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A2ATU0

- DHTK1_MOUSE

UniProt

A2ATU0 - DHTK1_MOUSE

Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

Dhtkd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. generation of precursor metabolites and energy Source: UniProtKB
    2. glycolytic process Source: UniProtKB-KW
    3. hematopoietic progenitor cell differentiation Source: MGI
    4. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    Dehydrogenase E1 and transketolase domain-containing protein 1
    Gene namesi
    Name:Dhtkd1
    Synonyms:Kiaa1630
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2445096. Dhtkd1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 921Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307937
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei184 – 1841N6-succinyllysine1 Publication
    Modified residuei189 – 1891N6-succinyllysine1 Publication
    Modified residuei801 – 8011N6-succinyllysine1 Publication
    Modified residuei819 – 8191N6-succinyllysine1 Publication

    Proteomic databases

    MaxQBiA2ATU0.
    PaxDbiA2ATU0.
    PRIDEiA2ATU0.

    PTM databases

    PhosphoSiteiA2ATU0.

    Expressioni

    Gene expression databases

    BgeeiA2ATU0.
    GenevestigatoriA2ATU0.

    Interactioni

    Protein-protein interaction databases

    IntActiA2ATU0. 2 interactions.
    MINTiMINT-1839549.

    Structurei

    3D structure databases

    ProteinModelPortaliA2ATU0.
    SMRiA2ATU0. Positions 60-919.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    GeneTreeiENSGT00530000063092.
    HOGENOMiHOG000259586.
    HOVERGENiHBG001892.
    InParanoidiA2ATU0.
    KOiK15791.
    OMAiLCSGKHY.
    OrthoDBiEOG7CZK4Z.
    PhylomeDBiA2ATU0.
    TreeFamiTF314198.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2ATU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAATVAAA GRALRRAVLL LRRGYQTERG VYGYRPRKAK SGEPRGDRAR    50
    PSVDHGLARL VTVYCEHGHK AAQINPLFPG QALLDTVPEI QALVRTLQGP 100
    FTTTGLLNLG KEAASLEEVL AYLNHIYCGP ISIETAQLQS QEERDWFARR 150
    FEELKKETFT TEERKYLSKL LLESQEFDHF LATKFATVKR YGGEGAESMM 200
    GFFHELLKLS AYGGITDIII GMPHRGRLNL LTGLLQLPPE LMFRKMRGLS 250
    EFPENVATIG DVLSHLTSSV DLDFGAHQPL HVTMLPNPSH LEAVNPVAVG 300
    KTRGRQQSRE DGDYSPNGSA QPGDKVICLQ VHGDASFCGQ GIVLETFTLS 350
    NLPHFRIGGS IHLIVNNQLG YTTPAERGRS SLYSSDIGKL VGCAIIHVNG 400
    DSPEEVVRAT RLAFEYQRQF RKDVIVDLLC YRQWGHNELD EPFFTNPVMY 450
    KIIRARKSIP DTYAEHLIAS GLMTQEEVSD IKTSYYTKLN DHLANVAHYS 500
    PPATNLQARW QGLVQPEACV TTWDTGVPLE LLRFIGVKSV EVPEELQVHS 550
    HLLKMYVQSR MEKVKNGSGL DWATAETLAL GSLLAQGFNV RLSGQDVGRG 600
    TFSQRHAMVV CQDTDDAYIP LNHMDPNQKG FLEVSNSPLS EEAVLGFEYG 650
    MSIESPTLLP LWEAQFGDFF NGAQIIFDTF ISGGEAKWLL QSGLVILLPH 700
    GYDGAGPEHS SCRIERFLQM CDSAEEGVDS DTVNMFVVHP TTPAQYFHLL 750
    RRQMIRNFRK PLIVASPKML LRYPAAVSTL EEMAPGTAFK PVIGDSSVDP 800
    KNVKTLIFCS GKHFYALLKQ RESLGTKKHD FAIIRLEELC PFPLDALQQE 850
    MSKYKHVRDV IWSQEEPQNM GPWSFVSPRF EKQLACRLRL VSRPPLPAPA 900
    VGIGTVHQQQ HEDILSKTFT Q 921
    Length:921
    Mass (Da):102,793
    Last modified:February 20, 2007 - v1
    Checksum:iE40170D7D26EED65
    GO

    Sequence cautioni

    The sequence BAD32501.1 differs from that shown. Reason: Intron retention.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241G → S in AAI17995. (PubMed:15489334)Curated
    Sequence conflicti436 – 4361H → R in AAI17995. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928924 Genomic DNA. Translation: CAM20352.1.
    BC117994 mRNA. Translation: AAI17995.1.
    AK173223 mRNA. Translation: BAD32501.1. Sequence problems.
    AK050057 mRNA. Translation: BAC34055.1.
    CCDSiCCDS38040.1.
    RefSeqiNP_001074600.1. NM_001081131.2.
    UniGeneiMm.222517.

    Genome annotation databases

    EnsembliENSMUST00000026924; ENSMUSP00000026924; ENSMUSG00000025815.
    ENSMUST00000095147; ENSMUSP00000092769; ENSMUSG00000025815.
    ENSMUST00000169865; ENSMUSP00000129194; ENSMUSG00000025815.
    GeneIDi209692.
    KEGGimmu:209692.
    UCSCiuc008iga.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928924 Genomic DNA. Translation: CAM20352.1 .
    BC117994 mRNA. Translation: AAI17995.1 .
    AK173223 mRNA. Translation: BAD32501.1 . Sequence problems.
    AK050057 mRNA. Translation: BAC34055.1 .
    CCDSi CCDS38040.1.
    RefSeqi NP_001074600.1. NM_001081131.2.
    UniGenei Mm.222517.

    3D structure databases

    ProteinModelPortali A2ATU0.
    SMRi A2ATU0. Positions 60-919.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi A2ATU0. 2 interactions.
    MINTi MINT-1839549.

    PTM databases

    PhosphoSitei A2ATU0.

    Proteomic databases

    MaxQBi A2ATU0.
    PaxDbi A2ATU0.
    PRIDEi A2ATU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026924 ; ENSMUSP00000026924 ; ENSMUSG00000025815 .
    ENSMUST00000095147 ; ENSMUSP00000092769 ; ENSMUSG00000025815 .
    ENSMUST00000169865 ; ENSMUSP00000129194 ; ENSMUSG00000025815 .
    GeneIDi 209692.
    KEGGi mmu:209692.
    UCSCi uc008iga.1. mouse.

    Organism-specific databases

    CTDi 55526.
    MGIi MGI:2445096. Dhtkd1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0567.
    GeneTreei ENSGT00530000063092.
    HOGENOMi HOG000259586.
    HOVERGENi HBG001892.
    InParanoidi A2ATU0.
    KOi K15791.
    OMAi LCSGKHY.
    OrthoDBi EOG7CZK4Z.
    PhylomeDBi A2ATU0.
    TreeFami TF314198.

    Miscellaneous databases

    ChiTaRSi DHTKD1. mouse.
    NextBioi 372765.
    PROi A2ATU0.
    SOURCEi Search...

    Gene expression databases

    Bgeei A2ATU0.
    Genevestigatori A2ATU0.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 330-587.
      Tissue: Brain.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 525-921.
      Strain: C57BL/6J.
      Tissue: Liver.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-184; LYS-189; LYS-801 AND LYS-819, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiDHTK1_MOUSE
    AccessioniPrimary (citable) accession number: A2ATU0
    Secondary accession number(s): Q0VFY3, Q69ZE3, Q8BWT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3