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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase eta

Gene

Ptprj

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1159Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6807004. Negative regulation of MET activity.

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase etaImported
Gene namesi
Name:PtprjImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104574. Ptprj.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei896 – 916HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiA2AWF9.
PaxDbiA2AWF9.
PRIDEiA2AWF9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025314.
ExpressionAtlasiA2AWF9. baseline and differential.
GenevisibleiA2AWF9. MM.

Structurei

3D structure databases

ProteinModelPortaliA2AWF9.
SMRiA2AWF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 141Fibronectin type-IIIInterPro annotationAdd BLAST84
Domaini289 – 377Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini378 – 462Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini463 – 546Fibronectin type-IIIInterPro annotationAdd BLAST84
Domaini547 – 640Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini641 – 737Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini961 – 1218Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini1136 – 1209TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00900000140785.
HOGENOMiHOG000232054.
HOVERGENiHBG053761.
PhylomeDBiA2AWF9.
TreeFamiTF351926.

Family and domain databases

CDDicd00063. FN3. 5 hits.
Gene3Di1.20.5.100. 1 hit.
2.60.40.10. 7 hits.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR021157. Cyt_c1_TM_anchor_C.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00060. FN3. 8 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 6 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

A2AWF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCMDNVLGGF EMPQALLAQG AAASAVQTSD YKDRTQHGSG GIRTMGDPGR
60 70 80 90 100
RVLCAGAAPN PIFDIEAVVS PTSVLLTWKH NDSGASECRI ENKMESNLTF
110 120 130 140 150
PVKNQTSCNI TGLSPGTSYT FSIISVTTNE TLNKTITTEP WPVSDLHVTS
160 170 180 190 200
VGVTQARLTW SNANGTASYR MLIEELTTHS SVNISGLKPG TNNSFAFPES
210 220 230 240 250
NETQADFAVA EEVPDANGTK RIPVTNLSQL HKNSLVSVDP PSGQDPSLTE
260 270 280 290 300
ILLTDLKPDT QYNATIYSQA ANGTEGQPRN KVFKTNSTQV SDVRAMNISA
310 320 330 340 350
SSMTLTWKSN YDGSRTSIVY KIHVAGGTHS VNQTVNKTEA IILGLSSSTL
360 370 380 390 400
YNITVHPFLG QTEGTPGFLQ VYTSPDQVSD FRVTNVSTRA IGLAWRSNDS
410 420 430 440 450
KSFEIFIKQD GGEKHRNAST GNQSYMVEDL KPGTSYHFEI IPRGPDGTEG
460 470 480 490 500
LSSTVNGSTD PSAVTDIRVV NISTTEMQLE WQNTDDASGY TYHLVLESKS
510 520 530 540 550
GSIIRTNSSQ KWITVGSLTP GTLYNVTIFP EVDQIQGISN SITQYTRPSS
560 570 580 590 600
VSHIEVNTTT TTAAIRWKNE DAASASYAYS VLILKTGDGS NVTSNFTKDP
610 620 630 640 650
SILIPELIPG VSYTVKILTQ VGDGTTSLVP GWNLFCTEPE PVTSFHCEVV
660 670 680 690 700
PKEPALVLKW ACPFGMYTGF ELGVRSDSWD NMTRLENCTS DDDTECRTEV
710 720 730 740 750
AYLNFSTSYN ISIATLSCGK MALPAQNICT TGITDPPTPD GSPNITSVSH
760 770 780 790 800
NSVKVKFSGF EASHGPIKAY AVILTTGEAA QPSADVLKYT YEDFKRGASD
810 820 830 840 850
TYVTYLIRIE EKGQSQGLSE VLNYEIDVGN QSTTLGYYNG RLEPLGSYRA
860 870 880 890 900
CVAGFTNITY NLQNDGLING DESYVSFSPY SEAVFLPQDP GVICGAVFGC
910 920 930 940 950
IFGALAITAV GGFIFWRKKR TDAKNNEVSF SQIKPKKSKL IRVENFEAYF
960 970 980 990 1000
KKQQADSNCG FAEEYEDLKL IGISLPKYTA EIAENRGKNR YNNVLPYDIS
1010 1020 1030 1040 1050
RVKLSVQTHS TDDYINANYM PGYHSKKDFI ATQGPLPNTL KDFWRMVWEK
1060 1070 1080 1090 1100
NVYAIVMLTK CVEQGRTKCE EYWPSKQAQD YGDITVAMTS EVVLPEWTIR
1110 1120 1130 1140 1150
DFVVKNMQNS ESHPLRQFHF TSWPDHGVPD TTDLLINFRY LVRDYMKQIP
1160 1170 1180 1190 1200
PESPILVHCS AGVGRTGTFI AIDRLIYQIE NENTVDVYGI VYDLRMHRPL
1210 1220 1230 1240 1250
MVQTEDQYVF LNQCVLDIIR AQKDSKVDLI YQNTTAMTIY ENLEPSSLNV
1260 1270 1280 1290
TMLLHPQLND FGCWVLGPGC CWSARIQGLV DIWEDVNCPA ESLSFRCGH
Length:1,299
Mass (Da):143,176
Last modified:February 20, 2007 - v1
Checksum:iB31B8B9CA803DADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935132 Genomic DNA. No translation available.
AL954341 Genomic DNA. No translation available.
AL954378 Genomic DNA. No translation available.
RefSeqiNP_001129129.1. NM_001135657.1.
UniGeneiMm.330393.

Genome annotation databases

EnsembliENSMUST00000111495; ENSMUSP00000107121; ENSMUSG00000025314.
GeneIDi19271.
UCSCiuc008ksu.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiA2AWF9_MOUSE
AccessioniPrimary (citable) accession number: A2AWF9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 22, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported