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Protein

Fibrinogen C domain-containing protein 1

Gene

Fibcd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi391CalciumBy similarity1
Metal bindingi393CalciumBy similarity1
Sitei403Implicated in ligand bindingBy similarity1
Sitei413Implicated in ligand bindingBy similarity1
Sitei429Implicated in ligand bindingBy similarity1
Sitei430Implicated in ligand bindingBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Chitin-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen C domain-containing protein 1
Gene namesi
Name:Fibcd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2138953. Fibcd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini55 – 459ExtracellularSequence analysisAdd BLAST405

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943171 – 459Fibrinogen C domain-containing protein 1Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi242 ↔ 271PROSITE-ProRule annotation
Glycosylationi338N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi399 ↔ 412PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA2AV25.
PRIDEiA2AV25.

PTM databases

iPTMnetiA2AV25.
PhosphoSitePlusiA2AV25.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026841.
CleanExiMM_FIBCD1.
GenevisibleiA2AV25. MM.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028188.

Structurei

3D structure databases

ProteinModelPortaliA2AV25.
SMRiA2AV25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 456Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST224

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiA2AV25.
OMAiRDNDHSE.
OrthoDBiEOG091G03M1.
TreeFamiTF351983.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AV25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHERWKTVG SASQLEDRPR DKPQRASCSY VLCTVLLSLA VLLAVAVTGV
60 70 80 90 100
VLFLNHTHTP GTAPPPIVST GTAGANSALV TVERADSSHL SLLIDPRCPD
110 120 130 140 150
LTDSFARLEG IQASILRALS EHQAQPRLDG APELLDALAD QLPRLLTRAS
160 170 180 190 200
ELQAECAGLR KGHSLLGQGL STLQSEQGRL IQLLSESQGH MAHLVNSVSD
210 220 230 240 250
VLEALQRERG LGRPRVKADL QRAPSRGARP RGCANGSRPR DCLDVLLSGQ
260 270 280 290 300
QDDGVYSIFP THYPAGFQVY CDMRTDGGGW TVFQRREDGS VNFFRGWEAY
310 320 330 340 350
REGFGKLTGE HWLGLKRIHA LTTQAAYELH VDLEDFDNGT AYAHYGSFGV
360 370 380 390 400
GLFSVDPEED GYPLTVADYS GTAGDSLLKH SGMRFTTKDR DSDHSENNCA
410 420 430 440 450
AFYRGAWWYR NCHTSNLNGQ YLRGAHASYA DGVEWSSWTG WQYSLKFSEM

KIRPVREDR
Length:459
Mass (Da):50,602
Last modified:April 17, 2007 - v1
Checksum:i63D94371CB91A900
GO
Isoform 2 (identifier: A2AV25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-190: Missing.

Show »
Length:269
Mass (Da):30,357
Checksum:i7BE8B01596D23370
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti427A → V in BAC32685 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0266211 – 190Missing in isoform 2. 2 PublicationsAdd BLAST190

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046338 mRNA. Translation: BAC32685.1.
AK084379 mRNA. Translation: BAC39169.1.
AL929275 Genomic DNA. Translation: CAM26567.1.
BC060634 mRNA. Translation: AAH60634.2.
CCDSiCCDS50564.1. [A2AV25-1]
RefSeqiNP_849218.2. NM_178887.4. [A2AV25-1]
UniGeneiMm.32080.

Genome annotation databases

EnsembliENSMUST00000028188; ENSMUSP00000028188; ENSMUSG00000026841. [A2AV25-1]
GeneIDi98970.
KEGGimmu:98970.
UCSCiuc008jee.2. mouse. [A2AV25-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046338 mRNA. Translation: BAC32685.1.
AK084379 mRNA. Translation: BAC39169.1.
AL929275 Genomic DNA. Translation: CAM26567.1.
BC060634 mRNA. Translation: AAH60634.2.
CCDSiCCDS50564.1. [A2AV25-1]
RefSeqiNP_849218.2. NM_178887.4. [A2AV25-1]
UniGeneiMm.32080.

3D structure databases

ProteinModelPortaliA2AV25.
SMRiA2AV25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028188.

PTM databases

iPTMnetiA2AV25.
PhosphoSitePlusiA2AV25.

Proteomic databases

PaxDbiA2AV25.
PRIDEiA2AV25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028188; ENSMUSP00000028188; ENSMUSG00000026841. [A2AV25-1]
GeneIDi98970.
KEGGimmu:98970.
UCSCiuc008jee.2. mouse. [A2AV25-1]

Organism-specific databases

CTDi84929.
MGIiMGI:2138953. Fibcd1.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiA2AV25.
OMAiRDNDHSE.
OrthoDBiEOG091G03M1.
TreeFamiTF351983.

Miscellaneous databases

PROiA2AV25.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026841.
CleanExiMM_FIBCD1.
GenevisibleiA2AV25. MM.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBCD1_MOUSE
AccessioniPrimary (citable) accession number: A2AV25
Secondary accession number(s): Q6P9R8, Q8BJE7, Q8BL54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.