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A2AQ92

- A2AQ92_MOUSE

UniProt

A2AQ92 - A2AQ92_MOUSE

Protein
Submitted name:

Protein Duox1

Gene

Duox1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heme binding Source: InterPro
    3. peroxidase activity Source: InterPro
    4. protein binding Source: MGI

    GO - Biological processi

    1. cuticle development Source: Ensembl
    2. cytokine-mediated signaling pathway Source: Ensembl
    3. reactive oxygen species metabolic process Source: MGI
    4. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseSAAS annotation

    Keywords - Ligandi

    CalciumUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Duox1Imported
    Gene namesi
    Name:Duox1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2139422. Duox1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PaxDbiA2AQ92.
    PRIDEiA2AQ92.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000097060.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AQ92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains FAD-binding FR-type domain.SAAS annotation
    Contains ferric oxidoreductase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    eggNOGiCOG5126.
    GeneTreeiENSGT00550000074350.
    HOGENOMiHOG000231774.
    HOVERGENiHBG080428.
    InParanoidiA2AQ92.
    KOiK13411.
    OMAiTRERRQK.
    OrthoDBiEOG7GN2KV.
    PhylomeDBiA2AQ92.
    TreeFamiTF105424.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.640.10. 1 hit.
    InterProiIPR029595. DUOX1.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR013112. FAD-bd_8.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR013130. Fe3_Rdtase_TM_dom.
    IPR013121. Fe_red_NAD-bd_6.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PANTHERiPTHR11972:SF37. PTHR11972:SF37. 1 hit.
    PfamiPF03098. An_peroxidase. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    PF08022. FAD_binding_8. 1 hit.
    PF01794. Ferric_reduct. 1 hit.
    PF08030. NAD_binding_6. 1 hit.
    [Graphical view]
    PRINTSiPR00457. ANPEROXIDASE.
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    SUPFAMiSSF48113. SSF48113. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS51384. FAD_FR. 1 hit.
    PS50292. PEROXIDASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2AQ92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFHLALAWI LLVGTLASLG AQNSISWEVQ RFDGWYNNLM EHRWGSKGSR     50
    LQRLVPASYA DGVYQPLKEP YLPNPRHLSN RVMRGSAGQP SLRNRTVLGV 100
    FFGYHVLSDL VSVETPGCPA EFLNIYIPHG DPVFDPDKRG NVVLPFQRSR 150
    WDRNTGQSPS NPRDQSNQVT GWLDGSAIYG SSHSWSDTLR SFSGGQLASG 200
    PDPAFPSDSQ SSLLMWMAPD PSTGQGGPRG VYAFGAQRGN REPFLQALGL 250
    LWFRYHNLCA RKLAQEHPHW GDEELFQHAR KRVIATYQNI AMYEWLPSFL 300
    KQTPPEYPGY RPFLDPSISP EFVVASEQFL STMVPSGVYM RNASCHFQGI 350
    PSHNSSVSGA LRVCNSYWSR EHPKLQRAED VDALLLGMAS QIAEREDHVV 400
    VEDMQDFWPG PLKFSRTDYL ASCLQRGRDL GLPSYTKARE ALGLSPISHW 450
    QDINPALSRS NGTVLEATAA LYNQDLSRLE LLPGGLLESH GDPGPLFSTI 500
    VLDQFVRLRD GDRYWFENTR NGLFSKEEIA EIRNTSLRDI LVAVTNVDPS 550
    ALQPNVFFWL AGDPCPQPSQ LSAKGLPACA PLFIRDYFEG SGFGFGLTIG 600
    TLCCFPLVSL LSAWIVARLR KRNFKRLQRQ DRQSIMSEKL VGGVEALEWQ 650
    GRNEPCRPVL VHLQPGQIRV VDGRLTVLRT IQLRPPQQVN LILSSNRGRR 700
    TLLLKIPKEY DLVLLFNMEE ERQALVENVR GALKENGLSF QEWELREQEL 750
    MRAAVTRQQR GHLLETFFRH LFSQVLDINQ ADAGTLPLDS STKVREALTC 800
    ELSRAEFADS LGLKPQDMFV ESMFSLADKD GNGYLSFREF LDILVVFMKG 850
    SPEEKSRLMF RMYDFDGNGL ISKDEFIRML RSFIEISNNC LSKAQLAEVV 900
    ESMFRESGFQ DKEELTWEDF HFMLRDHDSD LRFTQLCVKG VEVPEVIKNL 950
    CRRASYISQE KICPSPRMSA HCARNNMKTA SSPQRLQCPM DTDPPQEIRR 1000
    RFGKKVTSFQ PLLFTEAHRE KFQRSRRHQT VQQFKRFIEN YRRHIGCVAV 1050
    FYTITGALFL ERAYYYAFAA HHSGITDTTR VGIILSRGTA ASISFMFSYI 1100
    LLTMCRNLIT FLRETFLNRY IPFDAAVDFH RLIASTAIIL TVLHSAGHVV 1150
    NVYLFSISPL SVLSCLFPGL FHDDGSEFPQ KYYWWFFQTV PGLTGVLLLL 1200
    ALAIMYVFAS HHFRRRSFRG FWLTHHLYIF LYILLIIHGS FALIQMPRFH 1250
    IFFLVPAIIY VGDKLVSLSR KKVEISVVKA ELLPSGVTHL RFQRPQGFEY 1300
    KSGQWVRIAC LALGTTEYHP FTLTSAPHED TLSLHIRAAG PWTTRLREIY 1350
    SPPTGDTCAR YPKLYLDGPF GEGHQEWHKF EVSVLVGGGI GVTPFASILK 1400
    DLVFKSSVSC QVFCKKIYFI WVTRTQRQFE WLADIIREVE ENDRQDLVSV 1450
    HIYITQLAEK FDLRTTMLYI CERHFQKVLN RSLFTGLRSI THFGRPPFEP 1500
    FFNSLQEVHP QVRKIGVFSC GPPGMTKNVE KACQLINRQD RTHFSHHYEN 1550
    F 1551
    Length:1,551
    Mass (Da):177,132
    Last modified:February 20, 2007 - v1
    Checksum:i8B9729E2F23CAF1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844566 Genomic DNA. No translation available.
    RefSeqiNP_001092767.1. NM_001099297.1.
    XP_006500550.1. XM_006500487.1.
    UniGeneiMm.108582.

    Genome annotation databases

    EnsembliENSMUST00000099461; ENSMUSP00000097060; ENSMUSG00000033268.
    GeneIDi99439.
    KEGGimmu:99439.
    UCSCiuc008map.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844566 Genomic DNA. No translation available.
    RefSeqi NP_001092767.1. NM_001099297.1.
    XP_006500550.1. XM_006500487.1.
    UniGenei Mm.108582.

    3D structure databases

    ProteinModelPortali A2AQ92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000097060.

    Proteomic databases

    PaxDbi A2AQ92.
    PRIDEi A2AQ92.

    Protocols and materials databases

    DNASUi 99439.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099461 ; ENSMUSP00000097060 ; ENSMUSG00000033268 .
    GeneIDi 99439.
    KEGGi mmu:99439.
    UCSCi uc008map.1. mouse.

    Organism-specific databases

    CTDi 53905.
    MGIi MGI:2139422. Duox1.

    Phylogenomic databases

    eggNOGi COG5126.
    GeneTreei ENSGT00550000074350.
    HOGENOMi HOG000231774.
    HOVERGENi HBG080428.
    InParanoidi A2AQ92.
    KOi K13411.
    OMAi TRERRQK.
    OrthoDBi EOG7GN2KV.
    PhylomeDBi A2AQ92.
    TreeFami TF105424.

    Miscellaneous databases

    NextBioi 353935.
    PROi A2AQ92.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.640.10. 1 hit.
    InterProi IPR029595. DUOX1.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR013112. FAD-bd_8.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR013130. Fe3_Rdtase_TM_dom.
    IPR013121. Fe_red_NAD-bd_6.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    PANTHERi PTHR11972:SF37. PTHR11972:SF37. 1 hit.
    Pfami PF03098. An_peroxidase. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    PF08022. FAD_binding_8. 1 hit.
    PF01794. Ferric_reduct. 1 hit.
    PF08030. NAD_binding_6. 1 hit.
    [Graphical view ]
    PRINTSi PR00457. ANPEROXIDASE.
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48113. SSF48113. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS51384. FAD_FR. 1 hit.
    PS50292. PEROXIDASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2AQ92_MOUSE
    AccessioniPrimary (citable) accession number: A2AQ92
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3