ID   A2AWT5_MOUSE            Unreviewed;       764 AA.
AC   A2AWT5;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   SubName: Full=Upstream binding transcription factor, RNA polymerase I {ECO:0000313|Ensembl:ENSMUSP00000102740.4};
GN   Name=Ubtf {ECO:0000313|Ensembl:ENSMUSP00000102740.4,
GN   ECO:0000313|MGI:MGI:98512};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000102740.4, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000102740.4, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102740.4,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000102740.4}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000102740.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; NP_035681.2; NM_011551.6.
DR   RefSeq; XP_011247190.1; XM_011248888.2.
DR   RefSeq; XP_011247191.1; XM_011248889.2.
DR   ProteomicsDB; 336643; -.
DR   Antibodypedia; 1769; 446 antibodies from 34 providers.
DR   DNASU; 21429; -.
DR   Ensembl; ENSMUST00000079589.11; ENSMUSP00000078539.5; ENSMUSG00000020923.18.
DR   Ensembl; ENSMUST00000107123.10; ENSMUSP00000102740.4; ENSMUSG00000020923.18.
DR   Ensembl; ENSMUST00000173870.8; ENSMUSP00000133611.2; ENSMUSG00000020923.18.
DR   Ensembl; ENSMUST00000174302.8; ENSMUSP00000133844.2; ENSMUSG00000020923.18.
DR   GeneID; 21429; -.
DR   UCSC; uc007lri.2; mouse.
DR   AGR; MGI:98512; -.
DR   CTD; 7343; -.
DR   MGI; MGI:98512; Ubtf.
DR   VEuPathDB; HostDB:ENSMUSG00000020923; -.
DR   GeneTree; ENSGT00940000161141; -.
DR   HOGENOM; CLU_021068_1_0_1; -.
DR   OMA; RTAYKEY; -.
DR   OrthoDB; 4260911at2759; -.
DR   TreeFam; TF328989; -.
DR   BioGRID-ORCS; 21429; 31 hits in 77 CRISPR screens.
DR   ChiTaRS; Ubtf; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000020923; Expressed in floor plate of midbrain and 268 other cell types or tissues.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0001165; F:RNA polymerase I cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001164; F:RNA polymerase I core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001181; F:RNA polymerase I general transcription initiation factor activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   CDD; cd21998; HMG-box_UBF1_rpt1-like; 1.
DR   CDD; cd21999; HMG-box_UBF1_rpt2; 1.
DR   CDD; cd22000; HMG-box_UBF1_rpt3; 1.
DR   CDD; cd22001; HMG-box_UBF1_rpt4; 1.
DR   CDD; cd22002; HMG-box_UBF1_rpt5; 1.
DR   CDD; cd22003; HMG-box_UBF1_rpt6-like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 6.
DR   InterPro; IPR029215; HMG_box_5.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   PANTHER; PTHR46318:SF4; NUCLEOLAR TRANSCRIPTION FACTOR 1; 1.
DR   PANTHER; PTHR46318; UPSTREAM BINDING TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00505; HMG_box; 3.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   Pfam; PF14887; HMG_box_5; 1.
DR   SMART; SM00398; HMG; 6.
DR   SUPFAM; SSF47095; HMG-box; 6.
DR   PROSITE; PS50118; HMG_BOX_2; 6.
PE   1: Evidence at protein level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00267};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00267};
KW   Proteomics identification {ECO:0007829|EPD:A2AWT5,
KW   ECO:0007829|MaxQB:A2AWT5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          112..180
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DOMAIN          196..264
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DOMAIN          298..362
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DOMAIN          407..475
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DOMAIN          482..549
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DOMAIN          568..634
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        112..180
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        196..264
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        298..362
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        407..475
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        482..549
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        568..634
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          456..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          546..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          648..764
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..487
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        656..671
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        676..746
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        747..764
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   764 AA;  89479 MW;  788C8822CFEE5070 CRC64;
     MNGEADCPTD LEMAAPKGQD RWSQEDMLTL LECMKNNLPS NDSSKFKTTE SHMDWEKVAF
     KDFSGDMCKL KWVEISNEVR KFRTLTELIL DAQEHVKNPY KGKKLKKHPD FPKKPLTPYF
     RFFMEKRAKY AKLHPEMSNL DLTKILSKKY KELPEKKKMK YIQDFQREKQ EFERNLARFR
     EDHPDLIQNA KKSDIPEKPK TPQQLWYTHE KKVYLKVRPD ATTKEVKDSL GKQWSQLSDK
     KRLKWIHKAL EQRKEYEEIM RDYIQKHPEL NISEEGITKS TLTKAERQLK DKFDGRPTKP
     PPNSYSLYCA ELMANMKDVP STERMVLCSQ QWKLLSQKEK DAYHKKCDQK KKDYEVELLR
     FLESLPEEEQ QRVLGEEKML NINKKQTTSP ASKKPSQEGG KGGSEKPKRP VSAMFIFSEE
     KRRQLQEERP ELSESELTRL LARMWNDLSE KKKAKYKARE AALKAQSERK PGGEREDRGK
     LPESPKRAEE IWQQSVIGDY LARFKNDRVK ALKAMEMTWN NMEKKEKLMW IKKAAEDQKR
     YERELSEMRA PPAATNSSKK MKFQGEPKKP PMNGYQKFSQ ELLSNGELNH LPLKERMVEI
     GSRWQRISQS QKEHYKKLAE EQQRQYKVHL DLWVKSLSPQ DRAAYKEYIS NKRKNMTKLR
     GPNPKSSRTT LQSKSESEED DDEEEEDDEE EEEEEDDENG DSSEDGGDSS ESSSEDESED
     GDENDDDDDD EDDEDDDDED EDNESEGSSS SSSSSGDSSD SDSN
//