A2ARP1 (VIP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
EC=2.7.4.21
EC=2.7.4.24

Alternative name(s):
Diphosphoinositol pentakisphosphate kinase 1
Histidine acid phosphatase domain-containing protein 2A
InsP6 and PP-IP5 kinase 1
VIP1 homolog

Gene names

Name:	Ppip5k1
Synonyms:	Hisppd2a, Kiaa0377, Vip1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1436 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress By similarity.
Catalytic activity	ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown). ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown).
Subcellular location	Cytoplasm › cytosol By similarity. Cell membrane By similarity. Note: Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway By similarity.
Domain	The polyphosphoinositide-binding domain mediates binding of PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity By similarity.
Sequence similarities	Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Sequence caution	The sequence BAC32838.1 differs from that shown. Reason: Intron retention. The sequence BAC37198.1 differs from that shown. Reason: Frameshift at position 42. The sequence BAC65546.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inositol metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acid phosphatase activity Inferred from electronic annotation. Source: InterPro diphosphoinositol-pentakisphosphate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB inositol hexakisphosphate 1-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 3-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 5-kinase activity Inferred from sequence or structural similarity. Source: UniProtKB inositol-1,3,4,5,6-pentakisphosphate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2ARP1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2ARP1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     818-837: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: A2ARP1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1057-1077: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: A2ARP1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     261-266: YTVGPD → MVDAEI
     267-1436: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: A2ARP1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     403-439: RTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPE → HPSFVIEKLVPWRCCLKLHLQDLVATVCFHLHGHQQR
     440-1436: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: A2ARP1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     653-671: LAPTGSTSLLNSMSVIQNP → VTLFSSPCSNYIATQFLKF
     672-1436: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1436	1436	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1		PRO_0000315689
Regions
	Nucleotide binding	248 – 251	4	ATP By similarity
	Nucleotide binding	257 – 259	3	ATP By similarity
	Nucleotide binding	332 – 334	3	ATP By similarity
	Region	64 – 65	2	Substrate binding By similarity
	Region	224 – 225	2	Substrate binding By similarity
	Region	337 – 340	4	Substrate binding By similarity
	Region	382 – 453	72	Polyphosphoinositide-binding domain By similarity
Sites
	Binding site	145	1	ATP By similarity
	Binding site	198	1	ATP By similarity
	Binding site	205	1	ATP By similarity
	Binding site	224	1	ATP By similarity
	Binding site	259	1	Substrate By similarity
	Binding site	273	1	Substrate By similarity
	Binding site	275	1	ATP By similarity
	Binding site	320	1	ATP By similarity
Amino acid modifications
	Modified residue	1147	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	261 – 266	6	YTVGPD → MVDAEI in isoform 4.		VSP_030625
	Alternative sequence	267 – 1436	1170	Missing in isoform 4.		VSP_030626
	Alternative sequence	403 – 439	37	RTPKQ…LKRPE → HPSFVIEKLVPWRCCLKLHL QDLVATVCFHLHGHQQR in isoform 5.		VSP_030627
	Alternative sequence	440 – 1436	997	Missing in isoform 5.		VSP_030628
	Alternative sequence	653 – 671	19	LAPTG…VIQNP → VTLFSSPCSNYIATQFLKF in isoform 6.		VSP_030629
	Alternative sequence	672 – 1436	765	Missing in isoform 6.		VSP_030630
	Alternative sequence	818 – 837	20	Missing in isoform 2.		VSP_030631
	Alternative sequence	1057 – 1077	21	Missing in isoform 3.		VSP_030634
Experimental info
	Sequence conflict	441	1	L → I in BAC38780. Ref.3
	Sequence conflict	831	1	T → A in BAC32838. Ref.3
	Sequence conflict	1049	1	P → S in BAC65546. Ref.2
	Sequence conflict	1180	1	T → A in AAP46293. Ref.1
	Sequence conflict	1180	1	T → A in BAC65546. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: D160DDDA7F34B4F2	FASTA	1,436	159,923
	10 20 30 40 50 60 MWSLTANEDE STTAHFFLGA GDEGLGTCGI GMRTEESDSE LLEDEEDEVP PEPQIIVGIC 70 80 90 100 110 120 AMTKKSKSKP MTQILERLCR FDYLTVVILG EDVILNEPVE NWPSCHCLIS FHSKGFPLDK 130 140 150 160 170 180 AVAYSKLRNP FLINDLAMQY YIQDRREVYR ILQEEGIDLP RYAVLNRDPA CPEECSLIEG 190 200 210 220 230 240 EDQVEVNGAV FPKPFVEKPV SAEDHNVYIY YPSSAGGGSQ RLFRKIGSRS SVYSPESSVR 250 260 270 280 290 300 KTGSYIYEEF MPTDGTDVKV YTVGPDYAHA EARKSPALDG KVERDSEGKE VRYPVMLTAM 310 320 330 340 350 360 EKLVARKVCV AFKQTVCGFD LLRANGHSFV CDVNGFSFVK NSMKYYDDCA KILGNTIMRE 370 380 390 400 410 420 LAPQFQIPWS IPTEAEDIPI VPTTSGTMME LRCVIAIIRH GDRTPKQKMK MEVTHPRFFA 430 440 450 460 470 480 LFEKHGGYKT GKLKLKRPEQ LQEVLDITRL LLAELEKEPE AEIEEKTGKL EQLKSVLEMY 490 500 510 520 530 540 GHFSGINRKV QLTYYPHGVK ASNEGQDLQR EPLAPSLLLV LKWGGELTPD GRVQAEELGR 550 560 570 580 590 600 AFRCMYPGGQ GDYAGFPGCG LLRLHSTFRH DLKIYASDEG RVQMTAAAFA KGLLALEGEL 610 620 630 640 650 660 TPILVQMVKS ANMNGLLDSD SDSLSSCQHR VKARLHHILQ QDAPFGPEDY DQLAPTGSTS 670 680 690 700 710 720 LLNSMSVIQN PVKVCDQVFA LIENLTHQIR ERMQDPSSVD LQLYHSETLE LMLQRWSKLE 730 740 750 760 770 780 RDFRQKSGRY DISKIPDIYD CVKYDVQHNG SLGLQGTAEL LRLSKALADV VIPQEYGISR 790 800 810 820 830 840 EEKVEIAVGF CLPLLRKILL DLQRTHEDES VNKLHPLYSR GVLSPGRHVR TRLYFTSESH 850 860 870 880 890 900 VHSLLSVFRY GGLLDETQDA QWQRALAYLS AISELNYMTQ IVIMLYEDNT RDPLSEERFH 910 920 930 940 950 960 VELHFSPGVK GVEEGSAPAG CGFRPASSEN EEMKTDPGSI ENLCPGKASD EPDRALQTSP 970 980 990 1000 1010 1020 QPVEGTGLPR RSPLIRNRKA GSMEVLSETS SSRPGGYRLF SSSRPPTEMK QSGLGSQCTG 1030 1040 1050 1060 1070 1080 LFSTTVLGGS SSAPNLQDYA RTHGKKLPPA SLKHRDELLF VPAVKRFSVS FAKHPTNGFE 1090 1100 1110 1120 1130 1140 GCSMVPTIYP LETLHNALSL RQVSEFLTKV CQRHTDAHAQ ASAALFDSMH NHQASDSPFS 1150 1160 1170 1180 1190 1200 PPRTLHSPPL QLRHRSEKPP WYSSGPSSTV SSAGPSSPTT VDGNSHFGFS DQSSVNIHMT 1210 1220 1230 1240 1250 1260 EEKQGFGLLQ ETPGDGTREL HIERQQELVE PAQSPQELPV EICPSGSQGV TKVSQTCQEV 1270 1280 1290 1300 1310 1320 PDIVQPCHNI HEEIGQPQQE VPDISQLLLK DHDTTTNTCH LCQASQLSQK VCEEICQLCQ 1330 1340 1350 1360 1370 1380 DNHEESNQLC QEVSVKLGRM VHGFPVNVDS TAQETLMEIG RPTQEIPEDP YQEFSVKVGV 1390 1400 1410 1420 1430 LAQKAPAISE LSQDIPEADK PSQELSEETE LQAQEVSEEI DQESEVVDEL PPEAIS
	Isoform 2 [UniParc]. Checksum: 39D0CF8B9C48BF98	FASTA	1,416	157,588
	10 20 30 40 50 60 MWSLTANEDE STTAHFFLGA GDEGLGTCGI GMRTEESDSE LLEDEEDEVP PEPQIIVGIC 70 80 90 100 110 120 AMTKKSKSKP MTQILERLCR FDYLTVVILG EDVILNEPVE NWPSCHCLIS FHSKGFPLDK 130 140 150 160 170 180 AVAYSKLRNP FLINDLAMQY YIQDRREVYR ILQEEGIDLP RYAVLNRDPA CPEECSLIEG 190 200 210 220 230 240 EDQVEVNGAV FPKPFVEKPV SAEDHNVYIY YPSSAGGGSQ RLFRKIGSRS SVYSPESSVR 250 260 270 280 290 300 KTGSYIYEEF MPTDGTDVKV YTVGPDYAHA EARKSPALDG KVERDSEGKE VRYPVMLTAM 310 320 330 340 350 360 EKLVARKVCV AFKQTVCGFD LLRANGHSFV CDVNGFSFVK NSMKYYDDCA KILGNTIMRE 370 380 390 400 410 420 LAPQFQIPWS IPTEAEDIPI VPTTSGTMME LRCVIAIIRH GDRTPKQKMK MEVTHPRFFA 430 440 450 460 470 480 LFEKHGGYKT GKLKLKRPEQ LQEVLDITRL LLAELEKEPE AEIEEKTGKL EQLKSVLEMY 490 500 510 520 530 540 GHFSGINRKV QLTYYPHGVK ASNEGQDLQR EPLAPSLLLV LKWGGELTPD GRVQAEELGR 550 560 570 580 590 600 AFRCMYPGGQ GDYAGFPGCG LLRLHSTFRH DLKIYASDEG RVQMTAAAFA KGLLALEGEL 610 620 630 640 650 660 TPILVQMVKS ANMNGLLDSD SDSLSSCQHR VKARLHHILQ QDAPFGPEDY DQLAPTGSTS 670 680 690 700 710 720 LLNSMSVIQN PVKVCDQVFA LIENLTHQIR ERMQDPSSVD LQLYHSETLE LMLQRWSKLE 730 740 750 760 770 780 RDFRQKSGRY DISKIPDIYD CVKYDVQHNG SLGLQGTAEL LRLSKALADV VIPQEYGISR 790 800 810 820 830 840 EEKVEIAVGF CLPLLRKILL DLQRTHEDES VNKLHPLESH VHSLLSVFRY GGLLDETQDA 850 860 870 880 890 900 QWQRALAYLS AISELNYMTQ IVIMLYEDNT RDPLSEERFH VELHFSPGVK GVEEGSAPAG 910 920 930 940 950 960 CGFRPASSEN EEMKTDPGSI ENLCPGKASD EPDRALQTSP QPVEGTGLPR RSPLIRNRKA 970 980 990 1000 1010 1020 GSMEVLSETS SSRPGGYRLF SSSRPPTEMK QSGLGSQCTG LFSTTVLGGS SSAPNLQDYA 1030 1040 1050 1060 1070 1080 RTHGKKLPPA SLKHRDELLF VPAVKRFSVS FAKHPTNGFE GCSMVPTIYP LETLHNALSL 1090 1100 1110 1120 1130 1140 RQVSEFLTKV CQRHTDAHAQ ASAALFDSMH NHQASDSPFS PPRTLHSPPL QLRHRSEKPP 1150 1160 1170 1180 1190 1200 WYSSGPSSTV SSAGPSSPTT VDGNSHFGFS DQSSVNIHMT EEKQGFGLLQ ETPGDGTREL 1210 1220 1230 1240 1250 1260 HIERQQELVE PAQSPQELPV EICPSGSQGV TKVSQTCQEV PDIVQPCHNI HEEIGQPQQE 1270 1280 1290 1300 1310 1320 VPDISQLLLK DHDTTTNTCH LCQASQLSQK VCEEICQLCQ DNHEESNQLC QEVSVKLGRM 1330 1340 1350 1360 1370 1380 VHGFPVNVDS TAQETLMEIG RPTQEIPEDP YQEFSVKVGV LAQKAPAISE LSQDIPEADK 1390 1400 1410 PSQELSEETE LQAQEVSEEI DQESEVVDEL PPEAIS
	Isoform 3 [UniParc]. Checksum: F51E050A638DA33A	FASTA	1,415	157,553
	10 20 30 40 50 60 MWSLTANEDE STTAHFFLGA GDEGLGTCGI GMRTEESDSE LLEDEEDEVP PEPQIIVGIC 70 80 90 100 110 120 AMTKKSKSKP MTQILERLCR FDYLTVVILG EDVILNEPVE NWPSCHCLIS FHSKGFPLDK 130 140 150 160 170 180 AVAYSKLRNP FLINDLAMQY YIQDRREVYR ILQEEGIDLP RYAVLNRDPA CPEECSLIEG 190 200 210 220 230 240 EDQVEVNGAV FPKPFVEKPV SAEDHNVYIY YPSSAGGGSQ RLFRKIGSRS SVYSPESSVR 250 260 270 280 290 300 KTGSYIYEEF MPTDGTDVKV YTVGPDYAHA EARKSPALDG KVERDSEGKE VRYPVMLTAM 310 320 330 340 350 360 EKLVARKVCV AFKQTVCGFD LLRANGHSFV CDVNGFSFVK NSMKYYDDCA KILGNTIMRE 370 380 390 400 410 420 LAPQFQIPWS IPTEAEDIPI VPTTSGTMME LRCVIAIIRH GDRTPKQKMK MEVTHPRFFA 430 440 450 460 470 480 LFEKHGGYKT GKLKLKRPEQ LQEVLDITRL LLAELEKEPE AEIEEKTGKL EQLKSVLEMY 490 500 510 520 530 540 GHFSGINRKV QLTYYPHGVK ASNEGQDLQR EPLAPSLLLV LKWGGELTPD GRVQAEELGR 550 560 570 580 590 600 AFRCMYPGGQ GDYAGFPGCG LLRLHSTFRH DLKIYASDEG RVQMTAAAFA KGLLALEGEL 610 620 630 640 650 660 TPILVQMVKS ANMNGLLDSD SDSLSSCQHR VKARLHHILQ QDAPFGPEDY DQLAPTGSTS 670 680 690 700 710 720 LLNSMSVIQN PVKVCDQVFA LIENLTHQIR ERMQDPSSVD LQLYHSETLE LMLQRWSKLE 730 740 750 760 770 780 RDFRQKSGRY DISKIPDIYD CVKYDVQHNG SLGLQGTAEL LRLSKALADV VIPQEYGISR 790 800 810 820 830 840 EEKVEIAVGF CLPLLRKILL DLQRTHEDES VNKLHPLYSR GVLSPGRHVR TRLYFTSESH 850 860 870 880 890 900 VHSLLSVFRY GGLLDETQDA QWQRALAYLS AISELNYMTQ IVIMLYEDNT RDPLSEERFH 910 920 930 940 950 960 VELHFSPGVK GVEEGSAPAG CGFRPASSEN EEMKTDPGSI ENLCPGKASD EPDRALQTSP 970 980 990 1000 1010 1020 QPVEGTGLPR RSPLIRNRKA GSMEVLSETS SSRPGGYRLF SSSRPPTEMK QSGLGSQCTG 1030 1040 1050 1060 1070 1080 LFSTTVLGGS SSAPNLQDYA RTHGKKLPPA SLKHRDGFEG CSMVPTIYPL ETLHNALSLR 1090 1100 1110 1120 1130 1140 QVSEFLTKVC QRHTDAHAQA SAALFDSMHN HQASDSPFSP PRTLHSPPLQ LRHRSEKPPW 1150 1160 1170 1180 1190 1200 YSSGPSSTVS SAGPSSPTTV DGNSHFGFSD QSSVNIHMTE EKQGFGLLQE TPGDGTRELH 1210 1220 1230 1240 1250 1260 IERQQELVEP AQSPQELPVE ICPSGSQGVT KVSQTCQEVP DIVQPCHNIH EEIGQPQQEV 1270 1280 1290 1300 1310 1320 PDISQLLLKD HDTTTNTCHL CQASQLSQKV CEEICQLCQD NHEESNQLCQ EVSVKLGRMV 1330 1340 1350 1360 1370 1380 HGFPVNVDST AQETLMEIGR PTQEIPEDPY QEFSVKVGVL AQKAPAISEL SQDIPEADKP 1390 1400 1410 SQELSEETEL QAQEVSEEID QESEVVDELP PEAIS
	Isoform 4 [UniParc]. Checksum: 3058794BBECC2253	FASTA	266	29,888
	10 20 30 40 50 60 MWSLTANEDE STTAHFFLGA GDEGLGTCGI GMRTEESDSE LLEDEEDEVP PEPQIIVGIC 70 80 90 100 110 120 AMTKKSKSKP MTQILERLCR FDYLTVVILG EDVILNEPVE NWPSCHCLIS FHSKGFPLDK 130 140 150 160 170 180 AVAYSKLRNP FLINDLAMQY YIQDRREVYR ILQEEGIDLP RYAVLNRDPA CPEECSLIEG 190 200 210 220 230 240 EDQVEVNGAV FPKPFVEKPV SAEDHNVYIY YPSSAGGGSQ RLFRKIGSRS SVYSPESSVR 250 260 KTGSYIYEEF MPTDGTDVKV MVDAEI
	Isoform 5 [UniParc]. Checksum: 5886DD464B506F60	FASTA	439	49,416
	10 20 30 40 50 60 MWSLTANEDE STTAHFFLGA GDEGLGTCGI GMRTEESDSE LLEDEEDEVP PEPQIIVGIC 70 80 90 100 110 120 AMTKKSKSKP MTQILERLCR FDYLTVVILG EDVILNEPVE NWPSCHCLIS FHSKGFPLDK 130 140 150 160 170 180 AVAYSKLRNP FLINDLAMQY YIQDRREVYR ILQEEGIDLP RYAVLNRDPA CPEECSLIEG 190 200 210 220 230 240 EDQVEVNGAV FPKPFVEKPV SAEDHNVYIY YPSSAGGGSQ RLFRKIGSRS SVYSPESSVR 250 260 270 280 290 300 KTGSYIYEEF MPTDGTDVKV YTVGPDYAHA EARKSPALDG KVERDSEGKE VRYPVMLTAM 310 320 330 340 350 360 EKLVARKVCV AFKQTVCGFD LLRANGHSFV CDVNGFSFVK NSMKYYDDCA KILGNTIMRE 370 380 390 400 410 420 LAPQFQIPWS IPTEAEDIPI VPTTSGTMME LRCVIAIIRH GDHPSFVIEK LVPWRCCLKL 430 HLQDLVATVC FHLHGHQQR
	Isoform 6 [UniParc]. Checksum: DDF3D544D053FE04	FASTA	671	75,262
	10 20 30 40 50 60 MWSLTANEDE STTAHFFLGA GDEGLGTCGI GMRTEESDSE LLEDEEDEVP PEPQIIVGIC 70 80 90 100 110 120 AMTKKSKSKP MTQILERLCR FDYLTVVILG EDVILNEPVE NWPSCHCLIS FHSKGFPLDK 130 140 150 160 170 180 AVAYSKLRNP FLINDLAMQY YIQDRREVYR ILQEEGIDLP RYAVLNRDPA CPEECSLIEG 190 200 210 220 230 240 EDQVEVNGAV FPKPFVEKPV SAEDHNVYIY YPSSAGGGSQ RLFRKIGSRS SVYSPESSVR 250 260 270 280 290 300 KTGSYIYEEF MPTDGTDVKV YTVGPDYAHA EARKSPALDG KVERDSEGKE VRYPVMLTAM 310 320 330 340 350 360 EKLVARKVCV AFKQTVCGFD LLRANGHSFV CDVNGFSFVK NSMKYYDDCA KILGNTIMRE 370 380 390 400 410 420 LAPQFQIPWS IPTEAEDIPI VPTTSGTMME LRCVIAIIRH GDRTPKQKMK MEVTHPRFFA 430 440 450 460 470 480 LFEKHGGYKT GKLKLKRPEQ LQEVLDITRL LLAELEKEPE AEIEEKTGKL EQLKSVLEMY 490 500 510 520 530 540 GHFSGINRKV QLTYYPHGVK ASNEGQDLQR EPLAPSLLLV LKWGGELTPD GRVQAEELGR 550 560 570 580 590 600 AFRCMYPGGQ GDYAGFPGCG LLRLHSTFRH DLKIYASDEG RVQMTAAAFA KGLLALEGEL 610 620 630 640 650 660 TPILVQMVKS ANMNGLLDSD SDSLSSCQHR VKARLHHILQ QDAPFGPEDY DQVTLFSSPC 670 SNYIATQFLK F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 60kb genomic deletion is associated with non-syndromic deafness and sperm motility disorder but not with congenital dyserythropoietic anemia type I." Avidan N., Dgany O.D., Cattan D.C., Pariente A., Thulliez M., Borot N., Moati L., Alain B., Krasnov T., Olender T., Shalmon L., Ben-Asher E., Khen M., Shalev H., Fellous M., Delaunay J., Yaniv I., Zaizov R. , Beckmann J.S., Lancet D., Tamary H. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: Swiss Webster. Tissue: Brain.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6). Strain: C57BL/6J. Tissue: Adipose tissue, Hippocampus and Olfactory bulb.
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: C57BL/6J.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Strain: C57BL/6. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF502585 mRNA. Translation: AAP46293.1. AK122264 mRNA. Translation: BAC65546.1. Different initiation. AK046696 mRNA. Translation: BAC32838.1. Sequence problems. AK078268 mRNA. Translation: BAC37198.1. Frameshift. AK083140 mRNA. Translation: BAC38780.1. AL845466 Genomic DNA. Translation: CAM24220.1. AL845466 Genomic DNA. Translation: CAM24221.1. AL845466 Genomic DNA. Translation: CAM24222.1. BC065138 mRNA. Translation: AAH65138.1.
IPI	IPI00330220. IPI00624662. IPI00750816. IPI00751331. IPI00880404. IPI00974812.
RefSeq	NP_848910.3. NM_178795.4.
UniGene	Mm.386076.
3D structure databases
ProteinModelPortal	A2ARP1.
SMR	A2ARP1. Positions 54-371.
ModBase	Search...
PTM databases
PhosphoSite	A2ARP1.
Proteomic databases
PaxDb	A2ARP1.
PRIDE	A2ARP1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000052029; ENSMUSP00000057632; ENSMUSG00000033526. ENSMUST00000110625; ENSMUSP00000106255; ENSMUSG00000033526. ENSMUST00000110626; ENSMUSP00000106256; ENSMUSG00000033526. ENSMUST00000110627; ENSMUSP00000106257; ENSMUSG00000033526. ENSMUST00000110628; ENSMUSP00000106258; ENSMUSG00000033526.
GeneID	327655.
KEGG	mmu:327655.
UCSC	uc008lyl.1. mouse. uc008lyq.1. mouse. uc008lyr.1. mouse. uc008lys.1. mouse.
Organism-specific databases
CTD	9677.
MGI	MGI:2443281. Ppip5k1.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG245915.
GeneTree	ENSGT00390000009048.
HOVERGEN	HBG108657.
InParanoid	A2ARP1.
KO	K13024.
OMA	DSMHSNQ.
OrthoDB	EOG41VK25.
Gene expression databases
ArrayExpress	A2ARP1.
Bgee	A2ARP1.
CleanEx	MM_HISPPD2A.
Genevestigator	A2ARP1.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. [Graphical view]
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	397922.
SOURCE	Search...

Entry information

Entry name

VIP1_MOUSE

Accession

Primary (citable) accession number: A2ARP1
Secondary accession number(s): A2ARP2 , A2ARP3, A2ARP4, Q6P1C8, Q7TSP1, Q80U21, Q8BL16, Q8BUN6, Q8BVG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program