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Protein

Rab GTPase-activating protein 1

Gene

Rabgap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei603 – 6031Arginine fingerBy similarity
Sitei644 – 6441Glutamine fingerBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BRENDAi2.3.1.23. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GTPase-activating protein 1
Alternative name(s):
GAP and centrosome-associated protein
Rab6 GTPase-activating protein GAPCenA
Gene namesi
Name:Rabgap1Imported
Synonyms:Kiaa4104Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385139. Rabgap1.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

  • Note: Predominantly cytosolic but also associated with the centrosome.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10641064Rab GTPase-activating protein 1PRO_0000298780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421PhosphoserineCombined sources
Modified residuei355 – 3551PhosphoserineCombined sources
Modified residuei991 – 9911PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2AWA9.
PaxDbiA2AWA9.
PeptideAtlasiA2AWA9.
PRIDEiA2AWA9.

PTM databases

iPTMnetiA2AWA9.
PhosphoSiteiA2AWA9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035437.
CleanExiMM_RABGAP1.
ExpressionAtlasiA2AWA9. baseline and differential.
GenevisibleiA2AWA9. MM.

Interactioni

Subunit structurei

Interacts with RAB6A and tubulin gamma.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiA2AWA9. 1 interaction.
MINTiMINT-5095880.
STRINGi10090.ENSMUSP00000061624.

Structurei

3D structure databases

ProteinModelPortaliA2AWA9.
SMRiA2AWA9. Positions 533-820.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 293157PIDPROSITE-ProRule annotationAdd
BLAST
Domaini561 – 747187Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili805 – 1038234Sequence analysisAdd
BLAST

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1102. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00750000117238.
HOGENOMiHOG000007923.
HOVERGENiHBG063892.
InParanoidiA2AWA9.
KOiK20284.
OMAiKQDAMKP.
OrthoDBiEOG091G0AIH.
PhylomeDBiA2AWA9.
TreeFamiTF317184.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR022164. Kinesin-like.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR000195. Rab-GTPase-TBC_dom.
IPR033185. RabGAP1.
[Graphical view]
PANTHERiPTHR22957:SF208. PTHR22957:SF208. 1 hit.
PfamiPF12473. DUF3694. 1 hit.
PF00640. PID. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: A2AWA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDKASVGKI SVSSDSVSTL NSEDFVLVSR QGDETPSTNN GSDDEKTGLK
60 70 80 90 100
IVGNGSEQQL QKELADVLMD PPMDDQPGER SQLDGEGDGP LSNQLSASST
110 120 130 140 150
INPVPLVGLP KPEMSLPVKP GQGDSEVSSP FTPVADEDSV VFNKLTYLGC
160 170 180 190 200
ASVNAPRSEV EALRMMSILR SQCQISLDVT LSVPNVSEGT VRLLDPQTNT
210 220 230 240 250
EIANYPIYKI LFCVRGHDGT PESDCFAFTE SHYNAELFRI HVFRCEIQEA
260 270 280 290 300
VSRILYSFAT AFRRSAKQTP LSATAAPQTP DSDIFTFSVS LEIKEDDGKG
310 320 330 340 350
YFSAVPKDKD RQCFKLRQGI DKKIVICVQQ TANKELAIER CFGLLLSPGK
360 370 380 390 400
DVRNSDMHLL DLESMGKSSD GKSYVITGSW NPKSPHFQVV NEETPKDKVL
410 420 430 440 450
FMTTAVDLVI TEVQEPVRFL LETKVRVCSP NERLFWPFSK RSTTENFFLK
460 470 480 490 500
LKQIKQKEKK NNADTLYEVV CLESESERER RKTTASPSVR LPQSGSQSSM
510 520 530 540 550
IPSPPEDDEE EDNDEPLLSG FGDVSKECAE KILETWGELL SKWHLNLSVR
560 570 580 590 600
PKQLSSLVRS GVPEALRGEV WQLLAGCHNN DHLVEKYRIL ITKESPQDSA
610 620 630 640 650
ITRDINRTFP AHDYFKDTGG DGQDSLYKIC KAYSVYDEEI GYCQGQSFLA
660 670 680 690 700
AVLLLHMPEE QAFSVLVKIM FDYGLRELFK QNFEDLHCKF YQLERLMQEY
710 720 730 740 750
IPDLYNHFLD ISLEAHMYAS QWFLTLFTAK FPLYMVFHII DLLLCEGISV
760 770 780 790 800
IFNVALGLLK TSKDDLLLTD FEGALKFFRV QLPKRYRSEE NAKRLMELAC
810 820 830 840 850
NTKISQKKLK KFEKEYHTMR EQQAQQEDPI ERFERENRRL QEANMRLEQE
860 870 880 890 900
NDDLAHELVT SKIALRKDLD NAEEKADALN KELLMTKQKL IDAEDEKRRL
910 920 930 940 950
EEESAQLKEM CRRELDKAES EIKKNSSIIG DYKQICSQLS ERLEKQQTAN
960 970 980 990 1000
KVEIEKIRQK VDDCDRCRDF FNKEGRVKGI SSAKGVSDED TDEEKETLKN
1010 1020 1030 1040 1050
QLREMELELA QTKLQLVEAE CKIQDLEHHL GLALSEVQAA KKTWFNRTLS
1060
SIKTATGVQG KETC
Note: No experimental confirmation available.Curated
Length:1,064
Mass (Da):120,798
Last modified:February 20, 2007 - v1
Checksum:i8AFAB7C7827F0040
GO
Isoform 21 Publication (identifier: A2AWA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     804-809: ISQKKL → VQQRLL
     810-1064: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:809
Mass (Da):91,083
Checksum:i04E42DFEA2161061
GO
Isoform 31 Publication (identifier: A2AWA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     19-30: TLNSEDFVLVSR → MGLSSLSANKPW
     363-384: ESMGKSSDGKSYVITGSWNPKS → VRFCCCCCCGLFWLWLVFIRNL
     385-1064: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:366
Mass (Da):40,303
Checksum:i016708AC6D659B18
GO

Sequence cautioni

The sequence AAH26862 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH31714 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC34703 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD90509 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti646 – 6461Q → E in BAC34703 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818Missing in isoform 3. 1 PublicationVSP_052516Add
BLAST
Alternative sequencei19 – 3012TLNSE…VLVSR → MGLSSLSANKPW in isoform 3. 1 PublicationVSP_052517Add
BLAST
Alternative sequencei363 – 38422ESMGK…WNPKS → VRFCCCCCCGLFWLWLVFIR NL in isoform 3. 1 PublicationVSP_052518Add
BLAST
Alternative sequencei385 – 1064680Missing in isoform 3. 1 PublicationVSP_052519Add
BLAST
Alternative sequencei804 – 8096ISQKKL → VQQRLL in isoform 2. 1 PublicationVSP_052520
Alternative sequencei810 – 1064255Missing in isoform 2. 1 PublicationVSP_052521Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031315 mRNA. Translation: BAC27344.1.
AK044346 mRNA. Translation: BAC31880.1.
AK051644 mRNA. Translation: BAC34703.1. Different initiation.
AK220489 mRNA. Translation: BAD90509.1. Different initiation.
AL953890 Genomic DNA. Translation: CAM20742.1.
AL953890 Genomic DNA. Translation: CAM20743.1.
BC026862 mRNA. Translation: AAH26862.1. Different initiation.
BC031714 mRNA. Translation: AAH31714.1. Different initiation.
CCDSiCCDS16002.1. [A2AWA9-1]
CCDS16003.1. [A2AWA9-2]
RefSeqiNP_001029132.1. NM_001033960.1. [A2AWA9-2]
NP_666233.2. NM_146121.2. [A2AWA9-1]
XP_006498057.1. XM_006497994.2. [A2AWA9-1]
UniGeneiMm.383192.

Genome annotation databases

EnsembliENSMUST00000061179; ENSMUSP00000061624; ENSMUSG00000035437. [A2AWA9-1]
ENSMUST00000066055; ENSMUSP00000068835; ENSMUSG00000035437. [A2AWA9-2]
ENSMUST00000112920; ENSMUSP00000108542; ENSMUSG00000035437. [A2AWA9-1]
GeneIDi227800.
KEGGimmu:227800.
UCSCiuc008jmw.1. mouse. [A2AWA9-3]
uc008jmx.1. mouse. [A2AWA9-1]
uc008jmy.1. mouse. [A2AWA9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031315 mRNA. Translation: BAC27344.1.
AK044346 mRNA. Translation: BAC31880.1.
AK051644 mRNA. Translation: BAC34703.1. Different initiation.
AK220489 mRNA. Translation: BAD90509.1. Different initiation.
AL953890 Genomic DNA. Translation: CAM20742.1.
AL953890 Genomic DNA. Translation: CAM20743.1.
BC026862 mRNA. Translation: AAH26862.1. Different initiation.
BC031714 mRNA. Translation: AAH31714.1. Different initiation.
CCDSiCCDS16002.1. [A2AWA9-1]
CCDS16003.1. [A2AWA9-2]
RefSeqiNP_001029132.1. NM_001033960.1. [A2AWA9-2]
NP_666233.2. NM_146121.2. [A2AWA9-1]
XP_006498057.1. XM_006497994.2. [A2AWA9-1]
UniGeneiMm.383192.

3D structure databases

ProteinModelPortaliA2AWA9.
SMRiA2AWA9. Positions 533-820.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AWA9. 1 interaction.
MINTiMINT-5095880.
STRINGi10090.ENSMUSP00000061624.

PTM databases

iPTMnetiA2AWA9.
PhosphoSiteiA2AWA9.

Proteomic databases

EPDiA2AWA9.
PaxDbiA2AWA9.
PeptideAtlasiA2AWA9.
PRIDEiA2AWA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061179; ENSMUSP00000061624; ENSMUSG00000035437. [A2AWA9-1]
ENSMUST00000066055; ENSMUSP00000068835; ENSMUSG00000035437. [A2AWA9-2]
ENSMUST00000112920; ENSMUSP00000108542; ENSMUSG00000035437. [A2AWA9-1]
GeneIDi227800.
KEGGimmu:227800.
UCSCiuc008jmw.1. mouse. [A2AWA9-3]
uc008jmx.1. mouse. [A2AWA9-1]
uc008jmy.1. mouse. [A2AWA9-2]

Organism-specific databases

CTDi23637.
MGIiMGI:2385139. Rabgap1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1102. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00750000117238.
HOGENOMiHOG000007923.
HOVERGENiHBG063892.
InParanoidiA2AWA9.
KOiK20284.
OMAiKQDAMKP.
OrthoDBiEOG091G0AIH.
PhylomeDBiA2AWA9.
TreeFamiTF317184.

Enzyme and pathway databases

BRENDAi2.3.1.23. 3474.

Miscellaneous databases

PROiA2AWA9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035437.
CleanExiMM_RABGAP1.
ExpressionAtlasiA2AWA9. baseline and differential.
GenevisibleiA2AWA9. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR022164. Kinesin-like.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR000195. Rab-GTPase-TBC_dom.
IPR033185. RabGAP1.
[Graphical view]
PANTHERiPTHR22957:SF208. PTHR22957:SF208. 1 hit.
PfamiPF12473. DUF3694. 1 hit.
PF00640. PID. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBGP1_MOUSE
AccessioniPrimary (citable) accession number: A2AWA9
Secondary accession number(s): Q5DTN1
, Q8BQ32, Q8C8W3, Q8CD74, Q8R312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.