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Protein

Mitogen-activated protein kinase kinase kinase 15

Gene

Map3k15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-816, inhibited by phosphorylation at Ser-928 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei685 – 6851ATPBy similarityPROSITE-ProRule annotation
Active sitei777 – 7771Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi662 – 6709ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 15 (EC:2.7.11.25)
Alternative name(s):
MAPK/ERK kinase kinase 15
Short name:
MEK kinase 15
Short name:
MEKK 15
Gene namesi
Name:Map3k15Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2448588. Map3k15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13311331Mitogen-activated protein kinase kinase kinase 15PRO_0000307633Add
BLAST

Proteomic databases

PaxDbiA2AQW0.
PRIDEiA2AQW0.

PTM databases

PhosphoSiteiA2AQW0.

Expressioni

Gene expression databases

BgeeiA2AQW0.
GenevestigatoriA2AQW0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033665.

Structurei

3D structure databases

ProteinModelPortaliA2AQW0.
SMRiA2AQW0. Positions 616-965.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini656 – 912257Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1216 – 123621Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 8684Gly-richSequence AnalysisAdd
BLAST
Compositional biasi949 – 9524Poly-SerSequence Analysis
Compositional biasi1254 – 12574Poly-ProSequence Analysis

Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.By similarity
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119077.
HOGENOMiHOG000293286.
HOVERGENiHBG006305.
InParanoidiA2AQW0.
KOiK13986.
OMAiDSDCKDT.
OrthoDBiEOG7WDN1P.
TreeFamiTF105115.

Family and domain databases

InterProiIPR025136. DUF4071.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR013761. SAM/pointed.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13281. DUF4071. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AQW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGGGGSGGG GGPVPAEAPE EAGEPPQGRL PPGPEGAAGL AEPESTGDAA
60 70 80 90 100
GGEAEGGRGP RRALRAVYVR SESSQGAAAG GGPEAGALKC LLRACEAEGA
110 120 130 140 150
HLTSVPFGEL DFGETAVLDA FYDADVAIVD MSDISRQPSL FYHLGVRESF
160 170 180 190 200
DMANNVILYY DTDADTALSL KDMVTQKNTA SSGNYYFIPY TVTPCADYFC
210 220 230 240 250
CESDAQRRAS EYMQPNWDTI LGPLCMPLVD RFTSLLKDIR VTSCAYYKET
260 270 280 290 300
LLNDIRKARE KYQGDELAKE LTRIKFRMDN IEVLTSDIII NLLLSYRDIQ
310 320 330 340 350
DYDAMVKLVE TLKMLPTCDL ADQHNIKFHY AFALNRRNST GDREKALQVM
360 370 380 390 400
LQVLQSCDHP APDMFCLCGR IYKDIFLDSG CEEDASRDSA IEWYRKGFEL
410 420 430 440 450
QSSLYSGINL AVLLIVSGQQ FETSMELRKI GVRLNSLLGR KGSLEKMNNY
460 470 480 490 500
WDVGQFFTVS MLASDIGKAV QAAERLFKLK PPVWYLRSLV QNLLLIQRFK
510 520 530 540 550
KPITEHSPRQ ERLNFWLDII FEATNEVTNG LRFPVLVIEP TKVYQPSYVS
560 570 580 590 600
INNEAEERTV SLWHVSPTEM KQIHEWNFTA SSIKGISLSK FDERCCFLYV
610 620 630 640 650
HDNSDDFQIY FSTEDQCNRF CSLVKEMLNN GVGSTVELEG EADGDTLEYE
660 670 680 690 700
YDHDANGERV VLGKGSYGIV YAGRDLSNQV RIAIKEIPER DIRYSQPLHE
710 720 730 740 750
EIALHKYLKH RNIVQYLGSV SENGYIKIFM EQVPGGSLSA LLRSKWGPMK
760 770 780 790 800
EPTIKFYTKQ ILEGLKYLHE NQIVHRDIKG DNVLVNTYSG VVKISDFGTS
810 820 830 840 850
KRLAGINPCT ETFTGTLQYM APEIIDQGPR GYGAPADIWS LGCTIIEMAT
860 870 880 890 900
SRPPFHELGE PQAAMFKVGM FKIHPEIPEA LSAEARAFIL SCFEPDPQKR
910 920 930 940 950
VTAADLLQEG FLRQVNKGKK NRIAFKPSEG VRSGTGTLAL PSSGELVGSS
960 970 980 990 1000
SSEHGSISPD SDAQPDAFFE KVQVPKHQLS HLLSVPDESP ALDDRSTALP
1010 1020 1030 1040 1050
PEERDPGLFL LRKDSERRAI LYRILWEEQN QVASNLQECV VQSSEELLLS
1060 1070 1080 1090 1100
VSHIKQIIGI LRDFIRSPEH RVMAATISKL KVDLDFDSSS INQIHLILFG
1110 1120 1130 1140 1150
FQDAVNRILR NHLIRPHWMF AMDNIIRRAV QAAVTILIPE LQAHFEPASE
1160 1170 1180 1190 1200
TEGVDKDTEV EGDYPLVDLL SQEVHVTPRG TRPGSVAIQE GQPHQQDPSL
1210 1220 1230 1240 1250
QLSKLRQETN RLWEHLVQKE REYQNLLRLI LDQKTQELYH LQLQYKSNGG
1260 1270 1280 1290 1300
TENPPPPDGL GTDRELIDWL QLQGVDANTI EKIVEEDYTL SDILNDITKE
1310 1320 1330
DLRCLRLRGG VLCRLWHAVS QHRRQMQESS Q
Length:1,331
Mass (Da):149,327
Last modified:February 20, 2007 - v1
Checksum:i6BB38F2B8A59B942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845167, AL929452 Genomic DNA. Translation: CAM22391.1.
AL929452, AL845167 Genomic DNA. Translation: CAM21674.1.
CCDSiCCDS53236.1.
RefSeqiNP_001156557.2. NM_001163085.2.
UniGeneiMm.386889.

Genome annotation databases

EnsembliENSMUST00000033665; ENSMUSP00000033665; ENSMUSG00000031303.
GeneIDi270672.
KEGGimmu:270672.
UCSCiuc009utb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845167, AL929452 Genomic DNA. Translation: CAM22391.1.
AL929452, AL845167 Genomic DNA. Translation: CAM21674.1.
CCDSiCCDS53236.1.
RefSeqiNP_001156557.2. NM_001163085.2.
UniGeneiMm.386889.

3D structure databases

ProteinModelPortaliA2AQW0.
SMRiA2AQW0. Positions 616-965.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033665.

PTM databases

PhosphoSiteiA2AQW0.

Proteomic databases

PaxDbiA2AQW0.
PRIDEiA2AQW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033665; ENSMUSP00000033665; ENSMUSG00000031303.
GeneIDi270672.
KEGGimmu:270672.
UCSCiuc009utb.2. mouse.

Organism-specific databases

CTDi389840.
MGIiMGI:2448588. Map3k15.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119077.
HOGENOMiHOG000293286.
HOVERGENiHBG006305.
InParanoidiA2AQW0.
KOiK13986.
OMAiDSDCKDT.
OrthoDBiEOG7WDN1P.
TreeFamiTF105115.

Miscellaneous databases

ChiTaRSiMap3k15. mouse.
NextBioi393369.
PROiA2AQW0.
SOURCEiSearch...

Gene expression databases

BgeeiA2AQW0.
GenevestigatoriA2AQW0.

Family and domain databases

InterProiIPR025136. DUF4071.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR013761. SAM/pointed.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13281. DUF4071. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiM3K15_MOUSE
AccessioniPrimary (citable) accession number: A2AQW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.