A2ASI5 (A2ASI5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Scn3a Ensembl ENSMUSP00000065023 Ensembl ENSMUSP00000097647

Gene names

Name:

Scn3a Ensembl ENSMUSP00000065023 Ensembl ENSMUSP00000097647 MGI 98249

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000065023

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1947 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003809.
Sequence similarities	Belongs to the sodium channel family. RuleBase RU003809
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000065023 Ensembl ENSMUSP00000097647

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Sodium
Molecular function	Ion channel Sodium channel RuleBase RU003809 Voltage-gated channel RuleBase RU003809
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sodium ion transmembrane transport Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from direct assay PubMed 15746173. Source: MGI membrane Inferred from direct assay PubMed 17537961. Source: MGI voltage-gated sodium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	voltage-gated sodium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2ASI5 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: B5E01EEC78004E15	FASTA	1,947	220,880
	10 20 30 40 50 60 MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK PNSDLEAGKN 70 80 90 100 110 120 LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF RFSATSALYI LTPLNPVRKI 130 140 150 160 170 180 AIKILVHSLF SMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL 190 200 210 220 230 240 EDFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 250 260 270 280 290 300 IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFEIN TTSYFNGTMD 310 320 330 340 350 360 SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY ICVKAGRNPN 370 380 390 400 410 420 YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL 430 440 450 460 470 480 AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGIGGLGE 490 500 510 520 530 540 LLESSSEASK LSSKSAKEWR NRRKKRRQRE HLEGNHRPEG DRFPKSESED SVKRRSFLFS 550 560 570 580 590 600 LDGNPLSGDK KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 610 620 630 640 650 660 FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS SGRQRAMSIA 670 680 690 700 710 720 SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDSWLKV KHLVNLIVMD PFVDLAITIC 730 740 750 760 770 780 IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG 790 800 810 820 830 840 IIVSLSLMEL GLANVEGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL 850 860 870 880 890 900 AIIVFIFAVV GMQLFGKSYK ECVCKINEDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 910 920 930 940 950 960 DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN EMNNLQIAVG 970 980 990 1000 1010 1020 RMQKGIDYVK NKIRECFRKA FFRKPKVIEI HEGNKIDSCM SNNTGVVEIS KELNYLKDGN 1030 1040 1050 1060 1070 1080 GTTSGVGTGS SVEKYVIDEN DYMSFINNPS LTVTVPIAVG ESDFENLNTE EFSSESELEE 1090 1100 1110 1120 1130 1140 SKEKLNATSS SEGSTVDVAP PREGEQAEIE PEEDLKPEAC FTEGCIKKFP FCQVSTEEGK 1150 1160 1170 1180 1190 1200 GKIWWNLRKT CYSIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT 1210 1220 1230 1240 1250 1260 YIFILEMLLK WVAYGFQTYF TNAWCWLDFL IVDVSLVSLV ANALGYSELG AIKSLRTLRA 1270 1280 1290 1300 1310 1320 LRPLRALSRF EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYHCVNMT 1330 1340 1350 1360 1370 1380 TGSMFDMSEV NNFSDCQALG KQARWKNVKV NFDNVGAGYL ALLQVATFKG WMDIMYAAVD 1390 1400 1410 1420 1430 1440 SRDVKLQPVY EENLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE 1450 1460 1470 1480 1490 1500 QKKYYNAMKK LGSKKPQKPI PRPANKFQGM VFDFVTRQVF DISIMILICL NMVTMMVETD 1510 1520 1530 1540 1550 1560 DQSKYMTLVL SRINLVFIVL FTGEFLLKLI SLRYYYFTIG WNIFDFVVVI LSIVGMFLAE 1570 1580 1590 1600 1610 1620 LIEKYFVSPT LFRVIRLARI GRILRLIKGA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI 1630 1640 1650 1660 1670 1680 YAIFGMSNFA YVKKEAGIDD MFNFETFGNS MICLFQITTS AGWDGLLAPI LNSAPPDCDP 1690 1700 1710 1720 1730 1740 DAIHPGSSVK GDCGNPSVGI FFFVSYIIIS FLVVVNMYIA VILENFSVAT EESAEPLSED 1750 1760 1770 1780 1790 1800 DFEMFYEVWE KFDPDATQFI EFCKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH 1810 1820 1830 1840 1850 1860 CLDILFAFTK RVLGESGEMD ALRIQMEDRF MASNPSKVSY EPITTTLKRK QEEVSAAIIQ 1870 1880 1890 1900 1910 1920 RNYRCYLLKQ RLKNISNTYD KETIKGRIVL PIKGDMVIDK LNGNSTPEKT DGSSSTTSPP 1930 1940 SYDSVTKPDK EKFEKDKPEK ESKGKEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000065023 Ensembl ENSMUSP00000097647.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000065023 Ensembl ENSMUSP00000097647.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL772235 Genomic DNA. No translation available. AL928621 Genomic DNA. No translation available.
IPI	IPI00831467.
RefSeq	NP_061202.3. NM_018732.3.
UniGene	Mm.330256.
3D structure databases
SMR	A2ASI5. Positions 1724-1876.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000066432; ENSMUSP00000065023; ENSMUSG00000057182. ENSMUST00000100069; ENSMUSP00000097647; ENSMUSG00000057182.
GeneID	20269.
KEGG	mmu:20269.
UCSC	uc012bwa.1. mouse.
Organism-specific databases
CTD	6328.
MGI	MGI:98249. Scn3a.
Phylogenomic databases
eggNOG	COG1226.
GeneTree	ENSGT00560000076721.
HOGENOM	HOG000231755.
HOVERGEN	HBG053100.
KO	K04836.
OMA	NGTMDSN.
OrthoDB	EOG4Z36CT.
Family and domain databases
InterPro	IPR024583. DUF3451. IPR005821. Ion_trans_dom. IPR000048. IQ_motif_EF-hand-BS. IPR001696. Na_channel_asu. IPR010526. Na_trans_assoc. [Graphical view]
Pfam	PF11933. DUF3451. 1 hit. PF00520. Ion_trans. 4 hits. PF06512. Na_trans_assoc. 1 hit. [Graphical view]
PRINTS	PR00170. NACHANNEL.
SMART	SM00015. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	297943.
SOURCE	Search...

Entry information

Entry name

A2ASI5_MOUSE

Accession

Primary (citable) accession number: A2ASI5

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	March 6, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)