SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2AQW0

- M3K15_MOUSE

UniProt

A2AQW0 - M3K15_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mitogen-activated protein kinase kinase kinase 15
Gene
Map3k15
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium By similarity.By similarity

Enzyme regulationi

Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-816, inhibited by phosphorylation at Ser-928 By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei685 – 6851ATP By similarityBy similarity
Active sitei777 – 7771Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi662 – 6709ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: RefGenome
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. MAPK cascade Source: GOC
  2. activation of MAPKK activity Source: GOC
  3. intracellular signal transduction Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 15 (EC:2.7.11.25)
Alternative name(s):
MAPK/ERK kinase kinase 15
Short name:
MEK kinase 15
Short name:
MEKK 15
Gene namesi
Name:Map3k15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2448588. Map3k15.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13311331Mitogen-activated protein kinase kinase kinase 15
PRO_0000307633Add
BLAST

Proteomic databases

PaxDbiA2AQW0.
PRIDEiA2AQW0.

PTM databases

PhosphoSiteiA2AQW0.

Expressioni

Gene expression databases

BgeeiA2AQW0.
GenevestigatoriA2AQW0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033665.

Structurei

3D structure databases

ProteinModelPortaliA2AQW0.
SMRiA2AQW0. Positions 616-973.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini656 – 912257Protein kinase
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1216 – 123621 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 8684Gly-rich
Add
BLAST
Compositional biasi949 – 9524Poly-Ser
Compositional biasi1254 – 12574Poly-Pro

Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117243.
HOGENOMiHOG000293286.
HOVERGENiHBG006305.
InParanoidiA2AQW0.
KOiK13986.
OMAiCLLRACE.
OrthoDBiEOG7WDN1P.
TreeFamiTF105115.

Family and domain databases

InterProiIPR025136. DUF4071.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR013761. SAM/pointed.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13281. DUF4071. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AQW0-1 [UniParc]FASTAAdd to Basket

« Hide

MEGGGGSGGG GGPVPAEAPE EAGEPPQGRL PPGPEGAAGL AEPESTGDAA     50
GGEAEGGRGP RRALRAVYVR SESSQGAAAG GGPEAGALKC LLRACEAEGA 100
HLTSVPFGEL DFGETAVLDA FYDADVAIVD MSDISRQPSL FYHLGVRESF 150
DMANNVILYY DTDADTALSL KDMVTQKNTA SSGNYYFIPY TVTPCADYFC 200
CESDAQRRAS EYMQPNWDTI LGPLCMPLVD RFTSLLKDIR VTSCAYYKET 250
LLNDIRKARE KYQGDELAKE LTRIKFRMDN IEVLTSDIII NLLLSYRDIQ 300
DYDAMVKLVE TLKMLPTCDL ADQHNIKFHY AFALNRRNST GDREKALQVM 350
LQVLQSCDHP APDMFCLCGR IYKDIFLDSG CEEDASRDSA IEWYRKGFEL 400
QSSLYSGINL AVLLIVSGQQ FETSMELRKI GVRLNSLLGR KGSLEKMNNY 450
WDVGQFFTVS MLASDIGKAV QAAERLFKLK PPVWYLRSLV QNLLLIQRFK 500
KPITEHSPRQ ERLNFWLDII FEATNEVTNG LRFPVLVIEP TKVYQPSYVS 550
INNEAEERTV SLWHVSPTEM KQIHEWNFTA SSIKGISLSK FDERCCFLYV 600
HDNSDDFQIY FSTEDQCNRF CSLVKEMLNN GVGSTVELEG EADGDTLEYE 650
YDHDANGERV VLGKGSYGIV YAGRDLSNQV RIAIKEIPER DIRYSQPLHE 700
EIALHKYLKH RNIVQYLGSV SENGYIKIFM EQVPGGSLSA LLRSKWGPMK 750
EPTIKFYTKQ ILEGLKYLHE NQIVHRDIKG DNVLVNTYSG VVKISDFGTS 800
KRLAGINPCT ETFTGTLQYM APEIIDQGPR GYGAPADIWS LGCTIIEMAT 850
SRPPFHELGE PQAAMFKVGM FKIHPEIPEA LSAEARAFIL SCFEPDPQKR 900
VTAADLLQEG FLRQVNKGKK NRIAFKPSEG VRSGTGTLAL PSSGELVGSS 950
SSEHGSISPD SDAQPDAFFE KVQVPKHQLS HLLSVPDESP ALDDRSTALP 1000
PEERDPGLFL LRKDSERRAI LYRILWEEQN QVASNLQECV VQSSEELLLS 1050
VSHIKQIIGI LRDFIRSPEH RVMAATISKL KVDLDFDSSS INQIHLILFG 1100
FQDAVNRILR NHLIRPHWMF AMDNIIRRAV QAAVTILIPE LQAHFEPASE 1150
TEGVDKDTEV EGDYPLVDLL SQEVHVTPRG TRPGSVAIQE GQPHQQDPSL 1200
QLSKLRQETN RLWEHLVQKE REYQNLLRLI LDQKTQELYH LQLQYKSNGG 1250
TENPPPPDGL GTDRELIDWL QLQGVDANTI EKIVEEDYTL SDILNDITKE 1300
DLRCLRLRGG VLCRLWHAVS QHRRQMQESS Q 1331
Length:1,331
Mass (Da):149,327
Last modified:February 20, 2007 - v1
Checksum:i6BB38F2B8A59B942
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL845167, AL929452 Genomic DNA. Translation: CAM22391.1.
AL929452, AL845167 Genomic DNA. Translation: CAM21674.1.
CCDSiCCDS53236.1.
RefSeqiNP_001156557.2. NM_001163085.2.
UniGeneiMm.386889.

Genome annotation databases

EnsembliENSMUST00000033665; ENSMUSP00000033665; ENSMUSG00000031303.
GeneIDi270672.
KEGGimmu:270672.
UCSCiuc009utb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL845167 , AL929452 Genomic DNA. Translation: CAM22391.1 .
AL929452 , AL845167 Genomic DNA. Translation: CAM21674.1 .
CCDSi CCDS53236.1.
RefSeqi NP_001156557.2. NM_001163085.2.
UniGenei Mm.386889.

3D structure databases

ProteinModelPortali A2AQW0.
SMRi A2AQW0. Positions 616-973.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033665.

PTM databases

PhosphoSitei A2AQW0.

Proteomic databases

PaxDbi A2AQW0.
PRIDEi A2AQW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033665 ; ENSMUSP00000033665 ; ENSMUSG00000031303 .
GeneIDi 270672.
KEGGi mmu:270672.
UCSCi uc009utb.2. mouse.

Organism-specific databases

CTDi 389840.
MGIi MGI:2448588. Map3k15.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117243.
HOGENOMi HOG000293286.
HOVERGENi HBG006305.
InParanoidi A2AQW0.
KOi K13986.
OMAi CLLRACE.
OrthoDBi EOG7WDN1P.
TreeFami TF105115.

Miscellaneous databases

ChiTaRSi MAP3K15. mouse.
NextBioi 393369.
PROi A2AQW0.
SOURCEi Search...

Gene expression databases

Bgeei A2AQW0.
Genevestigatori A2AQW0.

Family and domain databases

InterProi IPR025136. DUF4071.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR013761. SAM/pointed.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF13281. DUF4071. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiM3K15_MOUSE
AccessioniPrimary (citable) accession number: A2AQW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi