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A2BDH2

- A2BDH2_PONAB

UniProt

A2BDH2 - A2BDH2_PONAB

Protein

Major prion protein

Gene

prnp

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. copper ion binding Source: Ensembl

    GO - Biological processi

    1. negative regulation of activated T cell proliferation Source: Ensembl
    2. negative regulation of apoptotic process Source: Ensembl
    3. negative regulation of calcineurin-NFAT signaling cascade Source: Ensembl
    4. negative regulation of interferon-gamma production Source: Ensembl
    5. negative regulation of interleukin-17 production Source: Ensembl
    6. negative regulation of interleukin-2 production Source: Ensembl
    7. negative regulation of protein phosphorylation Source: Ensembl
    8. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    9. negative regulation of T cell receptor signaling pathway Source: Ensembl
    10. protein homooligomerization Source: InterPro
    11. response to oxidative stress Source: Ensembl

    Keywords - Molecular functioni

    PrionUniRule annotationImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major prion proteinUniRule annotation
    Gene namesi
    Name:prnpImported
    Synonyms:PRNPImported
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 20

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. Golgi apparatus Source: Ensembl
    3. nucleolus Source: Ensembl
    4. plasma membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Amyloid, Cell membraneUniRule annotationSAAS annotation, Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliA2BDH2.
    SMRiA2BDH2. Positions 2-28, 119-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the prion family.UniRule annotation

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00510000049083.
    HOVERGENiHBG008260.
    KOiK05634.
    OMAiHNPGYPH.
    OrthoDBiEOG7DRJ4Q.
    TreeFamiTF105188.

    Family and domain databases

    Gene3Di1.10.790.10. 1 hit.
    InterProiIPR000817. Prion.
    IPR022416. Prion/Doppel_prot_b-ribbon_dom.
    IPR025860. Prion_N_dom.
    [Graphical view]
    PANTHERiPTHR11522. PTHR11522. 1 hit.
    PfamiPF00377. Prion. 1 hit.
    PF11587. Prion_bPrPp. 1 hit.
    [Graphical view]
    PRINTSiPR00341. PRION.
    SMARTiSM00157. PRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF54098. SSF54098. 1 hit.
    PROSITEiPS00291. PRION_1. 1 hit.
    PS00706. PRION_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2BDH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANLGCWMLV LFVATWSNLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP    50
    PQGGGGWGQP HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHSQWN 100
    KPSKPKTNMK HMAGAAAAGA VVGGLGGYML GSAMSRPIIH FGNDYEDRYY 150
    RENMYRYPNQ VYYRPVDQYS NQNNFVHDCV NITIKQHTVT TTTKGENFTE 200
    TDVKMMERVV EQMCITQYER ESQAYYQRGS SMVLFSSPPV ILLISFLIFL 250
    IVG 253
    Length:253
    Mass (Da):27,680
    Last modified:February 20, 2007 - v1
    Checksum:iA8D0E6972F1D5B26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGA01228014 Genomic DNA. No translation available.
    BN000848 Genomic DNA. Translation: CAJ43808.1.
    RefSeqiNP_001124544.1. NM_001131072.1.

    Genome annotation databases

    EnsembliENSPPYT00000012541; ENSPPYP00000012064; ENSPPYG00000010800.
    GeneIDi100173712.
    KEGGipon:100173712.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGA01228014 Genomic DNA. No translation available.
    BN000848 Genomic DNA. Translation: CAJ43808.1 .
    RefSeqi NP_001124544.1. NM_001131072.1.

    3D structure databases

    ProteinModelPortali A2BDH2.
    SMRi A2BDH2. Positions 2-28, 119-231.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000012541 ; ENSPPYP00000012064 ; ENSPPYG00000010800 .
    GeneIDi 100173712.
    KEGGi pon:100173712.

    Organism-specific databases

    CTDi 5621.

    Phylogenomic databases

    GeneTreei ENSGT00510000049083.
    HOVERGENi HBG008260.
    KOi K05634.
    OMAi HNPGYPH.
    OrthoDBi EOG7DRJ4Q.
    TreeFami TF105188.

    Family and domain databases

    Gene3Di 1.10.790.10. 1 hit.
    InterProi IPR000817. Prion.
    IPR022416. Prion/Doppel_prot_b-ribbon_dom.
    IPR025860. Prion_N_dom.
    [Graphical view ]
    PANTHERi PTHR11522. PTHR11522. 1 hit.
    Pfami PF00377. Prion. 1 hit.
    PF11587. Prion_bPrPp. 1 hit.
    [Graphical view ]
    PRINTSi PR00341. PRION.
    SMARTi SM00157. PRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54098. SSF54098. 1 hit.
    PROSITEi PS00291. PRION_1. 1 hit.
    PS00706. PRION_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of prion genes."
      Premzl M., Gamulin V.
      BMC Genomics 8:1-1(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
      Wilson R.K., Mardis E.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Positive selection in prion protein."
      Premzl M., Gamulin V.
      J. Mol. Evol. 68:205-207(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiA2BDH2_PONAB
    AccessioniPrimary (citable) accession number: A2BDH2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3