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A2AQ92

- A2AQ92_MOUSE

UniProt

A2AQ92 - A2AQ92_MOUSE

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Protein
Submitted name:

Protein Duox1

Gene

Duox1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heme binding Source: InterPro
  3. NAD(P)H oxidase activity Source: InterPro
  4. peroxidase activity Source: InterPro

GO - Biological processi

  1. cuticle development Source: Ensembl
  2. cytokine-mediated signaling pathway Source: Ensembl
  3. hydrogen peroxide biosynthetic process Source: InterPro
  4. reactive oxygen species metabolic process Source: MGI
  5. response to oxidative stress Source: InterPro
  6. thyroid hormone generation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotation

Keywords - Ligandi

CalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Duox1Imported
Gene namesi
Name:Duox1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2139422. Duox1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA2AQ92.
PRIDEiA2AQ92.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097060.

Structurei

3D structure databases

ProteinModelPortaliA2AQ92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains FAD-binding FR-type domain.SAAS annotation
Contains ferric oxidoreductase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00550000074350.
HOGENOMiHOG000231774.
HOVERGENiHBG080428.
InParanoidiA2AQ92.
KOiK13411.
OMAiTRERRQK.
OrthoDBiEOG7GN2KV.
PhylomeDBiA2AQ92.
TreeFamiTF105424.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.640.10. 1 hit.
InterProiIPR029595. DUOX1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR013112. FAD-bd_8.
IPR017927. Fd_Rdtase_FAD-bd.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PANTHERiPTHR11972:SF37. PTHR11972:SF37. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS51384. FAD_FR. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AQ92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFHLALAWI LLVGTLASLG AQNSISWEVQ RFDGWYNNLM EHRWGSKGSR
60 70 80 90 100
LQRLVPASYA DGVYQPLKEP YLPNPRHLSN RVMRGSAGQP SLRNRTVLGV
110 120 130 140 150
FFGYHVLSDL VSVETPGCPA EFLNIYIPHG DPVFDPDKRG NVVLPFQRSR
160 170 180 190 200
WDRNTGQSPS NPRDQSNQVT GWLDGSAIYG SSHSWSDTLR SFSGGQLASG
210 220 230 240 250
PDPAFPSDSQ SSLLMWMAPD PSTGQGGPRG VYAFGAQRGN REPFLQALGL
260 270 280 290 300
LWFRYHNLCA RKLAQEHPHW GDEELFQHAR KRVIATYQNI AMYEWLPSFL
310 320 330 340 350
KQTPPEYPGY RPFLDPSISP EFVVASEQFL STMVPSGVYM RNASCHFQGI
360 370 380 390 400
PSHNSSVSGA LRVCNSYWSR EHPKLQRAED VDALLLGMAS QIAEREDHVV
410 420 430 440 450
VEDMQDFWPG PLKFSRTDYL ASCLQRGRDL GLPSYTKARE ALGLSPISHW
460 470 480 490 500
QDINPALSRS NGTVLEATAA LYNQDLSRLE LLPGGLLESH GDPGPLFSTI
510 520 530 540 550
VLDQFVRLRD GDRYWFENTR NGLFSKEEIA EIRNTSLRDI LVAVTNVDPS
560 570 580 590 600
ALQPNVFFWL AGDPCPQPSQ LSAKGLPACA PLFIRDYFEG SGFGFGLTIG
610 620 630 640 650
TLCCFPLVSL LSAWIVARLR KRNFKRLQRQ DRQSIMSEKL VGGVEALEWQ
660 670 680 690 700
GRNEPCRPVL VHLQPGQIRV VDGRLTVLRT IQLRPPQQVN LILSSNRGRR
710 720 730 740 750
TLLLKIPKEY DLVLLFNMEE ERQALVENVR GALKENGLSF QEWELREQEL
760 770 780 790 800
MRAAVTRQQR GHLLETFFRH LFSQVLDINQ ADAGTLPLDS STKVREALTC
810 820 830 840 850
ELSRAEFADS LGLKPQDMFV ESMFSLADKD GNGYLSFREF LDILVVFMKG
860 870 880 890 900
SPEEKSRLMF RMYDFDGNGL ISKDEFIRML RSFIEISNNC LSKAQLAEVV
910 920 930 940 950
ESMFRESGFQ DKEELTWEDF HFMLRDHDSD LRFTQLCVKG VEVPEVIKNL
960 970 980 990 1000
CRRASYISQE KICPSPRMSA HCARNNMKTA SSPQRLQCPM DTDPPQEIRR
1010 1020 1030 1040 1050
RFGKKVTSFQ PLLFTEAHRE KFQRSRRHQT VQQFKRFIEN YRRHIGCVAV
1060 1070 1080 1090 1100
FYTITGALFL ERAYYYAFAA HHSGITDTTR VGIILSRGTA ASISFMFSYI
1110 1120 1130 1140 1150
LLTMCRNLIT FLRETFLNRY IPFDAAVDFH RLIASTAIIL TVLHSAGHVV
1160 1170 1180 1190 1200
NVYLFSISPL SVLSCLFPGL FHDDGSEFPQ KYYWWFFQTV PGLTGVLLLL
1210 1220 1230 1240 1250
ALAIMYVFAS HHFRRRSFRG FWLTHHLYIF LYILLIIHGS FALIQMPRFH
1260 1270 1280 1290 1300
IFFLVPAIIY VGDKLVSLSR KKVEISVVKA ELLPSGVTHL RFQRPQGFEY
1310 1320 1330 1340 1350
KSGQWVRIAC LALGTTEYHP FTLTSAPHED TLSLHIRAAG PWTTRLREIY
1360 1370 1380 1390 1400
SPPTGDTCAR YPKLYLDGPF GEGHQEWHKF EVSVLVGGGI GVTPFASILK
1410 1420 1430 1440 1450
DLVFKSSVSC QVFCKKIYFI WVTRTQRQFE WLADIIREVE ENDRQDLVSV
1460 1470 1480 1490 1500
HIYITQLAEK FDLRTTMLYI CERHFQKVLN RSLFTGLRSI THFGRPPFEP
1510 1520 1530 1540 1550
FFNSLQEVHP QVRKIGVFSC GPPGMTKNVE KACQLINRQD RTHFSHHYEN

F
Length:1,551
Mass (Da):177,132
Last modified:February 20, 2007 - v1
Checksum:i8B9729E2F23CAF1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844566 Genomic DNA. No translation available.
RefSeqiNP_001092767.1. NM_001099297.1.
XP_006500550.1. XM_006500487.1.
UniGeneiMm.108582.

Genome annotation databases

EnsembliENSMUST00000099461; ENSMUSP00000097060; ENSMUSG00000033268.
GeneIDi99439.
KEGGimmu:99439.
UCSCiuc008map.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844566 Genomic DNA. No translation available.
RefSeqi NP_001092767.1. NM_001099297.1.
XP_006500550.1. XM_006500487.1.
UniGenei Mm.108582.

3D structure databases

ProteinModelPortali A2AQ92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000097060.

Proteomic databases

PaxDbi A2AQ92.
PRIDEi A2AQ92.

Protocols and materials databases

DNASUi 99439.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099461 ; ENSMUSP00000097060 ; ENSMUSG00000033268 .
GeneIDi 99439.
KEGGi mmu:99439.
UCSCi uc008map.1. mouse.

Organism-specific databases

CTDi 53905.
MGIi MGI:2139422. Duox1.

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00550000074350.
HOGENOMi HOG000231774.
HOVERGENi HBG080428.
InParanoidi A2AQ92.
KOi K13411.
OMAi TRERRQK.
OrthoDBi EOG7GN2KV.
PhylomeDBi A2AQ92.
TreeFami TF105424.

Miscellaneous databases

NextBioi 353935.
PROi A2AQ92.
SOURCEi Search...

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.640.10. 1 hit.
InterProi IPR029595. DUOX1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR013112. FAD-bd_8.
IPR017927. Fd_Rdtase_FAD-bd.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
PANTHERi PTHR11972:SF37. PTHR11972:SF37. 1 hit.
Pfami PF03098. An_peroxidase. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS51384. FAD_FR. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AQ92_MOUSE
AccessioniPrimary (citable) accession number: A2AQ92
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3