Reviewed,
UniProtKB/Swiss-Prot A2AX52 (CO6A4_MOUSE)
Last modified
December 15, 2009.
Version 24.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Collagen alpha-4(VI) chain | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 2309 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Collagen VI acts as a cell-binding protein By similarity. |
| Subunit structure | Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI). Ref.1 |
| Subcellular location | Secreted › extracellular space › extracellular matrix By similarity. |
| Tissue specificity | In newborn, it is expressed in lung, kidney, brain, intestine, skin, sternum and, at weak level, calvaria. In adult, it is almost absent with some weak expression in ovary and very weak expression in spleen, lung, uterus and brain. Ref.1 |
| Post-translational modification | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity. |
| Miscellaneous | The human orthologous protein seems not to exist. |
| Sequence similarities | Belongs to the type VI collagen family. Contains 8 VWFA domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Extracellular matrix Secreted |
| Domain | Collagen Repeat Signal |
| PTM | Glycoprotein Hydroxylation |
| Gene Ontology (GO) | |
| Biological process | cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||
| Chain | 23 – 2309 | 2287 | Collagen alpha-4(VI) chain | PRO_5000214197 | |||||
Regions | |||||||||
| Domain | 34 – 206 | 173 | VWFA 1 | ||||||
| Domain | 235 – 413 | 179 | VWFA 2 | ||||||
| Domain | 430 – 653 | 224 | VWFA 3 | ||||||
| Domain | 634 – 811 | 178 | VWFA 4 | ||||||
| Domain | 849 – 1018 | 170 | VWFA 5 | ||||||
| Domain | 1030 – 1199 | 170 | VWFA 6 | ||||||
| Domain | 1776 – 1957 | 182 | VWFA 7 | ||||||
| Domain | 1982 – 2187 | 206 | VWFA 8 | ||||||
| Region | 21 – 1410 | 1390 | Nonhelical region | ||||||
| Region | 1411 – 1744 | 334 | Triple-helical region | ||||||
| Region | 1745 – 2309 | 565 | Nonhelical region | ||||||
| Motif | 1527 – 1529 | 3 | Cell attachment site Potential | ||||||
| Motif | 2208 – 2210 | 3 | Cell attachment site Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 188 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 754 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1114 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Three novel collagen VI chains with high homology to the alpha 3 chain." Gara S.K., Grumati P., Urciuolo A., Bonaldo P., Kobbe B., Koch M., Paulsson M., Wagener R. J. Biol. Chem. 283:10658-10670(2008) [PubMed: 18276594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY. Strain: C57BL/6J. Tissue: Brain and Uterus. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AM231151 mRNA. Translation: CAJ77150.1. AM231152 mRNA. Translation: CAJ77151.1. AM231153 mRNA. Translation: CAJ77152.1. | |
| IPI | IPI00828867. |
| RefSeq | NP_081039.2. |
| UniGene | Mm.28854 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | A2AX52. |
Genome annotation databases | |
| Ensembl | ENSMUST00000121963; ENSMUSP00000112472; ENSMUSG00000032572; Mus musculus. [Genome view] |
| GeneID | 68553. |
| KEGG | mmu:68553. |
Organism-specific databases | |
| CTD | 68553. |
| MGI | MGI:1915803. 1110001D15Rik. |
Phylogenomic databases | |
| HOGENOM | HBG444500. |
| HOVERGEN | A2AX52. |
| InParanoid | A2AX52. |
Gene expression databases | |
| Bgee | A2AX52. |
| Genevestigator | A2AX52. |
Family and domain databases | |
| InterPro | IPR008160. Collagen. IPR002035. VWF_A. [Graphical view] |
| Pfam | PF01391. Collagen. 5 hits. PF00092. VWA. 8 hits. [Graphical view] |
| SMART | SM00327. VWA. 9 hits. [Graphical view] |
| PROSITE | PS50234. VWFA. 8 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 327440. |
| SOURCE | Search... |
Entry information
| Entry name | CO6A4_MOUSE | ||||||||
| Accession | Primary (citable) accession number: A2AX52 Secondary accession number(s): A2AX53, A2AX54 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |
