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Protein

F-box only protein 31-B

Gene

fbxo31-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).By similarity

Pathway: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 31-B
Gene namesi
Name:fbxo31-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6255522. fbxo31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523F-box only protein 31-BPRO_0000378165Add
BLAST

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2BD94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 10547F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO31 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK10308.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BD94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVCARLCGV GQSGGCRRRR QRKGAGNDPE LEDEEEEDEV RIEAEVLVEG
60 70 80 90 100
QAAVAPLRPR SLLQLPPEIL VEIFSSLPGT ELPSLAQVCR KFRQILTTDT
110 120 130 140 150
IWKRRCKQEY GVCENLRKLE VTGVSCHDVY VKLLHQYRHI LGLWQPDIGP
160 170 180 190 200
YGGLLNVVVD GLFIIGWMYL PPHDPHVDEG MRLKPVFRIH LMERNNATVE
210 220 230 240 250
CMYGHKGPHN GQIQIVKKDE FSTKCLQTDY HRMSGGRQEE FRTWLREDLG
260 270 280 290 300
RTLEDIFHEH MQELILMKFI YICQYDKCLT YRRIYHPPNR PDDLLNPGFF
310 320 330 340 350
KGTYGSHGLE IVMFSFHGTI AKATKITGDP NVPAGQQTLE VDLTRPVQLP
360 370 380 390 400
DVEHLRNFDE ISRLILDVQS QIQREQRQTG NEEDDGKGAG PDRAEHSQQP
410 420 430 440 450
APVHRPAKED VNGVDNADDR EQKPPNVQSF VLPAGVMARN EEYPRSCKMC
460 470 480 490 500
FYGTGLIAGH GFSSPERTPG LFILFDEDRF GFIWLELKSF SLYSRMRDRF
510 520
QHSEAPSLEA FDEMLQHMQS WTT
Length:523
Mass (Da):59,954
Last modified:February 20, 2007 - v1
Checksum:iAD2C030667E04B79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130117 mRNA. Translation: AAI30118.1.
RefSeqiNP_001091269.1. NM_001097800.1.
UniGeneiXl.9166.

Genome annotation databases

GeneIDi100037076.
KEGGixla:100037076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130117 mRNA. Translation: AAI30118.1.
RefSeqiNP_001091269.1. NM_001097800.1.
UniGeneiXl.9166.

3D structure databases

ProteinModelPortaliA2BD94.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100037076.
KEGGixla:100037076.

Organism-specific databases

CTDi100037076.
XenbaseiXB-GENE-6255522. fbxo31.

Phylogenomic databases

KOiK10308.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiFB31B_XENLA
AccessioniPrimary (citable) accession number: A2BD94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: February 20, 2007
Last modified: May 27, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.