Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2BD94

- FB31B_XENLA

UniProt

A2BD94 - FB31B_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

F-box only protein 31-B

Gene

fbxo31-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).By similarity

Pathwayi

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: UniProtKB
  2. cyclin catabolic process Source: UniProtKB
  3. mitotic G1 DNA damage checkpoint Source: UniProtKB
  4. protein ubiquitination Source: UniProtKB-UniPathway
  5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 31-B
Gene namesi
Name:fbxo31-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6255522. fbxo31.

Subcellular locationi

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523F-box only protein 31-BPRO_0000378165Add
BLAST

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2BD94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 10547F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO31 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK10308.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2BD94-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVCARLCGV GQSGGCRRRR QRKGAGNDPE LEDEEEEDEV RIEAEVLVEG
60 70 80 90 100
QAAVAPLRPR SLLQLPPEIL VEIFSSLPGT ELPSLAQVCR KFRQILTTDT
110 120 130 140 150
IWKRRCKQEY GVCENLRKLE VTGVSCHDVY VKLLHQYRHI LGLWQPDIGP
160 170 180 190 200
YGGLLNVVVD GLFIIGWMYL PPHDPHVDEG MRLKPVFRIH LMERNNATVE
210 220 230 240 250
CMYGHKGPHN GQIQIVKKDE FSTKCLQTDY HRMSGGRQEE FRTWLREDLG
260 270 280 290 300
RTLEDIFHEH MQELILMKFI YICQYDKCLT YRRIYHPPNR PDDLLNPGFF
310 320 330 340 350
KGTYGSHGLE IVMFSFHGTI AKATKITGDP NVPAGQQTLE VDLTRPVQLP
360 370 380 390 400
DVEHLRNFDE ISRLILDVQS QIQREQRQTG NEEDDGKGAG PDRAEHSQQP
410 420 430 440 450
APVHRPAKED VNGVDNADDR EQKPPNVQSF VLPAGVMARN EEYPRSCKMC
460 470 480 490 500
FYGTGLIAGH GFSSPERTPG LFILFDEDRF GFIWLELKSF SLYSRMRDRF
510 520
QHSEAPSLEA FDEMLQHMQS WTT
Length:523
Mass (Da):59,954
Last modified:February 20, 2007 - v1
Checksum:iAD2C030667E04B79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130117 mRNA. Translation: AAI30118.1.
RefSeqiNP_001091269.1. NM_001097800.1.
UniGeneiXl.9166.

Genome annotation databases

GeneIDi100037076.
KEGGixla:100037076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130117 mRNA. Translation: AAI30118.1 .
RefSeqi NP_001091269.1. NM_001097800.1.
UniGenei Xl.9166.

3D structure databases

ProteinModelPortali A2BD94.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100037076.
KEGGi xla:100037076.

Organism-specific databases

CTDi 100037076.
Xenbasei XB-GENE-6255522. fbxo31.

Phylogenomic databases

KOi K10308.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

InterProi IPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view ]
PANTHERi PTHR10706:SF126. PTHR10706:SF126. 1 hit.
Pfami PF12937. F-box-like. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiFB31B_XENLA
AccessioniPrimary (citable) accession number: A2BD94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: February 20, 2007
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3