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Protein

Solute carrier family 43 member 3

Gene

Slc43a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative transporter.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 43 member 3
Alternative name(s):
Embryonic epithelia gene 1 protein
Gene namesi
Name:Slc43a3
Synonyms:Eeg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1931054. Slc43a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence analysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence analysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence analysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST
Transmembranei442 – 46221HelicalSequence analysisAdd
BLAST
Transmembranei468 – 48821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Solute carrier family 43 member 3PRO_0000305037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiA2AVZ9.
MaxQBiA2AVZ9.
PaxDbiA2AVZ9.
PRIDEiA2AVZ9.

PTM databases

PhosphoSiteiA2AVZ9.

Expressioni

Tissue specificityi

High expression in the heart, followed by the lung, liver, spleen and kidney.1 Publication

Developmental stagei

Highly expressed in the early embryo. High expression at embryonic day 7 and later in the fetal liver, lung, placenta and kidney.

Gene expression databases

BgeeiA2AVZ9.
CleanExiMM_SLC43A3.
ExpressionAtlasiA2AVZ9. baseline and differential.
GenevisibleiA2AVZ9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088227.

Structurei

3D structure databases

ProteinModelPortaliA2AVZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi263 – 28220Gln-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDBX. Eukaryota.
ENOG411150Y. LUCA.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000154238.
HOVERGENiHBG102974.
InParanoidiA2AVZ9.
KOiK08230.
OMAiCKAQDEK.
PhylomeDBiA2AVZ9.
TreeFamiTF328358.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR027197. SLC43A3.
[Graphical view]
PANTHERiPTHR20765. PTHR20765. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AVZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKGLPLYL ATLLTGLLEC IGFAGVLFGW TSLLFVFKAE NYFSEPCEQD
60 70 80 90 100
CLLQSNVTGP SDLKAQDEKF SLIFTLASFM NNFMTFPTGY IFDRFKTTVA
110 120 130 140 150
RLIAIFFYTC ATIIIAFTSA NTAMLLFLAM PMLAVGGILF LITNLQIGNL
160 170 180 190 200
FGKHRSTIIT LYNGAFDSSS AVFLVIKLLY EQGISLRSSF IFMSVCSVWH
210 220 230 240 250
IARTFLLMPK GHIPYPLPPN YSYGLCSRFG ASKKENKAAE HETKELRSKE
260 270 280 290 300
CLPPKEENSG PEQQQQQEQQ QQQQQQQEQH EQHSFRRCAL SRRFILHVVW
310 320 330 340 350
LSIIQLWHYL FIGTLNSLLT KLSGGDKVEV SAYTNAFAIT QFFGVLCAPW
360 370 380 390 400
NGLLMDRLKQ KYQKAAKRTG SSSEAVALCS MVPSLALTSL LSLGFALCAS
410 420 430 440 450
IPVMQLQYAT FILQVVSRSF LYGCNAAFLT LAFPSEHFGK LFGLVMALSA
460 470 480 490 500
IVSLLQFPLF KVSPESNAVY VSMGLAIFLT LVHPFLVYRE CRAEKTKSSV

DA
Length:502
Mass (Da):56,034
Last modified:February 20, 2007 - v1
Checksum:i4A268F1F2B786C8F
GO
Isoform 2 (identifier: A2AVZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-502: Missing.

Show »
Length:224
Mass (Da):24,916
Checksum:i67A6A66C651891AB
GO

Sequence cautioni

The sequence AAF26303.1 differs from that shown. Reason: Frameshift at position 395. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811N → S in AAH89603 (PubMed:11704567).Curated
Sequence conflicti362 – 3621Y → H in AAH89603 (PubMed:11704567).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 502278Missing in isoform 2. 1 PublicationVSP_028193Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188622 mRNA. Translation: AAF26303.1. Frameshift.
AK086962 mRNA. Translation: BAC39774.1.
AL935159 Genomic DNA. Translation: CAO77731.1.
AL935159 Genomic DNA. Translation: CAM18189.1.
BC089603 mRNA. Translation: AAH89603.1.
CCDSiCCDS38164.1. [A2AVZ9-1]
RefSeqiNP_067373.2. NM_021398.3. [A2AVZ9-1]
XP_006500020.1. XM_006499957.1. [A2AVZ9-1]
XP_006500021.1. XM_006499958.2. [A2AVZ9-1]
XP_006500022.1. XM_006499959.1. [A2AVZ9-1]
XP_006500023.1. XM_006499960.1. [A2AVZ9-1]
XP_006500024.1. XM_006499961.1. [A2AVZ9-1]
XP_011238020.1. XM_011239718.1. [A2AVZ9-1]
UniGeneiMm.290729.
Mm.490497.

Genome annotation databases

EnsembliENSMUST00000090726; ENSMUSP00000088227; ENSMUSG00000027074. [A2AVZ9-1]
GeneIDi58207.
KEGGimmu:58207.
UCSCiuc008kjn.2. mouse. [A2AVZ9-1]
uc008kjo.1. mouse. [A2AVZ9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188622 mRNA. Translation: AAF26303.1. Frameshift.
AK086962 mRNA. Translation: BAC39774.1.
AL935159 Genomic DNA. Translation: CAO77731.1.
AL935159 Genomic DNA. Translation: CAM18189.1.
BC089603 mRNA. Translation: AAH89603.1.
CCDSiCCDS38164.1. [A2AVZ9-1]
RefSeqiNP_067373.2. NM_021398.3. [A2AVZ9-1]
XP_006500020.1. XM_006499957.1. [A2AVZ9-1]
XP_006500021.1. XM_006499958.2. [A2AVZ9-1]
XP_006500022.1. XM_006499959.1. [A2AVZ9-1]
XP_006500023.1. XM_006499960.1. [A2AVZ9-1]
XP_006500024.1. XM_006499961.1. [A2AVZ9-1]
XP_011238020.1. XM_011239718.1. [A2AVZ9-1]
UniGeneiMm.290729.
Mm.490497.

3D structure databases

ProteinModelPortaliA2AVZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088227.

PTM databases

PhosphoSiteiA2AVZ9.

Proteomic databases

EPDiA2AVZ9.
MaxQBiA2AVZ9.
PaxDbiA2AVZ9.
PRIDEiA2AVZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090726; ENSMUSP00000088227; ENSMUSG00000027074. [A2AVZ9-1]
GeneIDi58207.
KEGGimmu:58207.
UCSCiuc008kjn.2. mouse. [A2AVZ9-1]
uc008kjo.1. mouse. [A2AVZ9-2]

Organism-specific databases

CTDi29015.
MGIiMGI:1931054. Slc43a3.

Phylogenomic databases

eggNOGiENOG410KDBX. Eukaryota.
ENOG411150Y. LUCA.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000154238.
HOVERGENiHBG102974.
InParanoidiA2AVZ9.
KOiK08230.
OMAiCKAQDEK.
PhylomeDBiA2AVZ9.
TreeFamiTF328358.

Miscellaneous databases

NextBioi314197.
PROiA2AVZ9.
SOURCEiSearch...

Gene expression databases

BgeeiA2AVZ9.
CleanExiMM_SLC43A3.
ExpressionAtlasiA2AVZ9. baseline and differential.
GenevisibleiA2AVZ9. MM.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR027197. SLC43A3.
[Graphical view]
PANTHERiPTHR20765. PTHR20765. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis."
    Stuart R.O., Pavlova A., Beier D., Li Z., Krijanovski Y., Nigam S.K.
    Am. J. Physiol. 281:F1148-F1156(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiS43A3_MOUSE
AccessioniPrimary (citable) accession number: A2AVZ9
Secondary accession number(s): A6PX00
, Q5FW65, Q8C345, Q9JLF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 20, 2007
Last modified: March 16, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.