Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Baculoviral IAP repeat-containing protein 7

Gene

Birc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of caspase-3, -7, and -9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130ZincPROSITE-ProRule annotation1
Metal bindingi133ZincPROSITE-ProRule annotation1
Metal bindingi150ZincPROSITE-ProRule annotation1
Metal bindingi157ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri239 – 273RING-typePROSITE-ProRule annotationAdd BLAST35

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor, Transferase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 7 (EC:2.3.2.27By similarity)
Alternative name(s):
Livin
RING-type E3 ubiquitin transferase BIRC7Curated
Cleaved into the following chain:
Baculoviral IAP repeat-containing protein 7 30 kDa subunit
Short name:
Truncated livin
Short name:
p30-Livin
Short name:
tLivin
Gene namesi
Name:Birc7
Synonyms:Livin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2676458. Birc7.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Golgi apparatus By similarity

  • Note: Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004162481 – 285Baculoviral IAP repeat-containing protein 7Add BLAST285
ChainiPRO_000041624953 – 285Baculoviral IAP repeat-containing protein 7 30 kDa subunitAdd BLAST233

Post-translational modificationi

Autoubiquitinated and undergoes proteasome-mediated degradation.By similarity
The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei52 – 53Cleavage; by CASP3 and CASP7By similarity2

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiA2AWP0.
PRIDEiA2AWP0.

PTM databases

PhosphoSitePlusiA2AWP0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038840.
GenevisibleiA2AWP0. MM.

Interactioni

Subunit structurei

Binds to caspase-9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to caspase-9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with caspase-3 and caspase-7 via its BIR domain.By similarity

Protein-protein interaction databases

BioGridi236795. 1 interactor.
STRINGi10090.ENSMUSP00000104503.

Structurei

3D structure databases

ProteinModelPortaliA2AWP0.
SMRiA2AWP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 161BIRAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi72 – 75Poly-Glu4

Domaini

The RING domain is essential for autoubiquitination.By similarity

Sequence similaritiesi

Belongs to the IAP family.Curated
Contains 1 BIR repeat.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri239 – 273RING-typePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000232059.
HOVERGENiHBG099136.
InParanoidiA2AWP0.
KOiK16061.
OMAiFPSCQFL.
OrthoDBiEOG091G0CXH.
TreeFamiTF105356.

Family and domain databases

CDDicd00022. BIR. 1 hit.
Gene3Di1.10.1170.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001370. BIR_rpt.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2AWP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSPADLFRA AVFSMGPESR ARDSVRGPEL SHREDGSGRT QEQDKPHCPC
60 70 80 90 100
NHVLGQDCLD GQILGQLRPL SEEEESSGAA FLGEPAFPEM DSEDLRLASF
110 120 130 140 150
YDWPSTAGIQ PEPLAAAGFF HTGQQDKVRC FFCYGGLQSW ERGDDPWTEH
160 170 180 190 200
ARWFPRCQFL LRSKGRDFVE RIQTYTPLLG SWDQREEPED AVSATPSAPA
210 220 230 240 250
HGSPELLRSR RETQPEDVSE PGAKDVQEQL RQLQEERRCK VCLDRAVSIV
260 270 280
FVPCGHFVCT ECAPNLQLCP ICRVPICSCV RTFLS
Length:285
Mass (Da):31,992
Last modified:February 20, 2007 - v1
Checksum:i34F08B4F5C660B80
GO

Sequence cautioni

The sequence AAI07261 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI25014 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954707 Genomic DNA. Translation: CAM22145.1.
BC107260 mRNA. Translation: AAI07261.1. Different initiation.
BC125013 mRNA. Translation: AAI25014.1. Different initiation.
CCDSiCCDS50840.1.
RefSeqiNP_001156719.1. NM_001163247.1.
UniGeneiMm.187879.

Genome annotation databases

EnsembliENSMUST00000108875; ENSMUSP00000104503; ENSMUSG00000038840.
GeneIDi329581.
KEGGimmu:329581.
UCSCiuc008oke.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954707 Genomic DNA. Translation: CAM22145.1.
BC107260 mRNA. Translation: AAI07261.1. Different initiation.
BC125013 mRNA. Translation: AAI25014.1. Different initiation.
CCDSiCCDS50840.1.
RefSeqiNP_001156719.1. NM_001163247.1.
UniGeneiMm.187879.

3D structure databases

ProteinModelPortaliA2AWP0.
SMRiA2AWP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236795. 1 interactor.
STRINGi10090.ENSMUSP00000104503.

PTM databases

PhosphoSitePlusiA2AWP0.

Proteomic databases

PaxDbiA2AWP0.
PRIDEiA2AWP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108875; ENSMUSP00000104503; ENSMUSG00000038840.
GeneIDi329581.
KEGGimmu:329581.
UCSCiuc008oke.2. mouse.

Organism-specific databases

CTDi79444.
MGIiMGI:2676458. Birc7.

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000232059.
HOVERGENiHBG099136.
InParanoidiA2AWP0.
KOiK16061.
OMAiFPSCQFL.
OrthoDBiEOG091G0CXH.
TreeFamiTF105356.

Miscellaneous databases

PROiA2AWP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038840.
GenevisibleiA2AWP0. MM.

Family and domain databases

CDDicd00022. BIR. 1 hit.
Gene3Di1.10.1170.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001370. BIR_rpt.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIRC7_MOUSE
AccessioniPrimary (citable) accession number: A2AWP0
Secondary accession number(s): A0AUK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.