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A2ASS6 (TITIN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Titin

EC=2.7.11.1
Alternative name(s):
Connectin
Gene names
Name:Ttn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length35213 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. Ref.4 Ref.6 UniProtKB Q8WZ42

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB Q8WZ42

Cofactor

Magnesium By similarity. UniProtKB Q8WZ42

Enzyme regulation

Full activation of the protein kinase domain requires both phosphorylation of Tyr-33203, preventing it from blocking the catalytic aspartate residue, and binding of Ca/CALM to the C-terminal regulatory tail of the molecule which results in ATP binding to the kinase By similarity. UniProtKB Q8WZ42

Subunit structure

Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts with actin, primarily via the PEVK domains and with MYPN. Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank15, via the first two N-terminal immunoglobulin domains. Interacts with TRIM63, TRIM55, ANKRD1, ANKRD2, ANKRD23, and CAPN3 through several Ig domains. Interacts with NBR1 through the protein kinase domain By similarity. Interacts with CMYA5 By similarity. UniProtKB Q8WZ42

Subcellular location

Cytoplasm Probable. Nucleus By similarity UniProtKB Q8WZ42.

Developmental stage

Expressed in cardiac muscle from 8 dpc and in skeletal muscle from 9 dpc. Ref.3

Domain

ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site By similarity. UniProtKB Q8WZ42

The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere By similarity. UniProtKB Q8WZ42

Post-translational modification

Autophosphorylated.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Contains 132 fibronectin type-III domains.

Contains 144 Ig-like (immunoglobulin-like) domains.

Contains 18 Kelch repeats.

Contains 1 protein kinase domain.

Contains 12 RCC1 repeats.

Contains 15 TPR repeats.

Contains 17 WD repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Immunoglobulin domain
Kelch repeat
Repeat
TPR repeat
WD repeat
   LigandATP-binding
Calcium
Calmodulin-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMDisulfide bond
Isopeptide bond
Phosphoprotein
Ubl conjugation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processadult heart development

Inferred from mutant phenotype Ref.4. Source: MGI

cardiac myofibril assembly

Inferred from mutant phenotype Ref.4. Source: MGI

forward locomotion

Inferred from mutant phenotype PubMed 16115818. Source: MGI

heart development

Inferred from expression pattern PubMed 9817758. Source: BHF-UCL

heart morphogenesis

Inferred from mutant phenotype Ref.4. Source: MGI

in utero embryonic development

Inferred from mutant phenotype Ref.4. Source: MGI

muscle contraction

Inferred from mutant phenotype PubMed 16115818. Source: MGI

regulation of relaxation of cardiac muscle

Inferred from mutant phenotype PubMed 23283722. Source: BHF-UCL

sarcomere organization

Inferred from mutant phenotype Ref.4. Source: MGI

somitogenesis

Inferred from expression pattern PubMed 9817758. Source: BHF-UCL

striated muscle cell development

Inferred from mutant phenotype PubMed 16115818. Source: MGI

   Cellular_componentA band

Inferred from direct assay PubMed 16481394Ref.4. Source: MGI

I band

Inferred from direct assay PubMed 16481394Ref.4. Source: MGI

M band

Inferred from direct assay PubMed 15138196Ref.4. Source: MGI

Z disc

Inferred from direct assay PubMed 15138196PubMed 16481394. Source: MGI

muscle myosin complex

Traceable author statement PubMed 2129545. Source: MGI

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

sarcomere

Inferred from direct assay PubMed 12651156. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ankyrin binding

Inferred from physical interaction PubMed 18310072. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein tyrosine kinase activity

Inferred from electronic annotation. Source: InterPro

structural constituent of cytoskeleton

Traceable author statement PubMed 8618961. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.4 (identifier: A2ASS6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.4 (identifier: A2ASS6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     556-601: Missing.
     4435-12715: Missing.
Isoform 3 Ref.4 (identifier: A2ASS6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     556-601: Missing.
     3461-5499: IASLLSAEED...FSGTKEISAK → ELFEGEADGS...ARSSAILTLS
     5500-35213: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3521335213Titin
PRO_0000311696

Regions

Domain6 – 9893Ig-like 1
Domain104 – 19289Ig-like 2
Repeat412 – 45443Z-repeat 1
Repeat463 – 50442Z-repeat 2
Repeat509 – 54840Z-repeat 3
Repeat553 – 59442Z-repeat 4
Repeat599 – 64042Z-repeat 5
Repeat645 – 68642Z-repeat 6
Domain946 – 103489Ig-like 3
Domain1084 – 117491Ig-like 4
Domain1293 – 138492Ig-like 5
Domain1463 – 155290Ig-like 6
Domain1562 – 165291Ig-like 7
Domain1709 – 179991Ig-like 8
Domain1847 – 193488Ig-like 9
Domain2084 – 217390Ig-like 10
Repeat2095 – 212834TPR 1
Domain2177 – 226892Ig-like 11
Domain2270 – 235687Ig-like 12
Domain2359 – 244991Ig-like 13
Domain2436 – 2535100Ig-like 14
Domain2626 – 270984Ig-like 15
Repeat2810 – 284435TPR 2
Domain2886 – 297186Ig-like 16
Repeat3028 – 306841WD 1
Domain3064 – 314784Ig-like 17
Repeat3208 – 324841WD 2
Domain3245 – 333389Ig-like 18
Domain3350 – 343889Ig-like 19
Domain3509 – 359991Ig-like 20
Domain3625 – 371692Ig-like 21
Domain4251 – 433787Ig-like 22
Domain4344 – 443289Ig-like 23
Domain4439 – 452789Ig-like 24
Domain4532 – 462089Ig-like 25
Domain4625 – 471692Ig-like 26
Domain4719 – 480789Ig-like 27
Domain4812 – 489786Ig-like 28
Domain4904 – 499390Ig-like 29
Domain5001 – 508989Ig-like 30
Domain5094 – 518289Ig-like 31
Repeat5131 – 516434TPR 3
Domain5186 – 527691Ig-like 32
Domain5281 – 536989Ig-like 33
Domain5374 – 546289Ig-like 34
Domain5466 – 555590Ig-like 35
Domain5563 – 565189Ig-like 36
Domain5656 – 574489Ig-like 37
Domain5749 – 583890Ig-like 38
Domain5842 – 593190Ig-like 39
Domain5936 – 602489Ig-like 40
Domain6028 – 611790Ig-like 41
Domain6125 – 621389Ig-like 42
Domain6218 – 630891Ig-like 43
Domain6311 – 640191Ig-like 44
Domain6405 – 649389Ig-like 45
Repeat6435 – 646834TPR 4
Domain6498 – 658790Ig-like 46
Domain6591 – 668292Ig-like 47
Repeat6615 – 665339WD 3
Domain6688 – 677689Ig-like 48
Domain6781 – 686989Ig-like 49
Domain6873 – 696290Ig-like 50
Domain6966 – 705489Ig-like 51
Domain7063 – 715189Ig-like 52
Domain7159 – 724789Ig-like 53
Domain7252 – 734392Ig-like 54
Domain7346 – 743489Ig-like 55
Domain7439 – 752890Ig-like 56
Domain7532 – 762392Ig-like 57
Domain7629 – 771789Ig-like 58
Domain7722 – 781089Ig-like 59
Domain7814 – 790390Ig-like 60
Domain7907 – 799690Ig-like 61
Domain8004 – 809491Ig-like 62
Domain8099 – 819092Ig-like 63
Domain8193 – 828290Ig-like 64
Domain8287 – 837589Ig-like 65
Domain8380 – 846990Ig-like 66
Domain8473 – 856492Ig-like 67
Domain8570 – 865889Ig-like 68
Domain8663 – 875189Ig-like 69
Domain8755 – 884490Ig-like 70
Domain8849 – 893789Ig-like 71
Domain8945 – 903591Ig-like 72
Domain9040 – 912990Ig-like 73
Domain9137 – 922690Ig-like 74
Repeat9145 – 918238TPR 5
Domain9233 – 932290Ig-like 75
Domain9331 – 9431101Ig-like 76
Domain9621 – 971696Ig-like 77
Repeat9662 – 969534TPR 6
Domain9721 – 981292Ig-like 78
Repeat9865 – 989228PEVK 1
Repeat9940 – 996324PEVK 2
Repeat9991 – 1002434TPR 7
Repeat10001 – 1005050Kelch 1
Repeat10062 – 1008524PEVK 3
Repeat10091 – 1011525PEVK 4
Repeat10145 – 1016925PEVK 5
Repeat10170 – 1019728PEVK 6
Repeat10198 – 1022528PEVK 7
Repeat10227 – 1025428PEVK 8
Repeat10255 – 1028127PEVK 9
Repeat10282 – 1030726PEVK 10
Repeat10308 – 1033225PEVK 11
Repeat10333 – 1035927PEVK 12
Repeat10397 – 1043135TPR 8
Repeat10404 – 1042724PEVK 13
Repeat10451 – 1047626PEVK 14
Repeat10477 – 1050428PEVK 15
Repeat10505 – 1053228PEVK 16
Repeat10533 – 1056028PEVK 17
Repeat10561 – 1058828PEVK 18
Repeat10683 – 1070725PEVK 19
Repeat10709 – 1073426PEVK 20
Repeat10739 – 1076426PEVK 21
Repeat10765 – 1079026PEVK 22
Repeat10850 – 1087728PEVK 23
Repeat10878 – 1090326PEVK 24
Repeat10904 – 1093128PEVK 25
Repeat10932 – 1095928PEVK 26
Repeat10960 – 1098728PEVK 27
Repeat10988 – 1101124PEVK 28
Repeat11084 – 1110926PEVK 29
Repeat11111 – 1113525PEVK 30
Repeat11136 – 1116025PEVK 31
Repeat11161 – 1118828PEVK 32
Repeat11201 – 1122525PEVK 33
Repeat11226 – 1124823PEVK 34
Repeat11249 – 1127224PEVK 35
Repeat11273 – 1129523PEVK 36
Repeat11373 – 1140028PEVK 37
Repeat11401 – 1142525PEVK 38
Repeat11426 – 1145328PEVK 39
Repeat11454 – 1148128PEVK 40
Repeat11508 – 1153326PEVK 41
Repeat11562 – 1158726PEVK 42
Repeat11671 – 1169828PEVK 43
Repeat11700 – 1172627PEVK 44
Repeat11727 – 1175428PEVK 45
Repeat11755 – 1178228PEVK 46
Repeat11783 – 1181028PEVK 47
Repeat11811 – 1183828PEVK 48
Repeat11839 – 1186628PEVK 49
Repeat11867 – 1189529PEVK 50
Repeat11896 – 1192328PEVK 51
Repeat11924 – 1195027PEVK 52
Repeat11954 – 1197724PEVK 53
Repeat11979 – 1199921PEVK 54
Repeat12004 – 1202623PEVK 55
Repeat12051 – 1207727PEVK 56
Repeat12080 – 1210425PEVK 57
Repeat12105 – 1212622PEVK 58
Repeat12129 – 1215426PEVK 59
Repeat12155 – 1218228PEVK 60
Repeat12183 – 1221028PEVK 61
Repeat12211 – 1223828PEVK 62
Repeat12239 – 1226628PEVK 63
Repeat12267 – 1229428PEVK 64
Repeat12295 – 1232228PEVK 65
Repeat12323 – 1235129PEVK 66
Repeat12352 – 1237928PEVK 67
Repeat12380 – 1240425PEVK 68
Repeat12405 – 1243026PEVK 69
Repeat12431 – 1245828PEVK 70
Repeat12459 – 1248628PEVK 71
Repeat12491 – 1251626PEVK 72
Repeat12517 – 1254226PEVK 73
Repeat12543 – 1257028PEVK 74
Repeat12572 – 1259827PEVK 75
Repeat12599 – 1262628PEVK 76
Domain12903 – 1299593Ig-like 79
Domain13000 – 1308485Ig-like 80
Domain13361 – 1344686Ig-like 81
Domain13452 – 1353483Ig-like 82
Domain13628 – 1371285Ig-like 83
Domain13807 – 1389488Ig-like 84
Repeat13817 – 1385034TPR 9
Domain13982 – 1406887Ig-like 85
Domain14072 – 1415786Ig-like 86
Domain14161 – 1424686Ig-like 87
Domain14250 – 1433586Ig-like 88
Domain14341 – 1442484Ig-like 89
Domain14427 – 1451791Ig-like 90
Domain14521 – 1461090Ig-like 91
Repeat14576 – 1461540WD 4
Domain14611 – 1469585Ig-like 92
Domain14789 – 1487486Ig-like 93
Domain14881 – 1497696Fibronectin type-III 1
Repeat14946 – 1499853RCC1 1
Domain14982 – 1507796Fibronectin type-III 2
Repeat15047 – 1510054RCC1 2
Domain15083 – 1517896Fibronectin type-III 3
Domain15279 – 1537496Fibronectin type-III 4
Domain15379 – 1547698Fibronectin type-III 5
Domain15477 – 1557094Ig-like 94
Domain15575 – 1566894Fibronectin type-III 6
Domain15674 – 1576996Fibronectin type-III 7
Repeat15690 – 1573849Kelch 2
Domain15775 – 1586995Fibronectin type-III 8
Repeat15794 – 1583946Kelch 3
Repeat15848 – 1589851Kelch 4
Domain15872 – 1596998Fibronectin type-III 9
Domain15975 – 1606995Fibronectin type-III 10
Domain16076 – 1617297Fibronectin type-III 11
Domain16176 – 1626489Ig-like 95
Domain16271 – 1636595Fibronectin type-III 12
Domain16371 – 1646696Fibronectin type-III 13
Repeat16436 – 1649257RCC1 3
Domain16470 – 16586117Ig-like 96
Domain16593 – 1668896Fibronectin type-III 14
Domain16694 – 16793100Fibronectin type-III 15
Domain16794 – 1688794Fibronectin type-III 16
Domain16988 – 1708093Fibronectin type-III 17
Repeat16996 – 1704247WD 5
Domain17086 – 1718095Fibronectin type-III 18
Domain17184 – 1728299Ig-like 97
Domain17289 – 1738496Fibronectin type-III 19
Repeat17309 – 1735547Kelch 5
Domain17390 – 17490101Fibronectin type-III 20
Domain17496 – 17596101Fibronectin type-III 21
Domain17589 – 17696108Ig-like 98
Domain17703 – 1779694Fibronectin type-III 22
Domain17803 – 17903101Fibronectin type-III 23
Domain17906 – 1800196Ig-like 99
Domain18009 – 1810294Fibronectin type-III 24
Domain18108 – 18207100Fibronectin type-III 25
Domain18210 – 1830798Fibronectin type-III 26
Domain18311 – 1839888Ig-like 100
Domain18407 – 1850296Fibronectin type-III 27
Domain18508 – 1860396Fibronectin type-III 28
Repeat18573 – 1863159RCC1 4
Domain18607 – 1869690Ig-like 101
Domain18703 – 1879795Fibronectin type-III 29
Repeat18792 – 1883140WD 6
Domain18803 – 1889896Fibronectin type-III 30
Repeat18868 – 1892154RCC1 5
Domain18904 – 1900198Fibronectin type-III 31
Domain19005 – 1909086Ig-like 102
Domain19101 – 1919595Fibronectin type-III 32
Repeat19120 – 1916546Kelch 6
Repeat19165 – 1922056RCC1 6
Domain19201 – 1929393Fibronectin type-III 33
Domain19297 – 1938892Ig-like 103
Repeat19330 – 1936334TPR 10
Domain19395 – 19494100Fibronectin type-III 34
Domain19495 – 1958995Fibronectin type-III 35
Domain19595 – 1969197Fibronectin type-III 36
Domain19695 – 1978692Ig-like 104
Domain19793 – 1988795Fibronectin type-III 37
Domain19892 – 1998695Fibronectin type-III 38
Domain19990 – 2008192Ig-like 105
Domain20088 – 2018396Fibronectin type-III 39
Repeat20152 – 2020857RCC1 7
Domain20187 – 2028296Fibronectin type-III 40
Repeat20252 – 2030554RCC1 8
Domain20288 – 20389102Fibronectin type-III 41
Domain20393 – 2047987Ig-like 106
Domain20490 – 2058495Fibronectin type-III 42
Repeat20509 – 2055446Kelch 7
Domain20590 – 2068596Fibronectin type-III 43
Domain20688 – 2077689Ig-like 107
Domain20783 – 2087795Fibronectin type-III 44
Domain20880 – 2097899Fibronectin type-III 45
Domain20981 – 2107999Fibronectin type-III 46
Domain21082 – 2117392Ig-like 108
Domain21180 – 2127394Fibronectin type-III 47
Domain21279 – 2137496Fibronectin type-III 48
Domain21380 – 2147596Fibronectin type-III 49
Domain21578 – 2167295Fibronectin type-III 50
Domain21675 – 2177096Fibronectin type-III 51
Domain21868 – 2196396Fibronectin type-III 52
Repeat21887 – 2193246Kelch 8
Domain21967 – 2206296Fibronectin type-III 53
Repeat22052 – 2209342WD 7
Domain22065 – 2216197Fibronectin type-III 54
Repeat22084 – 2212946Kelch 9
Domain22165 – 2225793Ig-like 109
Domain22264 – 2235794Fibronectin type-III 55
Domain22363 – 2245896Fibronectin type-III 56
Repeat22428 – 2248255RCC1 9
Domain22464 – 2255996Fibronectin type-III 57
Domain22659 – 2275395Fibronectin type-III 58
Domain22756 – 2284893Fibronectin type-III 59
Domain22950 – 2304495Fibronectin type-III 60
Domain23050 – 2314596Fibronectin type-III 61
Domain23148 – 2324497Fibronectin type-III 62
Repeat23168 – 2321245Kelch 10
Domain23248 – 2333992Ig-like 110
Domain23346 – 2344095Fibronectin type-III 63
Domain23446 – 2354196Fibronectin type-III 64
Domain23547 – 2364397Fibronectin type-III 65
Repeat23566 – 2361247Kelch 11
Domain23647 – 2373690Ig-like 111
Domain23743 – 2383896Fibronectin type-III 66
Domain23840 – 2393394Fibronectin type-III 67
Repeat23903 – 2395351RCC1 10
Domain23937 – 2402589Ig-like 112
Domain24032 – 2412695Fibronectin type-III 68
Repeat24041 – 2408747WD 8
Domain24132 – 2422796Fibronectin type-III 69
Domain24230 – 2432596Fibronectin type-III 70
Domain24330 – 2441788Ig-like 113
Domain24428 – 2452295Fibronectin type-III 71
Repeat24513 – 2455644WD 9
Domain24528 – 2462396Fibronectin type-III 72
Domain24629 – 2472597Fibronectin type-III 73
Domain24729 – 2481688Ig-like 114
Domain24825 – 2491995Fibronectin type-III 74
Domain24922 – 2501594Fibronectin type-III 75
Repeat24941 – 2498646Kelch 12
Domain25019 – 2510890Ig-like 115
Domain25114 – 2520895Fibronectin type-III 76
Repeat25123 – 2516947WD 10
Domain25214 – 2530895Fibronectin type-III 77
Domain25312 – 2540897Fibronectin type-III 78
Domain25412 – 2550392Ig-like 116
Domain25510 – 2560495Fibronectin type-III 79
Domain25610 – 2570596Fibronectin type-III 80
Domain25711 – 2580797Fibronectin type-III 81
Repeat25730 – 2577849Kelch 13
Repeat25891 – 2593545WD 11
Domain25907 – 2600296Fibronectin type-III 82
Domain26004 – 2609794Fibronectin type-III 83
Domain26101 – 2618787Ig-like 117
Domain26197 – 2629094Fibronectin type-III 84
Repeat26281 – 2632444WD 12
Domain26296 – 2639095Fibronectin type-III 85
Domain26394 – 2648996Fibronectin type-III 86
Domain26494 – 2658491Ig-like 118
Domain26593 – 2668795Fibronectin type-III 87
Domain26693 – 2678896Fibronectin type-III 88
Domain26794 – 2689097Fibronectin type-III 89
Domain26894 – 2698390Ig-like 119
Domain26990 – 2708495Fibronectin type-III 90
Domain27087 – 2718094Fibronectin type-III 91
Domain27168 – 27272105Ig-like 120
Domain27279 – 2737294Fibronectin type-III 92
Repeat27363 – 2740644WD 13
Domain27378 – 2747598Fibronectin type-III 93
Domain27476 – 2757297Fibronectin type-III 94
Domain27576 – 2766388Ig-like 121
Domain27674 – 2776895Fibronectin type-III 95
Domain27774 – 2786996Fibronectin type-III 96
Domain27875 – 2796995Fibronectin type-III 97
Repeat27939 – 2798951RCC1 11
Domain27963 – 2805896Ig-like 122
Domain28069 – 2816496Fibronectin type-III 98
Repeat28133 – 2818250RCC1 12
Domain28166 – 2825994Fibronectin type-III 99
Repeat28185 – 2823046Kelch 14
Domain28361 – 2845595Fibronectin type-III 100
Domain28461 – 2855696Fibronectin type-III 101
Domain28559 – 2865597Fibronectin type-III 102
Domain28659 – 2875092Ig-like 123
Repeat28669 – 2870638TPR 11
Domain28757 – 2885195Fibronectin type-III 103
Domain28857 – 2895296Fibronectin type-III 104
Repeat28923 – 2895735TPR 12
Domain28958 – 2905497Fibronectin type-III 105
Domain29058 – 2914891Ig-like 124
Domain29157 – 2925195Fibronectin type-III 106
Domain29254 – 2934693Fibronectin type-III 107
Domain29350 – 2943990Ig-like 125
Domain29445 – 2954298Fibronectin type-III 108
Repeat29468 – 2951346Kelch 15
Repeat29533 – 2957644WD 14
Domain29548 – 2964396Fibronectin type-III 109
Domain29646 – 2974196Fibronectin type-III 110
Domain29745 – 2983692Ig-like 126
Domain29844 – 2993794Fibronectin type-III 111
Domain29943 – 3003997Fibronectin type-III 112
Domain30045 – 3014096Fibronectin type-III 113
Domain30144 – 3022986Ig-like 127
Domain30240 – 3033596Fibronectin type-III 114
Domain30337 – 3043094Fibronectin type-III 115
Repeat30399 – 3043234TPR 13
Domain30430 – 3052394Ig-like 128
Domain30532 – 3062695Fibronectin type-III 116
Domain30632 – 3072796Fibronectin type-III 117
Domain30730 – 30829100Fibronectin type-III 118
Domain30833 – 3092189Ig-like 129
Domain30932 – 3102594Fibronectin type-III 119
Domain31028 – 31127100Fibronectin type-III 120
Domain31133 – 3122997Fibronectin type-III 121
Domain31233 – 3132290Ig-like 130
Domain31329 – 3142395Fibronectin type-III 122
Domain31426 – 3152196Fibronectin type-III 123
Domain31525 – 3161692Ig-like 131
Domain31623 – 3171795Fibronectin type-III 124
Domain31723 – 3181795Fibronectin type-III 125
Repeat31742 – 3178746Kelch 16
Domain31824 – 3192097Fibronectin type-III 126
Domain31923 – 3201290Ig-like 132
Domain32020 – 3211697Fibronectin type-III 127
Domain32120 – 3221697Fibronectin type-III 128
Domain32222 – 3231796Fibronectin type-III 129
Domain32322 – 3241089Ig-like 133
Domain32515 – 3261096Fibronectin type-III 130
Repeat32601 – 3264444WD 15
Domain32616 – 3271196Fibronectin type-III 131
Domain32717 – 3280791Ig-like 134
Repeat32754 – 3279946WD 16
Domain32817 – 3290892Ig-like 135
Domain32913 – 3300694Fibronectin type-III 132
Repeat32932 – 3297746Kelch 17
Domain33040 – 33294255Protein kinase
Repeat33152 – 3318938WD 17
Domain33358 – 3344689Ig-like 136
Repeat33366 – 3341146Kelch 18
Domain33478 – 3357194Ig-like 137
Domain33583 – 3367290Ig-like 138
Repeat34097 – 3413034TPR 14
Domain34163 – 3425391Ig-like 139
Domain34350 – 3443889Ig-like 140
Repeat34380 – 3441334TPR 15
Domain34507 – 3459690Ig-like 141
Domain34641 – 3472989Ig-like 142
Domain34923 – 3501189Ig-like 143
Domain35118 – 3520992Ig-like 144
Nucleotide binding33046 – 330549ATP By similarity UniProtKB P28523
Region252 – 34089ZIS1 By similarity UniProtKB Q8WZ42
Region1412 – 144635ZIS5 By similarity UniProtKB Q8WZ42
Coiled coil2031 – 205828 Potential
Coiled coil9495 – 953844 Potential
Compositional bias390 – 3978Poly-Ala
Compositional bias452 – 4554Poly-Thr
Compositional bias9461 – 94644Poly-Glu
Compositional bias9822 – 990988Pro-rich
Compositional bias9935 – 127932859Glu-rich
Compositional bias10170 – 128942725Pro-rich
Compositional bias33870 – 338745Poly-Arg
Compositional bias33988 – 339936Poly-Glu
Compositional bias34050 – 340556Poly-Ser
Compositional bias34059 – 340624Poly-Arg
Compositional bias35028 – 3510679Ser-rich

Sites

Active site331601Proton acceptor By similarity UniProtKB P28523
Binding site330691ATP By similarity UniProtKB P28523

Amino acid modifications

Modified residue91441Phosphoserine Ref.7
Modified residue91641Phosphoserine By similarity UniProtKB Q8WZ42
Modified residue91681Phosphothreonine By similarity UniProtKB Q8WZ42
Modified residue233871Phosphoserine By similarity UniProtKB Q8WZ42
Modified residue233961Phosphothreonine By similarity UniProtKB Q8WZ42
Modified residue332031Phosphotyrosine By similarity UniProtKB Q8WZ42
Disulfide bond967 ↔ 1018 By similarity
Disulfide bond1730 ↔ 1783 By similarity
Disulfide bond2202 ↔ 2252 By similarity
Disulfide bond3265 ↔ 3317 By similarity
Disulfide bond4365 ↔ 4416 By similarity
Disulfide bond4460 ↔ 4511 By similarity
Disulfide bond4553 ↔ 4604 By similarity
Disulfide bond4647 ↔ 4698 By similarity
Disulfide bond4740 ↔ 4791 By similarity
Disulfide bond5022 ↔ 5073 By similarity
Disulfide bond5209 ↔ 5260 By similarity
Disulfide bond5584 ↔ 5635 By similarity
Disulfide bond5771 ↔ 5822 By similarity
Disulfide bond5864 ↔ 5915 By similarity
Disulfide bond6146 ↔ 6197 By similarity
Disulfide bond6333 ↔ 6384 By similarity
Disulfide bond6426 ↔ 6477 By similarity
Disulfide bond6709 ↔ 6760 By similarity
Disulfide bond6988 ↔ 7039 By similarity
Disulfide bond7084 ↔ 7135 By similarity
Disulfide bond7180 ↔ 7231 By similarity
Disulfide bond7274 ↔ 7325 By similarity
Disulfide bond7367 ↔ 7418 By similarity
Disulfide bond7650 ↔ 7701 By similarity
Disulfide bond7929 ↔ 7980 By similarity
Disulfide bond8025 ↔ 8076 By similarity
Disulfide bond8121 ↔ 8172 By similarity
Disulfide bond8215 ↔ 8266 By similarity
Disulfide bond8308 ↔ 8359 By similarity
Disulfide bond8591 ↔ 8642 By similarity
Disulfide bond8870 ↔ 8921 By similarity
Disulfide bond8966 ↔ 9017 By similarity
Disulfide bond9062 ↔ 9113 By similarity
Disulfide bond9255 ↔ 9306 By similarity
Disulfide bond9654 ↔ 9704 By similarity
Disulfide bond12929 ↔ 12979 By similarity
Disulfide bond13473 ↔ 13522 By similarity
Disulfide bond13828 ↔ 13878 By similarity
Disulfide bond14095 ↔ 14145 By similarity
Disulfide bond14184 ↔ 14234 By similarity
Disulfide bond14273 ↔ 14323 By similarity
Disulfide bond14633 ↔ 14683 By similarity
Disulfide bond32343 ↔ 32394 By similarity
Disulfide bond33378 ↔ 33430 By similarity
Disulfide bond34526 ↔ 34580 By similarity
Cross-link10665Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5
Cross-link10679Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5
Cross-link10686Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5
Cross-link30428Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5
Cross-link31008Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5

Natural variations

Alternative sequence556 – 60146Missing in isoform 2 and isoform 3. Ref.4
VSP_052606
Alternative sequence3461 – 54992039IASLL…EISAK → ELFEGEADGSGDARGAFSDS EDIDHHSLMARRYANRTSST SSWPEYFKPTFTQKLTFQYA LEGEPIVFTCSLVAYPTPEM TWFHNNRPIPTGLRRVVRTE TDLHQHSSSLEVKRVQGRDS GSYRFLAVNSEGSAESSASL HVIQKGQDERYLEFLKRAEQ TWENTRGLGERREERIKVGL RFTGSPFNKKQDVEEKGMVR TIHFRSASPVRRADYVYNDE WSESKFDIRGCLSVGESFLD EETKMKLQRLREARKIFLEK KKLSLLEASSEVNSVTVRSE DIVGDAPLSREEGKRGFGRE FAEDRHRVDNSAEGVIENPY SVPNQIHQNREPPSSVRATG DEDLQTENSPDQETFLEESL QKGYLCEHVLVGENLQAVEW FEESVTSTVIREPLPFTSNE EVHGYKSRGICESPDKVSQV LTPYPSESLDTFVDAKETED VDSGGGTQRGWQEGQCHAST KVEEFKVEHEEKTRSFENYF QKHPQRCPPSFLQDIESQEV YEGDSCKFVCHFQGYPQPIV TWYNNEMPVPRSQGFTTHTF ENYSTLTFPSVQPQHGGSVT CVLFNQYGTVKATSMLRVKA KPRYESQPHKVPVWPDYADE EEELALVFDQARRIHPSFSQ ERQEHLHMLKAHLPELPSAD RELLSFPVEIQITAATPTPE QNKECRELFELEPEVTPRDQ AIQSPKHKFIFSSDITNEPP KMLQEMPRSASCREGNSVML ECLISGEPQPVVMWFHNGVL VKPNQRFEMEEVNCSYRLYI NDASSQDSGRYQCVAQNDSG IAESILDLTVEPITYREYSQ LENESRIYAQYSKNQQTQVQ GEPVRTHFYDHTVSPFAAQS NIKEYTIREYFQSLETVGEL EKKNEVYCPTTVEKLSKSMQ HASRPTDIEKPHRMEFLQCQ DEEHIGERSQSLQAGATICP FVDDFSKANIRNKVSDDVGY HGPDWGNMKGHSQSDYVLNI HSKRTSNTVQDVEDSPVPTY EEALEEERYYPGKKVRHKVI AFEKLQRAERGVVEKRRTKK SFVTAPQKKWDNREFSLTQN EPGSSNMYRAEEVASHTEAD SSNIIMDLKQLSSQAHEEFE IEERGRQEEILPLDQEKFEL EAPVTFDLKQFHSQIESTGM NFQGLANGQQDKSSLKTQQP ASEMANPEDVVFDLKQMYSH IEDPGEVFQGQETESKQETC HKEEISIYQSFQYAQEENTA ILKPDHVPESFSEVIHGEAR ALFQTPSADVEEANVSETGA SVENGDKTFISQLKRAASEE ECLEDHEMEDGPTLKPAFGM TQGYEGTLENPRGAVHGAEV PHRRLSLSQDLPFLMTGEQQ DLKEQLSESIEASGEETYHE VHVPSESSFSTMEGEKIEKS LLENLPRLEEAQTTKEGEYE TSLTQYLLAEGRYEVPEVRD TKHKAQLVQSDSTTSMEVEE VTFNTVYEYYNQKQESVGRP YSPESDISIDVGSTSSEDLS ELDQFYSPPSSVENLESPKS PDLYFKPSDRIEQPVANSRA EENGERYSTPSEGEIPERYS TPSGEALERYSTPPGEALER YSTPPGEALERYSTPPGEAL ERFSTPPGEALERFSTPPGE ALERYSTPPGEALERFSTPP GEKLERGFIPTRGPNHARNV SRNLSELEREDSTANEHFHT PTDERSSPYETWRSDSFGTP NEAIEPKDNEMPPSFIEPLS RRKIYENTTLGFIIEVEGLP VPGVKWYRNKSLLEPDDRIK MERVGNVCSLEIANIQKGDG GEYLCHAVNIIGEAKSFAIV DVIPQEERAVALPPPVTHQH IMEFDVANSNSSRTPSPQEI VLEVELSEKDVKEFEKQVKI VTVPEFTPDHKSMIVSLDIL PLSLVDPSAESQGQEGREFK IDLEAFEMPPRFITPICDFR IPENSSAVFKCSVIGIPPPE VRWYKEYMCIEPDDTKYVIS EEKGSHSLRIQDVGPSDCAT YRCRALNSAGEAICRGFLTM GDSQVSAVATRTSKVTLSSQ KEELVLRSRYADSFFEFQVV DGPPRFIKGISDCHAPLGTA AYFQCLVRGSPRPTVSWYKD GKLVQGSRFSAEESGIGFHN LFITGLVKGDEGEYSCVATN NSGMARSSAILTLS in isoform 3. Ref.4
VSP_052607
Alternative sequence4435 – 127158281Missing in isoform 2. Ref.4
VSP_052608
Alternative sequence5500 – 3521329714Missing in isoform 3. Ref.4
VSP_052609

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: C761D2E29FF1AC14

FASTA35,2133,906,488
        10         20         30         40         50         60 
MTTQAPMFTQ PLQSVVVLEG STATFEAHVS GSPVPEVSWF RDGQVISTST LPGVQISFSD 

        70         80         90        100        110        120 
GRARLMIPAV TKANSGRYSL RATNGSGQAT STAELLVTAE TAPPNFSQRL QSMTVRQGSQ 

       130        140        150        160        170        180 
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN 

       190        200        210        220        230        240 
SVGRATSTAE LVVQGEEVVP AKKTKTIVST AQISETRQTR IEKKIEAHFD ARSIATVEMV 

       250        260        270        280        290        300 
IDGATGQLPH KTPPRIPPKP KSRSPTPPSI AAKAQLARQQ SPSPIRHSPS PVRHVRAPTP 

       310        320        330        340        350        360 
SPVRSVSPAG RISTSPIRSV KSPLLIRKTQ TTTMATGPEV PPPWKQEGYV ASSTEAEMRE 

       370        380        390        400        410        420 
TTMTSSTQIR REERWEGRYG VQEQVTISGA AAAAASASVS SSFTAGAITT GTKEVKQETD 

       430        440        450        460        470        480 
KSAAVATVVA AVDMARVREP AISAVEQTAQ RTTTTAVHIQ PAQEQARKEA EKTAVTKVVV 

       490        500        510        520        530        540 
AADKAKEQEL KSRTREVMVT TQEQTHISHE QIRKETEKAF VPKVVISATK AKEQETRITG 

       550        560        570        580        590        600 
EITTKQEQKR ITQETIRQET EEIAASMVVV ATAKSTKLEA AVGVQEETAI QQDQMHLTHE 

       610        620        630        640        650        660 
QMMKETRKTV VPKVIVATPK IKEQDLVSRS REAITTKRDQ VQITQEKKRK EVETTALSTI 

       670        680        690        700        710        720 
AVATAKAKEQ ETVLRSREAM ATRQEHIQVT HGQVGVGKKA EAVATVVAAV DQARVREPRE 

       730        740        750        760        770        780 
PTHVEESHSQ QTTLEYGYKE HISTTKVPEQ PRRPASEPHV VPQAVKPAVI QAPSETHIKT 

       790        800        810        820        830        840 
TDQMGMHISS QVKKTTDIST ERLVHVDKRP RTASPHFTVS KISVPKTEHG YEASIAGSAI 

       850        860        870        880        890        900 
ATLQKELSAT SSTQKITKSV KAPTVKPGET RVRAEPTPSP QFPFADMPPP DTYKSQAGIE 

       910        920        930        940        950        960 
VKKEVGVSIS GSTVREEHFE VLRGREAKVT ETARVPAPAE VPVTPPTLVS GLKNVTVIEG 

       970        980        990       1000       1010       1020 
ESVTLECHIS GYPSPKVTWY REDYQIESSI DFQITFQGGI ARLMIREAFA EDSGRFTCSA 

      1030       1040       1050       1060       1070       1080 
VNEAGTVSTS CYLAVQVSEE FDKETTLTEK FATEEKRFVE SRDVVMTDTS ITEEQAGPGE 

      1090       1100       1110       1120       1130       1140 
PAAPFFISKP VVQKLVEGGS VVFECQIGGN PKPHVYWKKS GVPLTTGYRY KVSYNKQTGE 

      1150       1160       1170       1180       1190       1200 
CRLVISMTFA DDAGEYTIVI RNKHGETSAS ASLLEEADYE ALVKTQQEML YQTQMSTFIQ 

      1210       1220       1230       1240       1250       1260 
EPKVGEIAPG FAYSEYEKEY EKEQALIRKK MAKDTVMVRT FVEDQEFHIS SFEERLIKEI 

      1270       1280       1290       1300       1310       1320 
EYRIIKTTLE ELLEEDGEEK MAVDISESEA IESGFDIRIK NYRILEGMGV TFHCKMSGYP 

      1330       1340       1350       1360       1370       1380 
LPKIAWYKDG KRIRHGERYQ MDFLQDGRAS LRIPVVLPED EGIYTAFASN IKGNAICSGK 

      1390       1400       1410       1420       1430       1440 
LYVEPAAPFS APTYMPTPEA VSRIRSVSPR SLSRSPIRMS PAMSPARMSP ARMSPARMSP 

      1450       1460       1470       1480       1490       1500 
ARMSPGRRLE ETDESQLERL YKPVFVLKPA SFKCLEGQTA RFDLKVVGRP MPETFWFHNG 

      1510       1520       1530       1540       1550       1560 
QQIVNDYTHK VVIKEDGTQS LIIVPASPSD SGEWTVVAQN RAGKSTISVT LTVEAVEHQI 

      1570       1580       1590       1600       1610       1620 
KPAFVEKLKN VNIKEGSRLE MKVRATGNPN PDIVWLKNSD IIVPHKYPRI RIEGTRGEAA 

      1630       1640       1650       1660       1670       1680 
LKIDSIISQD SAWYTATAIN KAGRDTTRCK VNVEVEFAEP EPERKLIIPR GTYRAKEIAA 

      1690       1700       1710       1720       1730       1740 
PELEPLHLRY GQEQWEEGDL YDKEKQQKPF FKKKLTSLRL KRFGPAHFEC RLTPIGDPTM 

      1750       1760       1770       1780       1790       1800 
VVEWLHDGKP LEAANRLRMI NEFGYCSLDY GAAYSRDSGV ITCRATNKYG TDHTSATLIV 

      1810       1820       1830       1840       1850       1860 
KDEKSLVEES QLPDGKKGLQ RIEELERMAH EGALTGVTTD QKEKQKPDIV LFPEPVRVLE 

      1870       1880       1890       1900       1910       1920 
GETARFRCRV TGYPQPKVNW YLNGQLIRKS KRFRVRYDGI HYLDIVDCKS YDTGEVKVTA 

      1930       1940       1950       1960       1970       1980 
ENPEGVTEHK VKLEIQQRED FRSVLRRAPE PKPEFHVHEP GKLQFEVQKV DRPVDTSETK 

      1990       2000       2010       2020       2030       2040 
EVVKLKRAER ITHEKVSEES EELRSKFKRR TEEGYYEAIT AVELKSRKKD ESYEELLKKT 

      2050       2060       2070       2080       2090       2100 
KDELLHWTKE LTEEEKKALA EEGKITIPTF KPERIELSPS MEAPKIFERI QSQTVGQGSD 

      2110       2120       2130       2140       2150       2160 
AHFRVRVVGK PDPECEWYKN GVKIERSDRI YWYWPEDNVC ELVIRDVTAE DSASIMVKAI 

      2170       2180       2190       2200       2210       2220 
NIAGETSSHA FLLVQAKQLI TFTQELQDVV AKEKDTMATF ECETSEPFIK VKWYKDGIEV 

      2230       2240       2250       2260       2270       2280 
HAGDKYRMHS DRKVHFLSVL TIDTSDAEDY SCVLVEDENI KTTAKLIVEG AVVEFVKELQ 

      2290       2300       2310       2320       2330       2340 
DIEVPESYSG ELECIISPEN IEGKWYHNDV ELKSNGKYSI TSRRGRQNLT VKDVTKEDQG 

      2350       2360       2370       2380       2390       2400 
EYSFVVDGKK TTCKLKMKPR PIAILQGLSD QKVCEGDIVQ LEVKVSLENV EGVWMKDGQE 

      2410       2420       2430       2440       2450       2460 
VQHSDRVHIV IDKQSHMLLI EDMTKEDAGN YSFTIPALGL STSGNVSVYS VDVITPLKDV 

      2470       2480       2490       2500       2510       2520 
NVIEGTKAVL ECKVSVPDVT SVKWYLNDEQ IKPDDRVQSI VKGTKQRLVI NRTHASDEGP 

      2530       2540       2550       2560       2570       2580 
YKLMVGRVET SCNLSVEKIK IIRGLRDLTC TETQNVVFEV ELSHSGIDVV WNFKGKEIKP 

      2590       2600       2610       2620       2630       2640 
SSKYKIEAHG KIYKLTVLNM MKDDEGEYAF YAGENTTSGK LTVAGGAIST PLTDQTVAES 

      2650       2660       2670       2680       2690       2700 
QEAVFECEVA NPESEGEWLK DGKHLALSNN FRGESDGHKR RLVIAAAKLD DAGEYTYKVA 

      2710       2720       2730       2740       2750       2760 
TSKTSAKLKV EAVKIKKTLR NLTVTETQDA VFSVELTHPD VKGVQWIKNG VVLDSNDKYE 

      2770       2780       2790       2800       2810       2820 
ISVKGTLYSL KIKNCAMADE SVYGFKLGRL GASARLHVET VKIIKKPKDV TALENATVTF 

      2830       2840       2850       2860       2870       2880 
EVSVSHDTVP VKWFHKNVEI KPSDKHRLVS ERKVHKLMLQ SISPSDAGEY TAMVGQLECK 

      2890       2900       2910       2920       2930       2940 
AKLFVETLHI TKTMKSIEVP ETKAASFECE VSHFNVPSMW LKNGVEIEMS EKFKIVVQGK 

      2950       2960       2970       2980       2990       3000 
LHQLIIMNTS TEDSAEYTFV CGNDQVSATL TVTPIMITSM LKDINAEEKD TITFEVTVNY 

      3010       3020       3030       3040       3050       3060 
EGISYKWLKN GVEIKSTDRC QMRTKKLTHS LNIRNVHFGD AADYTFVAGK ATSTATLYVE 

      3070       3080       3090       3100       3110       3120 
ARHIEFRKHI KDIKVLEKKR AMFECEVSEP DITVQWMKDG QELQIADRIK IQKEKYVHRL 

      3130       3140       3150       3160       3170       3180 
LIPSTRMSDA GKYTVVAGGN MSTANLFVEG RDVRIRSIKK EVQVIEKQRA VVEFEVNEDD 

      3190       3200       3210       3220       3230       3240 
VDAHWYKDGI EINFQVQERH QYVVERRIHR MFISETRHSD AGEYTFVAGR NRSSVTLYVN 

      3250       3260       3270       3280       3290       3300 
APEPPQVLQE LQPVTVQSGK PARFCAVISG RPQPKISWYK EEQLLSTGFK CKFLHDGQEY 

      3310       3320       3330       3340       3350       3360 
TLLLIEAFPE DAAVYTCEAK NDYGVATTSA SLSVEVPEVV SPDQEMPVYP PAIVTPLQDT 

      3370       3380       3390       3400       3410       3420 
VTSEGRPARF QCQVSGTDLK VSWYCKDKKI KPSRFFRMTQ FEDTYQLEIA EAYPEDEGTY 

      3430       3440       3450       3460       3470       3480 
AFVANNAVGQ VSSTATLRLE APESILHERI GQQIEMEMKE IASLLSAEED FQTYSSDLRL 

      3490       3500       3510       3520       3530       3540 
PNANETLELL SEPPARSTQF DSRQEGAAPV FIREISDVEI SVEDVAKLSV TVTGCPKPKI 

      3550       3560       3570       3580       3590       3600 
QWFFNGMLLT PSADYKFVFD GDTHSLIILF TRFQDEGEYT CLASNEYGKA VCSAHLRISP 

      3610       3620       3630       3640       3650       3660 
RGERSTEMES GEKKALEKPK GPCPPYFFKE LKPVHCGPGI PAVFEYSVHG EPAPTVLWFK 

      3670       3680       3690       3700       3710       3720 
EDMPLYTSVC YTIIHSPDGS GTFIVNDPQR GDSGLYLCKA QNLWGESTCA AELLVLPEDT 

      3730       3740       3750       3760       3770       3780 
DVPDASCKEE STLGVPGDFL ETSARGPLVQ GVDSRQEITA FAEGTISKAA LIAEETLQLS 

      3790       3800       3810       3820       3830       3840 
YERSVDDSEV GTGVTIGAQK LPPVVLSTPQ GTGELPSIDG AVHTQPGRGP PPTLNLQAVQ 

      3850       3860       3870       3880       3890       3900 
AQTTLPKEAT LQFEEPEGVF PGASSAAQVS PVTIKPLITL TAEPKGNYPQ SSTAAPDHAL 

      3910       3920       3930       3940       3950       3960 
LSSVAAETLQ LGEKKIPEVD KAQRALLLSQ SLAEGCVESL EVPDVAVSNM RSEPQVPFQH 

      3970       3980       3990       4000       4010       4020 
TCTEGKILMA SADTLKSTGQ DVALRTEEGK SLSFPLALEE KQVLLKEEQS EVVAVPTSQT 

      4030       4040       4050       4060       4070       4080 
SKSEKEPEAI KGVKEVREQE LLSKETLFPS MPEEQRLHLK TQVRRALQAA VAREQANLFS 

      4090       4100       4110       4120       4130       4140 
EWLRNIDKVE VTAVNFTQEP KRILCTYLIT SVSSLTEELT VTIEDIDPQM ANLETGLKDA 

      4150       4160       4170       4180       4190       4200 
LCSIVCEERN ILMAEDPRIH EEDKIDVQGG RDHLSDAQKV ETVIEAEADS KYLVSKEEVS 

      4210       4220       4230       4240       4250       4260 
WSKVESQLKD GDTNEVPQAE TLKLAEESGT QKTSTEMSQE EAEGTLADLC PAVLKHLVDT 

      4270       4280       4290       4300       4310       4320 
ISEEGDTVHL TSSISNAKEV HWYFKGNLVP SDGKFKCLKE QNAYTLVIEA VKTEDEGEYV 

      4330       4340       4350       4360       4370       4380 
CEASNDSGKA KTSAKLTVGE RAAPVIKRRI EPLEVALGHL AKFTCEIQGA PNVRFQWFKA 

      4390       4400       4410       4420       4430       4440 
GREIYESDKC SIRSSNYVSS LEILRTQVVD CGEYTCKASN EYGSVSCTAT LTVTEAYPPT 

      4450       4460       4470       4480       4490       4500 
FLSRPKALTT FVGKAAKFLC TVSGTPVIEI IWQKDGAALS PSPDCRVTDA DNKHSLELSN 

      4510       4520       4530       4540       4550       4560 
LTVQDRGIYS CKASNKFGAD ICQAELTIID KPHFIKELEA VQSAINKKIH LECQVDEDRK 

      4570       4580       4590       4600       4610       4620 
VTITWSKDGQ KLPAGKDYKI YFEDKIASLE IPLAKLKDSG TYTCTASNEA GSSSSSAAVA 

      4630       4640       4650       4660       4670       4680 
VREPPSFVKK VDPSYLMLPG ESARLHCKLK GSPVIQVTWF KNNKELSESN TVRMSFVNSE 

      4690       4700       4710       4720       4730       4740 
AILDITDVKV DDSGTYSCEA TNDVGSDSCS TEVVIKEPPS FIKTLEPADI VRGANALLQC 

      4750       4760       4770       4780       4790       4800 
EIAGTGPFEV NWFKDKKQIR SSKKYRLFTQ KTFVYLEISS FNSADVGDYE CVVANEVGKC 

      4810       4820       4830       4840       4850       4860 
GCVATHLLKE PPTFVKKVDD FTALAGQTVT LQAAVRGSEP ISVMWMKGQE VIKEDGKIKM 

      4870       4880       4890       4900       4910       4920 
SFSNGVAVLT IPDVQISLGG KYTCLAENEA GSQTSVGELI VKEPAKIIER AELIQVTAGD 

      4930       4940       4950       4960       4970       4980 
PATLEYTVSG TPELKPKWYK DGRPLVASKK YRISFKNNIA QLKFYSAELH DSGQYTFEIS 

      4990       5000       5010       5020       5030       5040 
NEVGSSSCET TFTVLDRDIA PLFTKPLRNV DSVVGGACRL DCKIAGSLPM RVSWFKDGKE 

      5050       5060       5070       5080       5090       5100 
LTASDRYQIA FVEGTASLEI SRVDMNDAGN FTCRATNSVG SKDSSGALIV QEPPSFVTKP 

      5110       5120       5130       5140       5150       5160 
GSRDVLPGSA VCLKSAFQGS APLTIKWFKG DKELVSGGSC YITKETSESS LELYAVKTSD 

      5170       5180       5190       5200       5210       5220 
SGTYTCKVSN VAGSVECSAD LFVKEPATFI EKLEPSQLLK KGDGTQLACK VTGTPPIKIT 

      5230       5240       5250       5260       5270       5280 
WFANDRELRE SSKHKMSFAE STAVLRLTDV AIEDSGEYMC EAQNEAGSDH CTGIVIVKES 

      5290       5300       5310       5320       5330       5340 
PYFTKEFKSI EVLKEYDVML LAEVAGTPPF EITWFKDNTT LRSGRKYKTF LQDQLVSLQV 

      5350       5360       5370       5380       5390       5400 
LKFVAADAGE YQCRVTNEVG SSTCSARVTL REPPSFIKKI EATSSLRGGT AAFQATLKGS 

      5410       5420       5430       5440       5450       5460 
LPITVTWLKD NDEITEDDNI RMTFENNVAS LYLSGIEVKH DGKYVCQAKN DAGIQRCSAL 

      5470       5480       5490       5500       5510       5520 
LSVKEPATIM EEAVSIDVTQ GDPATLQVKF SGTKEISAKW FKDGQELTLG PKYKISVTDT 

      5530       5540       5550       5560       5570       5580 
VSILKIISTE KKDSGEYTFE VQNDVGRSSC KASINVLDLI IPPSFTKKLR KMDSIKGSFI 

      5590       5600       5610       5620       5630       5640 
DLECIVAGSH PISIQWFKDD QEISASDKHK FSFHDNTAFL EISQLEGTDS GTYTCSATNK 

      5650       5660       5670       5680       5690       5700 
AGHSQCSGHL TVKEPPYFVE KPQSQDVNPG TRVQLKALVG GTAPMTIKWF KDNKELHPGA 

      5710       5720       5730       5740       5750       5760 
ARSVWKDDTS TILELFSAKA ADSGTYICQL SNDVGTTSSK ATIFVKEPPQ FIKKPSPVLV 

      5770       5780       5790       5800       5810       5820 
LRNGQSTTFE CQVTGTPEIR VSWYLDGNEI TDLRKYGISF VDGLATFQIS NARVENSGTY 

      5830       5840       5850       5860       5870       5880 
VCEARNDAGT ASCSIELKVK EPPIFIRELE PVEVVKDSDV ELECEVMGTT PFEVTWLKNN 

      5890       5900       5910       5920       5930       5940 
KEIRSGKKYT MSEKMSVFYL HITKCDPSDV GEYQCIIANE GGSCACSARV ALKEPPSFIK 

      5950       5960       5970       5980       5990       6000 
KIENVTTVLK SSATFQSTVA GSPPISITWL KDDQILEEND NVHISFEDSV ATLQVRSVDN 

      6010       6020       6030       6040       6050       6060 
GHSGRYTCQA KNESGIERCY AFLLVQEPAQ IIEKAKSVDV TEKDPVTLEC VVAGTPELKV 

      6070       6080       6090       6100       6110       6120 
KWLKDGKQIV PSRYFSMSFE NNVASFRIQS VMKQDSGQYT FKVENDFGSS SCDAYLRVLD 

      6130       6140       6150       6160       6170       6180 
QDIPPSFTKK LTKMDKVLGS SIHMECKVSG SLPISAQWFK DGKEISTSAK YRLVCHENTV 

      6190       6200       6210       6220       6230       6240 
SLEVSNLELE DTANYTCKVS NVAGDNACSG ILTVKEPPSF LVKPERQQAI PDSTVEFKAV 

      6250       6260       6270       6280       6290       6300 
LKGTPPFKIK WLKDDVELVS GPKCFIGLEG STSFLNLYSV DSSKTGQYTC QVTNDVGSDS 

      6310       6320       6330       6340       6350       6360 
CTTMLLVTEP PKFVKKLEAS KIIKAGDSAR LECKITGSPE IQVVWYRNEH ELTASDKYQM 

      6370       6380       6390       6400       6410       6420 
TFIDSVAVIQ MNSLGTEDSG DFICEAQNPA GSTSCSTKVI VKEPPVFSSF PPIVETLKNT 

      6430       6440       6450       6460       6470       6480 
EVSLECELSG TPPFEVVWYK DKRQLRSSKK YKVASKNFHA SIHILNVEST DIGEYHCKAQ 

      6490       6500       6510       6520       6530       6540 
NEVGSDACVC AVKLKEPPKF ISKLNSLTVV AGEPAELQAS IEGAQPISVQ WLKEKEEVIR 

      6550       6560       6570       6580       6590       6600 
ESENIRISFV NNVATLQFAK VEPANAGKYI CQVKNDGGVR ENMATLTVLE PAVIIEKAGS 

      6610       6620       6630       6640       6650       6660 
MTVTVGETCA LECKVAGTPE LSVEWYKDGK LLTSSQKHKF SFYNKISSLK ILSVEKEDAG 

      6670       6680       6690       6700       6710       6720 
TYTFQVQNNV GKSSCTAVVD VSDRMVPPSF TRRLKDTGGV LGTSCILECK VAGSSPISIA 

      6730       6740       6750       6760       6770       6780 
WFHEKTKIVS GAKYQTTFSD NVCTLQLNSL DSSDMGSYTC VAANVAGSDE CRALLTVQEP 

      6790       6800       6810       6820       6830       6840 
PSFVKEPEPL EVLPGKNITF TSVIRGTPPF KVGWFRGARE LVKGNRCNIY FEDTVAELEL 

      6850       6860       6870       6880       6890       6900 
FNIDISQSGE YTCVVSNNAG QASCTTRLFV KEPATFVKKL SDHSVEPGKS IILEGTYTGT 

      6910       6920       6930       6940       6950       6960 
LPISVTWKKD GVSITPSERC NIVTTEKTCI LEILSSTKGD AGHYSCEIEN EAGRDACDAL 

      6970       6980       6990       7000       7010       7020 
VSTLEPPYFV TELEPLEASV GDSVSLQCQV AGTPEITVSW FKGDTKLRST PEYRTYFTNN 

      7030       7040       7050       7060       7070       7080 
VATLVFNKVS INDSGEYTCM AENSIGTAAS KTIFRIQERQ LPPSFARQLK DIEQTVGLPV 

      7090       7100       7110       7120       7130       7140 
TLTCRLNGSA PIQVCWYRDG VLLRDDENLQ MSFVDNVATL KILQTDLSHS GQYSCSASNP 

      7150       7160       7170       7180       7190       7200 
LGTASSTARL TAREPKKSPF FDIKPVSIDV IAGESADFEC HVTGAQPMRV TWSKDNKEIR 

      7210       7220       7230       7240       7250       7260 
PGGNYTITCV GNTPHLRILK VGKGDSGQYT CQATNDVGKD MCSAQLSVKE PPKFIKKLDA 

      7270       7280       7290       7300       7310       7320 
SKVAKQGESI QLECKISGSP EIKVVWFRND SELHESWKYN MSFVNSVALL TINEASAEDT 

      7330       7340       7350       7360       7370       7380 
GDYICEAHNG VGDASCSTAL KVKAPPVFTQ KPPPVGALKG SDVILQCEIS GTPPFEVVWV 

      7390       7400       7410       7420       7430       7440 
KDRKQVRSSK KFKITSKNFD TSLHIFNLEA PDIGEYHCKA TNEVGSDTCA CTVKFKEPPR 

      7450       7460       7470       7480       7490       7500 
FVKKLSDAST LIGDPVELQA VVEGFQPISV VWLKDKGEVI RESENVRISF VDNIATLQLG 

      7510       7520       7530       7540       7550       7560 
SPEASQSGKY VCQIKNDAGM RECSAVLTVL EPATIVEKPE PMTVTTGNPF TLECVVAGTP 

      7570       7580       7590       7600       7610       7620 
ELSAKWFKDG RELSSGSRHH ITFVRNLASL KIPSAEMNDK GLYTFEVENR VGKSSCTVSV 

      7630       7640       7650       7660       7670       7680 
HVSDRVVPPS FVRRLKDTSA TLGASVVLEC RVSGSAPISV GWFLDGNEII SSPKCQSSFA 

      7690       7700       7710       7720       7730       7740 
DNVCTLTLSS LEPSDTGAYT CVAANVAGQD ESSAVLTVQE PPSFEQTPDS VEVLPGMSLT 

      7750       7760       7770       7780       7790       7800 
FTSVIRGTPP FKVKWFKGSR ELVSGEACTI SLEDFVTELE LLEVEPGQSG DYSCLVTNDA 

      7810       7820       7830       7840       7850       7860 
GSASCTTHLF VKEPATFVKR LADTSVETGS PIVLEATYSG TPPISVSWMK NEYPLSQSPN 

      7870       7880       7890       7900       7910       7920 
CGITTTEKSS ILEILESTIE DYAQYACLIE NEAGQDICEA LVSVLEPPYF IEPLEHVEAA 

      7930       7940       7950       7960       7970       7980 
IGEPITLQCK VDGTPEIRIS WYKEHTKLRS APAYKMQFKN NVASLVINKV DHSDVGEYTC 

      7990       8000       8010       8020       8030       8040 
KAENSVGAVA SSAVLVIKER KLPPSFARKL KDVHETLGFP VAFECRINGS EPLQVSWYKD 

      8050       8060       8070       8080       8090       8100 
GELLKDDANL QMSFVHHVAT LQILQTDQSH VGQYNCSASN PLGTASSSAK LILSEHEVPP 

      8110       8120       8130       8140       8150       8160 
FFDLKPVSVD LALGESGSFK CHVTGTAPIK ITWAKDNREI RPGGNYKMTL VENTATLTVL 

      8170       8180       8190       8200       8210       8220 
KVAKGDAGQY TCYASNVAGK DSCSAQLGVQ EPPRFIKKLD QSRIVKQDEY TRYECKIGGS 

      8230       8240       8250       8260       8270       8280 
PEIKVLWYKD EVEIQESSKF RMSFEDSVAI LEMHSLSVED SGDYTCEARN AAGSASSSTS 

      8290       8300       8310       8320       8330       8340 
LKVKEPPVFR KKPFPVETLK GADVHLECEL QGTPPFQVSW HKDKRELRSG KKYKIMSENL 

      8350       8360       8370       8380       8390       8400 
LTSIHILNVD TADIGEYQCK ATNDVGSDTC VGSVTMKAPP QFVKKLTDIS TIIGKEVQLQ 

      8410       8420       8430       8440       8450       8460 
TTIEGAEPIS VAWFKDKGEI VRESDNIWIS YSENIATLQF SRAEPANAGK YTCQIKNDAG 

      8470       8480       8490       8500       8510       8520 
MQECYATLSV LEPAAIVEKP ESIKVTTGDT CTLECTVSGT PELSTKWFKD GKELTSDNKY 

      8530       8540       8550       8560       8570       8580 
KISFFNKVSG LKIINVVPGD SGVYSFEVQN PVGKDSCKVS IQVSDRIIPP SFTRKLKETN 

      8590       8600       8610       8620       8630       8640 
GLSGSSVVME CKVYGSPPIS VLWFHDGNEI SSGRKYQTTL TDNTCALTVN MLEEADAGDY 

      8650       8660       8670       8680       8690       8700 
TCIATNVAGS DECSAPLTVR EPPSFVQKPD PMDVLTGSNV TFTSIVKGSP PFTVSWFKGS 

      8710       8720       8730       8740       8750       8760 
TELVPGARCN VSLQDSVGEL ELFDVDTSQS GEYTCIVSNE AGRASCTTRL FVKAPAIFVK 

      8770       8780       8790       8800       8810       8820 
RLNDYSIEKG KPLILEGTFS GTPPISVTWK KNGINVIASQ RCNITTTEKS AILEILSSTV 

      8830       8840       8850       8860       8870       8880 
EDSGQYNCYI ENASGKDSCS AQILILEPPY FVKQLEPVKV TVGDSASLQC QLAGTPEIGV 

      8890       8900       8910       8920       8930       8940 
SWYKGDTKLR PTATCKMHFK NNVATLVFTQ VDSSDSGEYI CRAENSVGEV SSSTFLTVQE 

      8950       8960       8970       8980       8990       9000 
QKLPPSFSRQ LRDVQETVGL PVVFECAVSG SEPISVSWYK DGKPLKDSPN IQTSFLDNIA 

      9010       9020       9030       9040       9050       9060 
TLNIFKTDRS LSGQYSCTAT NPIGSASSGA KLILTEGKNP PFFDIPLAPM DAVVGESADL 

      9070       9080       9090       9100       9110       9120 
ECHVTGTQPI KVTWAKDNRE IRSGGNYQIS YLENSAHLTI VKVDKGDSGQ YTCYAVNEVG 

      9130       9140       9150       9160       9170       9180 
KDSCTAQLNI KERLIPPSFT KKLSETVEET EGNSFKLEGR VAGSQPITVA WYKNNVEIHP 

      9190       9200       9210       9220       9230       9240 
TSNCEIMFKN NALLLQVKRA SMADAGLYTC KATNDAGSAL CTSSIVIKEP KKPPVFDQHL 

      9250       9260       9270       9280       9290       9300 
APVTASEGDS VQLSCHVQGS EPIRIQWLKA GREVKPSDRC SFSFASGTAM LELKETAKAD 

      9310       9320       9330       9340       9350       9360 
SGDYVCKASN VAGSDTSKCK VTIKEKPAAA PAAKKAAVDG KLFFVSEPQS IRVVEKTTAT 

      9370       9380       9390       9400       9410       9420 
FIAKVGGDPI PNVKWTKGKW RQLNQGGRIL IHQKGDEAKL EIRDTTKTDS GLYRCVAFNK 

      9430       9440       9450       9460       9470       9480 
HGEIESNVNL QVDERKKQEK IEGDLRAMLK KTPALKKGSG EEEEIDIMEL LKNVDPKEYE 

      9490       9500       9510       9520       9530       9540 
KYARMYGITD FRGLLQAFEL LKQSQEEETH RLEIEELEKS ERDEKEFEEL VAFIQQRLTQ 

      9550       9560       9570       9580       9590       9600 
TEPVTLIKDI ENQTVLKDND AIFEIDIKIN YPEIKLSWYK GTEKLEPSNK YEISIDGDRH 

      9610       9620       9630       9640       9650       9660 
TLRVKNCQPK DQGNYRLVCG PHIASAKLTV IEPAWERHLQ DVTLKEGQTC TMTCQFSVPN 

      9670       9680       9690       9700       9710       9720 
VKSEWFRNGR VLKPQGRVKT EVEHKVHKLT IADVRAEDQG QYTCKHEDLE TSAELRIEAE 

      9730       9740       9750       9760       9770       9780 
PIQFTKRIQN IVVSEHQSAT FECEVSFDDA IVTWYKGPTE LTESQKYNFR NDGRCHYMTI 

      9790       9800       9810       9820       9830       9840 
HNVTPDDEGV YSVIARLEPR GEARSTAELY LTTKEIKLEM KPPDIPDSRV PIPTMPIRAV 

      9850       9860       9870       9880       9890       9900 
PPEEIPPAVA PSIPLLLPLP EEKKPPAKRI EVTKKGVKKD TKKVVTKPKE EAPPPPVAKK 

      9910       9920       9930       9940       9950       9960 
PPPPTPMIPA KASEIIDVSS KAEEVKITTI TRKKEVHKEK EAVYEREEAV YEKKVHIEPW 

      9970       9980       9990      10000      10010      10020 
EEPYEELETE PYTEPYEEPY YEEPDEDYEE IKVEAKKQVH EEWEEDFEEG QEYYEREEGY 

     10030      10040      10050      10060      10070      10080 
DEGEEEWEEI YHEREIIQVQ KEVHEELHEK KIPAKVPEKK VPPPKVVKKP VVEKVEKTTR 

     10090      10100      10110      10120      10130      10140 
RMEEEKVQVI KVPEVSKKIV PQKPSRTPVQ EEIIEVKVPA VHTKKMVISE EKMFFASHTE 

     10150      10160      10170      10180      10190      10200 
EEVSVSVPEV QKKTVTEEKI HVAVSKKIEP PPKVPEPPKK PVPEEVVPVP IPKKVEPPAA 

     10210      10220      10230      10240      10250      10260 
KVPEAPKKPV PEEKKPVPIP KKKEPAAPPQ VPEAPKKPAP EEKIPVPVTK KKEAPPAKVP 

     10270      10280      10290      10300      10310      10320 
EVQKKVVTEE KIAIITQREE SPPPAVPEIP KKKVPEEKRP VPRKEEVPPP KVPVPPKKAV 

     10330      10340      10350      10360      10370      10380 
PEAVVPAPIP KKAPPRAEVS KKTVVEEKRF AAEEKLSVAV PQRVELMRHE EEEWTYSEEE 

     10390      10400      10410      10420      10430      10440 
ERVSVSVYRE EERDEEEAEI TEYEVLEEPE EYVVEEKMHF ISKKVEVEPA KVPEKKIIPK 

     10450      10460      10470      10480      10490      10500 
PKVPAKIEEP PPTKVPEPPK KIVPEKKVPA PAPKKVPPAK APEESKRPVP EKRAPAEEVG 

     10510      10520      10530      10540      10550      10560 
IEEPPPTKVA ERHMKITQEE KVLVAVTKKE APPRARVPEE PKKVAPEERF PKLKPRREEE 

     10570      10580      10590      10600      10610      10620 
PPAKVTEVRK RAVKEEKVSI EVPKREPRPT KEVTVTEEKK WSYTREEETV SEHREEEYED 

     10630      10640      10650      10660      10670      10680 
YEDYEEYKEF EEYEPTEEYD QYDEYAEREV EHYEEHEEYV TEPKKPVPVK PAQEPVPAKP 

     10690      10700      10710      10720      10730      10740 
KAPPPKVLKK AVPEEKAPLP IQKKLKPLPP KAPEEPKKVV EEKIQISITK REKQQVTEPV 

     10750      10760      10770      10780      10790      10800 
AKVPMKPKRV VPEAKIPAPT KEVAVPVRVP GVPKKRELEE VVVFKEEVEA HEEYIVEEEE 

     10810      10820      10830      10840      10850      10860 
EYVHEEEYVH KEEYVHEEEY VHKEEYIHEE EEHLHEEEET IAEEEVVPVA PVKVPVVPKK 

     10870      10880      10890      10900      10910      10920 
PVPEEKKPVP VPKKKEAPPA KVPEIPKKPE EKVPVPIPKK EKAPPAKVPE VPKKPVPEEK 

     10930      10940      10950      10960      10970      10980 
PPVPVPKKVE PPPAKVPEVP KKPVPEKKVP APTPKKVEAP PAKVPEVPKK PIPEEKKPTA 

     10990      11000      11010      11020      11030      11040 
LLKKMEAPPP KAPKKREVVP VPVALPREEE EEEVPFEEVP EEEILPEEEV PSEEEAPPEE 

     11050      11060      11070      11080      11090      11100 
VPPEEEEVLP EEEEVLPEEE EVLPEEEEVQ PEEEALPEIK PKVPKPAPVP KKTVPEKKVP 

     11110      11120      11130      11140      11150      11160 
VPVPKKVEPP PPPKVPEIKK KVPEKKVVVP KKEEAPPTKV PEVSKKVEER RIIPPKEEEV 

     11170      11180      11190      11200      11210      11220 
PPAEVYEEAE EPTPEEIPEE PPSIEEEEIV EEEEEEEEVL PPRAPEVVKK AVPEAPTPVP 

     11230      11240      11250      11260      11270      11280 
KKAEAPPAKV PKKIPEEKVP VPVQKKEAPP AKVPEKKKIP EKKVPVPKKE AVPPAKGKAV 

     11290      11300      11310      11320      11330      11340 
FEEKISVAYQ QEELVQERIE LELVEAKVEE AFEEEEFHEV QEYFEEEEFH EVEEFIRVEE 

     11350      11360      11370      11380      11390      11400 
RRFQEEHKVE EVHRVIEFLE AEEVEVYEKP KIPPKKGPEV SEKVIPPKKP PTKVIPRKEP 

     11410      11420      11430      11440      11450      11460 
PAKVPEVTKK TVVEEKIRAP EEPKVPAPKA PEVPKKITPE EKVREAVPKK PEVPPPKVPE 

     11470      11480      11490      11500      11510      11520 
VPKKIIQEEK LPVVLPEDTE IYMYEASEET VIEEEHVTLP QKARLKVAKV PAPPQTVVTE 

     11530      11540      11550      11560      11570      11580 
EKTYVTIRKT RETLALKESE TTREAFPELK SYKAVPEIPE PPSPEDLEII EDVLPEKRPP 

     11590      11600      11610      11620      11630      11640 
ASKRRKTQLP TAPEAPREMP PEMNTFEEIS VEPEMLPTQV LDTYQEATVE KKTLRISRKK 

     11650      11660      11670      11680      11690      11700 
PELPSDEEVP EAPREVVAKK KVLPPQVPEV VPVKVPGAPK EVVSERKSLE EPPKKPAVRP 

     11710      11720      11730      11740      11750      11760 
VTVPEEPKEV IPEKKVSLVP PKKPAAPPVT VPEAPEEVFS EDEETLAPPQ EPEAPPAKVP 

     11770      11780      11790      11800      11810      11820 
EAPKEVVPEK KVSVVPPKKP EAPPAKVPEA PKEAAPEKKV PVAPKKKPEA PPVKVPEAPK 

     11830      11840      11850      11860      11870      11880 
KVVPEKKLPV AAPKKPEAPA AEVPEVPKTA VPQKKIPEAI PPKPESPPLE VPEVPPKEVT 

     11890      11900      11910      11920      11930      11940 
PEKKVPAAPP TKPEIPPPKV PEAPQAAVVE EKTPEALPKK AEAAPVPVPQ VQETVPEKTR 

     11950      11960      11970      11980      11990      12000 
PVGPPKKPEA TTVPVPKVQK TIPEKTRPEA PPKRPEARTV PETVPEKTRP MAPPKKPEAT 

     12010      12020      12030      12040      12050      12060 
TLPVPEVQET VPEKTRPVGP PKKPEATTVP VPEVQETIPE KTRPPKKPEA TPVPVPEVQE 

     12070      12080      12090      12100      12110      12120 
TVPEKTRPVG PPKKPEATTV SVPEVQETIP EKTRPAAPPK KPEATAVPET IPEKTRPEAP 

     12130      12140      12150      12160      12170      12180 
PKRPEATTVP VPEADQAVVP EKKVPRVPPK KVEAPPITVP EEPKEVIPEK KVSLVPPKKP 

     12190      12200      12210      12220      12230      12240 
AAPPVTVPEA PEEVFSEDEE TLAPPQEPEA PPAKVPEAPK EVVPEKKVSV VPPKKPEAPP 

     12250      12260      12270      12280      12290      12300 
AKVPEAPKEA APEKKVPVAP KKKPEAPPVK VPEAPKKVVP EKKLPVAAPK KPEAPAAEVP 

     12310      12320      12330      12340      12350      12360 
EVPKAAVPQK KIPEAIPPKP ESPPPEVYEE PEEEIVPEEP PEEAVEEPVP APPPKVTEPP 

     12370      12380      12390      12400      12410      12420 
KKPVPEKKAP PAVVKKPEPP PAKVPEVPKE APPEKKVPPK KPEAPPAKVP EVPKEVVTEK 

     12430      12440      12450      12460      12470      12480 
KVAVPKKPEV PPAKVPEVPK KPVIEEKPAI PVVEKVASPP AEVYEEPEEV TAEEEEPAPA 

     12490      12500      12510      12520      12530      12540 
VEEEEYEAPP PPAPVPEEPK KVVPEKKFPV IKKPEAPPPK VPEVPKKAVP VKKVPVVKKP 

     12550      12560      12570      12580      12590      12600 
EPPEAEVPEV PKKLVPVKKE PVPVTKKTEV LPEKVPEAPK KITPEKKESV PVPEEPEAPP 

     12610      12620      12630      12640      12650      12660 
ASVEETPEET IYEEKATITI GRKETPPVEE REIEKFIQPE EPELEPEPEE IPVQEPEPEK 

     12670      12680      12690      12700      12710      12720 
KVIEKPKLKP RPPARPPSPP KEDVKEKMFQ LKAVSKKKVP EKPEVVEKVE PAPLKVPTAE 

     12730      12740      12750      12760      12770      12780 
KKVRKLLPEP KPQPKEEVVL KSVLRKKPEE EEPKVEPKKV EKAKKPEEPQ PPPKAVEVEA 

     12790      12800      12810      12820      12830      12840 
PPEPTPKERK VPEPAKVPEI KPAIPLPGPE PKPKPEPEVK TMKAPPIEPA PTPIAAPVTA 

     12850      12860      12870      12880      12890      12900 
PVVGKKAEAK PKDEAAKPKG PIKGVAKKTP SPIEAERKKL RPGSGGEKPP DEAPFTYQLK 

     12910      12920      12930      12940      12950      12960 
AVPLKFVKEI KDIVLTEAES VGSSAIFECL VSPSTAITTW MKDGSNIRES PKHRFIADGK 

     12970      12980      12990      13000      13010      13020 
DRKLHIIDVQ LSDAGEYTCV LRLGNKEKTS TAKLIVEELP VRFVKTLEEE VTVVKGQPLY 

     13030      13040      13050      13060      13070      13080 
LSCELNKERD VVWRKDGKIV VEKPGRIVPG VIGLMRALTI NDADDTDAGT YTVTVENANN 

     13090      13100      13110      13120      13130      13140 
LECSSCVKVV EIIREWLVKP IRDQHVKPKG TAVFTCDIAK DTPNIKWFKG YDEIPLEPND 

     13150      13160      13170      13180      13190      13200 
KTEILKEGNH LFLKVKNAMP EDIDEYAVEI EGKRYPAKLT LGEREVELLK PIEDVTIYEK 

     13210      13220      13230      13240      13250      13260 
ESASFDAEIS EEDIPGEWKL KGELLRPSPT CEIKAEGGKR FLTLHKVKLD QAGEVLYQAC 

     13270      13280      13290      13300      13310      13320 
NAITTAILTV KEIELDFAVP LKDVTVPEKR QARFECVLTR EANVIWSKGP DIIKASDKFD 

     13330      13340      13350      13360      13370      13380 
IIADGKKHIL VINDSQFDDE GVYTAEVEGK KTSAQLFVTG IRLKFISPLE DQTVKEGQTA 

     13390      13400      13410      13420      13430      13440 
TFVCELSHEK MHVVWFKNDV KLHTTRTVLM SSEGKTYKLE IRETTLDDIS QIKAQVKNLS 

     13450      13460      13470      13480      13490      13500 
STANLKVLEA DPYFTVKLHD KTGVEKDEII LKCEVSKDVP VKWFKDGEEI VPSPKHSVKT 

     13510      13520      13530      13540      13550      13560 
DGLRRILKIK KAELKDKGEY VCDCGTDTTK ANVTVEARLI KVEKPLYGVE VFVGETARFE 

     13570      13580      13590      13600      13610      13620 
IELSEPDVHG QWKLKGEPLT ASPDCEIIED GKKHVLVLYN CQLDMTGEIS FQAANAKSAA 

     13630      13640      13650      13660      13670      13680 
NLKVKELPLI FITPLSDVKV FEKDEAKFEC EVSREPKTFR WLKGTQEITG DDRFELIKDG 

     13690      13700      13710      13720      13730      13740 
TRHSLVIKSA AFEDEAKYMF EAEDKRTSGK LIIEGIRLKF LTPLKDVTAK ERENAVFTVE 

     13750      13760      13770      13780      13790      13800 
LSHDNIPVSW FKNDQRLHTS KRVSMHDEGK THSITFKDLS IDDTSQIRVE AMGISSEAKL 

     13810      13820      13830      13840      13850      13860 
TVLEGDPYFT GKLQDYTGVE KDEVILQCEI SKADAPVKWF KDGKEIKPSK NVVIKADGKK 

     13870      13880      13890      13900      13910      13920 
RMLILKKALK SDIGQYTCDC GTDQTSGKLD IEDREIKLVR PLYSVEVMET ETARFETEIS 

     13930      13940      13950      13960      13970      13980 
EDDIHANWKL KGEALLQTPE CEIKEEGKIH VLILHNCRLD QTGGVDFQAA NVKSSAHLRV 

     13990      14000      14010      14020      14030      14040 
KPRVIGLLRP LKDVTVTAGE TATFDCELSY EDIPVEWYLK GKKLEPNDKV VTRSEGRVHT 

     14050      14060      14070      14080      14090      14100 
LTLRDVKLED AGEVQLTAKD FKTQANLFVK EPPVEFTKPL EDQTVEEEAT AVLECEVSRE 

     14110      14120      14130      14140      14150      14160 
NAKVKWFKNG TEILKSKKYE IVADGRVRKL IIHGCTPEDI KTYTCDAKDF KTSCNLNVVP 

     14170      14180      14190      14200      14210      14220 
PHVEFLRPLT DLQVKEKETA RFECEISKEN EKVQWFKDGA EIKKGKKYDI ISKGAVRILV 

     14230      14240      14250      14260      14270      14280 
INKCLLNDEA EYSCEVRTAR TSGMLTVLEE EAVFTKNLAN LEVSEGDTIK LVCEVSKPGA 

     14290      14300      14310      14320      14330      14340 
EVIWYKGDEE IIETGRFEIL TDGRKRILII QNAQLEDAGS YNCRLPSSRT DSKVKVHELA 

     14350      14360      14370      14380      14390      14400 
AEFISKPQNL EILEGEKAEF VCTISKESFE VQWKRDDQTL ESGDKYDIIA DGKKRVLVVK 

     14410      14420      14430      14440      14450      14460 
DATLQDMGTY VVMVGAARAA AHLTVIEKLR IIVPLKDTKV KEQQEVVFNC EVNTEGAKAK 

     14470      14480      14490      14500      14510      14520 
WFRNEEAIFD SSKYIILQKD LVYTLRIRDA RLDDQANFNV SLTNHRGENV KSAANLIVEE 

     14530      14540      14550      14560      14570      14580 
EDLRIVEPLK DIETMEKKSV TFWCKVNRLN VTLKWTKNGE EVAFDNRISY RIDKYKHSLI 

     14590      14600      14610      14620      14630      14640 
IKDCGFPDEG EYVVTAGQDK SVAELLIIEA PTEFVEHLED QTVTEFDDAV FSCQLSREKA 

     14650      14660      14670      14680      14690      14700 
NVKWYRNGRE IKEGKKYKFE KDGSIHRLII KDCRLEDECE YACGVEDRKS RARLFVEEIP 

     14710      14720      14730      14740      14750      14760 
VEIIRPPQDI LEAPGADVIF LAELNKDKVE VQWLRNNMIV VQGDKHQMMS EGKIHRLQIC 

     14770      14780      14790      14800      14810      14820 
DIKPRDQGEY RFIAKDKEAR AKLELAAAPK IKTADQDLVV DAGQPLTMVV PYDAYPKAEA 

     14830      14840      14850      14860      14870      14880 
EWFKENEPLS TKTVDTTAEQ TSFRISEAKK DDKGRYKIVL QNKHGKAEGF INLQVIDVPG 

     14890      14900      14910      14920      14930      14940 
PVRNLEVTET FDGEVSLAWE EPLTDGGSKI IGYVVERRDI KRKTWVLVTD RADSCEFTVT 

     14950      14960      14970      14980      14990      15000 
GLQKGGVEYL FRVSARNRVG TGEPVETDSP VEARSKYDVP GPPLNVTITD VNRFGVSLTW 

     15010      15020      15030      15040      15050      15060 
EPPEYDGGAE ITNYVIELRD KTSIRWDTAM TVRAEDLSAT VTDVVEGQEY SFRVRAQNRI 

     15070      15080      15090      15100      15110      15120 
GVGKPSAATP FVKVADPIER PSPPVNLNAS EQTQSSVQLT WEPPLKDGGS PILGYIIERR 

     15130      15140      15150      15160      15170      15180 
EEGKDNWIRC NMKPVPELTY KVTGLQKGNK YLYRVSAENA AGVSDPSEIL GPLTADDAFV 

     15190      15200      15210      15220      15230      15240 
EPTMDLSAFK DGLEVIVPNP IKILVPSTGY PRPKATWTFG DQVLEEGDRV KMKTISAYAE 

     15250      15260      15270      15280      15290      15300 
LVISPSERTD KGIYTLTLEN PVKSISGEIN VNVIAPPSAP KELKFSDITK DSVHLTWEPP 

     15310      15320      15330      15340      15350      15360 
DDDGGSPLTG YVVEKRDMSR KTWTKVMDFV TDLEFTVPDL VQGKEYLFKV CARNKCGPGE 

     15370      15380      15390      15400      15410      15420 
PAYTDEPVNM SAPATVPDPP ENVKWRDRTA NSIFLTWDPP KNDGGSRIKG YIVEKCPRGS 

     15430      15440      15450      15460      15470      15480 
DKWVACGEPV PDTKMEVTGL EEGKWYAYRV KALNRQGASK PSKPTEEIQA VDTQEAPEIF 

     15490      15500      15510      15520      15530      15540 
LDVKLLAGIT VKAGTKIELP ATVTGKPEPK ITWTKADTLL KPDQRITIEN VPKKSTVTIT 

     15550      15560      15570      15580      15590      15600 
DSKRSDTGTY IIEAVNVCGR ATAVVEVNVL DKPGPPAAFD ITDVTNESCL LTWNPPRDDG 

     15610      15620      15630      15640      15650      15660 
GSKITNYVVE RKATDSDVWH KLSSTVKDTN FKATKLTPNK EYIFRVAAEN MYGVGEPVQA 

     15670      15680      15690      15700      15710      15720 
APIIAKYQFD PPGPPTRLEP SDITKDAVTL TWCEPDDDGG SPITGYWVER LDPDTDKWVR 

     15730      15740      15750      15760      15770      15780 
CNKMPVKDTT YRVKGLTNKK KYRFRVLAEN LAGPGKPSRS TEPILIKDPI DPPWPPGKPT 

     15790      15800      15810      15820      15830      15840 
VKDIGKTSLV LNWTKPEHDG GAKIESYVIE MLKTGTDEWV RVAEGVPTTE HLLTGLMEGQ 

     15850      15860      15870      15880      15890      15900 
EYSFRVRAVN KAGESEPSEP SDPVLCREKL YPPSPPRWLE VINITKNTAD LKWTVPEKDG 

     15910      15920      15930      15940      15950      15960 
GSPITNYIVE KRDVRRKGWQ TVDTTVKDTK CTVTPLTEGS LYVFRVAAEN AIGQSDYTEI 

     15970      15980      15990      16000      16010      16020 
GDSVLAKDTF TTPGPPYALT VVDVTKRHVD LKWEPPKNDG GRPIQRYIIE KKEKLGTRWV 

     16030      16040      16050      16060      16070      16080 
KAGKTSGPDC NFRVTDVIEG TEVQFQVRAE NEAGVGHPSE PTEILSIEDP TSPPSPPLDL 

     16090      16100      16110      16120      16130      16140 
HVTDAGRKHI AIAWKPPEKN GGSPIIGYHV EMCPVGTEKW MRVNSRPIKD LKFKVEEGIV 

     16150      16160      16170      16180      16190      16200 
PDKEYVLRVR AVNAVGVSEP SEISENVVAK DPDCKPTIDL ETHDIVVIEG EKLNIPVPFR 

     16210      16220      16230      16240      16250      16260 
AVPVPTVSWH KDGKEVKASD RLTMKNDHIS AHLEVPKSVH ADAGVYTITL ENKLGSATAS 

     16270      16280      16290      16300      16310      16320 
INVKVIGLPG PCKDIKASDI TKSSCKLTWE PPEFDGGSPI LHYVLERREA GRRTYIPVMS 

     16330      16340      16350      16360      16370      16380 
GENKLSWTVK DLIPNGEYFF RVKAVNKIGG GEYIELKNPV IAQDPKQPPD PPVDVEVHNP 

     16390      16400      16410      16420      16430      16440 
TAKAMTITWK PPLYDGGSKI MGYIIEKITK GEDRWKRCNE HLVPVLTYTA KGLEEGKEYQ 

     16450      16460      16470      16480      16490      16500 
FRVRAENAAG IGEPSRATPP TKAVDPIDAP KVILRTSLEV KRGDEIALDA TISGSPYPTI 

     16510      16520      16530      16540      16550      16560 
TWIKDENVIV PEEIKKRAAP PVRRKKGEAE EEEPFSLPLT ERLSINNSKQ GESQLRIRDS 

     16570      16580      16590      16600      16610      16620 
LRPDHGQYMI KVENDHGVAK APCSVSVLDT PGPPINFVFE DIRKDSVLCK WEPPLDDGGS 

     16630      16640      16650      16660      16670      16680 
EIINYTLEKK DKTKPDSDWI VITSTLRNCK YSVTKLIEGK EYLFRVRAEN RFGPGPPCVS 

     16690      16700      16710      16720      16730      16740 
KPLLAKDPFE PPDAPDKPIV EDVTSNSMLV KWNEPKDNGS PILGYWLEKR EVNSTHWSRV 

     16750      16760      16770      16780      16790      16800 
NKTLLSSLKT KVDGLLEGLT YVFRVCAENA AGPGKFSPPS DPKTARDPIS PPGPPVPRVA 

     16810      16820      16830      16840      16850      16860 
DTSSTTIELE WEPPAFNGGG EIMGYFVDKQ LVGTNEWSRC TEKMIKVRQF TVKEIREGAD 

     16870      16880      16890      16900      16910      16920 
YKLRVSAVNA AGEGPPGETE PVTVAEPQEP PTVELDVSVK GGIQIMAGKT LRIPAEVTGR 

     16930      16940      16950      16960      16970      16980 
PVPTKVWTIE EGELDKERVI IENVGTKSEL IIKNALRKDH GRYVITATNS CGSKFAAVRV 

     16990      17000      17010      17020      17030      17040 
EVFDVPGPVL DLKPVVTNRK MCLLNWSDPA DDGGSDITGF IIERKDAKMH TWRQPIETER 

     17050      17060      17070      17080      17090      17100 
SKCDITGLIE GQEYKFRVIA KNKFGCGPPV EIGPILAVDP LGPPTSPERL TYTERTKSTI 

     17110      17120      17130      17140      17150      17160 
TLDWKEPRSD GGSPIQGYII EKRRHDKPDF ERVNKRLCPT TSFLVENLDE HQMYEFRVKA 

     17170      17180      17190      17200      17210      17220 
VNDVGESEPS LPLNVVIQDD EVPPTIKLRL AVRGDTIKVK AGEPVNIPAD VTGLPMPKIE 

     17230      17240      17250      17260      17270      17280 
WSKNEKVIDK PTDTLNITKE EVSRSEAKTE LSIPKAARED KGTYTITASN RLGSVFRNVH 

     17290      17300      17310      17320      17330      17340 
VEVYDRPSPP RNLAVTDIKA ESCYLTWDAP LDNGGSEITH YIIDKRDASR KKSEWEEVTN 

     17350      17360      17370      17380      17390      17400 
TAVERRYGIW KLIPNGQYEF RVRAVNKYGI SDECKSDKVV IQDPYRLPGP PGKPKVLERT 

     17410      17420      17430      17440      17450      17460 
KGSMLVSWTP PLDNGGSPIT GYWLEKREEG GTYWSRVSRA PITKVGLKGV EFNVPRLIEG 

     17470      17480      17490      17500      17510      17520 
VKYQFRAMAI NAAGIGPPSE PSDPAVAGDP IYPPGPPSCP EVKDKTKSSI SLAWKPPAKD 

     17530      17540      17550      17560      17570      17580 
GGSPIKGYIV EMQEEGTTDW KPVNEPDKLL TACECVVPNL KELRKYRFRV KAVNEAGESE 

     17590      17600      17610      17620      17630      17640 
PSDTTGEIPA TDIQEVPEVF IDIGAQDCLV CKAGSQVKIP AVIKGRPTPK SSWEFDGKAK 

     17650      17660      17670      17680      17690      17700 
KAMKDGVHDI PEDAQLETAE NSSVIIIPEC TRAHSGKYSI TAKNKAGQKT ANCRVKVMDA 

     17710      17720      17730      17740      17750      17760 
PGPPKDLKVS DITRGSCRLS WKMPDDDGGD RIKGYVIEKK TIDGKAWTKV NPNCGSTTFV 

     17770      17780      17790      17800      17810      17820 
VPDLISEQQY FFRVRAENRF GIGPPAETIQ RTTARDPIYP PDPPIKLKIG LITKNTVHLS 

     17830      17840      17850      17860      17870      17880 
WKPPKNDGGS PVTHYIVECL AWDPTGKKKE AWRQCNRRDV EELEFTVEDL IEGGEYEFRV 

     17890      17900      17910      17920      17930      17940 
KAVNEAGVSK PSATVGPVIV KDQTCPPAIE LKEFMEVEEG TDVNIVAKIK GVPFPTLTWF 

     17950      17960      17970      17980      17990      18000 
KAPPKKPDSK EPVVYDTHVN KQVVDDTCTL VIPQSRRSDT GLYSITAVNN LGTASKEMRL 

     18010      18020      18030      18040      18050      18060 
NVLGRPGPPV GPIKFESISA DQMTLSWLPP KDDGGSKITN YVIEKREANR KTWVRVSSEP 

     18070      18080      18090      18100      18110      18120 
KECMYTIPKL LEGHEYVFRI MAQNKYGIGE PLDSEPETAR NLFSVPGAPD KPTVSSVTRN 

     18130      18140      18150      18160      18170      18180 
SMTVNWEEPE YDGGSPVTGY WLEMKDTTSK RWKRVNRDPI KAMTLGVSYK VTGLIEGSDY 

     18190      18200      18210      18220      18230      18240 
QFRVYAINAA GVGPASLPSD PVTARDPVAP PGPPFPKVTD WTKSSVDLEW SPPLKDGGSK 

     18250      18260      18270      18280      18290      18300 
ITGYIVEYKE EGKEEWEKGK DKEVRGTKLV VTGLKEGAFY KFRVRAVNVA GVGEPGEVTD 

     18310      18320      18330      18340      18350      18360 
VIEMKDRIVS PDLQLDASVR DRIVVHAGGV IRIIAYVSGK PPPTVTWSMN ERALPQEAAI 

     18370      18380      18390      18400      18410      18420 
ETTAISSSMV IKNCQRSHQG VYSLLAKNEG GERKKTIIVD VLDVPGPVGI PFLSDNLTND 

     18430      18440      18450      18460      18470      18480 
SCKLTWFSPE DDGGSPITNY VIQKREADRR AWTPVTYTVT RQNATVQGLI QGKSYFFRIA 

     18490      18500      18510      18520      18530      18540 
AENSIGMGPF VETPNALVIR DPITVPERPE DLEVKEVTKN TVSLTWNPPK YDGGSEIINY 

     18550      18560      18570      18580      18590      18600 
VLESRLIGTE KFHKVTNDNL LSRKYTVKGL KEGDTYEYRV SAVNIVGQGK PSFCTKPITC 

     18610      18620      18630      18640      18650      18660 
KDELAPPTLD LDFRDKLTVR VGESFALTGR YSGKPKPKID WFKDEADVLE DDRTHIKTTP 

     18670      18680      18690      18700      18710      18720 
TTLALEKTKA KRSDSGKYCV VVENSTGSRK GFCQVNVVDR PGPPVGPVIF DEVTKEYMVI 

     18730      18740      18750      18760      18770      18780 
SWKPPLDDGG SEITNYIIEK KELGKDIWMP VTSASAKTTC KVPKLLEGKD YIFRIHAENL 

     18790      18800      18810      18820      18830      18840 
YGISDPLVSD SMKAKDRFRV PDAPEQPVVT EVTKDSALVT WNKPNDGGKP ITNYILEKRE 

     18850      18860      18870      18880      18890      18900 
TMSKRWVRVT KEPIHPYTKY RVPDLLEGCQ YEFRVSAENE IGIGDPSPPS KPVFARDPIA 

     18910      18920      18930      18940      18950      18960 
KPSPPINPEA IDTTCNSVEL TWQPPRHDGG SKILGYIVEY QKVGDEEWRR ANHTPESCPE 

     18970      18980      18990      19000      19010      19020 
TKYKVTGLRD GQSYKFRVLA VNEAGESDPA HVPEPVLVKD RLEPPELILD ANMAREQHIR 

     19030      19040      19050      19060      19070      19080 
VGDTLRLSAI IKGVPFPKVT WKKEDREAPT KAQIDVTPVG SKLEIRNAAH EDGGIYSLTV 

     19090      19100      19110      19120      19130      19140 
ENPAGTKTVS VKVLVLDKPG PPRDLEVSEI RKDSCYLTWK EPLDDGGSVV TNYVVERKDV 

     19150      19160      19170      19180      19190      19200 
ATAQWSPLST TSKKKSHMAK HLTEGNQYLF RVAAENQYGR GPFVETPKPI KALDPLHPPG 

     19210      19220      19230      19240      19250      19260 
PPKDLHHVDV DKTEVSLVWN KPDRDGGSPI TGYLVEYQEE GDKDWIKFKT VKNLDCVVTG 

     19270      19280      19290      19300      19310      19320 
LQQGKTYRFR VKAENIIGLG LPDTTIPIEC QEKLVPPSVE LDVKLIEGLV VKAGTTVRFP 

     19330      19340      19350      19360      19370      19380 
AIIRGVPVPT AKWTTDGTEI KTDDHYTVET DSFSSVLTIK NCLRKDTGEY QLTVSNAAGT 

     19390      19400      19410      19420      19430      19440 
KTVAVHLTVL DVPGPPTGPI NILDVTPEYM TISWQPPKDD GGSPVINYIV EKQDTRKGTW 

     19450      19460      19470      19480      19490      19500 
GVVSAGSSKL KLKVPHLQKG CEYVFRVKAE NKMGVGPPLD SIPTVAKHKF SPPSPPGKPV 

     19510      19520      19530      19540      19550      19560 
VTDITENAAT VSWTLPKSDG GSPITGYYVE RREITGKWVR VNKTPIADLK FRVTGLYEGN 

     19570      19580      19590      19600      19610      19620 
TYEFRVFAEN LAGLSNPSPS SDPIKACRPI KPPGPPINPK LKDKSKESAD LVWTKPLSDG 

     19630      19640      19650      19660      19670      19680 
GSPILGYVVE YQKPGTAQWD RINKDELIRQ CAFRVPGLIE GNEYRFRIRA ANIVGEGEPR 

     19690      19700      19710      19720      19730      19740 
ELAESVIAKD ILHPPEVELD VTCRDVITVR VGQTIRILAR VKGRPEPDIT WSKEGKVLVK 

     19750      19760      19770      19780      19790      19800 
DKRVDLIHDL PRVELQIKEA VRADHGKYII SAKNSSGHAQ GSAIVNVLDR PGPCQNLKVS 

     19810      19820      19830      19840      19850      19860 
NVTKENCTIS WENPLDNGGS EITNFIVEYR KPNQKGWSIV ASDVTKRLVK ANLLANNEYY 

     19870      19880      19890      19900      19910      19920 
FRVCAENKVG VGPTIETKTP ILAINPIDRP GEPENLHIAD KGKTFVYLKW RRPDYDGGSP 

     19930      19940      19950      19960      19970      19980 
NLSYHVERRL KGSADWERVH KGSIKETHYM VDKCVENQIY EFRVQTKNEG GESDWVRTEE 

     19990      20000      20010      20020      20030      20040 
VVVKEDLQKP VLDLKLSGVL TVKAGDTIRL EAGVRGKPFP EVAWTKDKDA TDLTRSPRVK 

     20050      20060      20070      20080      20090      20100 
IDTSAESSKF SLTKAKRSDG GKYVITATNP AGSFVAYATV NVLDKPGPVR NLKITDVSSD 

     20110      20120      20130      20140      20150      20160 
RCTIRWDPPE DDGGCEIQNY ILEKCESKRM VWSTYSANVL TPSATVTRLI EGNEYIFRVR 

     20170      20180      20190      20200      20210      20220 
AENKIGTGPP TESKPVIAKT KYDRPGRPDP PEVTKVSKEE MTVVWNAPEY DGGKSITGYY 

     20230      20240      20250      20260      20270      20280 
LEKKEKHAVR WVPVNKSAIP ERRLKVQNLL PGHEYQFRVK AENEVGIGEP SLPSRPVVAK 

     20290      20300      20310      20320      20330      20340 
DPIEPPGPPT NFKVVDTTKS SITLAWGKPV YDGGAPIIGY VVEMRPKIAD ASPDEGWKRC 

     20350      20360      20370      20380      20390      20400 
NAAAQLIRME FTVTSLDENQ EYEFRVCAQN QVGIGRPAEL KEAIKPKEIL EPPEIDLDAS 

     20410      20420      20430      20440      20450      20460 
MRKLVVVRAG CPIRLFAIVR GRPAPKVTWR KVGIDNVVRK GQVDLVDTMA FLVIPNSTRD 

     20470      20480      20490      20500      20510      20520 
DSGKYSLTLV NPAGEKAVFV NVKVLDTPGP VADLKVSDVT KTSCHVSWAP PENDGGSQVT 

     20530      20540      20550      20560      20570      20580 
HYIVEKREAE RKTWSTVTPE VKKTSFNVTN LVPGNEYFFR VTAVNEYGPG VPTDIPKPVL 

     20590      20600      20610      20620      20630      20640 
ASDPLSEPDP PRKLEVTEMT KNSATLAWLP PLRDGGAKID GYIISYREED QPADRWTEYS 

     20650      20660      20670      20680      20690      20700 
VVKDLSLIVT GLKEGKKYKF RVAARNAVGV SMPREAEGVY EAKEQLLPPK ILMPEQITIK 

     20710      20720      20730      20740      20750      20760 
AGKKLRVEAH VYGKPNPICK WKKGDDEVVT SSHLAIHKAD GSSVLIIKDV TRKDSGYYSL 

     20770      20780      20790      20800      20810      20820 
TAENSSGSDT QKIKVTVMDA PGPPQPPFDI SEIDADACSL SWHIPLEDGG SNITNYIVEK 

     20830      20840      20850      20860      20870      20880 
CDVSRGDWVT ALASVTKTSC RVGKLIPGQE YIFRVRAENR FGISEPLTSP KMLAKFPFDV 

     20890      20900      20910      20920      20930      20940 
PSEPKNARVT KVNKDCIFVA WDRPDSDGGS PITGYLIERK ERNSLLWVKA NDTIVRSTEY 

     20950      20960      20970      20980      20990      21000 
PCAGLVEGLE YSFRIYALNK AGSSPPSKPT EYVTARMPVD PPGKPEVVDV TKNSASLIWA 

     21010      21020      21030      21040      21050      21060 
RPKHDGGSRI IGYFVEACKL PGDKWVRCNT TPHQIPQEEY TATGLEENAQ YQFRAIAKTA 

     21070      21080      21090      21100      21110      21120 
VNISQPSEPS DPVTILAENV PPRIELSVEM KSLLTVKAGT NVCLDATVFG KPMPTVSWKK 

     21130      21140      21150      21160      21170      21180 
DTTPIKQAEG IKMAMKRNLC TLELFSVNRK DSGDYTITAE NSSGSKSATI KLKVLDKPGP 

     21190      21200      21210      21220      21230      21240 
PASVKINKMY ADRAMLSWEP PLEDGGSEIT NYIIDKRETS RPNWAQVSAT VPITSCTVEK 

     21250      21260      21270      21280      21290      21300 
LIEGHEYQFR ICAENKYGVG DPILTEPAIA KNPYDPPGRC DPPVISNITK DHMTVSWKAP 

     21310      21320      21330      21340      21350      21360 
ADDGGSPITG YLVEKRETQA VNWTKVNRKP VIERTLKATG LQEGTEYEFR VTAINKAGPG 

     21370      21380      21390      21400      21410      21420 
KPSDASKAVY AQDPLYPPGP PAFPKVYDTT RSSVSLSWGK PAYDGGSPII GYLVEVKRAD 

     21430      21440      21450      21460      21470      21480 
SDHWVRCNLP EKLQKTRFEV TGLMENTEYQ FRVYAVNKIG YSDPSDVPDK HCPKDILIPP 

     21490      21500      21510      21520      21530      21540 
EGELDAELRK TLILRAGVTM RLYVPVKGRP PPKITWSKPN VNLRERIGLD IKSTDFDTFL 

     21550      21560      21570      21580      21590      21600 
RCENVNKYDA GKYILTLENS CGKKEYTIVV KVLDTPGPPV NVTVKEVSKD SAYVTWDPPI 

     21610      21620      21630      21640      21650      21660 
IDGGSPIINY VVEKRDAERK SWSTVTTECS KTSFRVSNLE EGKSYFFRVF AENEYGIGDP 

     21670      21680      21690      21700      21710      21720 
GETRDAVKAS ETPGPVVDLK ALAITKSSCT IGWKKPRSDG GSRITGYVVD FLTEENKWQR 

     21730      21740      21750      21760      21770      21780 
VMKSLSLQYS TKDLKEGKEY TFRVSAENEN GEGTPSEIVV VAKDDVVAPD LDLKDLPDLC 

     21790      21800      21810      21820      21830      21840 
YLAKENSNFR LKIPIKGKPA PSVSWKKGED PLATDTRVSV ESTAVNTTLV VYDCQKSDAG 

     21850      21860      21870      21880      21890      21900 
KYTITLKNVA GTKEGTLSIK VVGKPGIPTG PIKFDEVTAE AMTLKWGPPK DDGGSEITNY 

     21910      21920      21930      21940      21950      21960 
VLEKRDSVNN KWVTCASAVQ KTTFRVTRLH EGIEYTFRVS AENKYGVGEG LKSEPIVAKH 

     21970      21980      21990      22000      22010      22020 
PFDVPDAPPP PNIVDVRHDS VSLTWTDPKK TGGSPITGYH IEFKERNSLL WKRANKTPIR 

     22030      22040      22050      22060      22070      22080 
MKDFKVTGLT EGLEYEFRVM AINLAGVGKP SLPSEPVVAL DPIDPPGKPE VISVTRNSVT 

     22090      22100      22110      22120      22130      22140 
LIWTEPKYDG GHKLTGYIVE KRDLPSKSWM KANHVNVPDC AFTVTDLVEG GKYEFRIRAK 

     22150      22160      22170      22180      22190      22200 
NTAGAISAPS ESTGTIICKD EYEAPTIVLD PTIKDGLTVK AGDSIVLSAI SILGKPLPKS 

     22210      22220      22230      22240      22250      22260 
SWSRAGKDIR PSDIAQITST PTSSMLTVKY ATRKDAGEYT ITATNPFGTK EEHVKVSVLD 

     22270      22280      22290      22300      22310      22320 
VPGPPGPIEI SNVSAEKATL TWTPPLEDGG SPIKAYVLEK RETSRLLWTV VSEDIQACRH 

     22330      22340      22350      22360      22370      22380 
VVTKLIQGNE YLFRVSAVNH YGKGEPVQSE PVKMVDRFGP PGPPGKPEIS NVTKNTATVS 

     22390      22400      22410      22420      22430      22440 
WKRPTDDGGS EITGYHVERR EKKGLRWVRA TKTPVSDLRC KVTGLQEGNT YEFRVSAENR 

     22450      22460      22470      22480      22490      22500 
AGIGPPSDAS NPVLMKDVAY PPGPPSNAHV TDTTKKSASL AWGKPHYDGG LEITGYVVEH 

     22510      22520      22530      22540      22550      22560 
QKVGDDAWIK DTTGTALRIT QFVVPDLQTK EKYNFRISAI NDAGVGEPAV IPNVEIVEKE 

     22570      22580      22590      22600      22610      22620 
VAPDFELDAE LRRTLVVRAG LSIRIFVPIK GRPAPEVTWT KDNINLKHRA NIENTESFTL 

     22630      22640      22650      22660      22670      22680 
LIIPECNRYD TGKFVMTIEN PAGKKSGFVN VRVLDTPGPV LNLRPTDITK DSVTLHWDLP 

     22690      22700      22710      22720      22730      22740 
LIDGGSRITN YIVEKREATR KSYSTVTTKC HKCTYKVTGL TEGCEYFFRV MAENEYGVGE 

     22750      22760      22770      22780      22790      22800 
PTETTEPVRA SEAPLPPDSL NIMDITKNTV SLAWPKPRHD GGSKITGYVI EAQRKGSDQW 

     22810      22820      22830      22840      22850      22860 
THISTVKGLE CVVRNLTEGE EYTFQVMAVN SAGRSAPRES RPVIVKEQTM LPELDLRGIY 

     22870      22880      22890      22900      22910      22920 
QKLVIARAGD NIKVEIPVLG RPKPTVTWKK GDQILKQTQR VNVENTATST ILNINECVRS 

     22930      22940      22950      22960      22970      22980 
DSGPYPLTAK NTVGEVGDVI TIQVHDIPGP PTGPIKFDEV SSDFVTFSWE PPENDGGVPI 

     22990      23000      23010      23020      23030      23040 
SNYVVEMRQT DSTTWVELAT TVIRTTYKAT RLTTGVEYQF RVRAQNRYGV GPGITSASVV 

     23050      23060      23070      23080      23090      23100 
ANYPFKVPGP PGTPQVTAVT KDSMTISWHE PLSDGGSPIL GYHIERKERN GILWQTVSKA 

     23110      23120      23130      23140      23150      23160 
LVPGNIFKST GLTDGIAYEF RVIAENMAGK SKPSKPSEPM FALDPIDPPG KPVPLNITRH 

     23170      23180      23190      23200      23210      23220 
TVALKWAKPE YTGGFKITSY VVEKRDLPNG RWLKANFSNI LENEFTVSGL TEDAAYEFRV 

     23230      23240      23250      23260      23270      23280 
IAKNAAGAIS PPSEPSDAIT CRDDLEAPRI MVDVRFKDTI TLKAGEAFKL EADVSGRPPP 

     23290      23300      23310      23320      23330      23340 
TMEWTKDGKE LEGTGKLEIK IADFSTHLIN KDSSRTDSGA YILTATNPGG FAKHIFNVKV 

     23350      23360      23370      23380      23390      23400 
LDRPGPPEGP LAVSDVTSEK CVLSWLPPLD DGGAKIDHYI VQKRETSRLA WTNVATEVQV 

     23410      23420      23430      23440      23450      23460 
TKLKVTKLLK GNEYIFRVMA VNKYGVGEPL ESEPVLAVDP YGPPDPPKNP EVTTITKDSM 

     23470      23480      23490      23500      23510      23520 
VVCWGHPDSD GGSEIINYIV ERRDKAGQRW VKCNKKALTD LRFKVSGLTE GHEYEFRIMA 

     23530      23540      23550      23560      23570      23580 
ENAAGISAPS ATSPFYKACD TVFKPGPPGN PRVLDTSRSS ISIAWNKPIY DGGSEITGYM 

     23590      23600      23610      23620      23630      23640 
VEIALPEEDE WQVVTPPAGL KATSYTITSL IENQEYKIRI YAMNSEGLGE PALVPGTPKA 

     23650      23660      23670      23680      23690      23700 
EERMLPPEIE LDADLRKVVT IRACCTLRLF VPIKGRPAPE VKWAREHGES LDKASIESTS 

     23710      23720      23730      23740      23750      23760 
SYTLLVVGNV NRFDSGKYIL TVENSSGSKS AFVNVRVLDT PGPPQNLKIK EVTKTSVTLT 

     23770      23780      23790      23800      23810      23820 
WEPPLLDGGS KIKNYIVEKR ESTRKAYSTV ATNCHKTSWK VDQLQEGCSY YFRVLAENEY 

     23830      23840      23850      23860      23870      23880 
GIGLPAETAE SVKASERPLP PGKITLTDVT RNSVSLSWEK PEHDGGSRIL GYIVEMQSKG 

     23890      23900      23910      23920      23930      23940 
SDRWATCATV KVTEATITGL IQGEEYSFRV SAQNEKGISD PRQLSVPVIA KDLVIPPAFK 

     23950      23960      23970      23980      23990      24000 
LLFNTFTVLA GEDLKIDVPF IGRPPPAVTW HKDDIPLKQT TRVNAESTEN NSLLTIKEAC 

     24010      24020      24030      24040      24050      24060 
REDVGHYTVK LTNSAGEATE TLNVIVLDKP GPPTGPVKMD EVTADSVTLS WEPPKYDGGS 

     24070      24080      24090      24100      24110      24120 
SINNYIVEKR DTSTTAWQIV SATVARTTIK ACRLKTGCEY QFRIAAENRY GKSTYLNSEP 

     24130      24140      24150      24160      24170      24180 
VVAQYPFKVP GPPGTPFVTL ASKDSMEVQW HEPVSDGGSK VIGYHLERKE RNSILWVKLN 

     24190      24200      24210      24220      24230      24240 
KTPIPQTKFK TTGLEEGIEY EFRVSAENIV GIGKPSKPSE CYAAHDPCDP PGRPEAIIVT 

     24250      24260      24270      24280      24290      24300 
RNSVTLQWKK PTYDGGSKIT GYIVEKKELP DGRWMKASFT NIIDTQFEVT GLLEDHRYEF 

     24310      24320      24330      24340      24350      24360 
RVIARNAAGV FSEPSESTGA ITARDEVEPP RISMDPKYRD TVVVQAGESF KIDADIYGKP 

     24370      24380      24390      24400      24410      24420 
IPTTQWVKGD QELSSTARLE IKSTDFATSL SVKDAVRVDS GNYILKAKNV AGEKSVTINV 

     24430      24440      24450      24460      24470      24480 
KVLDRPGPPE GPVAISGVTA EKCTLAWKPP LQDGGSDITN YIVERRETSR LVWTLVDANV 

     24490      24500      24510      24520      24530      24540 
QTLSCKVLKL LEGNEYIFRI MAVNKYGVGE PLESESLIAK NPFVVPDAPK APEVTAVTKD 

     24550      24560      24570      24580      24590      24600 
SMIVVWERPA SDGGSEILGY VLEKRDKEGI RWTRCHKRLI GELRLRVTGL LENHNYEFRV 

     24610      24620      24630      24640      24650      24660 
SAENAAGLSE PSPPSAYQKA CDPIYKPGPP NNPKVMDVTR SSVFLSWTKP IYDGGCEIQG 

     24670      24680      24690      24700      24710      24720 
YIVEKCDVSV GEWTMCTPPT GINKTNLEVE KLLEKHEYNF RICAINKAGV GEHADVPGPV 

     24730      24740      24750      24760      24770      24780 
MVEEKLEAPD IDLDLELRKV INIRAGGSLR LFVPIKGRPT PEVKWGKVDG DIRDAAIIDV 

     24790      24800      24810      24820      24830      24840 
TSSFTSLVLD NVNRYDSGKY TLTLENSSGT KSAFVTVRVL DTPSPPVNLK VTEITKDSVS 

     24850      24860      24870      24880      24890      24900 
ITWEPPLLDG GSKIKNYIVE KREATRKSYA AVVTNCHKNS WKIDQLQEGC SYYFRVTAEN 

     24910      24920      24930      24940      24950      24960 
EYGIGLPART ADPIKVAEVP QPPGKITVDD VTRNSVSLSW TKPEHDGGSK IIQYIVEMQA 

     24970      24980      24990      25000      25010      25020 
KNTDKWSECA RVKSLDAVIT NLTQGEEYLF RVIAVNEKGR SDPRSLAVPI IAKDLVIEPD 

     25030      25040      25050      25060      25070      25080 
VRPAFSSYSV QVGQDLKIEV PISGRPKPSI SWTKDGMPLK QTTRINVTDS LDLTTLSIKE 

     25090      25100      25110      25120      25130      25140 
THKDDGGQYG ITVSNVVGQK TAAIEIITLD KPDPPKGPVK FDEISAESIT LSWNPPLYTG 

     25150      25160      25170      25180      25190      25200 
GCQITNYIVQ KRDTTTTVWD VVSATVARTT LKVTKLKTGT EYQFRIFAEN RYGQSFALES 

     25210      25220      25230      25240      25250      25260 
EPVVAQYPYK EPGPPGTPFV TAISKESMVV QWHEPINNGG SPVIGYHLER KERNSILWTK 

     25270      25280      25290      25300      25310      25320 
VNKTIIHDTQ FKALNLEEGI EYEFRVYAEN IVGVGKASKN SECYVARDPC DPPGTPEAII 

     25330      25340      25350      25360      25370      25380 
VKRNEITLQW TKPVYDGGSM ITGYIVEKRD LPEGRWMKAS FTNVIETQFT VSGLTEDQRY 

     25390      25400      25410      25420      25430      25440 
EFRVIAKNAA GAISKPSDST GPITAKDEVE LPRISMDPKF RDTIVVNAGE TFRLEADVHG 

     25450      25460      25470      25480      25490      25500 
KPLPTIEWLR GDKEIEESAR CEIKNTDFKA LLIVKDAIRI DGGQYILRAS NVAGSKSFPV 

     25510      25520      25530      25540      25550      25560 
NVKVLDRPGP PEGPVQVTGV TAEKCTLAWS PPLQDGGSDI SHYVVEKRET SRLAWTVVAS 

     25570      25580      25590      25600      25610      25620 
EVVTNSLKVT KLLEGNKYIF RIMAVNKYGV GEPLESAPVL MKNPFVLPGP PKSLEVTNIA 

     25630      25640      25650      25660      25670      25680 
KDSMTVCWNR PDSDGGSEII GYIVEKRDRS GIRWIKCNKR RITDLRLRVT GLTEDHEYEF 

     25690      25700      25710      25720      25730      25740 
RVSAENAAGV GEPSPATVYY KACDPVFKPG PPTNAHVVDT TKNSITLAWS KPIYDGGSEI 

     25750      25760      25770      25780      25790      25800 
LGYVVEICKA DEEEWQIVTP QTGLRVTRFE IAKLIEHQEY KIRVCALNKV GLGEAASVPG 

     25810      25820      25830      25840      25850      25860 
TVKPEDKLEA PELDLDSELR KGIVVRAGGS ARIHIPFKGR PTPEITWSKE EGEFTDKVQI 

     25870      25880      25890      25900      25910      25920 
EKGINFTQLS IDNCDRNDAG KYILKLENSS GSKSAFVTVK VLDTPGPPQN LAVKEVRKDS 

     25930      25940      25950      25960      25970      25980 
VLLVWEPPII DGGAKVKNYV IDKRESTRKA YANVSSKCNK TSFRVENLTE GAIYYFRVMA 

     25990      26000      26010      26020      26030      26040 
ENEFGVGVPT ETSDAVKASE PPSPPGKVTL TDVSQTSASL MWEKPEHDGG SRILGYVVEM 

     26050      26060      26070      26080      26090      26100 
QPKGTEKWSV VAESKVCNAV VSGLSSGQEY QFRVKAYNEK GKSDPRVLGI PVIAKDLTIQ 

     26110      26120      26130      26140      26150      26160 
PSFKLPFNTY SVQAGEDLKI EIPVIGRPRP KISWVKDGEP LKQTTRVNVE ETATSTILHI 

     26170      26180      26190      26200      26210      26220 
KESSKDDFGK YSVTATNSAG TATENLSVIV LEKPGPPVGP VKFDEVSADF VVISWEPPAY 

     26230      26240      26250      26260      26270      26280 
TGGCQISNYI VEKRDTTTTN WQMVSATVAR TTIKISKLKT GTEYQFRIFA ENRYGKSTPL 

     26290      26300      26310      26320      26330      26340 
DSKPVVVQYP FKEPGPPGTP FVTSISKDQM LVQWHEPVND GGSKVTGYHL EQKEKNSILW 

     26350      26360      26370      26380      26390      26400 
VKLNKIPIQD TKFKTTGLDE GLEYEFRVSA ENIVGIGKPS KVSECYVARD PCDPPGRPEA 

     26410      26420      26430      26440      26450      26460 
IVITRNSVTL KWKKPVYDGG SKITGYIVEK KDLPDGRWMK ASFTNVVETE FTVTGLVEDQ 

     26470      26480      26490      26500      26510      26520 
RYEFRVIARN AADNFSEPSE SSGAITARDE IDAPNASLDP KYRDVIIVHA GETFVLEADI 

     26530      26540      26550      26560      26570      26580 
RGKPIPDIIW SKDGNELEET AARMEIKSTL QKTTLIVKDC IRTDGGQYTL KLSNVGGTKT 

     26590      26600      26610      26620      26630      26640 
IPITVKVLDR PGPPEGPLKV TGVTAEKCYL AWNPPLQDGG ASISHYIIEK RETSRLSWTQ 

     26650      26660      26670      26680      26690      26700 
VSNEVQALNY KVTKLLPGNE YIFRVMAVNK YGIGEALESE PVIACNPYKR PGPPSTPEAS 

     26710      26720      26730      26740      26750      26760 
AITKDSMVLT WTRPVDDGGA EIEGYILEKR DKEGIRWTKC NKKTLTDLRF RVTGLTEGHS 

     26770      26780      26790      26800      26810      26820 
YEFRVAAENA AGVGEPSEPS VFYRACDALY PPGPPSNPKV TDTSRSSVSL AWNKPIYDGG 

     26830      26840      26850      26860      26870      26880 
APVRGYVIEL KKAAADEWTT CTPPSGLQGK QFTVTKLKEN TEYNFRICAF NTEGVGEPAT 

     26890      26900      26910      26920      26930      26940 
IPGSVVAQER MEAPEIELDA DLRKVVTLRA SATLRLFVTI KGRPEPEVKW EKAEGILTER 

     26950      26960      26970      26980      26990      27000 
AQIEVTSSYT MLVIDNVTRF DSGRYNLTLE NNSGSKTAFV NVRVLDSPSA PVNLTIREVK 

     27010      27020      27030      27040      27050      27060 
KDSVTLSWEP PLIDGGAKIT NYIVEKRETT RKAYATITNN CTKNTFKIEN LQEGCSYYFR 

     27070      27080      27090      27100      27110      27120 
VLASNEYGIG LPAETAEPVK VSEPPLPPGR VTLVDVTRNT ATIKWEKPES DGGSKITGYV 

     27130      27140      27150      27160      27170      27180 
VEMQTKGSEK WSACTQVKTL ETTISGLTAG EEYVFRVAAV NEKGRSDPRQ LGVPVIAKDI 

     27190      27200      27210      27220      27230      27240 
EIKPSVELPF NTFNVKANDQ LKIDIPFKGR PQATVAWKKD GQVLRETTRV NVASSKTVTT 

     27250      27260      27270      27280      27290      27300 
LSIKEASRED VGTYELCVSN TAGSITVPIT VIVLDRPGPP GPIRIDEVSC DNVSISWNPP 

     27310      27320      27330      27340      27350      27360 
EYDGGCQISN YIVEKRETTS TTWQVVSQAV ARTSIKIVRL TTGSEYQFRV CAENRYGKSS 

     27370      27380      27390      27400      27410      27420 
YSESSAVVAE YPFSPPGPPG TPKVVHATKS TMVVSWQVPV NDGGSQVIGY HLEYKERSSI 

     27430      27440      27450      27460      27470      27480 
LWSKANKVLI ADTQMKVSGL DEGLMYEYRV YAENIAGIGK CSKACEPVPA RDPCDPPGQP 

     27490      27500      27510      27520      27530      27540 
EVTNITRKSV SLKWSKPRYD GGAKITGYIV ERRELPDGRW LKCNFTNVQE TYFEVTELTE 

     27550      27560      27570      27580      27590      27600 
DQRYEFRVFA RNAADSVSEP SESTGPITVK DDVEAPRIMM DVKFRDVIIV KAGEVLKINA 

     27610      27620      27630      27640      27650      27660 
DIAGRPLPVI SWAKDGVEIE ERAKTEIVST DYTTTLTVKD CVRRDTGQYV LTLKNVAGTR 

     27670      27680      27690      27700      27710      27720 
TMAVNCKVLD KPGPPAGPLE INGLTAEKCS LSWGRPQEDG GADIDYYIVE KRETSRLAWT 

     27730      27740      27750      27760      27770      27780 
ICEAELRTTS CKVTKLLKGN EYIFRVTGVN KYGVGEPLES MAVKALDPFT TPSPPTSLEI 

     27790      27800      27810      27820      27830      27840 
TSVTKDSMTL CWSRPETDGG SDISGYIIER REKNSLRWMR VNKKPVYDLR VKSTGLREGC 

     27850      27860      27870      27880      27890      27900 
EYEYRVFAEN AAGLSLPSET SPLVRAEDPV FLPSPPSKPK IVDSGKTTIT IGWVKPLFDG 

     27910      27920      27930      27940      27950      27960 
GAPITGYTVE YKKSEETDWK VAIQSFRGTE YTMSGLTTGD EYVFRVRSLN KMGASDPSDS 

     27970      27980      27990      28000      28010      28020 
SDPQVAKERE EEPVFDVDSE MRKTLIVKAG SSFTMTVPFR GRPIPNVSWS KPDTDLRTRA 

     28030      28040      28050      28060      28070      28080 
YIDSTDSRTL LTIENANRND SGKYTLTIQN VLSAASMTFV VKVLDSPGPP ANITVREVTK 

     28090      28100      28110      28120      28130      28140 
ETAMLSWDVP ENDGGAPVKN YHIEKREASK KAWVSVTNNC NRLSYKVTNL QEGAIYYFRV 

     28150      28160      28170      28180      28190      28200 
SGENEFGVGV PAETKEGVKI TEKPSPPEKL GVTSVSKDSV SLSWLKPEHD GGSRIIHYVV 

     28210      28220      28230      28240      28250      28260 
EALEKGQKTW VKCAVVKTTH HVVSGLRESH EYFFRVFAEN QAGLSDPREL LLPVLIKDQL 

     28270      28280      28290      28300      28310      28320 
EPPEIDMKNF PSHTVYVRAG SNLKVDIPIS GKPLPKVTLS RDGVPLKATM RFNTEITAEN 

     28330      28340      28350      28360      28370      28380 
LTINLKESVT TDAGRYEITA ANSSGTTKTF INIIVLDRPG PPTGPVAISD ITEESVTLKW 

     28390      28400      28410      28420      28430      28440 
EPPKYDGGSH VTNYIVLKRE TSTAVWSEVS ATVARTMIKV MKLTTGEEYQ FRIKAENRFG 

     28450      28460      28470      28480      28490      28500 
ISDHIDSVCV VVKLPYTTPG PPSTPWVSNV TRESITVGWH EPVSNGGSAV TGYHLEMKDR 

     28510      28520      28530      28540      28550      28560 
NSILWQKANK MIIRTTHFKV TTISAGLIYE FRVYAENAAG IGKPSHPSEP VLAIDACEPP 

     28570      28580      28590      28600      28610      28620 
RNVRITDISK NSVNLSWQQP AFDGGSKITG YIVERRDLPD GRWTKASFTN VIETQFTVSG 

     28630      28640      28650      28660      28670      28680 
LTQNSQYEFR VFARNAVGSV SNPSEVVGPI TCIDSYGGPV IDLPLEYTEV VKYRAGTSVK 

     28690      28700      28710      28720      28730      28740 
LRAGISGKPE PTIEWYKDDK ELQTNALVCV ENSTDLASIL IKDANRLNSG SYELKLRNAM 

     28750      28760      28770      28780      28790      28800 
GSASATIRVQ ILDKPGPPGG PIEFKTVTAE KITLLWRPPA DDGGAKITHY IVEKRETSRV 

     28810      28820      28830      28840      28850      28860 
VWSMVAENLE ECIVTTTKII KGNEYVFRVR AVNKYGIGEP LESEPVVAKN AFVTPGPPSI 

     28870      28880      28890      28900      28910      28920 
PEVTKITKNS MTVVWDRPTV DGGSEINGYF LERRDKKSLA WLKVLKETIR DTRQKVTGLT 

     28930      28940      28950      28960      28970      28980 
ENSDYQYRVC AVNAAGVGPF SEPSDFYKAA DPIDPPGPPA KIRIADSTKS SITLGWSKPV 

     28990      29000      29010      29020      29030      29040 
YDGGSDVTGY VVEMKQGDEE EWTIVSTRGE VRTTEYVVSN LKPGVNYYFQ VSAVNCAGQG 

     29050      29060      29070      29080      29090      29100 
EPITMTEPAQ AKDVLEEPEI DLDVALRTSV IAKAGEDVQL LIPFKGRPPP TVTWRKDEKN 

     29110      29120      29130      29140      29150      29160 
LGSDTRYSIQ NTDSSSLLVI PQVTRNDTGK YILTIENGVG QPKSSTVSVK VLDTPAACQK 

     29170      29180      29190      29200      29210      29220 
LQVKHVSLGT VTLLWDPPLI DGGSPIINYV IEKRDATKRT WSVVSHKCSG TSFKVTDLSE 

     29230      29240      29250      29260      29270      29280 
KTPFFFRVLA ENEIGIGEPC ETTEPVKAAE VPAPIRDLSM KDSTKTSVVL SWTKPDFDGG 

     29290      29300      29310      29320      29330      29340 
SIITDYLVER KGKGEQAWSH AGISKTCEIE IGQLKEQSVL EFRVSARNEK GQSDPVTIGP 

     29350      29360      29370      29380      29390      29400 
LTVKELVITP EVDLSEIPGA QISVRIGHNV HLELPYKGKP KPSISWLKDG LPLKESEYVR 

     29410      29420      29430      29440      29450      29460 
FSKTENKITL SIKNSKKEHG GKYTVILDNA VCRNSFPITI ITLGPPSKPK GPIRFDEIKA 

     29470      29480      29490      29500      29510      29520 
DSAIMSWDIP EDDGGGEITC YSIEKREASQ TNWKMVCSSV ARTTFKVSNL VKDSEYQFRV 

     29530      29540      29550      29560      29570      29580 
RAENRYGVSE PLASNIIVAK HQFRIPGPPG KPVIYNVTSD GMSLTWDAPV YDGGSEVTGF 

     29590      29600      29610      29620      29630      29640 
HVEKKERNSI LWQRVNTSPI SGREYRATGL IEGLDYQFRV YAENSAGLSS PSDPSKFTLA 

     29650      29660      29670      29680      29690      29700 
VSPVDPPGTP DYIDVTRETI TLKWNPPLRD GGSKIVAYSI EKRQGSDRWV RCNFTDVSEC 

     29710      29720      29730      29740      29750      29760 
QYTVTGLSPG DRYEFRIIAR NAVGTISPPS QSSGLIMTRD ENVPPTVEFG PEYFDGLVIK 

     29770      29780      29790      29800      29810      29820 
SGDSLRIKAL VQGRPVPRVT WFKDGVEIER RMNMEITDVL GSTSLFVRDA TRDHRGVYTV 

     29830      29840      29850      29860      29870      29880 
EAKNVSGSTK AEVTVKVQDT PGKVVGPIRF TNITGEKMTL WWEAPLNDGC APVTHYIIEK 

     29890      29900      29910      29920      29930      29940 
RETSRLAWAL IEDNCEALSY TAIKLITGNE YQFRISAVNK FGVGRPLESD PVVAQIQYTI 

     29950      29960      29970      29980      29990      30000 
PDAPGVPEPS NVTGNSITLT WTRPESDGGS EIQHYILERR EKKSTRWVKV ISKRPISETR 

     30010      30020      30030      30040      30050      30060 
FKVTGLVEGN EYEFHVMAEN AAGIGPASGI SRLIKCREPV NPPSAPSVVK VTDTSKTTVS 

     30070      30080      30090      30100      30110      30120 
LEWARPVFDG GMEIIGYIIE MCKADLGDWH KVNTEPCVKT RYTVTDLQAG EEYKFRVSAV 

     30130      30140      30150      30160      30170      30180 
NGAGKGDSCE VTGTIKAVDR LSAPELDIDA NFKQTHIVRA GVSIRLFIAY QGRPTPTAVW 

     30190      30200      30210      30220      30230      30240 
SKPDSNLSIR ADIHTTDSFS TLTVENCNRN DAGKYTLTVE NNSGKKSITF TVKVLDSPGP 

     30250      30260      30270      30280      30290      30300 
PGPITFKDVT RGSATLMWDA PLLDGGARIH HYVIEKREAS RRSWQVVSEK CTRQILKVSE 

     30310      30320      30330      30340      30350      30360 
LTEGVPYYFR VSAENEYGVG EPYEMPEPIV ATEQPAPPRR LDVVDTSKSS AVLAWLKPDH 

     30370      30380      30390      30400      30410      30420 
DGGSRITSYL LEMRQKGSDF WVEAGHTKQL TFTVERLVEN TEYEFRVKAK NDAGYSEPRE 

     30430      30440      30450      30460      30470      30480 
AFSSVIIKEP QIEPTADLTG ITNQLITCKA GSTFTIDVPI SGRPAPKVTW KLEEMRLKET 

     30490      30500      30510      30520      30530      30540 
DRMSIATTKD RTTLTVKDSM RGDSGRYFLT LENTAGVKTF TITVVVIGRP GPVTGPIEVS 

     30550      30560      30570      30580      30590      30600 
SVSAESCVLS WTEPKDDGGT EITNYIVEKR ESGTTAWQLI NSSVKRTQIK VTHLTKYKEY 

     30610      30620      30630      30640      30650      30660 
CFRVSSENRF GVSKPLESVP IVAEHPFVPP SAPTRPEVYY VSANAMSIRW EEPYHDGGSK 

     30670      30680      30690      30700      30710      30720 
IVGYWVEKKE RNTILWVKEN KVPCLECNYK VTGLVEGLEY QFRTYALNAA GVSKASEASR 

     30730      30740      30750      30760      30770      30780 
PIMAQNPVDP PGRPEVTDVT RSTVSLIWSA PVYDGGSKVV GYIIERKPVS EVGDGRWLKC 

     30790      30800      30810      30820      30830      30840 
NYTIVSDNFF TVTALSEGDT YEFRVLAKNA AGVISKGSES TGPVTCRDEY APPKAELDAR 

     30850      30860      30870      30880      30890      30900 
LQGDLVTIRA GSDLVLDAAV GGKPEPKIIW TKGDKELDLC EKISLQYTGK RATAVIKYCD 

     30910      30920      30930      30940      30950      30960 
RSDSGKYTLT VKNASGTKSV SVMVKVLDSP GPCGKLTVSR VTEEKCTLAW SLPQEDGGAE 

     30970      30980      30990      31000      31010      31020 
ITHYIVERRE TSRLNWVIVE GECLTASYVV TRLIKNNEYT FRVRAVNKYG LGVPVESEPI 

     31030      31040      31050      31060      31070      31080 
VARNSFTIPS QPGIPEEVGA GKEHIIIQWT KPESDGGNEI SNYLVDKREK KSLRWTRVNK 

     31090      31100      31110      31120      31130      31140 
DYVVYDTRLK VTSLMEGCDY QFRVTAVNAA GNSEPSEASN FISCREPSYT PGPPSAPRVV 

     31150      31160      31170      31180      31190      31200 
DTTKRSISLA WTKPMYDGGT DIIGYVLEMQ EKDTDQWCRV HTNATIRNNE FTVPDLKMGQ 

     31210      31220      31230      31240      31250      31260 
KYSFRVAAVN AKGMSDYSET TAEIEPVERL EIPDLELADD LKKTVIVRAG ASLRLMVSVS 

     31270      31280      31290      31300      31310      31320 
GRPSPVITWS KKGIDLANRA IIDNTESYSL LIVDKVNRYD AGKYTIEAEN QSGKKSATVL 

     31330      31340      31350      31360      31370      31380 
VKVYDTPGPC PSVSVKEVSR DSVTITWEIP TIDGGAPVNN YIIEKREAAM RAFKTVTTKC 

     31390      31400      31410      31420      31430      31440 
SKTLYRISGL VEGTMYYFRV LPENIYGIGE PCETSDAVLV SEVPLVPTKL EVVDVTKSTV 

     31450      31460      31470      31480      31490      31500 
TLAWEKPLYD GGSRLTGYVL EACKAGTERW MKVVTLKPTV LEHTVISLNE GEQYLFRVRA 

     31510      31520      31530      31540      31550      31560 
QNEKGVSEPR EIVTPVTVQD LRVLPTIDLS TMPQKTIHVP AGRPIELVIP ITGRPPPTAS 

     31570      31580      31590      31600      31610      31620 
WFFAGSKLRE SERVTVETHT KVTKLTIRET TIRDTGEYTL ELKNVTGTTS ETIKVIILDK 

     31630      31640      31650      31660      31670      31680 
PGPPTGPIKI DEIDATSVTI SWEPPELDGG APLSGYVVEQ RDAHRPGWLP VSESVTRPTF 

     31690      31700      31710      31720      31730      31740 
KFTRLTEGNE YVFRVAATNR FGIGSYLQSE VIECRSSISI PGPPETLQIF DVSRDGMTLT 

     31750      31760      31770      31780      31790      31800 
WYPPEDDGGS QVTGYIVERK EVRADRWVRV NKVPVTMTRY RSTGLIEGLE YEHRVTAINA 

     31810      31820      31830      31840      31850      31860 
RGTGKPSRPS KPTVAMDPIA PPGKPQNPRV TDTTRTSVSL AWSVPEDEGG SKVTGYLIEM 

     31870      31880      31890      31900      31910      31920 
QKVDQREWTK CNTTPTKIRE YTLTHLPQGA EYRFRVLACN AGGPGEPAEV PGTVKVTEML 

     31930      31940      31950      31960      31970      31980 
EYPDYELDER YQEGVFVRQG GVIRLTIPIK GKPFPVCKWT KEGQDISKRA MIATSETHTE 

     31990      32000      32010      32020      32030      32040 
LVIKEADRND SGTYDLVLEN KCGKKTVYIK VKVIGSPNTP EGPLEYDDIQ ARSVRVSWRP 

     32050      32060      32070      32080      32090      32100 
PADDGGADIL GYILERREVP KAAWYTIDSR VRGTSLVVKG LKENVEYHFR VSAENQFGIS 

     32110      32120      32130      32140      32150      32160 
KPLKSEEPVI PKTPLNPPEP PSNPPEVLDV TKSSVSLSWS RPKDDGGSRV TGYYIERKET 

     32170      32180      32190      32200      32210      32220 
STDKWVRHNK TQITTTMYTV TGLVPDAEYQ FRIIAQNDVG LSETSPASEP VVCKDPFDKP 

     32230      32240      32250      32260      32270      32280 
SQPGELEILS ISKDSVTLQW EKPECDGGKE ILGYWVEYRQ SGDSAWKKSN KERIKDRQFT 

     32290      32300      32310      32320      32330      32340 
IGGLLEATEY EFRVFAENET GLSRPRRTAM SVKTKLTSGE APGVRKEMAD VTTKLGEAAQ 

     32350      32360      32370      32380      32390      32400 
LSCQIVGRPL PDIKWYRFGK ELIQSRKYKM SSDGRTHTLT VMTDEQEDEG VYTCVATNEV 

     32410      32420      32430      32440      32450      32460 
GEVESSSKLL LQAAPQFHPG YPLKEKYYGA VGSTLRLHVM YIGRPVPAMT WFHGQKLLQN 

     32470      32480      32490      32500      32510      32520 
SEKITIENTE HYTHLVMKNV QRKTHAGKYK VQLSNAFGTV DATLDVEIQD KPDKPTGPIV 

     32530      32540      32550      32560      32570      32580 
IEALLKNSVV ISWKPPADDG GSWITNYVVE KCEAKEGAEW QLVSSAISVT TCRIVNLTEN 

     32590      32600      32610      32620      32630      32640 
AGYYFRVSAQ NTFGISEPLE VASIVIIKSP FEKPGVPGKP TITAVTKDSC VVAWKPPASD 

     32650      32660      32670      32680      32690      32700 
GGAKIRNYYL ERREKKQNKW IAVTTEEIRE TVFSVQNLIE GLEYEFRVKC ENLGGESEWS 

     32710      32720      32730      32740      32750      32760 
EISEPVTPKS DVPIQAPHFK EELRNLNVRY QSNATLVCKV TGHPKPIVKW YRQGKEIIAD 

     32770      32780      32790      32800      32810      32820 
GLKYRIQEFK GGYHQLIIAS VTDDDATVYQ VRATNQGGSV SGTASLEVEV PAKIHLPKTL 

     32830      32840      32850      32860      32870      32880 
EGMGAVHALR GEVVSIKIPF SGKPDPVITW QKGQDLIDNN GHYQVIVTRS FTSLVFSNGV 

     32890      32900      32910      32920      32930      32940 
ERKDAGFYVV CAKNRFGIDQ KTVELDVADV PDPPRGVKVS DVSRDSVNLT WTEPASDGGS 

     32950      32960      32970      32980      32990      33000 
KVTNYIVEKC ATTAERWLRV GQARETRYTV INLFGKTSYQ FRVIAENKFG LSKPSEPSEP 

     33010      33020      33030      33040      33050      33060 
TVTKEDKTRA MNYDDEVDET REVTTTKASH SKTKELYEKY MIAEDLGRGE FGIVHRCVET 

     33070      33080      33090      33100      33110      33120 
SSKRTFMAKF VKVKGTDQVL VKKEISILNI ARHRNILYLH ESFESMEELV MIFEFISGLD 

     33130      33140      33150      33160      33170      33180 
IFERINTSAF ELNEREIVSY VRQVCEALEF LHSQNIGHFD IRPENIIYQT RKNSTIKIIE 

     33190      33200      33210      33220      33230      33240 
FGQARQLKPG DNFRLLFTAP EYYAPEVHQH DVVSTATDMW SLGTLVYVLL SGINPFLAET 

     33250      33260      33270      33280      33290      33300 
NQQMIENIMN AEYTFDEEAF KEISLEAMDF VDRLLVKERK SRMTASEALQ HPWLKQRIDR 

     33310      33320      33330      33340      33350      33360 
VSTKVIRTLK HRRYYHTLIK KDLNMVVSAA RISCGGAIRS QRGVSVAKVK VASIEIGPVS 

     33370      33380      33390      33400      33410      33420 
GQIMHAIGEE GGYVKYVCKI ENYDQSTQVT WYFGVRQLEN SEKYEITYED GVATMYVKDI 

     33430      33440      33450      33460      33470      33480 
TKFDDGTYRC KVVNDYGEDS SYAELFVKGV REVYDYYCRR TKKVKRRTDA MRLLERPPEF 

     33490      33500      33510      33520      33530      33540 
TLPLYNKTAY VGENVRFGVT ITVHPEPRVT WYKSGQKIKP GDDEKKYTFE SDKGLYQLTI 

     33550      33560      33570      33580      33590      33600 
NSVTTDDDAE YTVVARNKHG EDSCKAKLTV TLHPPPTETT LRPMFKRLLA NAECHEGQSV 

     33610      33620      33630      33640      33650      33660 
CFEIRVSGIP APTLKWEKDG QPLSLGPHIE IVHEGLDYYA LHIRDTLPED TGYYRVTATN 

     33670      33680      33690      33700      33710      33720 
TAGSTSCQAH LQVERLRYVK QEFQSKEERE RHVQKQIDKT LRMAEILSGT ETVPLTPVAQ 

     33730      33740      33750      33760      33770      33780 
EALREAAILY KPAVSTKTVK GEYRLQTEEK KEERKLRMPY EVPEPRRFKQ ATVEEDQRIK 

     33790      33800      33810      33820      33830      33840 
QFVPMSDMKW YKKIRDQYEM PGKLDRVVQK RPKRIRLSRW EQFYVMPLPR ITDQYRPKWR 

     33850      33860      33870      33880      33890      33900 
IPKLTQDDLE MVRPARRRTP SPDYDLYYYR RRRRSLGDMS DEELLLPIDD YLAMKRTEEE 

     33910      33920      33930      33940      33950      33960 
RLRLEEELEL GFSASPPSRS PPRFELSSLR YSSPPAHVKV EDRRRDFRYS TYHVPTKEET 

     33970      33980      33990      34000      34010      34020 
STSYAELRER HAQASYRQPK LRQRIMAEKE EEELLRPVTT TQRLSEYKSE LDYMSKEEKS 

     34030      34040      34050      34060      34070      34080 
KKKSKRQRQV TEITEIEEEY EISRRAQRES SSSVSRLLRR RRSLSPTYIE LMRPVSELIR 

     34090      34100      34110      34120      34130      34140 
SHPRPAEEYE DDAERRSPTP ERTRPRSPSP VSSERSLSRF ERSARFDIFS RYESMKAALK 

     34150      34160      34170      34180      34190      34200 
TQKTSERKYE VLSQQPFTLD HAPRITLRMR SHRVPCGQNT RFILNVQSKP TAEVKWYHNG 

     34210      34220      34230      34240      34250      34260 
VELQESSKIH YTNTSGVLTL EILDCQTEDG GTYRAVCTNY KGEASDYATL DVTGGAYTTY 

     34270      34280      34290      34300      34310      34320 
ASQRRDEEVP KSVFPELTKT EAYAVSSFKR TSELEAASSV REVKSQMTET RESLSTYEHY 

     34330      34340      34350      34360      34370      34380 
ASAEMKSATS EEKSLEEKAT VRKIKTTLAA RILTKPRSIT VHEGESARFS CDTDGEPVPT 

     34390      34400      34410      34420      34430      34440 
VTWLREGQVV STSARHQVTT TKYKSTFEIS SVQASDEGNY SVVVENSDGK QEAQFTLTVQ 

     34450      34460      34470      34480      34490      34500 
KARVIEKAVT SPPRVKSPEP RVKSPETVKS PKRVKSPEPV TSHPKAVSPT ETKPTEKGQH 

     34510      34520      34530      34540      34550      34560 
LPVSAPPKIT QSLKAEASKD IAKLTCAVES SALCAKEVAW YKDGKKLKEN GHFQFHYSAD 

     34570      34580      34590      34600      34610      34620 
GTYELKIHNL SESDCGEYVC EVSGEGGTSK TSFQFTGQSF KSIHEQVSSI SETTKSVQKT 

     34630      34640      34650      34660      34670      34680 
AESPEAKKQE PIAPESISSK PVIVTGLRDT TVSSDSVAKF TIKVTGEPQP TITWTKDGKA 

     34690      34700      34710      34720      34730      34740 
IAQGSKYKLS SNKEEFILEI LKTETSDGGL YACTVTNSAG SVSSSCKLTI KAVKDTEAQK 

     34750      34760      34770      34780      34790      34800 
VSTQKTSEVT SQKKASAQEE ISQKALTSEE IKMSEVKSHE TLAIKEEASK VLIAEEVKRS 

     34810      34820      34830      34840      34850      34860 
AAASLEKSIV HEEVTKTSQA SEEVKTHAEI KTLSTQMNIT KGQRATLKAN IAGATDVKWV 

     34870      34880      34890      34900      34910      34920 
LNGTELPNSE EYRYGVSGSD QTLTIKQASH REEGILSCIG KTSQGVVKCQ FDLTLSEELS 

     34930      34940      34950      34960      34970      34980 
DAPSFITQPR SQNINEGQNV LFSCEVSGEP SPEIEWFKNN LPISISSNIS VSRSRNVYTL 

     34990      35000      35010      35020      35030      35040 
EIRNAAVSDS GKYTIKAKNF HGQCSATASL TVLPLVEEPP REVVLKTSSD VSLHGSVSSQ 

     35050      35060      35070      35080      35090      35100 
SVQMSASKQE ASFSSFSSSS ASSMTEMKFA SMSAQSMSSM QESFVEMSSS SFMGKSSMTQ 

     35110      35120      35130      35140      35150      35160 
LESSTSRMLK AGGRGIPPKI EALPSDISID EGKVLTVACA FTGEPTPEIT WSCGGRKIQN 

     35170      35180      35190      35200      35210 
QEQQGRFHIE NTDDLTTLII MDVQKQDGGL YTLSLGNEFG SDSATVNINI RSM 

« Hide

Isoform 2 [UniParc].

Checksum: BE4AE1E168D24495
Show »

FASTA26,8862,986,411
Isoform 3 [UniParc].

Checksum: 9A7C2E2116CC400E
Show »

FASTA5,508619,332

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 28297-28311 AND 34728-34734, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[3]"Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle."
Gautel M., Fuerst D.O., Cocco A., Schiaffino S.
Circ. Res. 82:124-129(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[4]"M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere."
Weinert S., Bergmann N., Luo X., Erdmann B., Gotthardt M.
J. Cell Biol. 173:559-570(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"A proteomics approach to identify the ubiquitinated proteins in mouse heart."
Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-10665; LYS-10679; LYS-10686; LYS-30428 AND LYS-31008.
Tissue: Heart.
[6]"Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region."
Peng J., Raddatz K., Molkentin J.D., Wu Y., Labeit S., Granzier H., Gotthardt M.
Circulation 115:743-751(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL928681, AL928721, AL928789 Genomic DNA. Translation: CAM27058.1.
AL928681, AL928721, AL928789 Genomic DNA. Translation: CAM27059.1.
AL928681, AL928721 Genomic DNA. Translation: CAM27060.1.
AL928721, AL928681, AL928789 Genomic DNA. Translation: CAM23448.1.
AL928721, AL928681, AL928789 Genomic DNA. Translation: CAM23449.1.
AL928721, AL928681 Genomic DNA. Translation: CAM23450.1.
AL928789, AL928681, AL928721 Genomic DNA. Translation: CAM24262.1.
AL928789, AL928681, AL928721 Genomic DNA. Translation: CAM24263.1.
UniGeneMm.373672.
Mm.446279.
Mm.473358.

3D structure databases

ProteinModelPortalA2ASS6.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteA2ASS6.

Proteomic databases

PaxDbA2ASS6.
PRIDEA2ASS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000011934; ENSMUSP00000011934; ENSMUSG00000051747. [A2ASS6-2]
ENSMUST00000099980; ENSMUSP00000097560; ENSMUSG00000051747. [A2ASS6-3]
ENSMUST00000099981; ENSMUSP00000097561; ENSMUSG00000051747. [A2ASS6-1]

Organism-specific databases

MGIMGI:98864. Ttn.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117320.
HOGENOMHOG000136636.
HOVERGENHBG080472.
InParanoidA2ASS6.
OMATWFHNNR.
OrthoDBEOG7N8ZTK.
PhylomeDBA2ASS6.
TreeFamTF316477.

Gene expression databases

ArrayExpressA2ASS6.
BgeeA2ASS6.
CleanExMM_TTN.
GenevestigatorA2ASS6.

Family and domain databases

Gene3D2.60.40.10. 299 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004168. PPAK_motif.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR015129. Titin_Z.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF00041. fn3. 132 hits.
PF07679. I-set. 161 hits.
PF00069. Pkinase. 1 hit.
PF02818. PPAK. 15 hits.
PF09042. Titin_Z. 7 hits.
[Graphical view]
SMARTSM00060. FN3. 132 hits.
SM00409. IG. 93 hits.
SM00408. IGc2. 70 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 83 hits.
SSF56112. SSF56112. 1 hit.
PROSITEPS50853. FN3. 132 hits.
PS50835. IG_LIKE. 140 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROA2ASS6.
SOURCESearch...

Entry information

Entry nameTITIN_MOUSE
AccessionPrimary (citable) accession number: A2ASS6
Secondary accession number(s): A2ASS5, A2ASS7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot