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A2ASI5

- A2ASI5_MOUSE

UniProt

A2ASI5 - A2ASI5_MOUSE

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Protein

Sodium channel protein

Gene

Scn3a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: RefGenome

GO - Biological processi

  1. membrane depolarization during action potential Source: RefGenome
  2. neuronal action potential Source: RefGenome
  3. sodium ion transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn3aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:98249. Scn3a.

Subcellular locationi

Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. membrane Source: MGI
  3. plasma membrane Source: RefGenome
  4. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118827.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04836.
OMAiSYFNGTM.
OrthoDBiEOG7DJSK9.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF200. PTHR10037:SF200. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ASI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF
110 120 130 140 150
RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP
160 170 180 190 200
PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM
210 220 230 240 250
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
260 270 280 290 300
MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFEIN TTSYFNGTMD
310 320 330 340 350
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY
360 370 380 390 400
ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY
410 420 430 440 450
MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE
460 470 480 490 500
QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR
510 520 530 540 550
NRRKKRRQRE HLEGNHRPEG DRFPKSESED SVKRRSFLFS LDGNPLSGDK
560 570 580 590 600
KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST
610 620 630 640 650
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS
660 670 680 690 700
SGRQRAMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDSWLKV
710 720 730 740 750
KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF
760 770 780 790 800
TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV
810 820 830 840 850
LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV
860 870 880 890 900
GMQLFGKSYK ECVCKINEDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW
910 920 930 940 950
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN
960 970 980 990 1000
EMNNLQIAVG RMQKGIDYVK NKIRECFRKA FFRKPKVIEI HEGNKIDSCM
1010 1020 1030 1040 1050
SNNTGVVEIS KELNYLKDGN GTTSGVGTGS SVEKYVIDEN DYMSFINNPS
1060 1070 1080 1090 1100
LTVTVPIAVG ESDFENLNTE EFSSESELEE SKEKLNATSS SEGSTVDVAP
1110 1120 1130 1140 1150
PREGEQAEIE PEEDLKPEAC FTEGCIKKFP FCQVSTEEGK GKIWWNLRKT
1160 1170 1180 1190 1200
CYSIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT
1210 1220 1230 1240 1250
YIFILEMLLK WVAYGFQTYF TNAWCWLDFL IVDVSLVSLV ANALGYSELG
1260 1270 1280 1290 1300
AIKSLRTLRA LRPLRALSRF EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI
1310 1320 1330 1340 1350
FSIMGVNLFA GKFYHCVNMT TGSMFDMSEV NNFSDCQALG KQARWKNVKV
1360 1370 1380 1390 1400
NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRDVKLQPVY EENLYMYLYF
1410 1420 1430 1440 1450
VIFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE QKKYYNAMKK
1460 1470 1480 1490 1500
LGSKKPQKPI PRPANKFQGM VFDFVTRQVF DISIMILICL NMVTMMVETD
1510 1520 1530 1540 1550
DQSKYMTLVL SRINLVFIVL FTGEFLLKLI SLRYYYFTIG WNIFDFVVVI
1560 1570 1580 1590 1600
LSIVGMFLAE LIEKYFVSPT LFRVIRLARI GRILRLIKGA KGIRTLLFAL
1610 1620 1630 1640 1650
MMSLPALFNI GLLLFLVMFI YAIFGMSNFA YVKKEAGIDD MFNFETFGNS
1660 1670 1680 1690 1700
MICLFQITTS AGWDGLLAPI LNSAPPDCDP DAIHPGSSVK GDCGNPSVGI
1710 1720 1730 1740 1750
FFFVSYIIIS FLVVVNMYIA VILENFSVAT EESAEPLSED DFEMFYEVWE
1760 1770 1780 1790 1800
KFDPDATQFI EFCKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH
1810 1820 1830 1840 1850
CLDILFAFTK RVLGESGEMD ALRIQMEDRF MASNPSKVSY EPITTTLKRK
1860 1870 1880 1890 1900
QEEVSAAIIQ RNYRCYLLKQ RLKNISNTYD KETIKGRIVL PIKGDMVIDK
1910 1920 1930 1940
LNGNSTPEKT DGSSSTTSPP SYDSVTKPDK EKFEKDKPEK ESKGKEV
Length:1,947
Mass (Da):220,880
Last modified:February 5, 2008 - v1
Checksum:iB5E01EEC78004E15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772235 Genomic DNA. No translation available.
AL928621 Genomic DNA. No translation available.
RefSeqiNP_061202.3. NM_018732.3.
UniGeneiMm.330256.

Genome annotation databases

EnsembliENSMUST00000066432; ENSMUSP00000065023; ENSMUSG00000057182.
ENSMUST00000100069; ENSMUSP00000097647; ENSMUSG00000057182.
GeneIDi20269.
KEGGimmu:20269.
UCSCiuc012bwa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772235 Genomic DNA. No translation available.
AL928621 Genomic DNA. No translation available.
RefSeqi NP_061202.3. NM_018732.3.
UniGenei Mm.330256.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066432 ; ENSMUSP00000065023 ; ENSMUSG00000057182 .
ENSMUST00000100069 ; ENSMUSP00000097647 ; ENSMUSG00000057182 .
GeneIDi 20269.
KEGGi mmu:20269.
UCSCi uc012bwa.1. mouse.

Organism-specific databases

CTDi 6328.
MGIi MGI:98249. Scn3a.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118827.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
KOi K04836.
OMAi SYFNGTM.
OrthoDBi EOG7DJSK9.
TreeFami TF323985.

Miscellaneous databases

NextBioi 297943.
PROi A2ASI5.
SOURCEi Search...

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF200. PTHR10037:SF200. 1 hit.
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2ASI5_MOUSE
AccessioniPrimary (citable) accession number: A2ASI5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3