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A2BDH2

- A2BDH2_PONAB

UniProt

A2BDH2 - A2BDH2_PONAB

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Protein

Major prion protein

Gene

prnp

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. copper ion binding Source: Ensembl

GO - Biological processi

  1. negative regulation of activated T cell proliferation Source: Ensembl
  2. negative regulation of apoptotic process Source: Ensembl
  3. negative regulation of calcineurin-NFAT signaling cascade Source: Ensembl
  4. negative regulation of interferon-gamma production Source: Ensembl
  5. negative regulation of interleukin-17 production Source: Ensembl
  6. negative regulation of interleukin-2 production Source: Ensembl
  7. negative regulation of protein phosphorylation Source: Ensembl
  8. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  9. negative regulation of T cell receptor signaling pathway Source: Ensembl
  10. protein homooligomerization Source: InterPro
  11. regulation of potassium ion transmembrane transport Source: Ensembl
  12. regulation of protein localization Source: Ensembl
  13. response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

PrionUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Major prion proteinUniRule annotation
Gene namesi
Name:prnpImported
Synonyms:PRNPImported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 20

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: Ensembl
  4. membrane raft Source: Ensembl
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membraneUniRule annotationSAAS annotation, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA2BDH2.
SMRiA2BDH2. Positions 2-28, 119-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prion family.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00510000049083.
HOVERGENiHBG008260.
InParanoidiA2BDH2.
KOiK05634.
OMAiHNPGYPH.
OrthoDBiEOG7DRJ4Q.
TreeFamiTF105188.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
[Graphical view]
PANTHERiPTHR11522. PTHR11522. 1 hit.
PfamiPF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
[Graphical view]
PRINTSiPR00341. PRION.
SMARTiSM00157. PRP. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiPS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BDH2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANLGCWMLV LFVATWSNLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP
60 70 80 90 100
PQGGGGWGQP HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHSQWN
110 120 130 140 150
KPSKPKTNMK HMAGAAAAGA VVGGLGGYML GSAMSRPIIH FGNDYEDRYY
160 170 180 190 200
RENMYRYPNQ VYYRPVDQYS NQNNFVHDCV NITIKQHTVT TTTKGENFTE
210 220 230 240 250
TDVKMMERVV EQMCITQYER ESQAYYQRGS SMVLFSSPPV ILLISFLIFL

IVG
Length:253
Mass (Da):27,680
Last modified:February 20, 2007 - v1
Checksum:iA8D0E6972F1D5B26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01228014 Genomic DNA. No translation available.
BN000848 Genomic DNA. Translation: CAJ43808.1.
RefSeqiNP_001124544.1. NM_001131072.1.

Genome annotation databases

EnsembliENSPPYT00000012541; ENSPPYP00000012064; ENSPPYG00000010800.
GeneIDi100173712.
KEGGipon:100173712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01228014 Genomic DNA. No translation available.
BN000848 Genomic DNA. Translation: CAJ43808.1 .
RefSeqi NP_001124544.1. NM_001131072.1.

3D structure databases

ProteinModelPortali A2BDH2.
SMRi A2BDH2. Positions 2-28, 119-231.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000012541 ; ENSPPYP00000012064 ; ENSPPYG00000010800 .
GeneIDi 100173712.
KEGGi pon:100173712.

Organism-specific databases

CTDi 5621.

Phylogenomic databases

GeneTreei ENSGT00510000049083.
HOVERGENi HBG008260.
InParanoidi A2BDH2.
KOi K05634.
OMAi HNPGYPH.
OrthoDBi EOG7DRJ4Q.
TreeFami TF105188.

Family and domain databases

Gene3Di 1.10.790.10. 1 hit.
InterProi IPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
[Graphical view ]
PANTHERi PTHR11522. PTHR11522. 1 hit.
Pfami PF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
[Graphical view ]
PRINTSi PR00341. PRION.
SMARTi SM00157. PRP. 1 hit.
[Graphical view ]
SUPFAMi SSF54098. SSF54098. 1 hit.
PROSITEi PS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genomic analysis of prion genes."
    Premzl M., Gamulin V.
    BMC Genomics 8:1-1(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
    Wilson R.K., Mardis E.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Positive selection in prion protein."
    Premzl M., Gamulin V.
    J. Mol. Evol. 68:205-207(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA2BDH2_PONAB
AccessioniPrimary (citable) accession number: A2BDH2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3