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A2BDH2 (A2BDH2_PONAB) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the prion family. RuleBase RU003882

Ontologies

Keywords
   Cellular componentAmyloid
Cell membrane SAAS SAAS022416 RuleBase RU003882
Membrane
   DomainRepeat SAAS SAAS022416
   Molecular functionPrion RuleBase RU003882 EMBL CAJ43808.1
   PTMDisulfide bond SAAS SAAS022416
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of T cell receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of activated T cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of calcineurin-NFAT signaling cascade

Inferred from electronic annotation. Source: Ensembl

negative regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-2 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

protein homooligomerization

Inferred from electronic annotation. Source: InterPro

response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

nucleolus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncopper ion binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A2BDH2 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: A8D0E6972F1D5B26

FASTA25327,680
        10         20         30         40         50         60 
MANLGCWMLV LFVATWSNLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP 

        70         80         90        100        110        120 
HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHSQWN KPSKPKTNMK HMAGAAAAGA 

       130        140        150        160        170        180 
VVGGLGGYML GSAMSRPIIH FGNDYEDRYY RENMYRYPNQ VYYRPVDQYS NQNNFVHDCV 

       190        200        210        220        230        240 
NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCITQYER ESQAYYQRGS SMVLFSSPPV 

       250 
ILLISFLIFL IVG 

« Hide

References

« Hide 'large scale' references
[1]"Comparative genomic analysis of prion genes."
Premzl M., Gamulin V.
BMC Genomics 8:1-1(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
Wilson R.K., Mardis E.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Positive selection in prion protein."
Premzl M., Gamulin V.
J. Mol. Evol. 68:205-207(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ABGA01228014 Genomic DNA. No translation available.
BN000848 Genomic DNA. Translation: CAJ43808.1.
RefSeqNP_001124544.1. NM_001131072.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000012541; ENSPPYP00000012064; ENSPPYG00000010800.
GeneID100173712.
KEGGpon:100173712.

Organism-specific databases

CTD5621.

Phylogenomic databases

GeneTreeENSGT00510000049083.
HOVERGENHBG008260.
KOK05634.
OMAGYPHNPG.
OrthoDBEOG7DRJ4Q.
TreeFamTF105188.

Family and domain databases

Gene3D1.10.790.10. 1 hit.
InterProIPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
[Graphical view]
PANTHERPTHR11522. PTHR11522. 1 hit.
PfamPF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
[Graphical view]
PRINTSPR00341. PRION.
SMARTSM00157. PRP. 1 hit.
[Graphical view]
SUPFAMSSF54098. SSF54098. 1 hit.
PROSITEPS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2BDH2_PONAB
AccessionPrimary (citable) accession number: A2BDH2
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)