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Protein

Protein PAT1 homolog 2

Gene

Patl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein that acts as a translational repressor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PAT1 homolog 2
Alternative name(s):
PAT1-like protein 2
Protein PAT1 homolog a
Short name:
Pat1a
Gene namesi
Name:Patl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914828. Patl2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045781 – 529Protein PAT1 homolog 2Add BLAST529

Proteomic databases

PaxDbiA2ARM1.
PRIDEiA2ARM1.

PTM databases

PhosphoSitePlusiA2ARM1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027233.
GenevisibleiA2ARM1. MM.

Interactioni

Subunit structurei

Interacts with LSM1.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2ARM1.
SMRiA2ARM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAT1 family.Curated

Phylogenomic databases

eggNOGiENOG410IJI7. Eukaryota.
ENOG410YH7J. LUCA.
GeneTreeiENSGT00520000055649.
HOGENOMiHOG000231836.
HOVERGENiHBG076566.
InParanoidiA2ARM1.
OMAiWSQQPDP.
OrthoDBiEOG091G0MYC.
PhylomeDBiA2ARM1.
TreeFamiTF323322.

Family and domain databases

InterProiView protein in InterPro
IPR019167. Topo_II-assoc_PAT1.
PfamiView protein in Pfam
PF09770. PAT1. 1 hit.

Sequencei

Sequence statusi: Complete.

A2ARM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCLEGLHLQ QRPSKFSVSL APEEGLVCAF QLEEEKENED ECVCSDQAPE
60 70 80 90 100
VKEEGCGLGD PAIVSAFQNT QVPQQRGLHS SHRVKVSGAL GMSSASLHFM
110 120 130 140 150
WQSVFPRASS PAHHFGPQQP SPDPFLFYSP LTPWPPKLSL PSHLTQLHPQ
160 170 180 190 200
HQQILQQQQR WRRRRSPTAR SVPAQKPWSR EPAASDAYAN LMTRKEKDWV
210 220 230 240 250
IRVQMVQLQS ENPRLDDYYY QKYYQKLEKR QADKELLGQK TRAESLKLVT
260 270 280 290 300
PYIQKPEVYE SVVRIEGSLG QVAVSTCFSP RRAIDAVSHG TQEQDTGAAS
310 320 330 340 350
SQRLRVLSQI EKMFLQLLKI EEGQNDGLPQ LYHTREQSSQ VEKLFQALKT
360 370 380 390 400
QEQNNLEEAA DNLLQVLSVR KGKVLVARLL PFLPPDQAVS LLLYITYHLP
410 420 430 440 450
LLIQRDMADQ GLHMLFKPLG KYISHLTFHQ LLHAMQGLML LSPGSSERPV
460 470 480 490 500
SVVLQNQFGI SLLYALLSHG EQLVSLDPSL RSSSDCATWT DLVILIAWEI
510 520
AQLPAASLAE PLAFPRNLLP CSAITWTSN
Length:529
Mass (Da):59,639
Last modified:February 20, 2007 - v1
Checksum:i4393AB954493943D
GO

Sequence cautioni

The sequence BAB29742 differs from that shown. Reason: Frameshift at positions 226, 231 and 234.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19S → P in AAI45647 (PubMed:15489334).Curated1
Sequence conflicti41E → K in AAI45647 (PubMed:15489334).Curated1
Sequence conflicti86V → A in AAI45647 (PubMed:15489334).Curated1
Sequence conflicti155L → LQ in AAI45647 (PubMed:15489334).Curated1
Sequence conflicti243 – 247AESLK → VEFLQ in BAB29742 (PubMed:16141072).Curated5
Sequence conflicti256P → L in BAB29742 (PubMed:16141072).Curated1
Sequence conflicti343K → E in AAI45647 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015195 mRNA. Translation: BAB29742.1. Frameshift.
AL845457 Genomic DNA. Translation: CAM21782.1.
BC145646 mRNA. Translation: AAI45647.1.
CCDSiCCDS16653.1.
RefSeqiNP_080527.2. NM_026251.2.
XP_017174713.1. XM_017319224.1.
UniGeneiMm.150462.

Genome annotation databases

EnsembliENSMUST00000028665; ENSMUSP00000028665; ENSMUSG00000027233.
GeneIDi67578.
KEGGimmu:67578.
UCSCiuc008mae.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPATL2_MOUSE
AccessioniPrimary (citable) accession number: A2ARM1
Secondary accession number(s): A6H5U9, Q9D5L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 20, 2007
Last modified: July 5, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families