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A2ASI5

- A2ASI5_MOUSE

UniProt

A2ASI5 - A2ASI5_MOUSE

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Protein
Sodium channel protein
Gene
Scn3a
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes By similarity.UniRule annotation

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. membrane depolarization during action potential Source: RefGenome
  2. neuronal action potential Source: RefGenome
  3. sodium ion transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn3aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:98249. Scn3a.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. membrane Source: MGI
  3. plasma membrane Source: RefGenome
  4. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00560000076721.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04836.
OMAiSYFNGTM.
OrthoDBiEOG7DJSK9.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF200. PTHR10037:SF200. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ASI5-1 [UniParc]FASTAAdd to Basket

« Hide

MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK     50
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF 100
RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP 150
PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM 200
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV 250
MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFEIN TTSYFNGTMD 300
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY 350
ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY 400
MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE 450
QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR 500
NRRKKRRQRE HLEGNHRPEG DRFPKSESED SVKRRSFLFS LDGNPLSGDK 550
KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 600
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS 650
SGRQRAMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDSWLKV 700
KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF 750
TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV 800
LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV 850
GMQLFGKSYK ECVCKINEDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 900
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN 950
EMNNLQIAVG RMQKGIDYVK NKIRECFRKA FFRKPKVIEI HEGNKIDSCM 1000
SNNTGVVEIS KELNYLKDGN GTTSGVGTGS SVEKYVIDEN DYMSFINNPS 1050
LTVTVPIAVG ESDFENLNTE EFSSESELEE SKEKLNATSS SEGSTVDVAP 1100
PREGEQAEIE PEEDLKPEAC FTEGCIKKFP FCQVSTEEGK GKIWWNLRKT 1150
CYSIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT 1200
YIFILEMLLK WVAYGFQTYF TNAWCWLDFL IVDVSLVSLV ANALGYSELG 1250
AIKSLRTLRA LRPLRALSRF EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI 1300
FSIMGVNLFA GKFYHCVNMT TGSMFDMSEV NNFSDCQALG KQARWKNVKV 1350
NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRDVKLQPVY EENLYMYLYF 1400
VIFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE QKKYYNAMKK 1450
LGSKKPQKPI PRPANKFQGM VFDFVTRQVF DISIMILICL NMVTMMVETD 1500
DQSKYMTLVL SRINLVFIVL FTGEFLLKLI SLRYYYFTIG WNIFDFVVVI 1550
LSIVGMFLAE LIEKYFVSPT LFRVIRLARI GRILRLIKGA KGIRTLLFAL 1600
MMSLPALFNI GLLLFLVMFI YAIFGMSNFA YVKKEAGIDD MFNFETFGNS 1650
MICLFQITTS AGWDGLLAPI LNSAPPDCDP DAIHPGSSVK GDCGNPSVGI 1700
FFFVSYIIIS FLVVVNMYIA VILENFSVAT EESAEPLSED DFEMFYEVWE 1750
KFDPDATQFI EFCKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH 1800
CLDILFAFTK RVLGESGEMD ALRIQMEDRF MASNPSKVSY EPITTTLKRK 1850
QEEVSAAIIQ RNYRCYLLKQ RLKNISNTYD KETIKGRIVL PIKGDMVIDK 1900
LNGNSTPEKT DGSSSTTSPP SYDSVTKPDK EKFEKDKPEK ESKGKEV 1947
Length:1,947
Mass (Da):220,880
Last modified:February 5, 2008 - v1
Checksum:iB5E01EEC78004E15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772235 Genomic DNA. No translation available.
AL928621 Genomic DNA. No translation available.
RefSeqiNP_061202.3. NM_018732.3.
UniGeneiMm.330256.

Genome annotation databases

EnsembliENSMUST00000066432; ENSMUSP00000065023; ENSMUSG00000057182.
ENSMUST00000100069; ENSMUSP00000097647; ENSMUSG00000057182.
GeneIDi20269.
KEGGimmu:20269.
UCSCiuc012bwa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772235 Genomic DNA. No translation available.
AL928621 Genomic DNA. No translation available.
RefSeqi NP_061202.3. NM_018732.3.
UniGenei Mm.330256.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066432 ; ENSMUSP00000065023 ; ENSMUSG00000057182 .
ENSMUST00000100069 ; ENSMUSP00000097647 ; ENSMUSG00000057182 .
GeneIDi 20269.
KEGGi mmu:20269.
UCSCi uc012bwa.1. mouse.

Organism-specific databases

CTDi 6328.
MGIi MGI:98249. Scn3a.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00560000076721.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
KOi K04836.
OMAi SYFNGTM.
OrthoDBi EOG7DJSK9.
TreeFami TF323985.

Miscellaneous databases

NextBioi 297943.
PROi A2ASI5.
SOURCEi Search...

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF200. PTHR10037:SF200. 1 hit.
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2ASI5_MOUSE
AccessioniPrimary (citable) accession number: A2ASI5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi