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Protein

Solute carrier family 43 member 3

Gene

Slc43a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative transporter.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 43 member 3
Alternative name(s):
Embryonic epithelia gene 1 protein
Gene namesi
Name:Slc43a3
Synonyms:Eeg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1931054 Slc43a3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050371 – 502Solute carrier family 43 member 3Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiA2AVZ9
MaxQBiA2AVZ9
PaxDbiA2AVZ9
PeptideAtlasiA2AVZ9
PRIDEiA2AVZ9

PTM databases

iPTMnetiA2AVZ9
PhosphoSitePlusiA2AVZ9
SwissPalmiA2AVZ9

Expressioni

Tissue specificityi

High expression in the heart, followed by the lung, liver, spleen and kidney.1 Publication

Developmental stagei

Highly expressed in the early embryo. High expression at embryonic day 7 and later in the fetal liver, lung, placenta and kidney.

Gene expression databases

BgeeiENSMUSG00000027074
CleanExiMM_SLC43A3
ExpressionAtlasiA2AVZ9 baseline and differential
GenevisibleiA2AVZ9 MM

Structurei

3D structure databases

ProteinModelPortaliA2AVZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi263 – 282Gln-richAdd BLAST20

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDBX Eukaryota
ENOG411150Y LUCA
GeneTreeiENSGT00530000063043
HOGENOMiHOG000154238
HOVERGENiHBG102974
InParanoidiA2AVZ9
KOiK08230
OMAiADCKAQD
OrthoDBiEOG091G04NL
PhylomeDBiA2AVZ9
TreeFamiTF328358

Family and domain databases

InterProiView protein in InterPro
IPR011701 MFS
IPR036259 MFS_trans_sf
IPR027197 SLC43A3
PANTHERiPTHR20765 PTHR20765, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AVZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKGLPLYL ATLLTGLLEC IGFAGVLFGW TSLLFVFKAE NYFSEPCEQD
60 70 80 90 100
CLLQSNVTGP SDLKAQDEKF SLIFTLASFM NNFMTFPTGY IFDRFKTTVA
110 120 130 140 150
RLIAIFFYTC ATIIIAFTSA NTAMLLFLAM PMLAVGGILF LITNLQIGNL
160 170 180 190 200
FGKHRSTIIT LYNGAFDSSS AVFLVIKLLY EQGISLRSSF IFMSVCSVWH
210 220 230 240 250
IARTFLLMPK GHIPYPLPPN YSYGLCSRFG ASKKENKAAE HETKELRSKE
260 270 280 290 300
CLPPKEENSG PEQQQQQEQQ QQQQQQQEQH EQHSFRRCAL SRRFILHVVW
310 320 330 340 350
LSIIQLWHYL FIGTLNSLLT KLSGGDKVEV SAYTNAFAIT QFFGVLCAPW
360 370 380 390 400
NGLLMDRLKQ KYQKAAKRTG SSSEAVALCS MVPSLALTSL LSLGFALCAS
410 420 430 440 450
IPVMQLQYAT FILQVVSRSF LYGCNAAFLT LAFPSEHFGK LFGLVMALSA
460 470 480 490 500
IVSLLQFPLF KVSPESNAVY VSMGLAIFLT LVHPFLVYRE CRAEKTKSSV

DA
Length:502
Mass (Da):56,034
Last modified:February 20, 2007 - v1
Checksum:i4A268F1F2B786C8F
GO
Isoform 2 (identifier: A2AVZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-502: Missing.

Show »
Length:224
Mass (Da):24,916
Checksum:i67A6A66C651891AB
GO

Sequence cautioni

The sequence AAF26303 differs from that shown. Reason: Frameshift at position 395.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81N → S in AAH89603 (PubMed:11704567).Curated1
Sequence conflicti362Y → H in AAH89603 (PubMed:11704567).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028193225 – 502Missing in isoform 2. 1 PublicationAdd BLAST278

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188622 mRNA Translation: AAF26303.1 Frameshift.
AK086962 mRNA Translation: BAC39774.1
AL935159 Genomic DNA No translation available.
BC089603 mRNA Translation: AAH89603.1
CCDSiCCDS38164.1 [A2AVZ9-1]
RefSeqiNP_067373.2, NM_021398.3 [A2AVZ9-1]
XP_006500020.1, XM_006499957.2 [A2AVZ9-1]
XP_006500021.1, XM_006499958.3 [A2AVZ9-1]
XP_006500022.1, XM_006499959.2 [A2AVZ9-1]
XP_006500023.1, XM_006499960.2 [A2AVZ9-1]
XP_006500024.1, XM_006499961.1 [A2AVZ9-1]
UniGeneiMm.290729
Mm.490497

Genome annotation databases

EnsembliENSMUST00000090726; ENSMUSP00000088227; ENSMUSG00000027074 [A2AVZ9-1]
GeneIDi58207
KEGGimmu:58207
UCSCiuc008kjn.2 mouse [A2AVZ9-1]
uc008kjo.1 mouse [A2AVZ9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS43A3_MOUSE
AccessioniPrimary (citable) accession number: A2AVZ9
Secondary accession number(s): A6PX00
, Q5FW65, Q8C345, Q9JLF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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