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A2AT91

- A2AT91_MOUSE

UniProt

A2AT91 - A2AT91_MOUSE

Protein

Phosphoinositide phospholipase C

Gene

Plcb4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    3. protein binding Source: MGI
    4. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseUniRule annotation, TransducerSAAS annotation

    Keywords - Biological processi

    Lipid degradationUniRule annotation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_196473. Synthesis of IP3 and IP4 in the cytosol.
    REACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
    Gene namesi
    Name:Plcb4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:107464. Plcb4.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: MGI
    2. nucleus Source: MGI
    3. postsynaptic density Source: MGI
    4. smooth endoplasmic reticulum Source: MGI

    PTM / Processingi

    Proteomic databases

    PaxDbiA2AT91.

    Expressioni

    Gene expression databases

    ArrayExpressiA2AT91.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AT91.
    SMRiA2AT91. Positions 5-872.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation
    Contains 1 PI-PLC X-box domain.UniRule annotation
    Contains 1 PI-PLC Y-box domain.UniRule annotation
    Contains C2 domain.SAAS annotation
    Contains PI-PLC X-box domain.SAAS annotation
    Contains PI-PLC Y-box domain.SAAS annotation

    Phylogenomic databases

    eggNOGiNOG149692.
    GeneTreeiENSGT00730000110266.
    HOGENOMiHOG000232046.
    HOVERGENiHBG053609.
    OrthoDBiEOG7WDN1N.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view]
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    A2AT91-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW    50
    KSEGKEGQVL ECSLINSIRQ AAIPKDPKIL AALEAVGKSE NDLEGRILCV 100
    CSGTDLVNIG FTYMVAENPE VTKQWVEGLR SIIHNFRANN VSPMTCLKKH 150
    WMKLAFLTNT TGKIPVRSIT RTFASGKTEK VIFQALKELG LPSGKNDEIE 200
    PAAFTYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD QLVSFLNEHQ 250
    RDPRLNEILF PFYDAKRAMQ IIEMYEPDEE LKKKGLISSD GFCRYLMSDE 300
    NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL 350
    LAGCRCVELD CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS 400
    EYPVILSFEN HCSKYQQYKM SKYCEDLFGD LLLKQALESH PLEPGRPLPS 450
    PNDLKRKILI KNKRLKPEVE KKQLEALKSM MEAGESAAPA SILEDDNEEE 500
    IESADQEEEA HPEYKFGNEL SADDYSHKEA VANSVKKTSD DLEHENNKKG 550
    LVTVEDEQAW MASYKYVGAT TNIHPYLSTM INYAQPVKFQ GFHVAEERNI 600
    HYNMSSFNES VGLGYLKTHA IEFVNYNKRQ MSRIYPKGGR VDSSNYMPQI 650
    FWNAGCQMVS LNYQTPDLAM QLNQGKFEYN GSCGYLLKPD FMRRPDRTFD 700
    PFSETPVDGV IAATCSVQVI SGQFLSDKKI GTYVEVDMYG LPTDTIRKEF 750
    RTRMVMNNGL NPVYNEESFV FRKVILPDLA VLRIAVYDDN NKLIGQRILP 800
    LDGLQAGYRH ISLRNEGNKP LSLPTIFCNI VLKTYVPDGF GDIVDALSDP 850
    KKFLSITEKR ADQMRAMGIE TSDIADVPSD TSK 883
    Length:883
    Mass (Da):100,651
    Last modified:February 20, 2007 - v1
    Checksum:i240286DCACF11AF6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei883 – 8831Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928798 Genomic DNA. No translation available.
    AL929052 Genomic DNA. No translation available.
    AL935301 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000134310; ENSMUSP00000117638; ENSMUSG00000039943.
    UCSCiuc008mob.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928798 Genomic DNA. No translation available.
    AL929052 Genomic DNA. No translation available.
    AL935301 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A2AT91.
    SMRi A2AT91. Positions 5-872.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi A2AT91.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000134310 ; ENSMUSP00000117638 ; ENSMUSG00000039943 .
    UCSCi uc008mob.1. mouse.

    Organism-specific databases

    MGIi MGI:107464. Plcb4.

    Phylogenomic databases

    eggNOGi NOG149692.
    GeneTreei ENSGT00730000110266.
    HOGENOMi HOG000232046.
    HOVERGENi HBG053609.
    OrthoDBi EOG7WDN1N.

    Enzyme and pathway databases

    Reactomei REACT_196473. Synthesis of IP3 and IP4 in the cytosol.
    REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 35544084.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2AT91.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view ]
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2AT91_MOUSE
    AccessioniPrimary (citable) accession number: A2AT91
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3