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A2BD94

- FB31B_XENLA

UniProt

A2BD94 - FB31B_XENLA

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Protein
F-box only protein 31-B
Gene
fbxo31-b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest By similarity.

Pathwayi

GO - Biological processi

  1. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. cyclin catabolic process Source: UniProtKB
  4. mitotic G1 DNA damage checkpoint Source: UniProtKB
  5. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 31-B
Gene namesi
Name:fbxo31-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6255522. fbxo31.

Subcellular locationi

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523F-box only protein 31-B
PRO_0000378165Add
BLAST

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Structurei

3D structure databases

ProteinModelPortaliA2BD94.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 10547F-box
Add
BLAST

Sequence similaritiesi

Belongs to the FBXO31 family.
Contains 1 F-box domain.

Phylogenomic databases

KOiK10308.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BD94-1 [UniParc]FASTAAdd to Basket

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MAVCARLCGV GQSGGCRRRR QRKGAGNDPE LEDEEEEDEV RIEAEVLVEG    50
QAAVAPLRPR SLLQLPPEIL VEIFSSLPGT ELPSLAQVCR KFRQILTTDT 100
IWKRRCKQEY GVCENLRKLE VTGVSCHDVY VKLLHQYRHI LGLWQPDIGP 150
YGGLLNVVVD GLFIIGWMYL PPHDPHVDEG MRLKPVFRIH LMERNNATVE 200
CMYGHKGPHN GQIQIVKKDE FSTKCLQTDY HRMSGGRQEE FRTWLREDLG 250
RTLEDIFHEH MQELILMKFI YICQYDKCLT YRRIYHPPNR PDDLLNPGFF 300
KGTYGSHGLE IVMFSFHGTI AKATKITGDP NVPAGQQTLE VDLTRPVQLP 350
DVEHLRNFDE ISRLILDVQS QIQREQRQTG NEEDDGKGAG PDRAEHSQQP 400
APVHRPAKED VNGVDNADDR EQKPPNVQSF VLPAGVMARN EEYPRSCKMC 450
FYGTGLIAGH GFSSPERTPG LFILFDEDRF GFIWLELKSF SLYSRMRDRF 500
QHSEAPSLEA FDEMLQHMQS WTT 523
Length:523
Mass (Da):59,954
Last modified:February 20, 2007 - v1
Checksum:iAD2C030667E04B79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC130117 mRNA. Translation: AAI30118.1.
RefSeqiNP_001091269.1. NM_001097800.1.
UniGeneiXl.9166.

Genome annotation databases

GeneIDi100037076.
KEGGixla:100037076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC130117 mRNA. Translation: AAI30118.1 .
RefSeqi NP_001091269.1. NM_001097800.1.
UniGenei Xl.9166.

3D structure databases

ProteinModelPortali A2BD94.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100037076.
KEGGi xla:100037076.

Organism-specific databases

CTDi 100037076.
Xenbasei XB-GENE-6255522. fbxo31.

Phylogenomic databases

KOi K10308.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

InterProi IPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view ]
PANTHERi PTHR10706:SF126. PTHR10706:SF126. 1 hit.
Pfami PF12937. F-box-like. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiFB31B_XENLA
AccessioniPrimary (citable) accession number: A2BD94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: February 20, 2007
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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