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A2ASI5

- A2ASI5_MOUSE

UniProt

A2ASI5 - A2ASI5_MOUSE

Protein

Sodium channel protein

Gene

Scn3a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

    GO - Molecular functioni

    1. voltage-gated sodium channel activity Source: RefGenome

    GO - Biological processi

    1. membrane depolarization during action potential Source: RefGenome
    2. neuronal action potential Source: RefGenome
    3. sodium ion transmembrane transport Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel proteinUniRule annotation
    Gene namesi
    Name:Scn3aImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:98249. Scn3a.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. membrane Source: MGI
    3. plasma membrane Source: RefGenome
    4. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00560000076721.
    HOGENOMiHOG000231755.
    HOVERGENiHBG053100.
    KOiK04836.
    OMAiSYFNGTM.
    OrthoDBiEOG7DJSK9.
    TreeFamiTF323985.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028808. Na_channel_a3su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PANTHERiPTHR10037:SF200. PTHR10037:SF200. 1 hit.
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2ASI5-1 [UniParc]FASTAAdd to Basket

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    MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK     50
    PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF 100
    RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP 150
    PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM 200
    AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV 250
    MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFEIN TTSYFNGTMD 300
    SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY 350
    ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY 400
    MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE 450
    QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR 500
    NRRKKRRQRE HLEGNHRPEG DRFPKSESED SVKRRSFLFS LDGNPLSGDK 550
    KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 600
    FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS 650
    SGRQRAMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDSWLKV 700
    KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF 750
    TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV 800
    LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV 850
    GMQLFGKSYK ECVCKINEDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 900
    DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN 950
    EMNNLQIAVG RMQKGIDYVK NKIRECFRKA FFRKPKVIEI HEGNKIDSCM 1000
    SNNTGVVEIS KELNYLKDGN GTTSGVGTGS SVEKYVIDEN DYMSFINNPS 1050
    LTVTVPIAVG ESDFENLNTE EFSSESELEE SKEKLNATSS SEGSTVDVAP 1100
    PREGEQAEIE PEEDLKPEAC FTEGCIKKFP FCQVSTEEGK GKIWWNLRKT 1150
    CYSIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT 1200
    YIFILEMLLK WVAYGFQTYF TNAWCWLDFL IVDVSLVSLV ANALGYSELG 1250
    AIKSLRTLRA LRPLRALSRF EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI 1300
    FSIMGVNLFA GKFYHCVNMT TGSMFDMSEV NNFSDCQALG KQARWKNVKV 1350
    NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRDVKLQPVY EENLYMYLYF 1400
    VIFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE QKKYYNAMKK 1450
    LGSKKPQKPI PRPANKFQGM VFDFVTRQVF DISIMILICL NMVTMMVETD 1500
    DQSKYMTLVL SRINLVFIVL FTGEFLLKLI SLRYYYFTIG WNIFDFVVVI 1550
    LSIVGMFLAE LIEKYFVSPT LFRVIRLARI GRILRLIKGA KGIRTLLFAL 1600
    MMSLPALFNI GLLLFLVMFI YAIFGMSNFA YVKKEAGIDD MFNFETFGNS 1650
    MICLFQITTS AGWDGLLAPI LNSAPPDCDP DAIHPGSSVK GDCGNPSVGI 1700
    FFFVSYIIIS FLVVVNMYIA VILENFSVAT EESAEPLSED DFEMFYEVWE 1750
    KFDPDATQFI EFCKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH 1800
    CLDILFAFTK RVLGESGEMD ALRIQMEDRF MASNPSKVSY EPITTTLKRK 1850
    QEEVSAAIIQ RNYRCYLLKQ RLKNISNTYD KETIKGRIVL PIKGDMVIDK 1900
    LNGNSTPEKT DGSSSTTSPP SYDSVTKPDK EKFEKDKPEK ESKGKEV 1947
    Length:1,947
    Mass (Da):220,880
    Last modified:February 5, 2008 - v1
    Checksum:iB5E01EEC78004E15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772235 Genomic DNA. No translation available.
    AL928621 Genomic DNA. No translation available.
    RefSeqiNP_061202.3. NM_018732.3.
    UniGeneiMm.330256.

    Genome annotation databases

    EnsembliENSMUST00000066432; ENSMUSP00000065023; ENSMUSG00000057182.
    ENSMUST00000100069; ENSMUSP00000097647; ENSMUSG00000057182.
    GeneIDi20269.
    KEGGimmu:20269.
    UCSCiuc012bwa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772235 Genomic DNA. No translation available.
    AL928621 Genomic DNA. No translation available.
    RefSeqi NP_061202.3. NM_018732.3.
    UniGenei Mm.330256.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000066432 ; ENSMUSP00000065023 ; ENSMUSG00000057182 .
    ENSMUST00000100069 ; ENSMUSP00000097647 ; ENSMUSG00000057182 .
    GeneIDi 20269.
    KEGGi mmu:20269.
    UCSCi uc012bwa.1. mouse.

    Organism-specific databases

    CTDi 6328.
    MGIi MGI:98249. Scn3a.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00560000076721.
    HOGENOMi HOG000231755.
    HOVERGENi HBG053100.
    KOi K04836.
    OMAi SYFNGTM.
    OrthoDBi EOG7DJSK9.
    TreeFami TF323985.

    Miscellaneous databases

    NextBioi 297943.
    PROi A2ASI5.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028808. Na_channel_a3su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    PANTHERi PTHR10037:SF200. PTHR10037:SF200. 1 hit.
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2ASI5_MOUSE
    AccessioniPrimary (citable) accession number: A2ASI5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3