Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A2AWS5

- A2AWS5_MOUSE

UniProt

A2AWS5 - A2AWS5_MOUSE

Protein
Submitted name:

Histone deacetylase 5

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. histone deacetylase activity Source: InterPro
    2. protein binding Source: MGI
    3. transcription corepressor activity Source: MGI

    GO - Biological processi

    1. heart development Source: MGI
    2. multicellular organismal response to stress Source: MGI
    3. negative regulation of osteoblast differentiation Source: MGI
    4. negative regulation of transcription, DNA-templated Source: MGI
    5. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    6. osteoblast development Source: MGI
    7. regulation of skeletal muscle fiber development Source: MGI
    8. regulation of striated muscle cell differentiation Source: MGI
    9. response to cocaine Source: MGI

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Histone deacetylase 5Imported
    Gene namesi
    Name:Hdac5Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1333784. Hdac5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. histone deacetylase complex Source: InterPro
    4. nuclear body Source: MGI
    5. nucleus Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiA2AWS5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000008999.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AWS5.
    SMRiA2AWS5. Positions 694-987.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000062809.
    HOGENOMiHOG000232065.
    HOVERGENiHBG057100.
    OrthoDBiEOG7RFTH5.

    Family and domain databases

    Gene3Di3.40.800.20. 2 hits.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF12203. HDAC4_Gln. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    A2AWS5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG     50
    GGGSPSPVEL RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ 100
    KQHDHLTRQH EVQLQKHLKQ QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ 150
    RLEQQLLILR NKEKSKESAI ASTEVKLRLQ EFLLSKSKEP TPGGLNHSLP 200
    QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS RDDFPLRKTA 250
    SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS 300
    SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP 350
    NQFSLYTSPS LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR 400
    QGGTLTGKFM STSSIPGCLL GVALEGDTSP HGHASLLQHV LLLEQARQQS 450
    TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP RHRPLSRTQS SPLPQSPQAL 500
    QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH PEETEEELTE 550
    QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG 600
    ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT 650
    QSSPAAPGSM KSPTDQPTVV KHLFTTGPIS QKMYAMLPCG GIGVDSDTVW 700
    NEMHSSSAVR MAVGCLVELA FKVAAGELKN GFAIIRPPGH HAEESTAMGF 750
    CFFNSVAITA KLLQQKLSVG KVLIVDWDIH HGNGTQQAFY NDPSVLYISL 800
    HRYDNGNFFP GSGAPEEVGG GPGVGYNVNV AWTGGVDPPI GDVEYLTAFR 850
    TVVMPIAQEF SPDVVLVSAG FDAVEGHLSP LGGYSVTARC FGHLTRQLMT 900
    LAGGRVVLAL EGGHDLTAIC DASEACVSAL LSVELQPLDE AVLQQKPSVN 950
    AVATLEKVIE IQSKHWSCVQ RFAAGLGCSL REAQTGEKEE AETVSAMALL 1000
    SVGAEQAQAV ATQEHSPRPA EEPMEQEPAL 1030
    Length:1,030
    Mass (Da):111,463
    Last modified:February 20, 2007 - v1
    Checksum:iBC08380109B0477B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954730 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000107151; ENSMUSP00000102769; ENSMUSG00000008855.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954730 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A2AWS5.
    SMRi A2AWS5. Positions 694-987.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000008999.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000107151 ; ENSMUSP00000102769 ; ENSMUSG00000008855 .

    Organism-specific databases

    MGIi MGI:1333784. Hdac5.

    Phylogenomic databases

    GeneTreei ENSGT00530000062809.
    HOGENOMi HOG000232065.
    HOVERGENi HBG057100.
    OrthoDBi EOG7RFTH5.

    Enzyme and pathway databases

    Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Miscellaneous databases

    ChiTaRSi HDAC5. mouse.
    NextBioi 35544266.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2AWS5.

    Family and domain databases

    Gene3Di 3.40.800.20. 2 hits.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF12203. HDAC4_Gln. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2AWS5_MOUSE
    AccessioniPrimary (citable) accession number: A2AWS5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3