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Protein
Submitted name:

eIF-2-alpha kinase GCN2

Gene

Eif2ak4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
eIF-2-alpha kinase GCN2Imported
Gene namesi
Name:Eif2ak4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1353427. Eif2ak4.

PTM / Processingi

Proteomic databases

MaxQBiA2AUM0.
PaxDbiA2AUM0.
PeptideAtlasiA2AUM0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005102.
ExpressionAtlasiA2AUM0. baseline and differential.
GenevisibleiA2AUM0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005233.

Structurei

3D structure databases

ProteinModelPortaliA2AUM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 137RWDInterPro annotationAdd BLAST113
Domaini286 – 538Protein kinaseInterPro annotationAdd BLAST253
Domaini589 – 1000Protein kinaseInterPro annotationAdd BLAST412

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili147 – 199Sequence analysisAdd BLAST53

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1035. Eukaryota.
COG0124. LUCA.
GeneTreeiENSGT00530000062984.
HOVERGENiHBG051432.
KOiK16196.
OMAiKCVCLDD.
OrthoDBiEOG091G0NNL.
TreeFamiTF101512.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR024435. HisRS-related_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR006575. RWD-domain.
IPR008271. Ser/Thr_kinase_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF12745. HGTP_anticodon2. 1 hit.
PF00069. Pkinase. 3 hits.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
SSF56112. SSF56112. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50908. RWD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AUM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGRGASGR GRAEPQESYS QRQDHELQAL EAIYGSDFQD LRPDARGRVR
60 70 80 90 100
EPPEINLVLY PQGLAGEEVY VQVELRVKCP PTYPDVVPEI DLKNAKGLSN
110 120 130 140 150
ESVNLLKSHL EELAKKQCGE VMIFELAHHV QSFLSEHNKP PPKSFHEEML
160 170 180 190 200
ERQAQEKQQR LLEARRKEEQ EQREILHEIQ RRKEEIKEEK KRKEMAKQER
210 220 230 240 250
LEITSLTNQD YASKRDPAGH RAAAILHGGS PDFVGNGKAR TYSSGRSRRE
260 270 280 290 300
RQYSVCSGEP SPGSCDILHF SVGSPDQLMV HKGRCVGSDE QLGKVVYNAL
310 320 330 340 350
ETATGSFVLL HEWVLQWQKM GPCLTSQEKE KIDKCKRQIQ GAETEFSSLV
360 370 380 390 400
KLSHPNIVRY FAMNSREEED SIVIDILAEH VSGISLATHL SHSGPVPAHQ
410 420 430 440 450
LRKYTAQLLA GLDYLHSNSV VHKVLSASSV LVDAEGTVKI TDYSISKRLA
460 470 480 490 500
DICKEDVFEQ ARVRFSDSAL PYKTGKKGDV WRLGLLLLSL SQGQECGEYP
510 520 530 540 550
VTIPSDLPAD FQDFLKKCVC LDDKERWSPQ QLLKHSFINP QPKLPLVEQS
560 570 580 590 600
PEDSGGQDYI ETVIPSNQLP SAAFFSETQK QFSRYFIEFE ELQLLGKGAF
610 620 630 640 650
GAVIKVQNKL DGCCYAVKRI PINPASRHFR RIKGEVTLLS RLHHENIVRY
660 670 680 690 700
YNAWIERHER PAVPGTPPPD CTPQAQDSPA TCGKTSGDTE ELGSVEAAAP
710 720 730 740 750
PPILSSSVEW STSAERSTST RFPVTGQDSS SDEEDEDERD GVFSQSFLPA
760 770 780 790 800
SDSDSDIIFD NEDENSKSQN QDEDCNQKDG SHEIEPSVTA EAVHYLYIQM
810 820 830 840 850
EYCEKSTLRD TIDQGLFRDT SRLWRLFREI LDGLAYIHEK GMIHRDLKPV
860 870 880 890 900
NIFLDSDDHV KIGDFGLATD HLAFTAEGKQ DDQAGDGVIK SDPSGHLTGM
910 920 930 940 950
VGTALYVSPE VQGSTKSAYN QKVDLFSLGI IFFEMSYHPM VTASERIFVL
960 970 980 990 1000
NQLRDPTSPK FPDDFDDGEH TKQKSVISWL LNHDPAKRPT AMELLKSELL
1010 1020 1030 1040 1050
PPPQMEESEL HEVLHHTLAN IDGKAYRTMM SQIFCQHISP AIDYTYDSDI
1060 1070 1080 1090 1100
LKGNFLIRTA KIQQLVCETI VRVFKRHGAV QLCTPLLLPR NRQIYEHNEA
1110 1120 1130 1140 1150
ALFMDHSGML VMLPFDLRVP FARYVARNNI LNLKRYCIER VFRPRKLDRF
1160 1170 1180 1190 1200
HPKELLECAF DIVTSTTNSS LPTAETIYTI YEIIQEFPAL QERNYSIYLN
1210 1220 1230 1240 1250
HTMLLKAILL HCGIPEDKLS QVYVILYDAV TEKLTRREVE AKFCNLSLSS
1260 1270 1280 1290 1300
NSLCRLYKFI EQKGDLQDLT PTINSLIKQK TGVAQLVKYS LKDLEDVVGL
1310 1320 1330 1340 1350
LKKLGVKLQV SINLGLVYKV QQHTGIIFQF LAFSKRRQRV VPEILAAGGR
1360 1370 1380 1390 1400
YDLLIPKFRG PQTVGPVPTA VGVSIAIDKI FAAVLNMEEP VTVSSCDLLV
1410 1420 1430 1440 1450
VSVGQMSMSR AINLTQKLWT AGITAEIMYD WSQSQEELQE YCRHHEITYV
1460 1470 1480 1490 1500
ALVSDKEGSH VKVKSFEKER QTEKRVLESD LVDHVMQKLR TKVGDERNFR
1510 1520 1530 1540 1550
DASDNLAVQT LKGSFSNASG LFEIHGTTVV PNVIVLAPEK LSASTRRRHE
1560 1570 1580 1590 1600
IQVQTRLQTT LANLHQKSSE IEILAVDLPK ETILQFLSLE WDADEQAFNT
1610 1620 1630 1640
TVKQLLSRLP KQRYLKLVCD EIYNIKVEKK VSVLFLYSYR DDYYRILF
Length:1,648
Mass (Da):186,501
Last modified:February 20, 2007 - v1
Checksum:iE141BFAAB8778FA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929163 Genomic DNA. No translation available.
RefSeqiNP_038747.2. NM_013719.3.
UniGeneiMm.217616.

Genome annotation databases

EnsembliENSMUST00000005233; ENSMUSP00000005233; ENSMUSG00000005102.
GeneIDi27103.
KEGGimmu:27103.
UCSCiuc008lrw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929163 Genomic DNA. No translation available.
RefSeqiNP_038747.2. NM_013719.3.
UniGeneiMm.217616.

3D structure databases

ProteinModelPortaliA2AUM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005233.

Proteomic databases

MaxQBiA2AUM0.
PaxDbiA2AUM0.
PeptideAtlasiA2AUM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005233; ENSMUSP00000005233; ENSMUSG00000005102.
GeneIDi27103.
KEGGimmu:27103.
UCSCiuc008lrw.2. mouse.

Organism-specific databases

CTDi440275.
MGIiMGI:1353427. Eif2ak4.

Phylogenomic databases

eggNOGiKOG1035. Eukaryota.
COG0124. LUCA.
GeneTreeiENSGT00530000062984.
HOVERGENiHBG051432.
KOiK16196.
OMAiKCVCLDD.
OrthoDBiEOG091G0NNL.
TreeFamiTF101512.

Miscellaneous databases

ChiTaRSiEif2ak4. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005102.
ExpressionAtlasiA2AUM0. baseline and differential.
GenevisibleiA2AUM0. MM.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR024435. HisRS-related_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR006575. RWD-domain.
IPR008271. Ser/Thr_kinase_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF12745. HGTP_anticodon2. 1 hit.
PF00069. Pkinase. 3 hits.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
SSF56112. SSF56112. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50908. RWD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2AUM0_MOUSE
AccessioniPrimary (citable) accession number: A2AUM0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.