##gff-version 3 A2ASI5 UniProtKB Chain 1 1947 . . . ID=PRO_0000444899;Note=Sodium channel protein type 3 subunit alpha A2ASI5 UniProtKB Topological domain 1 128 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 129 147 . . . Note=Helical%3B Name%3DS1 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 148 154 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 155 175 . . . Note=Helical%3B Name%3DS2 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 176 189 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 190 207 . . . Note=Helical%3B Name%3DS3 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 208 213 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 214 230 . . . Note=Helical%3B Name%3DS4 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 231 249 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 250 269 . . . Note=Helical%3B Name%3DS5 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 270 368 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Intramembrane 369 393 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 394 400 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 401 421 . . . Note=Helical%3B Name%3DS6 of repeat I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 422 711 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 712 730 . . . Note=Helical%3B Name%3DS1 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 731 741 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 742 761 . . . Note=Helical%3B Name%3DS2 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 762 775 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 776 795 . . . Note=Helical%3B Name%3DS3 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 796 797 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 798 815 . . . Note=Helical%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 816 831 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 832 850 . . . Note=Helical%3B Name%3DS5 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 851 879 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Intramembrane 880 900 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 901 913 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 914 934 . . . Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 935 1158 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1159 1177 . . . Note=Helical%3B Name%3DS1 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1178 1190 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1191 1209 . . . Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1210 1223 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1224 1242 . . . Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1243 1250 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1251 1269 . . . Note=Helical%3B Name%3DS4 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1270 1286 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1287 1306 . . . Note=Helical%3B Name%3DS5 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1307 1355 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Intramembrane 1356 1377 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1378 1394 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1395 1416 . . . Note=Helical%3B Name%3DS6 of repeat III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1417 1479 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1480 1497 . . . Note=Helical%3B Name%3DS1 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1498 1508 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1509 1527 . . . Note=Helical%3B Name%3DS2 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1528 1539 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1540 1557 . . . Note=Helical%3B Name%3DS3 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1558 1570 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1571 1587 . . . Note=Helical%3B Name%3DS4 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1588 1606 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1607 1624 . . . Note=Helical%3B Name%3DS5 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1625 1646 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Intramembrane 1647 1669 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1670 1699 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Transmembrane 1700 1722 . . . Note=Helical%3B Name%3DS6 of repeat IV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Topological domain 1723 1947 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Repeat 110 455 . . . Note=I;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Repeat 693 965 . . . Note=II;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Repeat 1140 1451 . . . Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Repeat 1460 1758 . . . Note=IV;Ontology_term=ECO:0000305;evidence=ECO:0000305 A2ASI5 UniProtKB Domain 1852 1881 . . . Note=IQ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116 A2ASI5 UniProtKB Region 28 60 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Region 493 529 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Region 587 632 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Region 1070 1113 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Region 1901 1947 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Compositional bias 28 53 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Compositional bias 497 511 . . . Note=Basic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Compositional bias 512 529 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Compositional bias 587 616 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Compositional bias 1903 1924 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Compositional bias 1925 1947 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A2ASI5 UniProtKB Modified residue 484 484 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08104 A2ASI5 UniProtKB Modified residue 485 485 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08104 A2ASI5 UniProtKB Modified residue 486 486 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08104 A2ASI5 UniProtKB Modified residue 1453 1453 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14524 A2ASI5 UniProtKB Glycosylation 211 211 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 A2ASI5 UniProtKB Glycosylation 290 290 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 A2ASI5 UniProtKB Glycosylation 296 296 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 A2ASI5 UniProtKB Glycosylation 302 302 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 A2ASI5 UniProtKB Glycosylation 307 307 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 A2ASI5 UniProtKB Glycosylation 339 339 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 A2ASI5 UniProtKB Glycosylation 1318 1318 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 A2ASI5 UniProtKB Glycosylation 1332 1332 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 A2ASI5 UniProtKB Disulfide bond 277 346 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Disulfide bond 862 862 . . . Note=Interchain%3B with SCN2B or SCN4B;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04775 A2ASI5 UniProtKB Disulfide bond 862 862 . . . Note=Interchain%3B with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B%3B the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04775 A2ASI5 UniProtKB Disulfide bond 902 911 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 A2ASI5 UniProtKB Alternative sequence 208 208 . . . ID=VSP_059662;Note=In isoform 3. D->S A2ASI5 UniProtKB Alternative sequence 624 624 . . . ID=VSP_059663;Note=In isoform 2 and isoform 3. N->NVSQ A2ASI5 UniProtKB Natural variant 494 494 . . . Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25937544;Dbxref=PMID:25937544