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Protein

BCL-6 corepressor-like protein 1

Gene

Bcorl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BCL-6 corepressor-like protein 1
Short name:
BCoR-L1
Short name:
BCoR-like protein 1
Gene namesi
Name:Bcorl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2443910. Bcorl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17811781BCL-6 corepressor-like protein 1PRO_0000312269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei490 – 4901PhosphoserineBy similarity
Modified residuei593 – 5931PhosphoserineBy similarity
Modified residuei607 – 6071PhosphoserineBy similarity
Modified residuei1024 – 10241PhosphoserineBy similarity
Cross-linki1087 – 1087Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1162 – 11621PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiA2AQH4.
PaxDbiA2AQH4.
PeptideAtlasiA2AQH4.
PRIDEiA2AQH4.

PTM databases

iPTMnetiA2AQH4.
PhosphoSiteiA2AQH4.

Expressioni

Gene expression databases

BgeeiA2AQH4.
CleanExiMM_BCORL1.
ExpressionAtlasiA2AQH4. baseline and differential.
GenevisibleiA2AQH4. MM.

Interactioni

Subunit structurei

Interacts with CTBP1. Interacts with HDAC4, HDAC5 and HDAC7 (By similarity). Interacts with PCGF1; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039898.

Structurei

3D structure databases

ProteinModelPortaliA2AQH4.
SMRiA2AQH4. Positions 1664-1781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1493 – 152331ANK 1Add
BLAST
Repeati1527 – 155630ANK 2Add
BLAST
Repeati1560 – 158930ANK 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi200 – 454255Pro-richAdd
BLAST
Compositional biasi1253 – 12575Poly-Glu
Compositional biasi1316 – 13194Poly-Glu

Sequence similaritiesi

Belongs to the BCOR family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IFKH. Eukaryota.
ENOG411028G. LUCA.
GeneTreeiENSGT00760000119090.
HOGENOMiHOG000095190.
HOVERGENiHBG104815.
InParanoidiA2AQH4.
OMAiWVKNSTA.
OrthoDBiEOG7KWSGQ.
TreeFamiTF333317.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032365. PUFD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF16553. PUFD. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AQH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GGCQHFGSQE
60 70 80 90 100
FCVSSSFSKV ELTAVGSGSN ARGTNPDGNT TEKLGHRSED QSDDPQPKMD
110 120 130 140 150
YVGNPAEAEG LLVPLSSPGD GLKLPTPDST EASHSRANCS WTPLSTQMSK
160 170 180 190 200
QVDCSPAGVK ALDSRHGVGE KNTFILATLG TGVPVEGTLP LVTTNFSQLP
210 220 230 240 250
APICPPAPGS ASGTPSVPDP FQVPLSVPAP VPHSGLVPVQ VATSASAPSP
260 270 280 290 300
PLAPAAPSVP TLISDSNPLS VSASVLVPVP VSAPHSVPVP LSAPAPTPLT
310 320 330 340 350
VSVSAPPLAL IQAPVPPSAP TLVLASVPTP VLAPMPASTP PAAPAPPSVP
360 370 380 390 400
MPTPTPSSGP PSTPTLIPAF APTPVPAPTP APIFTPAPTP MPAATPAAIP
410 420 430 440 450
TSAPIPASFS LSRVCFPAAQ APAMQKVPLS FQPGTVLTPN QPLVYIPPPS
460 470 480 490 500
CGQPLSVATL PTTLGVSSTL TLPVLPSYLQ DRCLPGVLAS PDLRSYPCAF
510 520 530 540 550
SVARPLASDS KLVSLEVNRL SCTSPSSSTN SQPAPDGVPG PLADTSLTTA
560 570 580 590 600
SAKVLPTSQL LLPAPSGSSV PPHPSKMPGG TDQQTEGTSV TFSPLKSPPQ
610 620 630 640 650
LEREMASPPE CSEMPLDLSA KSNRQKLPLP NQRKTPPMPV LTPVHTSSKA
660 670 680 690 700
LLSTVLSRSQ RTTQAAGSNV TSCLGSTSSP FVIFPEMVRN GDPSTWVKNS
710 720 730 740 750
TALISTIPGT YVGVANPVPA SLLLNKDPNL GLNRDPRHLP KQEPISIIDQ
760 770 780 790 800
GEPKSTSATC GKKGSQAGAE GQPSTVKSRY TPARIAPGLP GCQTKELSLW
810 820 830 840 850
KPTGLTNMYP RCSINGKPTS TQVLPVGWSP YHQASLLSIG ISSAGQLTPS
860 870 880 890 900
QGVPIRPTSI VSEFSGVSPL GSSETVHGLP EGQPRPGGPF APEQDAVTKN
910 920 930 940 950
KNCRIAAKPY EEQVNPVLLT LSPQSGTLAL SVQPSSGDMG VNQGSEESES
960 970 980 990 1000
HLCSDSTPKM EGPQAACGLK LAGDTKPKNQ VLATYMSHEL VLANPQNLCK
1010 1020 1030 1040 1050
MPELPLLPHD SHSKELILDV VPSSERGPST DLSQLGSQVD LGRVKMEKAD
1060 1070 1080 1090 1100
GDVVFNLANC FRADGLPAVP QRGQAEARAN AGQARVKRES IGVFTCKNSW
1110 1120 1130 1140 1150
QPDEETESLP PKKVKCNKEK EIEEEPRQQP PPQPHDKPMV RSSLGSKCRK
1160 1170 1180 1190 1200
LPGDPQEPTK KSPRGALDSG KEHNGVRGKH KHRKPTKPES QPPGKRTDGH
1210 1220 1230 1240 1250
EEGSLEKKAK NSFRDFIPVV LSTRTRSQSG SICSSFAGMA DSDMGSQEVF
1260 1270 1280 1290 1300
PTEEEEEVAP TPAKRRKVRK TQRDTQYRSH HAQDKTLLSQ GRRHLWRARE
1310 1320 1330 1340 1350
MPWRTEAARQ MWDTNEEEED DEEEGLVKRK KRRRQKSRKY QTGEYLIEQE
1360 1370 1380 1390 1400
EQRRKGRADS KARKQKTSSQ SSEHCLRNRN LLLSSKAQGI SDSPNGFLPD
1410 1420 1430 1440 1450
NLEEPACLEN PEKPSGKRKC KTKHMANASE EARSKGRWSQ QKTRSSKSPT
1460 1470 1480 1490 1500
PVKPTEPCTP SKYRSAGPEE ASESPTARQI PPEARRLIVN KNAGETLLQR
1510 1520 1530 1540 1550
AARLGYKDVV LYCLQKHSED VNHRDNAGYT ALHEACSRGW TDILNILLQH
1560 1570 1580 1590 1600
GANVNCSSQD GTRPVHDAVV NDNLETIWLL LSYGADPTLA TYSGQTAMKL
1610 1620 1630 1640 1650
ASSDNMKRFL SDHLSDLQGR AEGDPRASWD FYSSSVLEKK DGFACDLLHN
1660 1670 1680 1690 1700
PPGSAEQGDD SEQDDFMFEL SDKPLLPCYN LQVSVSRGPC NWFLFSDVLK
1710 1720 1730 1740 1750
RLKLSSRIFQ ARFPHLEITT LPKAEFYRQV ASSQLLSPAE RPGSLEDRSP
1760 1770 1780
PGSSETVELV QYEPELLRLL GSEVEYQSWS S
Length:1,781
Mass (Da):190,487
Last modified:February 20, 2007 - v1
Checksum:iC7A689F5D0A76A9F
GO

Sequence cautioni

The sequence BAC27262.1 differs from that shown. Reason: Frameshift at position 1423. Curated
The sequence BAC27262.1 differs from that shown. Reason: Erroneous termination at position 1632. Translated as Tyr.Curated
The sequence BAC35708.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC38112.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1209 – 12091A → V in BAC27262 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844594 Genomic DNA. Translation: CAM18941.1.
AK031119 mRNA. Translation: BAC27262.1. Sequence problems.
AK054259 mRNA. Translation: BAC35708.1. Different initiation.
AK081004 mRNA. Translation: BAC38112.1. Different initiation.
CCDSiCCDS40961.1.
RefSeqiNP_848897.3. NM_178782.4.
XP_006541560.1. XM_006541497.2.
XP_006541561.1. XM_006541498.2.
XP_006541562.1. XM_006541499.2.
XP_006541563.1. XM_006541500.2.
UniGeneiMm.210146.

Genome annotation databases

EnsembliENSMUST00000037596; ENSMUSP00000039898; ENSMUSG00000036959.
ENSMUST00000136348; ENSMUSP00000122000; ENSMUSG00000036959.
GeneIDi320376.
KEGGimmu:320376.
UCSCiuc009tcc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844594 Genomic DNA. Translation: CAM18941.1.
AK031119 mRNA. Translation: BAC27262.1. Sequence problems.
AK054259 mRNA. Translation: BAC35708.1. Different initiation.
AK081004 mRNA. Translation: BAC38112.1. Different initiation.
CCDSiCCDS40961.1.
RefSeqiNP_848897.3. NM_178782.4.
XP_006541560.1. XM_006541497.2.
XP_006541561.1. XM_006541498.2.
XP_006541562.1. XM_006541499.2.
XP_006541563.1. XM_006541500.2.
UniGeneiMm.210146.

3D structure databases

ProteinModelPortaliA2AQH4.
SMRiA2AQH4. Positions 1664-1781.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039898.

PTM databases

iPTMnetiA2AQH4.
PhosphoSiteiA2AQH4.

Proteomic databases

MaxQBiA2AQH4.
PaxDbiA2AQH4.
PeptideAtlasiA2AQH4.
PRIDEiA2AQH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037596; ENSMUSP00000039898; ENSMUSG00000036959.
ENSMUST00000136348; ENSMUSP00000122000; ENSMUSG00000036959.
GeneIDi320376.
KEGGimmu:320376.
UCSCiuc009tcc.1. mouse.

Organism-specific databases

CTDi63035.
MGIiMGI:2443910. Bcorl1.

Phylogenomic databases

eggNOGiENOG410IFKH. Eukaryota.
ENOG411028G. LUCA.
GeneTreeiENSGT00760000119090.
HOGENOMiHOG000095190.
HOVERGENiHBG104815.
InParanoidiA2AQH4.
OMAiWVKNSTA.
OrthoDBiEOG7KWSGQ.
TreeFamiTF333317.

Miscellaneous databases

PROiA2AQH4.
SOURCEiSearch...

Gene expression databases

BgeeiA2AQH4.
CleanExiMM_BCORL1.
ExpressionAtlasiA2AQH4. baseline and differential.
GenevisibleiA2AQH4. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032365. PUFD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF16553. PUFD. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 395-1781.
    Strain: C57BL/6J.
    Tissue: Cerebellum, Fetal forelimb and Ovary.

Entry informationi

Entry nameiBCORL_MOUSE
AccessioniPrimary (citable) accession number: A2AQH4
Secondary accession number(s): Q8BMH7, Q8BV26, Q8BW58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.