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Protein
Submitted name:

Protein Upf2

Gene

Upf2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • liver development Source: MGI
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: MGI
  • organ regeneration Source: MGI
  • response to unfolded protein Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Upf2Imported
Submitted name:
UPF2 regulator of nonsense transcripts homolog (Yeast)Imported
Gene namesi
Name:Upf2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2449307. Upf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiA2AT37.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043241.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058375.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 363197MIF4GInterPro annotationAdd
BLAST
Domaini567 – 756190MIF4GInterPro annotationAdd
BLAST
Domaini771 – 984214MIF4GInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili57 – 13377Sequence analysisAdd
BLAST
Coiled coili532 – 55524Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2051. Eukaryota.
ENOG410XQ1E. LUCA.
GeneTreeiENSGT00530000064318.
HOGENOMiHOG000180856.
HOVERGENiHBG079124.
KOiK14327.
OMAiLHWEESE.
OrthoDBiEOG091G01PX.
TreeFamiTF300543.

Family and domain databases

Gene3Di1.25.40.180. 4 hits.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR007193. Up-fram_suppressor-2.
[Graphical view]
PfamiPF02854. MIF4G. 3 hits.
PF04050. Upf2. 1 hit.
[Graphical view]
SMARTiSM00543. MIF4G. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

A2AT37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAERKKSAS MEEKESLLNN KEKDCSERRP VSSKEKPRDD LKVTAKKEVS
60 70 80 90 100
KVPEDKKKRL EEDKRKKEDK ERKKKEEEKV KAEEELKKKE EEEKKKQEEE
110 120 130 140 150
ERKKQEEQAK RQQEEAAAQL KEKEESLQLH QEAWERHQLR KELRSKNQNA
160 170 180 190 200
PDNRPEENFF SRLDSSLKKN TAFVKKLKTI TEQQRDSLSH DFNGLNLSKY
210 220 230 240 250
IAEAVASIVE AKLKLSDVNC AAHLCSLFHQ RYSDFAPSLL QVWKKHFEAR
260 270 280 290 300
KEEKTPNITK LRTDLRFIAE LTIVGIFTDK EGLSLIYEQL KSIINADRES
310 320 330 340 350
HTHVSVVISF CRHCGDDIAG LVPRKVKSAA EKFNLSFPPS EIISPEKQQP
360 370 380 390 400
FQNLLKEYFT SLTKHLKRDH RELQNTERQN RRILHSKGEL SEDRHKQYEE
410 420 430 440 450
FAMSYQKLLA NSQSLADLLD ENMPDLPQDK PTPEEHGPGI DIFTPGKPGE
460 470 480 490 500
YDLEGGIWED EDARNFYENL IDLKAFVPAI LFKDNEKSQN KDSNKDDSKE
510 520 530 540 550
AKEPKDNKEA SSPDDLELEL ENLEINDDTL ELEGADEAED LTKKLLDEQE
560 570 580 590 600
QEDEEASTGS HLKLIVDAFL QQLPNCVNRD LIDKAAMDFC MNMNTKANRK
610 620 630 640 650
KLVRALFIVP RQRLDLLPFY ARLVATLHPC MSDVAEDLCS MLRGDFRFHV
660 670 680 690 700
RKKDQINIET KNKTVRFIGE LTKFKMFTKN DTLHCLKMLL SDFSHHHIEM
710 720 730 740 750
ACTLLETCGR FLFRSPESHL RTSVLLEQMM RKKQAMHLDA RYVTMVENAY
760 770 780 790 800
YYCNPPPAEK TVRKKRPPLQ EYVRKLLYKD LSKVTTEKVL RQMRKLPWQD
810 820 830 840 850
QEVKDYVICC MINIWNVKYN SIHCVANLLA GLVLYQEDVG IHVVDGVLED
860 870 880 890 900
IRLGMEVNQP KFNQRRISSA KFLGELYNYR MVESAVIFRT LYSFTSFGVN
910 920 930 940 950
PDGSPSSLDP PEHLFRIRLV CTILDTCGQY FDRGSSKRKL DCFLVYFQRY
960 970 980 990 1000
VWWKKSLEVW TKDHPFPIDI DYMISDTLEL LRPKIKLCNS LEESIRQVQD
1010 1020 1030 1040 1050
LEREFLIKLG LVNDKESKDS MTEGENLEED EEEEEGGAET EEQSGNESEV
1060 1070 1080 1090 1100
NEPEEEEGSE EEEEGEEEEE ENTDYLTDSN KENETDEENA EVMIKGGGLK
1110 1120 1130 1140 1150
HVPCVEDEDF IQALDKMMLE NLQQRSGESV KVHQLDVAIP LHLKSQLRKG
1160 1170 1180 1190 1200
PPLGGGEGET ESADTMPFVM LTRKGNKQQF KILNVPMSSQ LAANHWNQQQ
1210 1220 1230 1240 1250
AEQEERMRMK KLTLDINERQ EQEDYQEMLQ SLAQRPAPAN TNRERRPRYQ
1260
HPKGAPNADL IFKTGGRRR
Length:1,269
Mass (Da):147,553
Last modified:February 20, 2007 - v1
Checksum:iE95314FDF923F01E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928735 Genomic DNA. No translation available.
AL928924 Genomic DNA. No translation available.
CR388026 Genomic DNA. No translation available.
BC138358 mRNA. Translation: AAI38359.1.
BC138359 mRNA. Translation: AAI38360.1.
RefSeqiNP_001074601.1. NM_001081132.1.
XP_006497548.1. XM_006497485.2.
UniGeneiMm.31102.

Genome annotation databases

EnsembliENSMUST00000060092; ENSMUSP00000058375; ENSMUSG00000043241.
GeneIDi326622.
KEGGimmu:326622.
UCSCiuc008igc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928735 Genomic DNA. No translation available.
AL928924 Genomic DNA. No translation available.
CR388026 Genomic DNA. No translation available.
BC138358 mRNA. Translation: AAI38359.1.
BC138359 mRNA. Translation: AAI38360.1.
RefSeqiNP_001074601.1. NM_001081132.1.
XP_006497548.1. XM_006497485.2.
UniGeneiMm.31102.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058375.

PTM databases

PhosphoSiteiA2AT37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060092; ENSMUSP00000058375; ENSMUSG00000043241.
GeneIDi326622.
KEGGimmu:326622.
UCSCiuc008igc.1. mouse.

Organism-specific databases

CTDi26019.
MGIiMGI:2449307. Upf2.

Phylogenomic databases

eggNOGiKOG2051. Eukaryota.
ENOG410XQ1E. LUCA.
GeneTreeiENSGT00530000064318.
HOGENOMiHOG000180856.
HOVERGENiHBG079124.
KOiK14327.
OMAiLHWEESE.
OrthoDBiEOG091G01PX.
TreeFamiTF300543.

Enzyme and pathway databases

ReactomeiR-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiUpf2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043241.

Family and domain databases

Gene3Di1.25.40.180. 4 hits.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR007193. Up-fram_suppressor-2.
[Graphical view]
PfamiPF02854. MIF4G. 3 hits.
PF04050. Upf2. 1 hit.
[Graphical view]
SMARTiSM00543. MIF4G. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiA2AT37_MOUSE
AccessioniPrimary (citable) accession number: A2AT37
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.