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A2AQW0

- M3K15_MOUSE

UniProt

A2AQW0 - M3K15_MOUSE

Protein

Mitogen-activated protein kinase kinase kinase 15

Gene

Map3k15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.By similarity

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-816, inhibited by phosphorylation at Ser-928 By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei685 – 6851ATPBy similarityPROSITE-ProRule annotation
    Active sitei777 – 7771Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi662 – 6709ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase kinase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 15 (EC:2.7.11.25)
    Alternative name(s):
    MAPK/ERK kinase kinase 15
    Short name:
    MEK kinase 15
    Short name:
    MEKK 15
    Gene namesi
    Name:Map3k15Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2448588. Map3k15.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13311331Mitogen-activated protein kinase kinase kinase 15PRO_0000307633Add
    BLAST

    Proteomic databases

    PaxDbiA2AQW0.
    PRIDEiA2AQW0.

    PTM databases

    PhosphoSiteiA2AQW0.

    Expressioni

    Gene expression databases

    BgeeiA2AQW0.
    GenevestigatoriA2AQW0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000033665.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AQW0.
    SMRiA2AQW0. Positions 616-973.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini656 – 912257Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1216 – 123621Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 8684Gly-richSequence AnalysisAdd
    BLAST
    Compositional biasi949 – 9524Poly-SerSequence Analysis
    Compositional biasi1254 – 12574Poly-ProSequence Analysis

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.By similarity
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117243.
    HOGENOMiHOG000293286.
    HOVERGENiHBG006305.
    InParanoidiA2AQW0.
    KOiK13986.
    OMAiCLLRACE.
    OrthoDBiEOG7WDN1P.
    TreeFamiTF105115.

    Family and domain databases

    InterProiIPR025136. DUF4071.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR013761. SAM/pointed.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF13281. DUF4071. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2AQW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGGGGSGGG GGPVPAEAPE EAGEPPQGRL PPGPEGAAGL AEPESTGDAA     50
    GGEAEGGRGP RRALRAVYVR SESSQGAAAG GGPEAGALKC LLRACEAEGA 100
    HLTSVPFGEL DFGETAVLDA FYDADVAIVD MSDISRQPSL FYHLGVRESF 150
    DMANNVILYY DTDADTALSL KDMVTQKNTA SSGNYYFIPY TVTPCADYFC 200
    CESDAQRRAS EYMQPNWDTI LGPLCMPLVD RFTSLLKDIR VTSCAYYKET 250
    LLNDIRKARE KYQGDELAKE LTRIKFRMDN IEVLTSDIII NLLLSYRDIQ 300
    DYDAMVKLVE TLKMLPTCDL ADQHNIKFHY AFALNRRNST GDREKALQVM 350
    LQVLQSCDHP APDMFCLCGR IYKDIFLDSG CEEDASRDSA IEWYRKGFEL 400
    QSSLYSGINL AVLLIVSGQQ FETSMELRKI GVRLNSLLGR KGSLEKMNNY 450
    WDVGQFFTVS MLASDIGKAV QAAERLFKLK PPVWYLRSLV QNLLLIQRFK 500
    KPITEHSPRQ ERLNFWLDII FEATNEVTNG LRFPVLVIEP TKVYQPSYVS 550
    INNEAEERTV SLWHVSPTEM KQIHEWNFTA SSIKGISLSK FDERCCFLYV 600
    HDNSDDFQIY FSTEDQCNRF CSLVKEMLNN GVGSTVELEG EADGDTLEYE 650
    YDHDANGERV VLGKGSYGIV YAGRDLSNQV RIAIKEIPER DIRYSQPLHE 700
    EIALHKYLKH RNIVQYLGSV SENGYIKIFM EQVPGGSLSA LLRSKWGPMK 750
    EPTIKFYTKQ ILEGLKYLHE NQIVHRDIKG DNVLVNTYSG VVKISDFGTS 800
    KRLAGINPCT ETFTGTLQYM APEIIDQGPR GYGAPADIWS LGCTIIEMAT 850
    SRPPFHELGE PQAAMFKVGM FKIHPEIPEA LSAEARAFIL SCFEPDPQKR 900
    VTAADLLQEG FLRQVNKGKK NRIAFKPSEG VRSGTGTLAL PSSGELVGSS 950
    SSEHGSISPD SDAQPDAFFE KVQVPKHQLS HLLSVPDESP ALDDRSTALP 1000
    PEERDPGLFL LRKDSERRAI LYRILWEEQN QVASNLQECV VQSSEELLLS 1050
    VSHIKQIIGI LRDFIRSPEH RVMAATISKL KVDLDFDSSS INQIHLILFG 1100
    FQDAVNRILR NHLIRPHWMF AMDNIIRRAV QAAVTILIPE LQAHFEPASE 1150
    TEGVDKDTEV EGDYPLVDLL SQEVHVTPRG TRPGSVAIQE GQPHQQDPSL 1200
    QLSKLRQETN RLWEHLVQKE REYQNLLRLI LDQKTQELYH LQLQYKSNGG 1250
    TENPPPPDGL GTDRELIDWL QLQGVDANTI EKIVEEDYTL SDILNDITKE 1300
    DLRCLRLRGG VLCRLWHAVS QHRRQMQESS Q 1331
    Length:1,331
    Mass (Da):149,327
    Last modified:February 20, 2007 - v1
    Checksum:i6BB38F2B8A59B942
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL845167, AL929452 Genomic DNA. Translation: CAM22391.1.
    AL929452, AL845167 Genomic DNA. Translation: CAM21674.1.
    CCDSiCCDS53236.1.
    RefSeqiNP_001156557.2. NM_001163085.2.
    UniGeneiMm.386889.

    Genome annotation databases

    EnsembliENSMUST00000033665; ENSMUSP00000033665; ENSMUSG00000031303.
    GeneIDi270672.
    KEGGimmu:270672.
    UCSCiuc009utb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL845167 , AL929452 Genomic DNA. Translation: CAM22391.1 .
    AL929452 , AL845167 Genomic DNA. Translation: CAM21674.1 .
    CCDSi CCDS53236.1.
    RefSeqi NP_001156557.2. NM_001163085.2.
    UniGenei Mm.386889.

    3D structure databases

    ProteinModelPortali A2AQW0.
    SMRi A2AQW0. Positions 616-973.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000033665.

    PTM databases

    PhosphoSitei A2AQW0.

    Proteomic databases

    PaxDbi A2AQW0.
    PRIDEi A2AQW0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033665 ; ENSMUSP00000033665 ; ENSMUSG00000031303 .
    GeneIDi 270672.
    KEGGi mmu:270672.
    UCSCi uc009utb.2. mouse.

    Organism-specific databases

    CTDi 389840.
    MGIi MGI:2448588. Map3k15.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117243.
    HOGENOMi HOG000293286.
    HOVERGENi HBG006305.
    InParanoidi A2AQW0.
    KOi K13986.
    OMAi CLLRACE.
    OrthoDBi EOG7WDN1P.
    TreeFami TF105115.

    Miscellaneous databases

    ChiTaRSi MAP3K15. mouse.
    NextBioi 393369.
    PROi A2AQW0.
    SOURCEi Search...

    Gene expression databases

    Bgeei A2AQW0.
    Genevestigatori A2AQW0.

    Family and domain databases

    InterProi IPR025136. DUF4071.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR013761. SAM/pointed.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF13281. DUF4071. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiM3K15_MOUSE
    AccessioniPrimary (citable) accession number: A2AQW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3