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A2AQM9

- A2AQM9_MOUSE

UniProt

A2AQM9 - A2AQM9_MOUSE

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Protein
Submitted name:

Nuclear receptor coactivator 6

Gene

Ncoa6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  3. transcription coactivator activity Source: MGI

GO - Biological processi

  1. brain development Source: MGI
  2. cellular response to DNA damage stimulus Source: MGI
  3. DNA-templated transcription, initiation Source: Ensembl
  4. heart development Source: MGI
  5. labyrinthine layer blood vessel development Source: MGI
  6. myeloid cell differentiation Source: Ensembl
  7. positive regulation of transcription, DNA-templated Source: MGI
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_118837. Rora activates circadian gene expression.
REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_198351. RORA activates circadian gene expression.
REACT_198352. REV-ERBA represses gene expression.
REACT_198602. PPARA activates gene expression.
REACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_205251. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor coactivator 6Imported
Gene namesi
Name:Ncoa6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1929915. Ncoa6.

Subcellular locationi

GO - Cellular componenti

  1. histone methyltransferase complex Source: MGI
  2. nucleus Source: MGI
  3. transcription factor complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiA2AQM9.

Expressioni

Gene expression databases

ExpressionAtlasiA2AQM9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045386.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000113745.
HOVERGENiHBG052586.
OrthoDBiEOG7W9RSX.

Family and domain databases

InterProiIPR026638. NCOA6.
[Graphical view]
PANTHERiPTHR15690. PTHR15690. 1 hit.

Sequencei

Sequence statusi: Fragment.

A2AQM9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLDDLPNFE DIYTSLCSST MGDSEVEFDS GLEDDDTKSD SILEDSTIFV
60 70 80 90 100
AFKGNIDDKD FKWKLDAILK NVPNLLHMES SKLKVQKVEP WNSVRVTFNI
110 120 130 140 150
PREAAERLRI LAQSNNQQLR DLGILSVQIE GEGAINLALG QNRSQDVRMN
160 170 180 190 200
GPVASGNSVR MEAGFPMASG PGLIRMTSPA AVMTPQGGNM SSSMMAPGPN
210 220 230 240 250
PELQPRTPRP ASQSDAMDPL LSGLHIQQQS HPSGSLPPAH HSMQPVPVNR
260 270 280 290 300
QMNPANFPQL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQLQTRPLQQ
310 320 330 340 350
HQQQPQGIRP QFTAPTQVPV PPGWNQLPSG ALQPPPAQGS LGTMTTNQGW
360 370 380 390 400
KKAPLPSPMQ AQLQARPSLA TVQTPSHPPP PYPFGSQQAS QAHTNFPQMS
410 420 430 440 450
NPGQFTAPQM KGLQGGPSRV PTPLQQPHLT NKSPASSPSS FQQGSPASSP
460 470 480 490 500
TVNQTQQQMG PRPPQNNPLS QGFQQPVSSP GRNPMVQQGN VPPNFMVMQQ
510 520 530 540 550
QPPNQGPQSL HPGLGGMPKR LPPGFSAGQA NPNFMQGQVP STTAATPGNS
560 570 580 590 600
GALQLQANQN VQHAGGQGAG PPQNQMQVSH GPPNMMQPSL MGIHGNINNQ
610 620 630 640 650
QAGSSGVPQV TLGNMQGQPQ QGPPSQLMGM HQQIVPSQGQ MAQQQGTLNP
660 670 680 690 700
QNPMILSRAQ LMPQGQMMVN AQNQNLGPSP QRMTPPKQML PQQGPQMMAP
710 720 730 740 750
HNQMMGPQGQ VLLQQNPMIE QIMTNQMQGN KAQFNSQNQS NVMPGPAQIM
760 770 780 790 800
RGPTPNMQGN MVQFTGQMSG QMLPQQGPVN NSPSQVMGIQ GQVLRPPGPS
810 820 830 840 850
PHMAQQHNDP VTTANNDVNL SQMMPDVSMQ QASMVPPHVQ SMQGNSASGS
860 870 880 890 900
HFSGHGVSFN APFGGAPNGS QMSCGQNPGF PVNKDVTLTS PLLVNLLQSD
910 920 930 940 950
ISAGHFGVNN KQNNTNANKP KKKKPPRKKK NCHQDLNTPD NRPTGLEEVD
960 970 980 990 1000
QQSLPGEQGI NLDTTGPKLP DFSNRPPGYP TQPVEQRPLP QMPPQLMQHV
1010 1020 1030 1040 1050
APPPQPPQQQ PQPQLPQQQQ PPPPSQPQSQ QQQQQQQMMM MLMMQQDPKS
1060 1070 1080 1090 1100
IRLPVSQNVH PPRGPLNPDS QRMPVQQSGN VPVMVGLQGP ASVPPSPDKQ
1110 1120 1130 1140 1150
RMPMSVNTPM GSNSRKMVYQ ENPQNSSSSP LGEMSSLPEA SGSEVPSVAG
1160 1170 1180 1190 1200
GPNNMPSHLV VSQNQLMMTG PKPGPSPLSA TQGATPQQPP VNSLPSSHGH
1210 1220 1230 1240 1250
HFPNVAAPTQ TSRPKTPNRA SPRPYYPQTP NNRPPSTEPS EISLSPERLN
1260 1270 1280 1290 1300
ASIAGLFPPQ INIPLPPRPN LNRGFDQQGL NPTTLKAIGQ APSNLTITNP
1310 1320 1330 1340 1350
PNFAAPQAHK LDSVVVNSGK QSNPGTTKRA SPSNSRRSSP GSSRKTTPSP
1360 1370 1380 1390 1400
GRQNSKAPKL TLASQTSTTM LQNMELPRNV LVGPTPLANP PLPGSFPNNT
1410 1420 1430 1440 1450
GLNPQNPTVP VPAMGTVLED NKESVNIPQD SDCQNAQGRK EQVNTELKVV
1460 1470 1480 1490 1500
PTQEAKMAVP EDQSKKDGQP LDPNKLPSVE ENKNLMSPAM REAPTSLSQL
1510
LDNSGAPNVT IKPPGLT
Length:1,517
Mass (Da):163,194
Last modified:October 29, 2014 - v3
Checksum:iBF3644982132B397
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1517 – 15171Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844852 Genomic DNA. No translation available.
AL845325 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000123293; ENSMUSP00000118113; ENSMUSG00000038369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844852 Genomic DNA. No translation available.
AL845325 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000045386.

Proteomic databases

PRIDEi A2AQM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000123293 ; ENSMUSP00000118113 ; ENSMUSG00000038369 .

Organism-specific databases

MGIi MGI:1929915. Ncoa6.

Phylogenomic databases

HOGENOMi HOG000113745.
HOVERGENi HBG052586.
OrthoDBi EOG7W9RSX.

Enzyme and pathway databases

Reactomei REACT_118837. Rora activates circadian gene expression.
REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_198351. RORA activates circadian gene expression.
REACT_198352. REV-ERBA represses gene expression.
REACT_198602. PPARA activates gene expression.
REACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_205251. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

ChiTaRSi NCOA6. mouse.
NextBioi 35543896.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi A2AQM9. baseline and differential.

Family and domain databases

InterProi IPR026638. NCOA6.
[Graphical view ]
PANTHERi PTHR15690. PTHR15690. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AQM9_MOUSE
AccessioniPrimary (citable) accession number: A2AQM9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: October 29, 2014
Last modified: October 29, 2014
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3