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Protein

Mitogen-activated protein kinase kinase kinase 15

Gene

Map3k15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-816, inhibited by phosphorylation at Ser-928 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei685ATPPROSITE-ProRule annotationBy similarity1
Active sitei777Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi662 – 670ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 15 (EC:2.7.11.25)
Alternative name(s):
MAPK/ERK kinase kinase 15
Short name:
MEK kinase 15
Short name:
MEKK 15
Gene namesi
Name:Map3k15Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2448588 Map3k15

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076331 – 1331Mitogen-activated protein kinase kinase kinase 15Add BLAST1331

Proteomic databases

MaxQBiA2AQW0
PaxDbiA2AQW0
PRIDEiA2AQW0

PTM databases

PhosphoSitePlusiA2AQW0

Expressioni

Gene expression databases

BgeeiENSMUSG00000031303

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033665

Structurei

3D structure databases

ProteinModelPortaliA2AQW0
SMRiA2AQW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini656 – 912Protein kinasePROSITE-ProRule annotationAdd BLAST257

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1216 – 1236Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 86Gly-richSequence analysisAdd BLAST84
Compositional biasi949 – 952Poly-SerSequence analysis4
Compositional biasi1254 – 1257Poly-ProSequence analysis4

Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4279 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00800000124036
HOGENOMiHOG000293286
HOVERGENiHBG006305
InParanoidiA2AQW0
KOiK13986
OMAiLYHDTDA
OrthoDBiEOG091G00SJ
TreeFamiTF105115

Family and domain databases

InterProiView protein in InterPro
IPR025136 DUF4071
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR013761 SAM/pointed_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13281 DUF4071, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A2AQW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGGGSGGG GGPVPAEAPE EAGEPPQGRL PPGPEGAAGL AEPESTGDAA
60 70 80 90 100
GGEAEGGRGP RRALRAVYVR SESSQGAAAG GGPEAGALKC LLRACEAEGA
110 120 130 140 150
HLTSVPFGEL DFGETAVLDA FYDADVAIVD MSDISRQPSL FYHLGVRESF
160 170 180 190 200
DMANNVILYY DTDADTALSL KDMVTQKNTA SSGNYYFIPY TVTPCADYFC
210 220 230 240 250
CESDAQRRAS EYMQPNWDTI LGPLCMPLVD RFTSLLKDIR VTSCAYYKET
260 270 280 290 300
LLNDIRKARE KYQGDELAKE LTRIKFRMDN IEVLTSDIII NLLLSYRDIQ
310 320 330 340 350
DYDAMVKLVE TLKMLPTCDL ADQHNIKFHY AFALNRRNST GDREKALQVM
360 370 380 390 400
LQVLQSCDHP APDMFCLCGR IYKDIFLDSG CEEDASRDSA IEWYRKGFEL
410 420 430 440 450
QSSLYSGINL AVLLIVSGQQ FETSMELRKI GVRLNSLLGR KGSLEKMNNY
460 470 480 490 500
WDVGQFFTVS MLASDIGKAV QAAERLFKLK PPVWYLRSLV QNLLLIQRFK
510 520 530 540 550
KPITEHSPRQ ERLNFWLDII FEATNEVTNG LRFPVLVIEP TKVYQPSYVS
560 570 580 590 600
INNEAEERTV SLWHVSPTEM KQIHEWNFTA SSIKGISLSK FDERCCFLYV
610 620 630 640 650
HDNSDDFQIY FSTEDQCNRF CSLVKEMLNN GVGSTVELEG EADGDTLEYE
660 670 680 690 700
YDHDANGERV VLGKGSYGIV YAGRDLSNQV RIAIKEIPER DIRYSQPLHE
710 720 730 740 750
EIALHKYLKH RNIVQYLGSV SENGYIKIFM EQVPGGSLSA LLRSKWGPMK
760 770 780 790 800
EPTIKFYTKQ ILEGLKYLHE NQIVHRDIKG DNVLVNTYSG VVKISDFGTS
810 820 830 840 850
KRLAGINPCT ETFTGTLQYM APEIIDQGPR GYGAPADIWS LGCTIIEMAT
860 870 880 890 900
SRPPFHELGE PQAAMFKVGM FKIHPEIPEA LSAEARAFIL SCFEPDPQKR
910 920 930 940 950
VTAADLLQEG FLRQVNKGKK NRIAFKPSEG VRSGTGTLAL PSSGELVGSS
960 970 980 990 1000
SSEHGSISPD SDAQPDAFFE KVQVPKHQLS HLLSVPDESP ALDDRSTALP
1010 1020 1030 1040 1050
PEERDPGLFL LRKDSERRAI LYRILWEEQN QVASNLQECV VQSSEELLLS
1060 1070 1080 1090 1100
VSHIKQIIGI LRDFIRSPEH RVMAATISKL KVDLDFDSSS INQIHLILFG
1110 1120 1130 1140 1150
FQDAVNRILR NHLIRPHWMF AMDNIIRRAV QAAVTILIPE LQAHFEPASE
1160 1170 1180 1190 1200
TEGVDKDTEV EGDYPLVDLL SQEVHVTPRG TRPGSVAIQE GQPHQQDPSL
1210 1220 1230 1240 1250
QLSKLRQETN RLWEHLVQKE REYQNLLRLI LDQKTQELYH LQLQYKSNGG
1260 1270 1280 1290 1300
TENPPPPDGL GTDRELIDWL QLQGVDANTI EKIVEEDYTL SDILNDITKE
1310 1320 1330
DLRCLRLRGG VLCRLWHAVS QHRRQMQESS Q
Length:1,331
Mass (Da):149,327
Last modified:February 20, 2007 - v1
Checksum:i6BB38F2B8A59B942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845167, AL929452 Genomic DNA Translation: CAM22391.1
AL929452, AL845167 Genomic DNA Translation: CAM21674.1
CCDSiCCDS53236.1
RefSeqiNP_001156557.2, NM_001163085.2
UniGeneiMm.386889

Genome annotation databases

EnsembliENSMUST00000033665; ENSMUSP00000033665; ENSMUSG00000031303
GeneIDi270672
KEGGimmu:270672
UCSCiuc009utb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiM3K15_MOUSE
AccessioniPrimary (citable) accession number: A2AQW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health