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Protein

Rho guanine nucleotide exchange factor 10-like protein

Gene

Arhgef10l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 10-like protein
Alternative name(s):
GrinchGEF
Gene namesi
Name:Arhgef10l
Synonyms:Kiaa1626
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920004 Arhgef10l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003423621 – 1280Rho guanine nucleotide exchange factor 10-like proteinAdd BLAST1280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineBy similarity1
Modified residuei131PhosphotyrosineCombined sources1
Modified residuei152PhosphotyrosineCombined sources1
Modified residuei279PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AWP8
PaxDbiA2AWP8
PeptideAtlasiA2AWP8
PRIDEiA2AWP8

PTM databases

iPTMnetiA2AWP8
PhosphoSitePlusiA2AWP8

Expressioni

Gene expression databases

BgeeiENSMUSG00000040964
ExpressionAtlasiA2AWP8 baseline and differential
GenevisibleiA2AWP8 MM

Interactioni

Subunit structurei

Interacts with RHOA, RHOB and RHOC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiA2AWP8, 1 interactor
STRINGi10090.ENSMUSP00000040531

Structurei

3D structure databases

ProteinModelPortaliA2AWP8
SMRiA2AWP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini314 – 501DHPROSITE-ProRule annotationAdd BLAST188

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
KOG4305 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00670000097546
HOVERGENiHBG050570
InParanoidiA2AWP8
KOiK16727
OMAiCGPRVTV
OrthoDBiEOG091G0A3T
PhylomeDBiA2AWP8
TreeFamiTF331430

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AWP8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSNPPPQP AIGAPLAPSA PGPSPEVEED SGEAFEFDDS DEEEDTSSGL
60 70 80 90 100
VVPGLAPERD TEPSLICFDT VPGSDLDPAA APPQTEAPTV VSNGDAVGAA
110 120 130 140 150
ISGVRRSSWK RKSSRRIDRF TFPALEEDVI YDDVPCESPD AHQPGAERGL
160 170 180 190 200
VYEDVHRAGA PRETEDLGWS SSEFESYSED SGEETKPEAE PTKHRGSFQP
210 220 230 240 250
KLSPDLTRLK ERYVRTKRDI LALRVGGRDM QELKLKCDCK MTQLMKAAKS
260 270 280 290 300
GTRDGLEKTR MAVMRKVSFL HRKDVLGDSE EEDMGLLEVG VTDIKPPAPE
310 320 330 340 350
LGPMPDGLSP QQVVRRHILG SIVQSEGSYV ESLKRILQDY RNPLMEMEPK
360 370 380 390 400
ALSARKCQVV FFRVKEILHC HSMFQIALSS RVAEWDSTEK IGDLFVASFS
410 420 430 440 450
KSMVLDVYSD YVNNFTNAMS IIKKACLTKP AFLEFLKRRQ VCSTDRVTLY
460 470 480 490 500
GLMVKPVQRF PQFILLLQDM LKNTPRGHPD RLSLQLALTE LETLAEKLNE
510 520 530 540 550
QKRLADQVAE IQQLTKSVSD RSSLNKLLTS GQRQLLLCET LTETVYGDRG
560 570 580 590 600
QLIKSKERRV FLLNDMLVCA NINFKPSNHR GQLEISSLVP LGPKYVVKWN
610 620 630 640 650
TALPQVQVVE VGQDGGTYDK DNLLIQHAGA KKATAAGQAQ NKVYLGPPRL
660 670 680 690 700
FQELQDLQKD LAVVEQITLL ISTLHGTYQN LNMTVAQDWC LALQRLMRVK
710 720 730 740 750
EEEIHSANKC RLRLLLPGKP DKSGRPISFM VVFITPNPLS KISWVNRLHL
760 770 780 790 800
AKIGLREENQ PGWLCPDEDK KSKAPFWCPI LACCVPAFSS RTLSLQLGGL
810 820 830 840 850
VHSPVNSPLL GFSAVSTSLP QGYLWVGGGQ EGAGGQVEIF SLNRPSPRTV
860 870 880 890 900
KSFPVAAPVL CIEYIPDPEE EAEGAEESRA ATDPSVTVHP TVCLGLQDGS
910 920 930 940 950
ILLYGSVDTG TQCLATCKSP GPQPVLCLRH SPFYLLAGLQ DGTLAAYPRT
960 970 980 990 1000
SGDIPWDLES PPMCITVGPG PIRTLLSLED AAWASCGPRV TVLDAATLQT
1010 1020 1030 1040 1050
QQSFEAHQDE AVSVTHMVKA GSGVWMAFSS GSSIRLFHTE TLEHLQEINI
1060 1070 1080 1090 1100
ATRTTFLLPG QKHLCVTSLL ICQGLLWVGT DQGVIVLLPV PRLEGIPKIT
1110 1120 1130 1140 1150
GKGMVSLNGH CGPVAFLAVA MSILAPDILR SDQEEAEGPQ AEEDKPDGQA
1160 1170 1180 1190 1200
HETVPGPDSH TARELTRKKG ILLQYRLRST AHLPGPLLSV REPAPADGSA
1210 1220 1230 1240 1250
LEHSEEDGSI YEMADDPDVW VRSRPCARDA HRKEICSVAI ISGGQGYRHF
1260 1270 1280
GGAPGGLSGR AAPCSETDST LLIWQVPLAL
Length:1,280
Mass (Da):139,987
Last modified:February 5, 2008 - v1
Checksum:i4A9C924B4D437252
GO
Isoform 2 (identifier: A2AWP8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-239: Missing.

Show »
Length:1,241
Mass (Da):135,386
Checksum:iBF08D9E93B2A2A0E
GO
Isoform 3 (identifier: A2AWP8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-239: Missing.
     576-580: Missing.

Show »
Length:1,236
Mass (Da):134,795
Checksum:iFBF0CE68F96DC823
GO
Isoform 4 (identifier: A2AWP8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-580: Missing.

Show »
Length:1,275
Mass (Da):139,395
Checksum:i22A892D801F32872
GO
Isoform 5 (identifier: A2AWP8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-215: Missing.
     216-276: TKRDILALRV...VSFLHRKDVL → MLPSSSWGKR...SSSSSSVSCS
     399-468: Missing.
     576-580: Missing.

Show »
Length:988
Mass (Da):107,747
Checksum:iE0F6129CDBB645A8
GO

Sequence cautioni

The sequence BAC98218 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280 – 281Missing in AAH59220 (PubMed:15489334).Curated2
Sequence conflicti453M → V in BAC26047 (PubMed:16141072).Curated1
Sequence conflicti850V → I in BAC98218 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0344271 – 215Missing in isoform 5. CuratedAdd BLAST215
Alternative sequenceiVSP_034428201 – 239Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_034429216 – 276TKRDI…RKDVL → MLPSSSWGKRKPRSQRLGWV RCDARGNMWARQEGLRQPHP HPHALIRCPSSSSSSVSCS in isoform 5. CuratedAdd BLAST61
Alternative sequenceiVSP_034430399 – 468Missing in isoform 5. CuratedAdd BLAST70
Alternative sequenceiVSP_034431576 – 580Missing in isoform 3, isoform 4 and isoform 5. 2 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129408 mRNA Translation: BAC98218.1 Different initiation.
AK028648 mRNA Translation: BAC26047.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14356.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14358.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14359.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14360.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14361.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14469.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14471.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14472.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14473.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14474.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19324.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19327.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19328.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19329.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19330.1
BC021843 mRNA Translation: AAH21843.1
BC059220 mRNA Translation: AAH59220.1
CCDSiCCDS51342.1 [A2AWP8-3]
CCDS51343.1 [A2AWP8-2]
CCDS51344.1 [A2AWP8-4]
CCDS71507.1 [A2AWP8-1]
RefSeqiNP_001106193.1, NM_001112722.1 [A2AWP8-2]
NP_001106194.1, NM_001112723.1 [A2AWP8-3]
NP_001277732.1, NM_001290803.1 [A2AWP8-1]
NP_766003.3, NM_172415.3 [A2AWP8-4]
XP_006539264.1, XM_006539201.3 [A2AWP8-1]
XP_006539265.1, XM_006539202.1 [A2AWP8-1]
XP_011248639.1, XM_011250337.2 [A2AWP8-1]
XP_011248642.1, XM_011250340.2 [A2AWP8-3]
XP_017175885.1, XM_017320396.1 [A2AWP8-1]
UniGeneiMm.29329

Genome annotation databases

EnsembliENSMUST00000039204; ENSMUSP00000040531; ENSMUSG00000040964 [A2AWP8-4]
ENSMUST00000069623; ENSMUSP00000066249; ENSMUSG00000040964 [A2AWP8-2]
ENSMUST00000097820; ENSMUSP00000095431; ENSMUSG00000040964 [A2AWP8-3]
ENSMUST00000105797; ENSMUSP00000101423; ENSMUSG00000040964 [A2AWP8-5]
ENSMUST00000105799; ENSMUSP00000101425; ENSMUSG00000040964 [A2AWP8-1]
GeneIDi72754
KEGGimmu:72754
UCSCiuc008vmw.2 mouse [A2AWP8-4]
uc008vmx.2 mouse [A2AWP8-3]
uc008vmy.2 mouse [A2AWP8-2]
uc056zye.1 mouse [A2AWP8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARGAL_MOUSE
AccessioniPrimary (citable) accession number: A2AWP8
Secondary accession number(s): A2AWP5
, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health