A2BDH2 (A2BDH2_PONAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Major prion protein RuleBase RU003882

Gene names

Name:	prnp EMBL CAJ43808.1
Synonyms:	PRNP Ensembl ENSPPYP00000012064

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the prion family. RuleBase RU003882

Ontologies

Keywords
Cellular component	Amyloid Cell membrane RuleBase RU003882 SAAS SAAS022416 Membrane
Domain	Repeat SAAS SAAS022416
Molecular function	Prion RuleBase RU003882 EMBL CAJ43808.1
PTM	Disulfide bond SAAS SAAS022416
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of T cell receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of activated T cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of calcineurin-NFAT signaling cascade Inferred from electronic annotation. Source: Compara negative regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-17 production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-2 production Inferred from electronic annotation. Source: Compara negative regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara negative regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from electronic annotation. Source: InterPro response to oxidative stress Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara nucleolus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2BDH2 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: A8D0E6972F1D5B26	FASTA	253	27,680
	10 20 30 40 50 60 MANLGCWMLV LFVATWSNLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP 70 80 90 100 110 120 HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHSQWN KPSKPKTNMK HMAGAAAAGA 130 140 150 160 170 180 VVGGLGGYML GSAMSRPIIH FGNDYEDRYY RENMYRYPNQ VYYRPVDQYS NQNNFVHDCV 190 200 210 220 230 240 NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCITQYER ESQAYYQRGS SMVLFSSPPV 250 ILLISFLIFL IVG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genomic analysis of prion genes." Premzl M., Gamulin V. BMC Genomics 8:0-0(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome." Wilson R.K., Mardis E. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Positive selection in prion protein." Premzl M., Gamulin V. J. Mol. Evol. 68:205-207(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABGA01228014 Genomic DNA. No translation available. BN000848 Genomic DNA. Translation: CAJ43808.1.
RefSeq	NP_001124544.1. NM_001131072.1.
UniGene	Pab.18649.
3D structure databases
SMR	A2BDH2. Positions 2-28, 119-231.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000012541; ENSPPYP00000012064; ENSPPYG00000010800.
GeneID	100173712.
KEGG	pon:100173712.
Organism-specific databases
CTD	5621.
Phylogenomic databases
GeneTree	ENSGT00510000049083.
HOVERGEN	HBG008260.
KO	K05634.
OMA	GYPHNPG.
Family and domain databases
Gene3D	1.10.790.10. 1 hit.
InterPro	IPR000817. Prion. IPR022416. Prion/Doppel_prot_b-ribbon_dom. IPR025860. Prion_N_dom. [Graphical view]
PANTHER	PTHR11522. PTHR11522. 1 hit.
Pfam	PF00377. Prion. 1 hit. PF11587. Prion_bPrPp. 1 hit. [Graphical view]
PRINTS	PR00341. PRION.
SMART	SM00157. PRP. 1 hit. [Graphical view]
SUPFAM	SSF54098. Prion. 1 hit.
PROSITE	PS00291. PRION_1. 1 hit. PS00706. PRION_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A2BDH2_PONAB

Accession

Primary (citable) accession number: A2BDH2

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)