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Protein

Arginine-hydroxylase NDUFAF5, mitochondrial

Gene

Ndufaf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Oxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine-hydroxylase NDUFAF5, mitochondrial (EC:1.-.-.-By similarity)
Alternative name(s):
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5Imported
Putative methyltransferase NDUFAF5Curated (EC:2.1.1.-Curated)
Gene namesi
Name:Ndufaf5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916737. Ndufaf5.

Subcellular locationi

  • Mitochondrion inner membrane By similarity

  • Note: Peripherally localized on the matrix face of the mitochondrial inner membrane.By similarity

GO - Cellular componenti

  • extrinsic component of mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000030721430 – 343Arginine-hydroxylase NDUFAF5, mitochondrialAdd BLAST314

Proteomic databases

EPDiA2APY7.
MaxQBiA2APY7.
PaxDbiA2APY7.
PeptideAtlasiA2APY7.
PRIDEiA2APY7.

PTM databases

iPTMnetiA2APY7.
PhosphoSitePlusiA2APY7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027384.
CleanExiMM_2310003L22RIK.
GenevisibleiA2APY7. MM.

Interactioni

Subunit structurei

Interacts with NDUFAF8, leading to stabilize NDUFAF5. Interacts with NDUFS7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035325.

Structurei

3D structure databases

ProteinModelPortaliA2APY7.
SMRiA2APY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2940. Eukaryota.
COG0500. LUCA.
GeneTreeiENSGT00390000014687.
HOGENOMiHOG000265011.
HOVERGENiHBG107772.
InParanoidiA2APY7.
KOiK18162.
OMAiCRRPWAA.
OrthoDBiEOG091G0EZO.
PhylomeDBiA2APY7.
TreeFamiTF315222.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2APY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRKVVLLRL CPLLGRPAVS ASSGSRREVA SGVPPSGSTS PRALNIFDRE
60 70 80 90 100
LKRKQKNWAA RQPDPMKFDY LKEEVGSRIA DRVYDIARDF PLALDIGCGR
110 120 130 140 150
GYIAQHLDKE TVGKIFQTDI AEHALKNSLE TDIPTVNILA DEEFLPFQEN
160 170 180 190 200
TFDLVVSSLS LHWVNDLPRA LEQIHYVLKP DGVFVGAMFG GDTLYELRCS
210 220 230 240 250
LQLAETEREG GFSPHISPFT AVNDLGHLLG RAGFNTLTVD TDEIQVNYPG
260 270 280 290 300
MFELMEDLKG MGESNCSWNR KALLHRDTML AAAAVYREMY RNEDGSIPAT
310 320 330 340
FQIYHMIGWK YHDSQARPAE RGSATVSFGE LAKLNDVMSH EKK
Length:343
Mass (Da):38,405
Last modified:February 20, 2007 - v1
Checksum:i5B9766C0840643A0
GO
Isoform 2 (identifier: A2APY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Show »
Length:156
Mass (Da):17,526
Checksum:iBA8F84D7A8517A03
GO

Sequence cautioni

The sequence AAH05630 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0286381 – 187Missing in isoform 2. 1 PublicationAdd BLAST187

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009123 mRNA. Translation: BAB26088.1.
AL844528 Genomic DNA. Translation: CAM14882.1.
BC005630 mRNA. Translation: AAH05630.1. Different initiation.
CCDSiCCDS16804.2. [A2APY7-1]
RefSeqiNP_081369.2. NM_027093.4. [A2APY7-1]
UniGeneiMm.287921.

Genome annotation databases

EnsembliENSMUST00000044825; ENSMUSP00000035325; ENSMUSG00000027384. [A2APY7-1]
GeneIDi69487.
KEGGimmu:69487.
UCSCiuc008mpo.2. mouse. [A2APY7-1]
uc008mpp.2. mouse. [A2APY7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009123 mRNA. Translation: BAB26088.1.
AL844528 Genomic DNA. Translation: CAM14882.1.
BC005630 mRNA. Translation: AAH05630.1. Different initiation.
CCDSiCCDS16804.2. [A2APY7-1]
RefSeqiNP_081369.2. NM_027093.4. [A2APY7-1]
UniGeneiMm.287921.

3D structure databases

ProteinModelPortaliA2APY7.
SMRiA2APY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035325.

PTM databases

iPTMnetiA2APY7.
PhosphoSitePlusiA2APY7.

Proteomic databases

EPDiA2APY7.
MaxQBiA2APY7.
PaxDbiA2APY7.
PeptideAtlasiA2APY7.
PRIDEiA2APY7.

Protocols and materials databases

DNASUi69487.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044825; ENSMUSP00000035325; ENSMUSG00000027384. [A2APY7-1]
GeneIDi69487.
KEGGimmu:69487.
UCSCiuc008mpo.2. mouse. [A2APY7-1]
uc008mpp.2. mouse. [A2APY7-2]

Organism-specific databases

CTDi79133.
MGIiMGI:1916737. Ndufaf5.

Phylogenomic databases

eggNOGiKOG2940. Eukaryota.
COG0500. LUCA.
GeneTreeiENSGT00390000014687.
HOGENOMiHOG000265011.
HOVERGENiHBG107772.
InParanoidiA2APY7.
KOiK18162.
OMAiCRRPWAA.
OrthoDBiEOG091G0EZO.
PhylomeDBiA2APY7.
TreeFamiTF315222.

Enzyme and pathway databases

ReactomeiR-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiA2APY7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027384.
CleanExiMM_2310003L22RIK.
GenevisibleiA2APY7. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUF5_MOUSE
AccessioniPrimary (citable) accession number: A2APY7
Secondary accession number(s): Q9D7L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.