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A2AQW0 (M3K15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase kinase kinase 15

EC=2.7.11.25
Alternative name(s):
MAPK/ERK kinase kinase 15
Short name=MEK kinase 15
Short name=MEKK 15
Gene names
Name:Map3k15
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB Q99683

Cofactor

Magnesium By similarity. UniProtKB Q99683

Enzyme regulation

Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-816, inhibited by phosphorylation at Ser-928 By similarity. UniProtKB Q99683

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. UniProtKB Q99683

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13311331Mitogen-activated protein kinase kinase kinase 15
PRO_0000307633

Regions

Domain656 – 912257Protein kinase
Nucleotide binding662 – 6709ATP By similarity UniProtKB P28523
Coiled coil1216 – 123621 Potential
Compositional bias3 – 8684Gly-rich
Compositional bias949 – 9524Poly-Ser
Compositional bias1254 – 12574Poly-Pro

Sites

Active site7771Proton acceptor By similarity UniProtKB P28523
Binding site6851ATP By similarity UniProtKB Q99683

Sequences

Sequence LengthMass (Da)Tools
A2AQW0 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 6BB38F2B8A59B942

FASTA1,331149,327
        10         20         30         40         50         60 
MEGGGGSGGG GGPVPAEAPE EAGEPPQGRL PPGPEGAAGL AEPESTGDAA GGEAEGGRGP 

        70         80         90        100        110        120 
RRALRAVYVR SESSQGAAAG GGPEAGALKC LLRACEAEGA HLTSVPFGEL DFGETAVLDA 

       130        140        150        160        170        180 
FYDADVAIVD MSDISRQPSL FYHLGVRESF DMANNVILYY DTDADTALSL KDMVTQKNTA 

       190        200        210        220        230        240 
SSGNYYFIPY TVTPCADYFC CESDAQRRAS EYMQPNWDTI LGPLCMPLVD RFTSLLKDIR 

       250        260        270        280        290        300 
VTSCAYYKET LLNDIRKARE KYQGDELAKE LTRIKFRMDN IEVLTSDIII NLLLSYRDIQ 

       310        320        330        340        350        360 
DYDAMVKLVE TLKMLPTCDL ADQHNIKFHY AFALNRRNST GDREKALQVM LQVLQSCDHP 

       370        380        390        400        410        420 
APDMFCLCGR IYKDIFLDSG CEEDASRDSA IEWYRKGFEL QSSLYSGINL AVLLIVSGQQ 

       430        440        450        460        470        480 
FETSMELRKI GVRLNSLLGR KGSLEKMNNY WDVGQFFTVS MLASDIGKAV QAAERLFKLK 

       490        500        510        520        530        540 
PPVWYLRSLV QNLLLIQRFK KPITEHSPRQ ERLNFWLDII FEATNEVTNG LRFPVLVIEP 

       550        560        570        580        590        600 
TKVYQPSYVS INNEAEERTV SLWHVSPTEM KQIHEWNFTA SSIKGISLSK FDERCCFLYV 

       610        620        630        640        650        660 
HDNSDDFQIY FSTEDQCNRF CSLVKEMLNN GVGSTVELEG EADGDTLEYE YDHDANGERV 

       670        680        690        700        710        720 
VLGKGSYGIV YAGRDLSNQV RIAIKEIPER DIRYSQPLHE EIALHKYLKH RNIVQYLGSV 

       730        740        750        760        770        780 
SENGYIKIFM EQVPGGSLSA LLRSKWGPMK EPTIKFYTKQ ILEGLKYLHE NQIVHRDIKG 

       790        800        810        820        830        840 
DNVLVNTYSG VVKISDFGTS KRLAGINPCT ETFTGTLQYM APEIIDQGPR GYGAPADIWS 

       850        860        870        880        890        900 
LGCTIIEMAT SRPPFHELGE PQAAMFKVGM FKIHPEIPEA LSAEARAFIL SCFEPDPQKR 

       910        920        930        940        950        960 
VTAADLLQEG FLRQVNKGKK NRIAFKPSEG VRSGTGTLAL PSSGELVGSS SSEHGSISPD 

       970        980        990       1000       1010       1020 
SDAQPDAFFE KVQVPKHQLS HLLSVPDESP ALDDRSTALP PEERDPGLFL LRKDSERRAI 

      1030       1040       1050       1060       1070       1080 
LYRILWEEQN QVASNLQECV VQSSEELLLS VSHIKQIIGI LRDFIRSPEH RVMAATISKL 

      1090       1100       1110       1120       1130       1140 
KVDLDFDSSS INQIHLILFG FQDAVNRILR NHLIRPHWMF AMDNIIRRAV QAAVTILIPE 

      1150       1160       1170       1180       1190       1200 
LQAHFEPASE TEGVDKDTEV EGDYPLVDLL SQEVHVTPRG TRPGSVAIQE GQPHQQDPSL 

      1210       1220       1230       1240       1250       1260 
QLSKLRQETN RLWEHLVQKE REYQNLLRLI LDQKTQELYH LQLQYKSNGG TENPPPPDGL 

      1270       1280       1290       1300       1310       1320 
GTDRELIDWL QLQGVDANTI EKIVEEDYTL SDILNDITKE DLRCLRLRGG VLCRLWHAVS 

      1330 
QHRRQMQESS Q 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL845167, AL929452 Genomic DNA. Translation: CAM22391.1.
AL929452, AL845167 Genomic DNA. Translation: CAM21674.1.
RefSeqNP_001156557.2. NM_001163085.2.
UniGeneMm.386889.

3D structure databases

ProteinModelPortalA2AQW0.
SMRA2AQW0. Positions 610-973.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000033665.

PTM databases

PhosphoSiteA2AQW0.

Proteomic databases

PaxDbA2AQW0.
PRIDEA2AQW0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033665; ENSMUSP00000033665; ENSMUSG00000031303.
GeneID270672.
KEGGmmu:270672.
UCSCuc009utb.2. mouse.

Organism-specific databases

CTD389840.
MGIMGI:2448588. Map3k15.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117243.
HOGENOMHOG000293286.
HOVERGENHBG006305.
InParanoidA2AQW0.
KOK13986.
OMACLLRACE.
OrthoDBEOG7WDN1P.
TreeFamTF105115.

Gene expression databases

BgeeA2AQW0.
GenevestigatorA2AQW0.

Family and domain databases

InterProIPR025136. DUF4071.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR013761. SAM/pointed.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF13281. DUF4071. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMAP3K15. mouse.
NextBio393369.
PROA2AQW0.
SOURCESearch...

Entry information

Entry nameM3K15_MOUSE
AccessionPrimary (citable) accession number: A2AQW0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot