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A2AQ92

- A2AQ92_MOUSE

UniProt

A2AQ92 - A2AQ92_MOUSE

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Protein
Submitted name: Protein Duox1
Gene
Duox1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heme binding Source: InterPro
  3. peroxidase activity Source: InterPro
  4. protein binding Source: MGI

GO - Biological processi

  1. cuticle development Source: Ensembl
  2. cytokine-mediated signaling pathway Source: Ensembl
  3. reactive oxygen species metabolic process Source: MGI
  4. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotations

Keywords - Ligandi

CalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Duox1Imported
Gene namesi
Name:Duox1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2139422. Duox1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA2AQ92.
PRIDEiA2AQ92.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097060.

Structurei

3D structure databases

ProteinModelPortaliA2AQ92.

Family & Domainsi

Sequence similaritiesi

Contains FAD-binding FR-type domain.SAAS annotations
Contains ferric oxidoreductase domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00550000074350.
HOGENOMiHOG000231774.
HOVERGENiHBG080428.
InParanoidiA2AQ92.
KOiK13411.
OMAiTRERRQK.
OrthoDBiEOG7GN2KV.
PhylomeDBiA2AQ92.
TreeFamiTF105424.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.640.10. 1 hit.
InterProiIPR029595. DUOX1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR013112. FAD-bd_8.
IPR017927. Fd_Rdtase_FAD-bd.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PANTHERiPTHR11972:SF37. PTHR11972:SF37. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS51384. FAD_FR. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AQ92-1 [UniParc]FASTAAdd to Basket

« Hide

MGFHLALAWI LLVGTLASLG AQNSISWEVQ RFDGWYNNLM EHRWGSKGSR     50
LQRLVPASYA DGVYQPLKEP YLPNPRHLSN RVMRGSAGQP SLRNRTVLGV 100
FFGYHVLSDL VSVETPGCPA EFLNIYIPHG DPVFDPDKRG NVVLPFQRSR 150
WDRNTGQSPS NPRDQSNQVT GWLDGSAIYG SSHSWSDTLR SFSGGQLASG 200
PDPAFPSDSQ SSLLMWMAPD PSTGQGGPRG VYAFGAQRGN REPFLQALGL 250
LWFRYHNLCA RKLAQEHPHW GDEELFQHAR KRVIATYQNI AMYEWLPSFL 300
KQTPPEYPGY RPFLDPSISP EFVVASEQFL STMVPSGVYM RNASCHFQGI 350
PSHNSSVSGA LRVCNSYWSR EHPKLQRAED VDALLLGMAS QIAEREDHVV 400
VEDMQDFWPG PLKFSRTDYL ASCLQRGRDL GLPSYTKARE ALGLSPISHW 450
QDINPALSRS NGTVLEATAA LYNQDLSRLE LLPGGLLESH GDPGPLFSTI 500
VLDQFVRLRD GDRYWFENTR NGLFSKEEIA EIRNTSLRDI LVAVTNVDPS 550
ALQPNVFFWL AGDPCPQPSQ LSAKGLPACA PLFIRDYFEG SGFGFGLTIG 600
TLCCFPLVSL LSAWIVARLR KRNFKRLQRQ DRQSIMSEKL VGGVEALEWQ 650
GRNEPCRPVL VHLQPGQIRV VDGRLTVLRT IQLRPPQQVN LILSSNRGRR 700
TLLLKIPKEY DLVLLFNMEE ERQALVENVR GALKENGLSF QEWELREQEL 750
MRAAVTRQQR GHLLETFFRH LFSQVLDINQ ADAGTLPLDS STKVREALTC 800
ELSRAEFADS LGLKPQDMFV ESMFSLADKD GNGYLSFREF LDILVVFMKG 850
SPEEKSRLMF RMYDFDGNGL ISKDEFIRML RSFIEISNNC LSKAQLAEVV 900
ESMFRESGFQ DKEELTWEDF HFMLRDHDSD LRFTQLCVKG VEVPEVIKNL 950
CRRASYISQE KICPSPRMSA HCARNNMKTA SSPQRLQCPM DTDPPQEIRR 1000
RFGKKVTSFQ PLLFTEAHRE KFQRSRRHQT VQQFKRFIEN YRRHIGCVAV 1050
FYTITGALFL ERAYYYAFAA HHSGITDTTR VGIILSRGTA ASISFMFSYI 1100
LLTMCRNLIT FLRETFLNRY IPFDAAVDFH RLIASTAIIL TVLHSAGHVV 1150
NVYLFSISPL SVLSCLFPGL FHDDGSEFPQ KYYWWFFQTV PGLTGVLLLL 1200
ALAIMYVFAS HHFRRRSFRG FWLTHHLYIF LYILLIIHGS FALIQMPRFH 1250
IFFLVPAIIY VGDKLVSLSR KKVEISVVKA ELLPSGVTHL RFQRPQGFEY 1300
KSGQWVRIAC LALGTTEYHP FTLTSAPHED TLSLHIRAAG PWTTRLREIY 1350
SPPTGDTCAR YPKLYLDGPF GEGHQEWHKF EVSVLVGGGI GVTPFASILK 1400
DLVFKSSVSC QVFCKKIYFI WVTRTQRQFE WLADIIREVE ENDRQDLVSV 1450
HIYITQLAEK FDLRTTMLYI CERHFQKVLN RSLFTGLRSI THFGRPPFEP 1500
FFNSLQEVHP QVRKIGVFSC GPPGMTKNVE KACQLINRQD RTHFSHHYEN 1550
F 1551
Length:1,551
Mass (Da):177,132
Last modified:February 20, 2007 - v1
Checksum:i8B9729E2F23CAF1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844566 Genomic DNA. No translation available.
RefSeqiNP_001092767.1. NM_001099297.1.
XP_006500550.1. XM_006500487.1.
UniGeneiMm.108582.

Genome annotation databases

EnsembliENSMUST00000099461; ENSMUSP00000097060; ENSMUSG00000033268.
GeneIDi99439.
KEGGimmu:99439.
UCSCiuc008map.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844566 Genomic DNA. No translation available.
RefSeqi NP_001092767.1. NM_001099297.1.
XP_006500550.1. XM_006500487.1.
UniGenei Mm.108582.

3D structure databases

ProteinModelPortali A2AQ92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000097060.

Proteomic databases

PaxDbi A2AQ92.
PRIDEi A2AQ92.

Protocols and materials databases

DNASUi 99439.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099461 ; ENSMUSP00000097060 ; ENSMUSG00000033268 .
GeneIDi 99439.
KEGGi mmu:99439.
UCSCi uc008map.1. mouse.

Organism-specific databases

CTDi 53905.
MGIi MGI:2139422. Duox1.

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00550000074350.
HOGENOMi HOG000231774.
HOVERGENi HBG080428.
InParanoidi A2AQ92.
KOi K13411.
OMAi TRERRQK.
OrthoDBi EOG7GN2KV.
PhylomeDBi A2AQ92.
TreeFami TF105424.

Miscellaneous databases

NextBioi 353935.
PROi A2AQ92.
SOURCEi Search...

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.640.10. 1 hit.
InterProi IPR029595. DUOX1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR013112. FAD-bd_8.
IPR017927. Fd_Rdtase_FAD-bd.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
PANTHERi PTHR11972:SF37. PTHR11972:SF37. 1 hit.
Pfami PF03098. An_peroxidase. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS51384. FAD_FR. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AQ92_MOUSE
AccessioniPrimary (citable) accession number: A2AQ92
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi