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Protein

Potassium voltage-gated channel subfamily G member 1

Gene

Kcng1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.1
Gene namesi
Name:Kcng1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3616086. Kcng1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 224224CytoplasmicBy similarityAdd
BLAST
Transmembranei225 – 24622Helical; Name=Segment S1By similarityAdd
BLAST
Topological domaini247 – 26721ExtracellularBy similarityAdd
BLAST
Transmembranei268 – 28922Helical; Name=Segment S2By similarityAdd
BLAST
Topological domaini290 – 30011CytoplasmicBy similarityAdd
BLAST
Transmembranei301 – 32121Helical; Name=Segment S3By similarityAdd
BLAST
Topological domaini322 – 33817ExtracellularBy similarityAdd
BLAST
Transmembranei339 – 35921Helical; Voltage-sensor; Name=Segment S4By similarityAdd
BLAST
Topological domaini360 – 37415CytoplasmicBy similarityAdd
BLAST
Transmembranei375 – 39622Helical; Name=Segment S5By similarityAdd
BLAST
Topological domaini397 – 41115ExtracellularBy similarityAdd
BLAST
Intramembranei412 – 42312Helical; Name=Pore helixBy similarityAdd
BLAST
Intramembranei424 – 4318By similarity
Topological domaini432 – 4387ExtracellularBy similarity
Transmembranei439 – 46729Helical; Name=Segment S6By similarityAdd
BLAST
Topological domaini468 – 51447CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Potassium voltage-gated channel subfamily G member 1PRO_0000320106Add
BLAST

Proteomic databases

PaxDbiA2BDX4.
PRIDEiA2BDX4.

PTM databases

PhosphoSiteiA2BDX4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074575.
ExpressionAtlasiA2BDX4. baseline and differential.
GenevisibleiA2BDX4. MM.

Interactioni

Subunit structurei

Heterotetramer with KCNB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096668.

Structurei

3D structure databases

ProteinModelPortaliA2BDX4.
SMRiA2BDX4. Positions 64-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi424 – 4296Selectivity filterBy similarity

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiA2BDX4.
KOiK04900.
OMAiGQCSQMC.
OrthoDBiEOG091G05DD.
PhylomeDBiA2BDX4.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

A2BDX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLLPGDNSH YDYSALSCAS DTSFHPAFFP QRQAIKGVFY RRAQRLRPQD
60 70 80 90 100
DLHQSCSLGD RRRQIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD
110 120 130 140 150
ILSVCDDYDV TCNEFFFDRN PGAFGTILTF LRAGKLRLLR EMCALSFQEE
160 170 180 190 200
LLYWGIAEDH LDGCCKRRYL QKIEEFAEMM EREEEEEPLD SEDQESEGPS
210 220 230 240 250
ASEGRLSRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT AVNLSVSTLP
260 270 280 290 300
SLREEEEQGQ CSQMCHNVFI VESVCVGWFS LEFLLRFIQA PSKFAFLRSP
310 320 330 340 350
LTLIDLVAIL PYYVTLLVDG AASSRRKPST GNSYLDKVGL VLRVLRALRI
360 370 380 390 400
LYVMRLARHS LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN
410 420 430 440 450
EMADSPEFTS IPACYWWAVI TMTTVGYGDM VPRSTPGQVV ALSSILSGIL
460 470 480 490 500
LMAFPVTSIF HTFSRSYLEL KQEQERVLIR RAQYLIKTKS QLSGMSQDSD
510
ILFGSASSDT RDNN
Length:514
Mass (Da):58,176
Last modified:February 20, 2007 - v1
Checksum:i775318D70706A92A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005039 Genomic DNA. Translation: CAM22979.1.
CCDSiCCDS38344.1.
RefSeqiNP_001074603.1. NM_001081134.1.
XP_006499601.1. XM_006499538.2.
XP_006499602.1. XM_006499539.2.
UniGeneiMm.425102.

Genome annotation databases

EnsembliENSMUST00000099069; ENSMUSP00000096668; ENSMUSG00000074575.
ENSMUST00000109191; ENSMUSP00000104815; ENSMUSG00000074575.
GeneIDi241794.
KEGGimmu:241794.
UCSCiuc008oat.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005039 Genomic DNA. Translation: CAM22979.1.
CCDSiCCDS38344.1.
RefSeqiNP_001074603.1. NM_001081134.1.
XP_006499601.1. XM_006499538.2.
XP_006499602.1. XM_006499539.2.
UniGeneiMm.425102.

3D structure databases

ProteinModelPortaliA2BDX4.
SMRiA2BDX4. Positions 64-467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096668.

PTM databases

PhosphoSiteiA2BDX4.

Proteomic databases

PaxDbiA2BDX4.
PRIDEiA2BDX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099069; ENSMUSP00000096668; ENSMUSG00000074575.
ENSMUST00000109191; ENSMUSP00000104815; ENSMUSG00000074575.
GeneIDi241794.
KEGGimmu:241794.
UCSCiuc008oat.1. mouse.

Organism-specific databases

CTDi3755.
MGIiMGI:3616086. Kcng1.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiA2BDX4.
KOiK04900.
OMAiGQCSQMC.
OrthoDBiEOG091G05DD.
PhylomeDBiA2BDX4.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

PROiA2BDX4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074575.
ExpressionAtlasiA2BDX4. baseline and differential.
GenevisibleiA2BDX4. MM.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNG1_MOUSE
AccessioniPrimary (citable) accession number: A2BDX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.