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Protein

Rab GTPase-activating protein 1

Gene

Rabgap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei603Arginine fingerBy similarity1
Sitei644Glutamine fingerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processCell cycle

Enzyme and pathway databases

BRENDAi2.3.1.23 3474
ReactomeiR-MMU-8854214 TBC/RABGAPs

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GTPase-activating protein 1
Alternative name(s):
GAP and centrosome-associated protein
Rab6 GTPase-activating protein GAPCenA
Gene namesi
Name:Rabgap1Imported
Synonyms:Kiaa4104Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385139 Rabgap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002987801 – 1064Rab GTPase-activating protein 1Add BLAST1064

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei991PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2AWA9
PaxDbiA2AWA9
PeptideAtlasiA2AWA9
PRIDEiA2AWA9

PTM databases

iPTMnetiA2AWA9
PhosphoSitePlusiA2AWA9

Expressioni

Gene expression databases

BgeeiENSMUSG00000035437
CleanExiMM_RABGAP1
ExpressionAtlasiA2AWA9 baseline and differential
GenevisibleiA2AWA9 MM

Interactioni

Subunit structurei

Interacts with RAB6A and tubulin gamma.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiA2AWA9, 1 interactor
MINTiA2AWA9
STRINGi10090.ENSMUSP00000061624

Structurei

3D structure databases

ProteinModelPortaliA2AWA9
SMRiA2AWA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 293PIDPROSITE-ProRule annotationAdd BLAST157
Domaini561 – 747Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST187

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili805 – 1038Sequence analysisAdd BLAST234

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1102 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00750000117238
HOGENOMiHOG000007923
HOVERGENiHBG063892
InParanoidiA2AWA9
KOiK20284
OMAiKERKNNT
OrthoDBiEOG091G0AIH
PhylomeDBiA2AWA9
TreeFamiTF317184

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR022164 Kinesin-like
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR033185 RabGAP1
PANTHERiPTHR22957:SF205 PTHR22957:SF205, 1 hit
PfamiView protein in Pfam
PF12473 DUF3694, 1 hit
PF00640 PID, 1 hit
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50086 TBC_RABGAP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: A2AWA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDKASVGKI SVSSDSVSTL NSEDFVLVSR QGDETPSTNN GSDDEKTGLK
60 70 80 90 100
IVGNGSEQQL QKELADVLMD PPMDDQPGER SQLDGEGDGP LSNQLSASST
110 120 130 140 150
INPVPLVGLP KPEMSLPVKP GQGDSEVSSP FTPVADEDSV VFNKLTYLGC
160 170 180 190 200
ASVNAPRSEV EALRMMSILR SQCQISLDVT LSVPNVSEGT VRLLDPQTNT
210 220 230 240 250
EIANYPIYKI LFCVRGHDGT PESDCFAFTE SHYNAELFRI HVFRCEIQEA
260 270 280 290 300
VSRILYSFAT AFRRSAKQTP LSATAAPQTP DSDIFTFSVS LEIKEDDGKG
310 320 330 340 350
YFSAVPKDKD RQCFKLRQGI DKKIVICVQQ TANKELAIER CFGLLLSPGK
360 370 380 390 400
DVRNSDMHLL DLESMGKSSD GKSYVITGSW NPKSPHFQVV NEETPKDKVL
410 420 430 440 450
FMTTAVDLVI TEVQEPVRFL LETKVRVCSP NERLFWPFSK RSTTENFFLK
460 470 480 490 500
LKQIKQKEKK NNADTLYEVV CLESESERER RKTTASPSVR LPQSGSQSSM
510 520 530 540 550
IPSPPEDDEE EDNDEPLLSG FGDVSKECAE KILETWGELL SKWHLNLSVR
560 570 580 590 600
PKQLSSLVRS GVPEALRGEV WQLLAGCHNN DHLVEKYRIL ITKESPQDSA
610 620 630 640 650
ITRDINRTFP AHDYFKDTGG DGQDSLYKIC KAYSVYDEEI GYCQGQSFLA
660 670 680 690 700
AVLLLHMPEE QAFSVLVKIM FDYGLRELFK QNFEDLHCKF YQLERLMQEY
710 720 730 740 750
IPDLYNHFLD ISLEAHMYAS QWFLTLFTAK FPLYMVFHII DLLLCEGISV
760 770 780 790 800
IFNVALGLLK TSKDDLLLTD FEGALKFFRV QLPKRYRSEE NAKRLMELAC
810 820 830 840 850
NTKISQKKLK KFEKEYHTMR EQQAQQEDPI ERFERENRRL QEANMRLEQE
860 870 880 890 900
NDDLAHELVT SKIALRKDLD NAEEKADALN KELLMTKQKL IDAEDEKRRL
910 920 930 940 950
EEESAQLKEM CRRELDKAES EIKKNSSIIG DYKQICSQLS ERLEKQQTAN
960 970 980 990 1000
KVEIEKIRQK VDDCDRCRDF FNKEGRVKGI SSAKGVSDED TDEEKETLKN
1010 1020 1030 1040 1050
QLREMELELA QTKLQLVEAE CKIQDLEHHL GLALSEVQAA KKTWFNRTLS
1060
SIKTATGVQG KETC
Note: No experimental confirmation available.Curated
Length:1,064
Mass (Da):120,798
Last modified:February 20, 2007 - v1
Checksum:i8AFAB7C7827F0040
GO
Isoform 21 Publication (identifier: A2AWA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     804-809: ISQKKL → VQQRLL
     810-1064: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:809
Mass (Da):91,083
Checksum:i04E42DFEA2161061
GO
Isoform 31 Publication (identifier: A2AWA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     19-30: TLNSEDFVLVSR → MGLSSLSANKPW
     363-384: ESMGKSSDGKSYVITGSWNPKS → VRFCCCCCCGLFWLWLVFIRNL
     385-1064: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:366
Mass (Da):40,303
Checksum:i016708AC6D659B18
GO

Sequence cautioni

The sequence AAH26862 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH31714 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC34703 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD90509 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti646Q → E in BAC34703 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0525161 – 18Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_05251719 – 30TLNSE…VLVSR → MGLSSLSANKPW in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_052518363 – 384ESMGK…WNPKS → VRFCCCCCCGLFWLWLVFIR NL in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_052519385 – 1064Missing in isoform 3. 1 PublicationAdd BLAST680
Alternative sequenceiVSP_052520804 – 809ISQKKL → VQQRLL in isoform 2. 1 Publication6
Alternative sequenceiVSP_052521810 – 1064Missing in isoform 2. 1 PublicationAdd BLAST255

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031315 mRNA Translation: BAC27344.1
AK044346 mRNA Translation: BAC31880.1
AK051644 mRNA Translation: BAC34703.1 Different initiation.
AK220489 mRNA Translation: BAD90509.1 Different initiation.
AL953890 Genomic DNA No translation available.
BC026862 mRNA Translation: AAH26862.1 Different initiation.
BC031714 mRNA Translation: AAH31714.1 Different initiation.
CCDSiCCDS16002.1 [A2AWA9-1]
CCDS16003.1 [A2AWA9-2]
RefSeqiNP_001029132.1, NM_001033960.1 [A2AWA9-2]
NP_666233.2, NM_146121.2 [A2AWA9-1]
XP_006498057.1, XM_006497994.3 [A2AWA9-1]
XP_017172964.1, XM_017317475.1
UniGeneiMm.383192

Genome annotation databases

EnsembliENSMUST00000061179; ENSMUSP00000061624; ENSMUSG00000035437 [A2AWA9-1]
ENSMUST00000066055; ENSMUSP00000068835; ENSMUSG00000035437 [A2AWA9-2]
ENSMUST00000112920; ENSMUSP00000108542; ENSMUSG00000035437 [A2AWA9-1]
GeneIDi227800
KEGGimmu:227800
UCSCiuc008jmw.1 mouse [A2AWA9-3]
uc008jmx.1 mouse [A2AWA9-1]
uc008jmy.1 mouse [A2AWA9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBGP1_MOUSE
AccessioniPrimary (citable) accession number: A2AWA9
Secondary accession number(s): Q5DTN1
, Q8BQ32, Q8C8W3, Q8CD74, Q8R312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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