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A2BE28 (LAS1L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal biogenesis protein LAS1L
Alternative name(s):
Protein LAS1 homolog
Gene names
Name:Las1l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length776 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA By similarity. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Ref.5

Subunit structure

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 By similarity. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Ref.5

Subcellular location

Nucleusnucleolus By similarity. Nucleusnucleoplasm. Cytoplasm. Note: Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export By similarity. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. Ref.5

Sequence similarities

Belongs to the LAS1 family.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processrRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentMLL1 complex

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A2BE28-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A2BE28-2)

The sequence of this isoform differs from the canonical sequence as follows:
     332-349: DGQTEVQKGEVTEPNSHK → E

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 776776Ribosomal biogenesis protein LAS1L
PRO_0000390998

Amino acid modifications

Modified residue5091Phosphoserine By similarity
Modified residue6581Phosphoserine By similarity

Natural variations

Alternative sequence332 – 34918DGQTE…PNSHK → E in isoform 2.
VSP_038670

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 6855167CD37D57EC

FASTA77689,414
        10         20         30         40         50         60 
MDRVWRAWDG QSFKENQPES PSARGIVVSW LSRAEWEQVT VYLFCDDHKL QQYALNRITV 

        70         80         90        100        110        120 
WRSRLGNELP LAVASTADLV RCKLIDAAGT LGTDELRLLY GMALVRFVNL ISERKTKCSN 

       130        140        150        160        170        180 
LPLKYLAQEV NIPDWIVELR HNLTHKKMPH INECRRGCYF VLNWLQKTYW SRQLEGSLKE 

       190        200        210        220        230        240 
TWELDEDQLD AEDPEEEERE IIADDVLEEI PEPQDDDKDE ELAVEDDANT KGNEEVASHP 

       250        260        270        280        290        300 
EPSSRHKELY EKARELLVSY EEEQFKVLEK HRHLLQAIKV WNNLSPRVQC ILEELKSISW 

       310        320        330        340        350        360 
ENRDAVLDAF LDDGFLIPTF EQLAALQIEY EDGQTEVQKG EVTEPNSHKN IDLNEVLVPK 

       370        380        390        400        410        420 
PFSQFWQPLL RGLHSQTFTQ ALLERMFSEL STVGSTGIRP TYILRWTVEL IVANTKTGRN 

       430        440        450        460        470        480 
ARRFSASQWE ARKSWRLFNC SATLDWPQVI ESCLGSPCWA SPQLLQVVFK AMGQVLPDEE 

       490        500        510        520        530        540 
QEKLLRVCSI YTQNGENGLA KAIEGSSSSS TGKAPYTLDT LHEDLQPPGT NCESEESIQQ 

       550        560        570        580        590        600 
KEQGNLKDVK QEEKKENEEE EKEEEEMEEE EEEEEEEKEE EEEEQEQEEH QEEEQEEEEE 

       610        620        630        640        650        660 
EENQKVFQDQ MEADVEESDD VEEEEEVDDE EEDEDDDYDD DEEEDRMEVG AFSLAQGSSV 

       670        680        690        700        710        720 
FENTRTTSRK REALQGSAWQ VSSEDVRWGT FPLGRLPGQT EDPAELMLDN YDTMYLLDQP 

       730        740        750        760        770 
VIEHRLEPQK SKSSTLSLCC GGSNTNSSSS SSSGNMEGLL WNQGQMHGLK AGLQLF 

« Hide

Isoform 2 [UniParc].

Checksum: 93701CFEE32B2326
Show »

FASTA75987,578

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 253-575 (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Stomach.
[4]"Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 541-776.
Tissue: Spleen.
[5]"Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation."
Fanis P., Gillemans N., Aghajanirefah A., Pourfarzad F., Demmers J., Esteghamat F., Vadlamudi R.K., Grosveld F., Philipsen S., van Dijk T.B.
Mol. Cell. Proteomics 11:1263-1273(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE 5FMC COMPLEX, INTERACTION OF THE 5FMC COMPLEX WITH CHTOP AND ZNF148, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX005184 Genomic DNA. Translation: CAM25407.1.
BX005184 Genomic DNA. Translation: CAM25408.1.
BC141155 mRNA. Translation: AAI41156.1.
AK052578 mRNA. Translation: BAC35047.1.
AK131142 mRNA. Translation: BAD21392.1.
CCDSCCDS30287.1. [A2BE28-2]
RefSeqNP_690035.2. NM_152822.3. [A2BE28-2]
XP_006528397.1. XM_006528334.1. [A2BE28-1]
UniGeneMm.274318.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid217980. 3 interactions.

Proteomic databases

MaxQBA2BE28.
PaxDbA2BE28.
PRIDEA2BE28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079987; ENSMUSP00000078901; ENSMUSG00000057421. [A2BE28-2]
ENSMUST00000113864; ENSMUSP00000109495; ENSMUSG00000057421. [A2BE28-1]
GeneID76130.
KEGGmmu:76130.
UCSCuc009tud.1. mouse. [A2BE28-2]

Organism-specific databases

CTD81887.
MGIMGI:1923380. Las1l.

Phylogenomic databases

eggNOGNOG323169.
GeneTreeENSGT00390000014785.
HOGENOMHOG000232090.
HOVERGENHBG080556.
InParanoidQ6KAR5.
KOK16912.
OMAPFSQFWQ.
OrthoDBEOG7G7KPC.
TreeFamTF314042.

Gene expression databases

ArrayExpressA2BE28.
BgeeA2BE28.
GenevestigatorA2BE28.

Family and domain databases

InterProIPR007174. Las1.
[Graphical view]
PANTHERPTHR15002. PTHR15002. 1 hit.
PfamPF04031. Las1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio344645.
PROA2BE28.
SOURCESearch...

Entry information

Entry nameLAS1L_MOUSE
AccessionPrimary (citable) accession number: A2BE28
Secondary accession number(s): A2BE30, Q6KAR5, Q8C742
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot