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Protein

Baculoviral IAP repeat-containing protein 7

Gene

Birc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of caspase-3, -7, and -9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi130 – 1301ZincPROSITE-ProRule annotation
Metal bindingi133 – 1331ZincPROSITE-ProRule annotation
Metal bindingi150 – 1501ZincPROSITE-ProRule annotation
Metal bindingi157 – 1571ZincPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri239 – 27335RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase, Protease inhibitor, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 7 (EC:6.3.2.-)
Alternative name(s):
Livin
Cleaved into the following chain:
Baculoviral IAP repeat-containing protein 7 30 kDa subunit
Short name:
Truncated livin
Short name:
p30-Livin
Short name:
tLivin
Gene namesi
Name:Birc7
Synonyms:Livin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2676458. Birc7.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Golgi apparatus By similarity

  • Note: Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Baculoviral IAP repeat-containing protein 7PRO_0000416248Add
BLAST
Chaini53 – 285233Baculoviral IAP repeat-containing protein 7 30 kDa subunitPRO_0000416249Add
BLAST

Post-translational modificationi

Autoubiquitinated and undergoes proteasome-mediated degradation.By similarity
The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei52 – 532Cleavage; by CASP3 and CASP7By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiA2AWP0.
PRIDEiA2AWP0.

Expressioni

Gene expression databases

BgeeiA2AWP0.
GenevisibleiA2AWP0. MM.

Interactioni

Subunit structurei

Binds to caspase-9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to caspase-9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with caspase-3 and caspase-7 via its BIR domain (By similarity).By similarity

Protein-protein interaction databases

BioGridi236795. 1 interaction.
STRINGi10090.ENSMUSP00000104503.

Structurei

3D structure databases

ProteinModelPortaliA2AWP0.
SMRiA2AWP0. Positions 85-173, 229-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati96 – 16166BIRAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi72 – 754Poly-Glu

Domaini

The RING domain is essential for autoubiquitination.By similarity

Sequence similaritiesi

Belongs to the IAP family.Curated
Contains 1 BIR repeat.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri239 – 27335RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000232059.
HOVERGENiHBG099136.
InParanoidiA2AWP0.
KOiK16061.
OMAiFPSCQFL.
OrthoDBiEOG78H3TF.
TreeFamiTF105356.

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001370. BIR_rpt.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2AWP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSPADLFRA AVFSMGPESR ARDSVRGPEL SHREDGSGRT QEQDKPHCPC
60 70 80 90 100
NHVLGQDCLD GQILGQLRPL SEEEESSGAA FLGEPAFPEM DSEDLRLASF
110 120 130 140 150
YDWPSTAGIQ PEPLAAAGFF HTGQQDKVRC FFCYGGLQSW ERGDDPWTEH
160 170 180 190 200
ARWFPRCQFL LRSKGRDFVE RIQTYTPLLG SWDQREEPED AVSATPSAPA
210 220 230 240 250
HGSPELLRSR RETQPEDVSE PGAKDVQEQL RQLQEERRCK VCLDRAVSIV
260 270 280
FVPCGHFVCT ECAPNLQLCP ICRVPICSCV RTFLS
Length:285
Mass (Da):31,992
Last modified:February 20, 2007 - v1
Checksum:i34F08B4F5C660B80
GO

Sequence cautioni

The sequence AAI07261.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI25014.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954707 Genomic DNA. Translation: CAM22145.1.
BC107260 mRNA. Translation: AAI07261.1. Different initiation.
BC125013 mRNA. Translation: AAI25014.1. Different initiation.
CCDSiCCDS50840.1.
RefSeqiNP_001156719.1. NM_001163247.1.
UniGeneiMm.187879.

Genome annotation databases

EnsembliENSMUST00000108875; ENSMUSP00000104503; ENSMUSG00000038840.
GeneIDi329581.
KEGGimmu:329581.
UCSCiuc008oke.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954707 Genomic DNA. Translation: CAM22145.1.
BC107260 mRNA. Translation: AAI07261.1. Different initiation.
BC125013 mRNA. Translation: AAI25014.1. Different initiation.
CCDSiCCDS50840.1.
RefSeqiNP_001156719.1. NM_001163247.1.
UniGeneiMm.187879.

3D structure databases

ProteinModelPortaliA2AWP0.
SMRiA2AWP0. Positions 85-173, 229-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236795. 1 interaction.
STRINGi10090.ENSMUSP00000104503.

Proteomic databases

PaxDbiA2AWP0.
PRIDEiA2AWP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108875; ENSMUSP00000104503; ENSMUSG00000038840.
GeneIDi329581.
KEGGimmu:329581.
UCSCiuc008oke.2. mouse.

Organism-specific databases

CTDi79444.
MGIiMGI:2676458. Birc7.

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000232059.
HOVERGENiHBG099136.
InParanoidiA2AWP0.
KOiK16061.
OMAiFPSCQFL.
OrthoDBiEOG78H3TF.
TreeFamiTF105356.

Miscellaneous databases

NextBioi398855.
PROiA2AWP0.
SOURCEiSearch...

Gene expression databases

BgeeiA2AWP0.
GenevisibleiA2AWP0. MM.

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001370. BIR_rpt.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-266.

Entry informationi

Entry nameiBIRC7_MOUSE
AccessioniPrimary (citable) accession number: A2AWP0
Secondary accession number(s): A0AUK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: February 20, 2007
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.