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Protein

Calcium-binding mitochondrial carrier protein SCaMC-2

Gene

Slc25a25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi60 – 711PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • adipose tissue development Source: MGI
  • ATP metabolic process Source: MGI
  • calcium ion transmembrane transport Source: MGI
  • camera-type eye development Source: MGI
  • cellular respiration Source: MGI
  • multicellular organism growth Source: MGI
  • response to activity Source: MGI
  • response to dietary excess Source: MGI
  • response to food Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-2
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 2
Solute carrier family 25 member 25
Gene namesi
Name:Slc25a25
Synonyms:Kiaa1896, Scamc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915913. Slc25a25.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 189Mitochondrial intermembraneSequence analysisAdd BLAST189
Transmembranei190 – 207Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini208 – 244Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei245 – 264Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini265 – 287Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei288 – 301Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini302 – 337Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei338 – 357Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini358 – 380Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei381 – 398Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini399 – 437Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei438 – 457Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini458 – 469Mitochondrial intermembraneSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176031 – 469Calcium-binding mitochondrial carrier protein SCaMC-2Add BLAST469

Proteomic databases

MaxQBiA2ASZ8.
PaxDbiA2ASZ8.
PRIDEiA2ASZ8.

PTM databases

iPTMnetiA2ASZ8.
PhosphoSitePlusiA2ASZ8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026819.
ExpressionAtlasiA2ASZ8. baseline and differential.
GenevisibleiA2ASZ8. MM.

Interactioni

Protein-protein interaction databases

IntActiA2ASZ8. 1 interactor.
MINTiMINT-4119296.
STRINGi10090.ENSMUSP00000028160.

Structurei

3D structure databases

ProteinModelPortaliA2ASZ8.
SMRiA2ASZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 80EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini78 – 113EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini114 – 149EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Repeati184 – 270Solcar 1Add BLAST87
Repeati278 – 363Solcar 2Add BLAST86
Repeati375 – 463Solcar 3Add BLAST89

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOVERGENiHBG108464.
InParanoidiA2ASZ8.
KOiK14684.
OMAiKLLTRMD.
OrthoDBiEOG091G0C8S.
PhylomeDBiA2ASZ8.
TreeFamiTF313492.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2ASZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCLCLYVPI AGAAQTEFQY FESKGLPAEL KSIFKLSVFI PSQEFSTYRQ
60 70 80 90 100
WKQKIVQAGD KDLDGQLDFE EFVHYLQDHE KKLRLVFKSL DKKNDGRIDA
110 120 130 140 150
QEIMQSLRDL GVKISEQQAE KILKSMDKNG TMTIDWNEWR DYHLLHPVEN
160 170 180 190 200
IPEIILYWKH STIFDVGENL TVPDEFTVEE RQTGMWWRHL VAGGGAGAVS
210 220 230 240 250
RTCTAPLDRL KVLMQVHASR SNNMCIVGGF TQMIREGGAK SLWRGNGINV
260 270 280 290 300
LKIAPESAIK FMAYEQMKRL VGSDQETLRI HERLVAGSLA GAIAQSSIYP
310 320 330 340 350
MEVLKTRMAL RKTGQYSGML DCARRILAKE GVAAFYKGYI PNMLGIIPYA
360 370 380 390 400
GIDLAVYETL KNTWLQRYAV NSADPGVFVL LACGTISSTC GQLASYPLAL
410 420 430 440 450
VRTRMQAQAS IEGAPEVTMS SLFKQILRTE GAFGLYRGLA PNFMKVIPAV
460
SISYVVYENL KITLGVQSR
Length:469
Mass (Da):52,621
Last modified:February 20, 2007 - v1
Checksum:iBFB0CC840738B63B
GO
Isoform 2 (identifier: A2ASZ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPI...EFSTYRQWKQ → MVSSVLCRCV...GLHRTEGELR

Show »
Length:502
Mass (Da):55,288
Checksum:i21ABC9B940B361FE
GO
Isoform 3 (identifier: A2ASZ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPI...EFSTYRQWKQ → MVSSVLCRCV...GLHRTEGELR
     125-125: S → RIRTGHFWGPVTY

Show »
Length:514
Mass (Da):56,773
Checksum:i46A493F31D98299F
GO
Isoform 4 (identifier: A2ASZ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPI...EFSTYRQWKQ → MLQTLWHFLS...VVGPAEQFPK

Show »
Length:489
Mass (Da):54,593
Checksum:i922EFB5FAF79FBC4
GO
Isoform 5 (identifier: A2ASZ8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPI...EFSTYRQWKQ → MLQTLWHFLS...VVGPAEQFPK
     125-125: S → RIRTGHFWGPVTY

Show »
Length:501
Mass (Da):56,078
Checksum:i7FCC4FB5B8977778
GO

Sequence cautioni

The sequence AAH19978 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH22114 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65850 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM18798 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM18799 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310711 – 53MLCLC…RQWKQ → MVSSVLCRCVASPPPDAAAT ASSSASSPASVGDPCGGAVC GGPDHQLRLWSLFQTLDVNR DGGLCVNDLAVGLRRLGLHR TEGELR in isoform 2 and isoform 3. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_0310721 – 53MLCLC…RQWKQ → MLQTLWHFLSSFLPRAECQD SREGIDHGVRGTQAPARGDQ MSTFLGKQNGRAEATEKRPT ILLVVGPAEQFPK in isoform 4 and isoform 5. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_031073125S → RIRTGHFWGPVTY in isoform 3 and isoform 5. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122568 mRNA. Translation: BAC65850.1. Different initiation.
AK049392 mRNA. Translation: BAC33730.1.
AK082756 mRNA. Translation: BAC38604.1.
AK132204 mRNA. Translation: BAE21031.1.
AL928710 Genomic DNA. Translation: CAM18795.1.
AL928710 Genomic DNA. Translation: CAM18796.1.
AL928710 Genomic DNA. Translation: CAM18797.1.
AL928710 Genomic DNA. Translation: CAM18798.1. Sequence problems.
AL928710 Genomic DNA. Translation: CAM18799.1. Sequence problems.
AL928710 Genomic DNA. Translation: CAM18800.1.
AL928710 Genomic DNA. Translation: CAM18801.1.
BC004720 mRNA. Translation: AAH04720.1.
BC019978 mRNA. Translation: AAH19978.1. Different initiation.
BC022114 mRNA. Translation: AAH22114.1. Different initiation.
BC037109 mRNA. Translation: AAH37109.1.
BC066998 mRNA. Translation: AAH66998.1.
CCDSiCCDS15915.1. [A2ASZ8-3]
CCDS50567.1. [A2ASZ8-5]
CCDS50568.1. [A2ASZ8-2]
CCDS71028.1. [A2ASZ8-1]
RefSeqiNP_001157829.1. NM_001164357.1. [A2ASZ8-2]
NP_001157830.1. NM_001164358.1. [A2ASZ8-5]
NP_001277487.1. NM_001290558.1. [A2ASZ8-1]
NP_666230.2. NM_146118.3. [A2ASZ8-3]
XP_006498017.1. XM_006497954.1. [A2ASZ8-4]
UniGeneiMm.37395.

Genome annotation databases

EnsembliENSMUST00000028160; ENSMUSP00000028160; ENSMUSG00000026819. [A2ASZ8-3]
ENSMUST00000052119; ENSMUSP00000060581; ENSMUSG00000026819. [A2ASZ8-5]
ENSMUST00000113307; ENSMUSP00000108932; ENSMUSG00000026819. [A2ASZ8-1]
ENSMUST00000113308; ENSMUSP00000108933; ENSMUSG00000026819. [A2ASZ8-4]
ENSMUST00000113310; ENSMUSP00000108936; ENSMUSG00000026819. [A2ASZ8-2]
GeneIDi227731.
KEGGimmu:227731.
UCSCiuc008jfn.2. mouse. [A2ASZ8-1]
uc008jfo.2. mouse. [A2ASZ8-5]
uc008jfp.2. mouse. [A2ASZ8-3]
uc008jfq.2. mouse. [A2ASZ8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122568 mRNA. Translation: BAC65850.1. Different initiation.
AK049392 mRNA. Translation: BAC33730.1.
AK082756 mRNA. Translation: BAC38604.1.
AK132204 mRNA. Translation: BAE21031.1.
AL928710 Genomic DNA. Translation: CAM18795.1.
AL928710 Genomic DNA. Translation: CAM18796.1.
AL928710 Genomic DNA. Translation: CAM18797.1.
AL928710 Genomic DNA. Translation: CAM18798.1. Sequence problems.
AL928710 Genomic DNA. Translation: CAM18799.1. Sequence problems.
AL928710 Genomic DNA. Translation: CAM18800.1.
AL928710 Genomic DNA. Translation: CAM18801.1.
BC004720 mRNA. Translation: AAH04720.1.
BC019978 mRNA. Translation: AAH19978.1. Different initiation.
BC022114 mRNA. Translation: AAH22114.1. Different initiation.
BC037109 mRNA. Translation: AAH37109.1.
BC066998 mRNA. Translation: AAH66998.1.
CCDSiCCDS15915.1. [A2ASZ8-3]
CCDS50567.1. [A2ASZ8-5]
CCDS50568.1. [A2ASZ8-2]
CCDS71028.1. [A2ASZ8-1]
RefSeqiNP_001157829.1. NM_001164357.1. [A2ASZ8-2]
NP_001157830.1. NM_001164358.1. [A2ASZ8-5]
NP_001277487.1. NM_001290558.1. [A2ASZ8-1]
NP_666230.2. NM_146118.3. [A2ASZ8-3]
XP_006498017.1. XM_006497954.1. [A2ASZ8-4]
UniGeneiMm.37395.

3D structure databases

ProteinModelPortaliA2ASZ8.
SMRiA2ASZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2ASZ8. 1 interactor.
MINTiMINT-4119296.
STRINGi10090.ENSMUSP00000028160.

PTM databases

iPTMnetiA2ASZ8.
PhosphoSitePlusiA2ASZ8.

Proteomic databases

MaxQBiA2ASZ8.
PaxDbiA2ASZ8.
PRIDEiA2ASZ8.

Protocols and materials databases

DNASUi227731.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028160; ENSMUSP00000028160; ENSMUSG00000026819. [A2ASZ8-3]
ENSMUST00000052119; ENSMUSP00000060581; ENSMUSG00000026819. [A2ASZ8-5]
ENSMUST00000113307; ENSMUSP00000108932; ENSMUSG00000026819. [A2ASZ8-1]
ENSMUST00000113308; ENSMUSP00000108933; ENSMUSG00000026819. [A2ASZ8-4]
ENSMUST00000113310; ENSMUSP00000108936; ENSMUSG00000026819. [A2ASZ8-2]
GeneIDi227731.
KEGGimmu:227731.
UCSCiuc008jfn.2. mouse. [A2ASZ8-1]
uc008jfo.2. mouse. [A2ASZ8-5]
uc008jfp.2. mouse. [A2ASZ8-3]
uc008jfq.2. mouse. [A2ASZ8-2]

Organism-specific databases

CTDi114789.
MGIiMGI:1915913. Slc25a25.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOVERGENiHBG108464.
InParanoidiA2ASZ8.
KOiK14684.
OMAiKLLTRMD.
OrthoDBiEOG091G0C8S.
PhylomeDBiA2ASZ8.
TreeFamiTF313492.

Miscellaneous databases

ChiTaRSiSlc25a25. mouse.
PROiA2ASZ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026819.
ExpressionAtlasiA2ASZ8. baseline and differential.
GenevisibleiA2ASZ8. MM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCMC2_MOUSE
AccessioniPrimary (citable) accession number: A2ASZ8
Secondary accession number(s): A2ASZ1
, A2ASZ5, A2ASZ9, Q6NXM8, Q80T78, Q8BHG0, Q8JZT8, Q8VBT4, Q99KD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.