .
    CCDSi CCDS30287.1. [A2BE28-2 ]
    RefSeqi NP_690035.2. NM_152822.3. [A2BE28-2 ]
    XP_006528397.1. XM_006528334.1. [A2BE28-1 ]
    UniGenei Mm.274318.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 217980. 3 interactions.

    Proteomic databases

    MaxQBi A2BE28.
    PaxDbi A2BE28.
    PRIDEi A2BE28.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079987 ; ENSMUSP00000078901 ; ENSMUSG00000057421 . [A2BE28-2 ]
    ENSMUST00000113864 ; ENSMUSP00000109495 ; ENSMUSG00000057421 . [A2BE28-1 ]
    GeneIDi 76130.
    KEGGi mmu:76130.
    UCSCi uc009tud.1. mouse. [A2BE28-2 ]

    Organism-specific databases

    CTDi 81887.
    MGIi MGI:1923380. Las1l.

    Phylogenomic databases

    eggNOGi NOG323169.
    GeneTreei ENSGT00390000014785.
    HOGENOMi HOG000232090.
    HOVERGENi HBG080556.
    InParanoidi Q6KAR5.
    KOi K16912.
    OMAi PFSQFWQ.
    OrthoDBi EOG7G7KPC.
    TreeFami TF314042.

    Miscellaneous databases

    NextBioi 344645.
    PROi A2BE28.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2BE28.
    Bgeei A2BE28.
    Genevestigatori A2BE28.

    Family and domain databases

    InterProi IPR007174. Las1.
    [Graphical view ]
    PANTHERi PTHR15002. PTHR15002. 1 hit.
    Pfami PF04031. Las1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 253-575 (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Stomach.
    4. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
      DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 541-776.
      Tissue: Spleen.
    5. "Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation."
      Fanis P., Gillemans N., Aghajanirefah A., Pourfarzad F., Demmers J., Esteghamat F., Vadlamudi R.K., Grosveld F., Philipsen S., van Dijk T.B.
      Mol. Cell. Proteomics 11:1263-1273(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE 5FMC COMPLEX, INTERACTION OF THE 5FMC COMPLEX WITH CHTOP AND ZNF148, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiLAS1L_MOUSE
    AccessioniPrimary (citable) accession number: A2BE28
    Secondary accession number(s): A2BE30, Q6KAR5, Q8C742
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3