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A2BD94

- FB31B_XENLA

UniProt

A2BD94 - FB31B_XENLA

Protein

F-box only protein 31-B

Gene

fbxo31-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest By similarity.By similarity

    Pathwayi

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: UniProtKB
    2. cyclin catabolic process Source: UniProtKB
    3. mitotic G1 DNA damage checkpoint Source: UniProtKB
    4. protein ubiquitination Source: UniProtKB-UniPathway
    5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, DNA damage, Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box only protein 31-B
    Gene namesi
    Name:fbxo31-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6255522. fbxo31.

    Subcellular locationi

    GO - Cellular componenti

    1. SCF ubiquitin ligase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523F-box only protein 31-BPRO_0000378165Add
    BLAST

    Interactioni

    Subunit structurei

    Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA2BD94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 10547F-boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FBXO31 family.Curated
    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK10308.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    IPR026941. FBXO31.
    [Graphical view]
    PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
    PfamiPF12937. F-box-like. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2BD94-1 [UniParc]FASTAAdd to Basket

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    MAVCARLCGV GQSGGCRRRR QRKGAGNDPE LEDEEEEDEV RIEAEVLVEG    50
    QAAVAPLRPR SLLQLPPEIL VEIFSSLPGT ELPSLAQVCR KFRQILTTDT 100
    IWKRRCKQEY GVCENLRKLE VTGVSCHDVY VKLLHQYRHI LGLWQPDIGP 150
    YGGLLNVVVD GLFIIGWMYL PPHDPHVDEG MRLKPVFRIH LMERNNATVE 200
    CMYGHKGPHN GQIQIVKKDE FSTKCLQTDY HRMSGGRQEE FRTWLREDLG 250
    RTLEDIFHEH MQELILMKFI YICQYDKCLT YRRIYHPPNR PDDLLNPGFF 300
    KGTYGSHGLE IVMFSFHGTI AKATKITGDP NVPAGQQTLE VDLTRPVQLP 350
    DVEHLRNFDE ISRLILDVQS QIQREQRQTG NEEDDGKGAG PDRAEHSQQP 400
    APVHRPAKED VNGVDNADDR EQKPPNVQSF VLPAGVMARN EEYPRSCKMC 450
    FYGTGLIAGH GFSSPERTPG LFILFDEDRF GFIWLELKSF SLYSRMRDRF 500
    QHSEAPSLEA FDEMLQHMQS WTT 523
    Length:523
    Mass (Da):59,954
    Last modified:February 20, 2007 - v1
    Checksum:iAD2C030667E04B79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC130117 mRNA. Translation: AAI30118.1.
    RefSeqiNP_001091269.1. NM_001097800.1.
    UniGeneiXl.9166.

    Genome annotation databases

    GeneIDi100037076.
    KEGGixla:100037076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC130117 mRNA. Translation: AAI30118.1 .
    RefSeqi NP_001091269.1. NM_001097800.1.
    UniGenei Xl.9166.

    3D structure databases

    ProteinModelPortali A2BD94.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100037076.
    KEGGi xla:100037076.

    Organism-specific databases

    CTDi 100037076.
    Xenbasei XB-GENE-6255522. fbxo31.

    Phylogenomic databases

    KOi K10308.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    IPR026941. FBXO31.
    [Graphical view ]
    PANTHERi PTHR10706:SF126. PTHR10706:SF126. 1 hit.
    Pfami PF12937. F-box-like. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiFB31B_XENLA
    AccessioniPrimary (citable) accession number: A2BD94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3