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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase eta

Gene

Ptprj

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1066Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6807004. Negative regulation of MET activity.

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase etaImported
Gene namesi
Name:PtprjImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104574. Ptprj.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiA2AWF8.
PaxDbiA2AWF8.
PeptideAtlasiA2AWF8.
PRIDEiA2AWF8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025314.
ExpressionAtlasiA2AWF8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2AWF8.
SMRiA2AWF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48Fibronectin type-IIIInterPro annotationAdd BLAST48
Domaini196 – 284Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini285 – 369Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini370 – 453Fibronectin type-IIIInterPro annotationAdd BLAST84
Domaini454 – 547Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini548 – 644Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini868 – 1125Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini1043 – 1116TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00900000140785.
HOVERGENiHBG053761.

Family and domain databases

CDDicd00063. FN3. 5 hits.
Gene3Di1.20.5.100. 1 hit.
2.60.40.10. 7 hits.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR021157. Cyt_c1_TM_anchor_C.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00060. FN3. 7 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF49265. SSF49265. 4 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 6 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

A2AWF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESNLTFPVK NQTSCNITGL SPGTSYTFSI ISVTTNETLN KTITTEPWPV
60 70 80 90 100
SDLHVTSVGV TQARLTWSNA NGTASYRMLI EELTTHSSVN ISGLKPGTNN
110 120 130 140 150
SFAFPESNET QADFAVAEEV PDANGTKRIP VTNLSQLHKN SLVSVDPPSG
160 170 180 190 200
QDPSLTEILL TDLKPDTQYN ATIYSQAANG TEGQPRNKVF KTNSTQVSDV
210 220 230 240 250
RAMNISASSM TLTWKSNYDG SRTSIVYKIH VAGGTHSVNQ TVNKTEAIIL
260 270 280 290 300
GLSSSTLYNI TVHPFLGQTE GTPGFLQVYT SPDQVSDFRV TNVSTRAIGL
310 320 330 340 350
AWRSNDSKSF EIFIKQDGGE KHRNASTGNQ SYMVEDLKPG TSYHFEIIPR
360 370 380 390 400
GPDGTEGLSS TVNGSTDPSA VTDIRVVNIS TTEMQLEWQN TDDASGYTYH
410 420 430 440 450
LVLESKSGSI IRTNSSQKWI TVGSLTPGTL YNVTIFPEVD QIQGISNSIT
460 470 480 490 500
QYTRPSSVSH IEVNTTTTTA AIRWKNEDAA SASYAYSVLI LKTGDGSNVT
510 520 530 540 550
SNFTKDPSIL IPELIPGVSY TVKILTQVGD GTTSLVPGWN LFCTEPEPVT
560 570 580 590 600
SFHCEVVPKE PALVLKWACP FGMYTGFELG VRSDSWDNMT RLENCTSDDD
610 620 630 640 650
TECRTEVAYL NFSTSYNISI ATLSCGKMAL PAQNICTTGI TDPPTPDGSP
660 670 680 690 700
NITSVSHNSV KVKFSGFEAS HGPIKAYAVI LTTGEAAQPS ADVLKYTYED
710 720 730 740 750
FKRGASDTYV TYLIRIEEKG QSQGLSEVLN YEIDVGNQST TLGYYNGRLE
760 770 780 790 800
PLGSYRACVA GFTNITYNLQ NDGLINGDES YVSFSPYSEA VFLPQDPGVI
810 820 830 840 850
CGAVFGCIFG ALAITAVGGF IFWRKKRTDA KNNEVSFSQI KPKKSKLIRV
860 870 880 890 900
ENFEAYFKKQ QADSNCGFAE EYEDLKLIGI SLPKYTAEIA ENRGKNRYNN
910 920 930 940 950
VLPYDISRVK LSVQTHSTDD YINANYMPGY HSKKDFIATQ GPLPNTLKDF
960 970 980 990 1000
WRMVWEKNVY AIVMLTKCVE QGRTKCEEYW PSKQAQDYGD ITVAMTSEVV
1010 1020 1030 1040 1050
LPEWTIRDFV VKNMQNSESH PLRQFHFTSW PDHGVPDTTD LLINFRYLVR
1060 1070 1080 1090 1100
DYMKQIPPES PILVHCSAGV GRTGTFIAID RLIYQIENEN TVDVYGIVYD
1110 1120 1130 1140 1150
LRMHRPLMVQ TEDQYVFLNQ CVLDIIRAQK DSKVDLIYQN TTAMTIYENL
1160
EPVSMFGKTN GYIA
Length:1,164
Mass (Da):128,713
Last modified:February 20, 2007 - v1
Checksum:i317803F63FC4ED58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935132 Genomic DNA. No translation available.
AL954341 Genomic DNA. No translation available.
AL954378 Genomic DNA. No translation available.
RefSeqiXP_006499057.1. XM_006498994.2.
UniGeneiMm.330393.

Genome annotation databases

EnsembliENSMUST00000111493; ENSMUSP00000107119; ENSMUSG00000025314.
GeneIDi19271.

Similar proteinsi

Entry informationi

Entry nameiA2AWF8_MOUSE
AccessioniPrimary (citable) accession number: A2AWF8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 22, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported