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A2AQM9

- A2AQM9_MOUSE

UniProt

A2AQM9 - A2AQM9_MOUSE

Protein
Submitted name:

Nuclear receptor coactivator 6

Gene

Ncoa6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (14 May 2014)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
    3. transcription coactivator activity Source: MGI

    GO - Biological processi

    1. brain development Source: MGI
    2. cellular response to DNA damage stimulus Source: MGI
    3. DNA-templated transcription, initiation Source: Ensembl
    4. heart development Source: MGI
    5. labyrinthine layer blood vessel development Source: MGI
    6. myeloid cell differentiation Source: Ensembl
    7. positive regulation of transcription, DNA-templated Source: MGI
    8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_118837. Rora activates circadian gene expression.
    REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_198351. RORA activates circadian gene expression.
    REACT_198352. REV-ERBA represses gene expression.
    REACT_198602. PPARA activates gene expression.
    REACT_198969. Activation of gene expression by SREBF (SREBP).
    REACT_205251. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nuclear receptor coactivator 6Imported
    Gene namesi
    Name:Ncoa6Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1929915. Ncoa6.

    Subcellular locationi

    GO - Cellular componenti

    1. histone methyltransferase complex Source: MGI
    2. nucleus Source: MGI
    3. transcription factor complex Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiA2AQM9.

    Expressioni

    Gene expression databases

    ArrayExpressiA2AQM9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000045386.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00730000111114.
    HOGENOMiHOG000113745.
    HOVERGENiHBG052586.
    InParanoidiA2AQM9.
    OrthoDBiEOG7W9RSX.

    Family and domain databases

    InterProiIPR026638. NCOA6.
    [Graphical view]
    PANTHERiPTHR15690. PTHR15690. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    A2AQM9-1 [UniParc]FASTAAdd to Basket

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    MVLDDLPNFE DIYTSLCSST MGDSEVEFDS GLEDDDTKSD SILEDSTIFV     50
    AFKGNIDDKD FKWKLDAILK NVPNLLHMES SKLKVQKVEP WNSVRVTFNI 100
    PREAAERLRI LAQSNNQQLR DLGILSVQIE GEGAINLALG QNRSQDVRMN 150
    GPVASGNSVR MEAGFPMASG PGLIRMTSPA AVMTPQGGNM SSSMMAPGPN 200
    PELQPRTPRP ASQSDAMDPL LSGLHIQQQS HPSGSLPPAH HSMQPVPVNR 250
    QMNPANFPQL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQLQTRPLQQ 300
    HQQQPQGIRP QFTAPTQVPV PPGWNQLPSG ALQPPPAQGS LGTMTTNQGW 350
    KKAPLPSPMQ AQLQARPSLA TVQTPSHPPP PYPFGSQQAS QAHTNFPQMS 400
    NPGQFTAPQM KGLQGGPSRV PTPLQQPHLT NKSPASSPSS FQQGSPASSP 450
    TVNQTQQQMG PRPPQNNPLS QGFQQPVSSP GRNPMVQQGN VPPNFMVMQQ 500
    QPPNQGPQSL HPGLGGMPKR LPPGFSAGQA NPNFMQGQVP STTAATPGNS 550
    GALQLQANQN VQHAGGQGAG PPQNQMQVSH GPPNMMQPSL MGIHGNINNQ 600
    QAGSSGVPQV TLGNMQGQPQ QGPPSQLMGM HQQIVPSQGQ MAQQQGTLNP 650
    QNPMILSRAQ LMPQGQMMVN AQNQNLGPSP QRMTPPKQML PQQGPQMMAP 700
    HNQMMGPQGQ VLLQQNPMIE QIMTNQMQGN KAQFNSQNQS NVMPGPAQIM 750
    RGPTPNMQGN MVQFTGQMSG QMLPQQGPVN NSPSQVMGIQ GQVLRPPGPS 800
    PHMAQQHNDP VTTANNDVNL SQMMPDVSMQ QASMVPPHVQ SMQGNSASGS 850
    HFSGHGVSFN APFGGAPNGS QMSCGQNPGF PVNKDVTLTS PLLVNLLQSD 900
    ISAGHFGVNN KQNNTNANKP KKKKPPRKKK NCHQDLNTPD NRPTGLEEVD 950
    QQSLPGEQGI NLDTTGPKLP DFSNRPPGYP TQPVEQRPLP QMPPQLMQHV 1000
    APPPQPPQQQ PQPQLPQQQQ PPPPSQPQSQ QQQQQQQMMM MLMMQQDPKS 1050
    IRLPVSQNVH PPRGPLNPDS QRMPVQQSGN VPVMVGLQGP ASVPPSPDKQ 1100
    RMPMSVNTPM GSNSRKMVYQ ENPQNSSSSP LGEMSSLPEA SGSEVPSVAG 1150
    GPNNMPSHLV VSQNQLMMTG PKPGPSPLSA TQGATPQQPP VNSLPSSHGH 1200
    HFPNVAAPTQ TSRPKTPNRA SPRPYYPQTP NNRPPSTEPS EISLSPERLN 1250
    ASIAGLFPPQ INIPLPPRPN LNRGFDQQGL NPTTLKAIGQ APSNLTITNP 1300
    PNFAAPQAHK LDSVVVNSGK QSNPGTTKRA SPSNSRRSSP GSSRKTTPSP 1350
    GRQNSKAPKL TLASQTSTTM LQNMELPRNV LVGPTPLANP PLPGSFPNNT 1400
    GLNPQNPTVP VPAMGTVLED NKESVNIPQD SDCQNAQGRK EQVNTELKVV 1450
    PTQEAKMAVP EDQSKKDGQP LDPNKLPSVE ENKNLMSPAM REAPTSLSQL 1500
    LDNSGAPNVT IKPPGL 1516
    Length:1,516
    Mass (Da):163,093
    Last modified:May 14, 2014 - v2
    Checksum:i7644982132B39798
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1516 – 15161Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844852 Genomic DNA. No translation available.
    AL845325 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000123293; ENSMUSP00000118113; ENSMUSG00000038369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844852 Genomic DNA. No translation available.
    AL845325 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000045386.

    Proteomic databases

    PRIDEi A2AQM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000123293 ; ENSMUSP00000118113 ; ENSMUSG00000038369 .

    Organism-specific databases

    MGIi MGI:1929915. Ncoa6.

    Phylogenomic databases

    GeneTreei ENSGT00730000111114.
    HOGENOMi HOG000113745.
    HOVERGENi HBG052586.
    InParanoidi A2AQM9.
    OrthoDBi EOG7W9RSX.

    Enzyme and pathway databases

    Reactomei REACT_118837. Rora activates circadian gene expression.
    REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_198351. RORA activates circadian gene expression.
    REACT_198352. REV-ERBA represses gene expression.
    REACT_198602. PPARA activates gene expression.
    REACT_198969. Activation of gene expression by SREBF (SREBP).
    REACT_205251. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    ChiTaRSi NCOA6. mouse.
    NextBioi 35543896.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2AQM9.

    Family and domain databases

    InterProi IPR026638. NCOA6.
    [Graphical view ]
    PANTHERi PTHR15690. PTHR15690. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2AQM9_MOUSE
    AccessioniPrimary (citable) accession number: A2AQM9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3