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A2ASI5 (A2ASI5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length1947 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes By similarity. RuleBase RU361132

Subcellular location

Membrane; Multi-pass membrane protein By similarity RuleBase RU361132.

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification] RuleBase RU361132

Caution

Lacks conserved residue(s) required for the propagation of feature annotation. RuleBase RU361132

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000065023 Ensembl ENSMUSP00000097647

Sequences

Sequence LengthMass (Da)Tools
A2ASI5 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: B5E01EEC78004E15

FASTA1,947220,880
        10         20         30         40         50         60 
MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK PNSDLEAGKN 

        70         80         90        100        110        120 
LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF RFSATSALYI LTPLNPVRKI 

       130        140        150        160        170        180 
AIKILVHSLF SMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL 

       190        200        210        220        230        240 
EDFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 

       250        260        270        280        290        300 
IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFEIN TTSYFNGTMD 

       310        320        330        340        350        360 
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY ICVKAGRNPN 

       370        380        390        400        410        420 
YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL 

       430        440        450        460        470        480 
AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGIGGLGE 

       490        500        510        520        530        540 
LLESSSEASK LSSKSAKEWR NRRKKRRQRE HLEGNHRPEG DRFPKSESED SVKRRSFLFS 

       550        560        570        580        590        600 
LDGNPLSGDK KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 

       610        620        630        640        650        660 
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS SGRQRAMSIA 

       670        680        690        700        710        720 
SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDSWLKV KHLVNLIVMD PFVDLAITIC 

       730        740        750        760        770        780 
IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG 

       790        800        810        820        830        840 
IIVSLSLMEL GLANVEGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL 

       850        860        870        880        890        900 
AIIVFIFAVV GMQLFGKSYK ECVCKINEDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 

       910        920        930        940        950        960 
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN EMNNLQIAVG 

       970        980        990       1000       1010       1020 
RMQKGIDYVK NKIRECFRKA FFRKPKVIEI HEGNKIDSCM SNNTGVVEIS KELNYLKDGN 

      1030       1040       1050       1060       1070       1080 
GTTSGVGTGS SVEKYVIDEN DYMSFINNPS LTVTVPIAVG ESDFENLNTE EFSSESELEE 

      1090       1100       1110       1120       1130       1140 
SKEKLNATSS SEGSTVDVAP PREGEQAEIE PEEDLKPEAC FTEGCIKKFP FCQVSTEEGK 

      1150       1160       1170       1180       1190       1200 
GKIWWNLRKT CYSIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT 

      1210       1220       1230       1240       1250       1260 
YIFILEMLLK WVAYGFQTYF TNAWCWLDFL IVDVSLVSLV ANALGYSELG AIKSLRTLRA 

      1270       1280       1290       1300       1310       1320 
LRPLRALSRF EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYHCVNMT 

      1330       1340       1350       1360       1370       1380 
TGSMFDMSEV NNFSDCQALG KQARWKNVKV NFDNVGAGYL ALLQVATFKG WMDIMYAAVD 

      1390       1400       1410       1420       1430       1440 
SRDVKLQPVY EENLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE 

      1450       1460       1470       1480       1490       1500 
QKKYYNAMKK LGSKKPQKPI PRPANKFQGM VFDFVTRQVF DISIMILICL NMVTMMVETD 

      1510       1520       1530       1540       1550       1560 
DQSKYMTLVL SRINLVFIVL FTGEFLLKLI SLRYYYFTIG WNIFDFVVVI LSIVGMFLAE 

      1570       1580       1590       1600       1610       1620 
LIEKYFVSPT LFRVIRLARI GRILRLIKGA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI 

      1630       1640       1650       1660       1670       1680 
YAIFGMSNFA YVKKEAGIDD MFNFETFGNS MICLFQITTS AGWDGLLAPI LNSAPPDCDP 

      1690       1700       1710       1720       1730       1740 
DAIHPGSSVK GDCGNPSVGI FFFVSYIIIS FLVVVNMYIA VILENFSVAT EESAEPLSED 

      1750       1760       1770       1780       1790       1800 
DFEMFYEVWE KFDPDATQFI EFCKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH 

      1810       1820       1830       1840       1850       1860 
CLDILFAFTK RVLGESGEMD ALRIQMEDRF MASNPSKVSY EPITTTLKRK QEEVSAAIIQ 

      1870       1880       1890       1900       1910       1920 
RNYRCYLLKQ RLKNISNTYD KETIKGRIVL PIKGDMVIDK LNGNSTPEKT DGSSSTTSPP 

      1930       1940 
SYDSVTKPDK EKFEKDKPEK ESKGKEV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL772235 Genomic DNA. No translation available.
AL928621 Genomic DNA. No translation available.
RefSeqNP_061202.3. NM_018732.3.
UniGeneMm.330256.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000066432; ENSMUSP00000065023; ENSMUSG00000057182.
ENSMUST00000100069; ENSMUSP00000097647; ENSMUSG00000057182.
GeneID20269.
KEGGmmu:20269.
UCSCuc012bwa.1. mouse.

Organism-specific databases

CTD6328.
MGIMGI:98249. Scn3a.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00560000076721.
HOGENOMHOG000231755.
HOVERGENHBG053100.
KOK04836.
OMASYFNGTM.
OrthoDBEOG7DJSK9.
TreeFamTF323985.

Family and domain databases

Gene3D1.20.120.350. 4 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERPTHR10037:SF200. PTHR10037:SF200. 1 hit.
PfamPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSPR00170. NACHANNEL.
SMARTSM00015. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297943.
PROA2ASI5.
SOURCESearch...

Entry information

Entry nameA2ASI5_MOUSE
AccessionPrimary (citable) accession number: A2ASI5
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)