Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ataxin-7-like protein 3

Gene

Atxn7l3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri84 – 10522SGF11-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-7-like protein 3UniRule annotation
Alternative name(s):
SAGA-associated factor 11 homologUniRule annotation
Gene namesi
Name:Atxn7l3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3036270. Atxn7l3.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Ataxin-7-like protein 3PRO_0000367516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291PhosphoserineBy similarity
Modified residuei131 – 1311PhosphoserineBy similarity
Modified residuei278 – 2781PhosphoserineBy similarity
Modified residuei281 – 2811PhosphoserineCombined sources
Modified residuei326 – 3261PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2AWT3.
MaxQBiA2AWT3.
PaxDbiA2AWT3.
PeptideAtlasiA2AWT3.
PRIDEiA2AWT3.

PTM databases

iPTMnetiA2AWT3.
PhosphoSiteiA2AWT3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059995.
ExpressionAtlasiA2AWT3. baseline and differential.
GenevisibleiA2AWT3. MM.

Interactioni

Subunit structurei

Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.UniRule annotation

Protein-protein interaction databases

IntActiA2AWT3. 2 interactions.
MINTiMINT-7984980.
STRINGi10090.ENSMUSP00000102750.

Structurei

3D structure databases

ProteinModelPortaliA2AWT3.
SMRiA2AWT3. Positions 198-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 26368SCA7UniRule annotationAdd
BLAST

Domaini

The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.UniRule annotation
The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.UniRule annotation

Sequence similaritiesi

Belongs to the SGF11 family.UniRule annotation
Contains 1 SCA7 domain.UniRule annotation
Contains 1 SGF11-type zinc finger.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri84 – 10522SGF11-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2612. Eukaryota.
ENOG4111IPI. LUCA.
GeneTreeiENSGT00390000012202.
HOGENOMiHOG000006954.
HOVERGENiHBG071455.
InParanoidiA2AWT3.
KOiK11363.
OMAiPFKYSNS.
OrthoDBiEOG091G0LQK.
PhylomeDBiA2AWT3.
TreeFamiTF324580.

Family and domain databases

HAMAPiMF_03047. Sgf11. 1 hit.
InterProiIPR013246. SAGA_su_Sgf11.
IPR013243. SCA7_dom.
[Graphical view]
PfamiPF08313. SCA7. 1 hit.
PF08209. Sgf11. 1 hit.
[Graphical view]
PROSITEiPS51505. SCA7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AWT3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMEEMSLSG LDNSKLEAIA QEIYADLVED SCLGFCFEVH RAVKCGYFFL
60 70 80 90 100
DDTDPDSMKD FEIVDQPGLD IFGQVFNQWK SKECVCPNCS RSIAASRFAP
110 120 130 140 150
HLEKCLGMGR NSSRIANRRI ANSNNMNKSE SDQEDNDDIN DNDWSYGSEK
160 170 180 190 200
KAKKRKSDKN PNSPRRSKSL KHKNGELSNS DPFKYSNSTG ISYETLGPEE
210 220 230 240 250
LRSLLTTQCG VISEHTKKMC TRSLRCPQHT DEQRRTVRIY FLGPSAVLPE
260 270 280 290 300
VESSLDNDGF DMTDSQALIS RLQWDGSSDL SPSDSGSSKT SENQGWGLGT
310 320 330 340
NSSESRKTKK KKSHLSLVGT ASGLGSNKKK KPKPPAPPTP SIYDDIN
Length:347
Mass (Da):38,594
Last modified:February 20, 2007 - v1
Checksum:iEB5A4DC807B674D0
GO
Isoform 2 (identifier: A2AWT3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-159: K → KLWYLPFQ

Show »
Length:354
Mass (Da):39,542
Checksum:i72C1D07FFC39A4C6
GO

Sequence cautioni

The sequence CAM25078 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei159 – 1591K → KLWYLPFQ in isoform 2. CuratedVSP_036728

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA. Translation: CAM25078.1. Sequence problems.
AL954730 Genomic DNA. Translation: CAM25079.1.
AL954730 Genomic DNA. Translation: CAM25080.1.
CH466558 Genomic DNA. Translation: EDL34107.1.
AK090368 mRNA. Translation: BAC41186.1.
CCDSiCCDS48941.1. [A2AWT3-1]
CCDS48942.1. [A2AWT3-2]
RefSeqiNP_001092306.1. NM_001098836.1. [A2AWT3-2]
NP_001092307.1. NM_001098837.1. [A2AWT3-1]
UniGeneiMm.390381.

Genome annotation databases

EnsembliENSMUST00000073234; ENSMUSP00000072967; ENSMUSG00000059995. [A2AWT3-1]
ENSMUST00000107132; ENSMUSP00000102750; ENSMUSG00000059995. [A2AWT3-2]
ENSMUST00000107134; ENSMUSP00000102752; ENSMUSG00000059995. [A2AWT3-1]
GeneIDi217218.
KEGGimmu:217218.
UCSCiuc007lrg.1. mouse. [A2AWT3-2]
uc007lrh.1. mouse. [A2AWT3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA. Translation: CAM25078.1. Sequence problems.
AL954730 Genomic DNA. Translation: CAM25079.1.
AL954730 Genomic DNA. Translation: CAM25080.1.
CH466558 Genomic DNA. Translation: EDL34107.1.
AK090368 mRNA. Translation: BAC41186.1.
CCDSiCCDS48941.1. [A2AWT3-1]
CCDS48942.1. [A2AWT3-2]
RefSeqiNP_001092306.1. NM_001098836.1. [A2AWT3-2]
NP_001092307.1. NM_001098837.1. [A2AWT3-1]
UniGeneiMm.390381.

3D structure databases

ProteinModelPortaliA2AWT3.
SMRiA2AWT3. Positions 198-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AWT3. 2 interactions.
MINTiMINT-7984980.
STRINGi10090.ENSMUSP00000102750.

PTM databases

iPTMnetiA2AWT3.
PhosphoSiteiA2AWT3.

Proteomic databases

EPDiA2AWT3.
MaxQBiA2AWT3.
PaxDbiA2AWT3.
PeptideAtlasiA2AWT3.
PRIDEiA2AWT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073234; ENSMUSP00000072967; ENSMUSG00000059995. [A2AWT3-1]
ENSMUST00000107132; ENSMUSP00000102750; ENSMUSG00000059995. [A2AWT3-2]
ENSMUST00000107134; ENSMUSP00000102752; ENSMUSG00000059995. [A2AWT3-1]
GeneIDi217218.
KEGGimmu:217218.
UCSCiuc007lrg.1. mouse. [A2AWT3-2]
uc007lrh.1. mouse. [A2AWT3-1]

Organism-specific databases

CTDi56970.
MGIiMGI:3036270. Atxn7l3.

Phylogenomic databases

eggNOGiKOG2612. Eukaryota.
ENOG4111IPI. LUCA.
GeneTreeiENSGT00390000012202.
HOGENOMiHOG000006954.
HOVERGENiHBG071455.
InParanoidiA2AWT3.
KOiK11363.
OMAiPFKYSNS.
OrthoDBiEOG091G0LQK.
PhylomeDBiA2AWT3.
TreeFamiTF324580.

Miscellaneous databases

PROiA2AWT3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059995.
ExpressionAtlasiA2AWT3. baseline and differential.
GenevisibleiA2AWT3. MM.

Family and domain databases

HAMAPiMF_03047. Sgf11. 1 hit.
InterProiIPR013246. SAGA_su_Sgf11.
IPR013243. SCA7_dom.
[Graphical view]
PfamiPF08313. SCA7. 1 hit.
PF08209. Sgf11. 1 hit.
[Graphical view]
PROSITEiPS51505. SCA7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT7L3_MOUSE
AccessioniPrimary (citable) accession number: A2AWT3
Secondary accession number(s): A2AWT2, A2AWT4, Q8C1T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.