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A2AWS5

- A2AWS5_MOUSE

UniProt

A2AWS5 - A2AWS5_MOUSE

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Protein
Submitted name:

Histone deacetylase 5

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi689 – 6891ZincUniRule annotation
Active sitei741 – 7411UniRule annotation

GO - Molecular functioni

  1. histone deacetylase activity Source: InterPro
  2. transcription corepressor activity Source: MGI

GO - Biological processi

  1. heart development Source: MGI
  2. multicellular organismal response to stress Source: MGI
  3. negative regulation of osteoblast differentiation Source: MGI
  4. negative regulation of transcription, DNA-templated Source: MGI
  5. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  6. osteoblast development Source: MGI
  7. regulation of skeletal muscle fiber development Source: MGI
  8. regulation of striated muscle cell differentiation Source: MGI
  9. response to cocaine Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 5Imported
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1333784. Hdac5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. histone deacetylase complex Source: InterPro
  4. nuclear body Source: MGI
  5. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiA2AWS5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008999.

Structurei

3D structure databases

ProteinModelPortaliA2AWS5.
SMRiA2AWS5. Positions 683-971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.
OrthoDBiEOG7RFTH5.

Family and domain databases

Gene3Di3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

A2AWS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG
60 70 80 90 100
GGGSPSPVEL RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ
110 120 130 140 150
KQHDHLTRQH EVQLQKHLKQ QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ
160 170 180 190 200
RLEQQLLILR NKEKSKESAI ASTEVKLRLQ EFLLSKSKEP TPGGLNHSLP
210 220 230 240 250
QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS RDDFPLRKTA
260 270 280 290 300
SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS
310 320 330 340 350
SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP
360 370 380 390 400
NQFSLYTSPS LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR
410 420 430 440 450
QGGTLTGKFM STSSIPGCLL GVALEGDTSP HGHASLLQHV LLLEQARQQS
460 470 480 490 500
TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP RHRPLSRTQS SPLPQSPQAL
510 520 530 540 550
QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH PEETEEELTE
560 570 580 590 600
QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG
610 620 630 640 650
ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT
660 670 680 690 700
QSSPAAPGSM KSPTDQPTVV KHLFTTGPIS QKMYAMLPCG GIGVDSDTVW
710 720 730 740 750
NEMHSSSAVR MAVGCLVELA FKVAAGELKN GFAIIRPPGH HAEESTAMGF
760 770 780 790 800
CFFNSVAITA KLLQQKLSVG KVLIVDWDIH HGNGTQQAFY NDPSVLYISL
810 820 830 840 850
HRYDNGNFFP GSGAPEEVGG GPGVGYNVNV AWTGGVDPPI GDVEYLTAFR
860 870 880 890 900
TVVMPIAQEF SPDVVLVSAG FDAVEGHLSP LGGYSVTARC FGHLTRQLMT
910 920 930 940 950
LAGGRVVLAL EGGHDLTAIC DASEACVSAL LSVELQPLDE AVLQQKPSVN
960 970 980 990 1000
AVATLEKVIE IQSKHWSCVQ RFAAGLGCSL REAQTGEKEE AETVSAMALL
1010 1020 1030
SVGAEQAQAV ATQEHSPRPA EEPMEQEPAL
Length:1,030
Mass (Da):111,463
Last modified:February 20, 2007 - v1
Checksum:iBC08380109B0477B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954730 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000107151; ENSMUSP00000102769; ENSMUSG00000008855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954730 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali A2AWS5.
SMRi A2AWS5. Positions 683-971.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000008999.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107151 ; ENSMUSP00000102769 ; ENSMUSG00000008855 .

Organism-specific databases

MGIi MGI:1333784. Hdac5.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
HOGENOMi HOG000232065.
HOVERGENi HBG057100.
OrthoDBi EOG7RFTH5.

Enzyme and pathway databases

Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

ChiTaRSi HDAC5. mouse.
NextBioi 35544266.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi A2AWS5. baseline and differential.

Family and domain databases

Gene3Di 3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AWS5_MOUSE
AccessioniPrimary (citable) accession number: A2AWS5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3