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Protein

Ankyrin repeat domain-containing protein 16

Gene

Ankrd16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 16
Gene namesi
Name:Ankrd16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2444796. Ankrd16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Ankyrin repeat domain-containing protein 16PRO_0000320068Add
BLAST

Proteomic databases

MaxQBiA2AS55.
PaxDbiA2AS55.
PRIDEiA2AS55.

PTM databases

PhosphoSiteiA2AS55.

Expressioni

Gene expression databases

BgeeiA2AS55.
CleanExiMM_ANKRD16.
ExpressionAtlasiA2AS55. baseline and differential.
GenevisibleiA2AS55. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052056.

Structurei

3D structure databases

ProteinModelPortaliA2AS55.
SMRiA2AS55. Positions 8-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 6631ANK 1Add
BLAST
Repeati70 – 9930ANK 2Add
BLAST
Repeati103 – 13230ANK 3Add
BLAST
Repeati136 – 16530ANK 4Add
BLAST
Repeati170 – 20031ANK 5Add
BLAST
Repeati204 – 23330ANK 6Add
BLAST
Repeati238 – 26831ANK 7Add
BLAST
Repeati273 – 30230ANK 8Add
BLAST
Repeati306 – 33530ANK 9Add
BLAST

Sequence similaritiesi

Contains 9 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOGENOMiHOG000015234.
HOVERGENiHBG056770.
InParanoidiA2AS55.
OMAiHMACIGQ.
OrthoDBiEOG7N63NG.
PhylomeDBiA2AS55.
TreeFamiTF329520.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AS55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPGDPRRL CRLVQEGRLR DLQEELAVAR GCRGPAGDTL LHCAARHGRQ
60 70 80 90 100
DILAYLVEAW SMDIEATNRD YKRPLHEAAS MGHRDCVRYL LGRGAVVDSL
110 120 130 140 150
KKADWTPLMM ACTRKNLDVI QDLVEHGANP LLKNKDGWNS FHIASREGHP
160 170 180 190 200
VILRYLLTVC PDAWKTESNI RRTPLHTAAM HGCLEAVQVL LERCHYEPDC
210 220 230 240 250
RDNCGVTPFM DAIQCGHVSI AKLLLEQHKA CSSAADSMGA QALHRAAVTG
260 270 280 290 300
QDEAIRFLVC GLGIDVDVRA KSSQLTALHY AAKEGQTNTV QTLLSLGADI
310 320 330 340 350
NSTDERNRSV LHLACAGQHV ACTRLLLQSG LKDSEDLTGT LAQQLTRSVD
360
ILQDFDHDVK S
Length:361
Mass (Da):39,776
Last modified:February 20, 2007 - v1
Checksum:i4570C30C3B1316CA
GO
Isoform 2 (identifier: A2AS55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-187: AMHGCLEAV → GTPCKLWSL
     188-361: Missing.

Show »
Length:187
Mass (Da):21,083
Checksum:i42AB7F73A64785CC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei179 – 1879AMHGCLEAV → GTPCKLWSL in isoform 2. 2 PublicationsVSP_031593
Alternative sequencei188 – 361174Missing in isoform 2. 2 PublicationsVSP_031594Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052460 mRNA. Translation: BAC35002.1.
AK085853 mRNA. Translation: BAC39552.1.
AL845548 Genomic DNA. Translation: CAM20367.1.
BC116229 mRNA. Translation: AAI16230.1.
BC116230 mRNA. Translation: AAI16231.1.
CCDSiCCDS50502.1. [A2AS55-1]
RefSeqiNP_796242.2. NM_177268.4. [A2AS55-1]
UniGeneiMm.260201.

Genome annotation databases

EnsembliENSMUST00000056108; ENSMUSP00000052056; ENSMUSG00000047909. [A2AS55-1]
GeneIDi320816.
KEGGimmu:320816.
UCSCiuc008ijg.2. mouse. [A2AS55-2]
uc012bqv.1. mouse. [A2AS55-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052460 mRNA. Translation: BAC35002.1.
AK085853 mRNA. Translation: BAC39552.1.
AL845548 Genomic DNA. Translation: CAM20367.1.
BC116229 mRNA. Translation: AAI16230.1.
BC116230 mRNA. Translation: AAI16231.1.
CCDSiCCDS50502.1. [A2AS55-1]
RefSeqiNP_796242.2. NM_177268.4. [A2AS55-1]
UniGeneiMm.260201.

3D structure databases

ProteinModelPortaliA2AS55.
SMRiA2AS55. Positions 8-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052056.

PTM databases

PhosphoSiteiA2AS55.

Proteomic databases

MaxQBiA2AS55.
PaxDbiA2AS55.
PRIDEiA2AS55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056108; ENSMUSP00000052056; ENSMUSG00000047909. [A2AS55-1]
GeneIDi320816.
KEGGimmu:320816.
UCSCiuc008ijg.2. mouse. [A2AS55-2]
uc012bqv.1. mouse. [A2AS55-1]

Organism-specific databases

CTDi54522.
MGIiMGI:2444796. Ankrd16.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOGENOMiHOG000015234.
HOVERGENiHBG056770.
InParanoidiA2AS55.
OMAiHMACIGQ.
OrthoDBiEOG7N63NG.
PhylomeDBiA2AS55.
TreeFamiTF329520.

Miscellaneous databases

ChiTaRSiAnkrd16. mouse.
NextBioi397493.
PROiA2AS55.
SOURCEiSearch...

Gene expression databases

BgeeiA2AS55.
CleanExiMM_ANKRD16.
ExpressionAtlasiA2AS55. baseline and differential.
GenevisibleiA2AS55. MM.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Heart and Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiANR16_MOUSE
AccessioniPrimary (citable) accession number: A2AS55
Secondary accession number(s): Q8BH84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.