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A2AWS5 (A2AWS5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length1030 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000102769

Ontologies

Keywords
   Molecular functionHydrolase SAAS SAAS000286
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheart development

Inferred from genetic interaction PubMed 15367668. Source: MGI

multicellular organismal response to stress

Inferred from mutant phenotype PubMed 17988634. Source: MGI

negative regulation of osteoblast differentiation

Inferred from mutant phenotype PubMed 15990875. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10640276. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 16260608. Source: MGI

osteoblast development

Inferred from mutant phenotype PubMed 15990875. Source: MGI

regulation of skeletal muscle fiber development

Inferred from genetic interaction PubMed 17786239. Source: MGI

regulation of striated muscle cell differentiation

Inferred from genetic interaction PubMed 17786239. Source: MGI

response to cocaine

Inferred from direct assay PubMed 17988634. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 11081517. Source: MGI

cytosol

Inferred from direct assay PubMed 18198354PubMed 18332106. Source: MGI

histone deacetylase complex

Inferred from electronic annotation. Source: InterPro

nuclear body

Inferred from direct assay PubMed 11641275. Source: MGI

nucleus

Inferred from direct assay PubMed 11081517PubMed 18198354. Source: MGI

   Molecular_functionhistone deacetylase activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 10640276PubMed 11641275PubMed 15601857PubMed 15990875PubMed 16260608PubMed 18332106. Source: MGI

transcription corepressor activity

Inferred from direct assay PubMed 10640276. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A2AWS5 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: BC08380109B0477B

FASTA1,030111,463
        10         20         30         40         50         60 
MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG GGGSPSPVEL 

        70         80         90        100        110        120 
RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ KQHDHLTRQH EVQLQKHLKQ 

       130        140        150        160        170        180 
QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ RLEQQLLILR NKEKSKESAI ASTEVKLRLQ 

       190        200        210        220        230        240 
EFLLSKSKEP TPGGLNHSLP QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS 

       250        260        270        280        290        300 
RDDFPLRKTA SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS 

       310        320        330        340        350        360 
SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP NQFSLYTSPS 

       370        380        390        400        410        420 
LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR QGGTLTGKFM STSSIPGCLL 

       430        440        450        460        470        480 
GVALEGDTSP HGHASLLQHV LLLEQARQQS TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP 

       490        500        510        520        530        540 
RHRPLSRTQS SPLPQSPQAL QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH 

       550        560        570        580        590        600 
PEETEEELTE QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG 

       610        620        630        640        650        660 
ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT QSSPAAPGSM 

       670        680        690        700        710        720 
KSPTDQPTVV KHLFTTGPIS QKMYAMLPCG GIGVDSDTVW NEMHSSSAVR MAVGCLVELA 

       730        740        750        760        770        780 
FKVAAGELKN GFAIIRPPGH HAEESTAMGF CFFNSVAITA KLLQQKLSVG KVLIVDWDIH 

       790        800        810        820        830        840 
HGNGTQQAFY NDPSVLYISL HRYDNGNFFP GSGAPEEVGG GPGVGYNVNV AWTGGVDPPI 

       850        860        870        880        890        900 
GDVEYLTAFR TVVMPIAQEF SPDVVLVSAG FDAVEGHLSP LGGYSVTARC FGHLTRQLMT 

       910        920        930        940        950        960 
LAGGRVVLAL EGGHDLTAIC DASEACVSAL LSVELQPLDE AVLQQKPSVN AVATLEKVIE 

       970        980        990       1000       1010       1020 
IQSKHWSCVQ RFAAGLGCSL REAQTGEKEE AETVSAMALL SVGAEQAQAV ATQEHSPRPA 

      1030 
EEPMEQEPAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL954730 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalA2AWS5.
SMRA2AWS5. Positions 683-971.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000008999.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000107151; ENSMUSP00000102769; ENSMUSG00000008855.

Organism-specific databases

MGIMGI:1333784. Hdac5.

Phylogenomic databases

GeneTreeENSGT00530000062809.
HOGENOMHOG000232065.
HOVERGENHBG057100.
OrthoDBEOG7RFTH5.

Gene expression databases

ArrayExpressA2AWS5.

Family and domain databases

Gene3D3.40.800.20. 2 hits.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Other

ChiTaRSHDAC5. mouse.
NextBio35544266.
SOURCESearch...

Entry information

Entry nameA2AWS5_MOUSE
AccessionPrimary (citable) accession number: A2AWS5
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)