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Protein

Sodium channel protein type 1 subunit alpha

Gene

Scn1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:16921370, PubMed:17928448, PubMed:27281198). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons (PubMed:16921370, PubMed:22914087). Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli (PubMed:27281198).4 Publications

Enzyme regulationi

Specifically activated by the H.maculata toxins Hm1a and Hm1b in somatosensory neurons to elicit acute pain and mechanical allodynia (PubMed:27281198).2 Publications

GO - Molecular functioni

  • voltage-gated sodium channel activity Source: UniProtKB

GO - Biological processi

  • action potential Source: MGI
  • adult walking behavior Source: MGI
  • detection of mechanical stimulus involved in sensory perception of pain Source: UniProtKB
  • membrane depolarization during action potential Source: GO_Central
  • neuromuscular process controlling posture Source: MGI
  • neuronal action potential Source: MGI
  • neuronal action potential propagation Source: MGI
  • regulation of membrane potential Source: MGI
  • sodium ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 1 subunit alpha
Alternative name(s):
Sodium channel protein brain I subunit alpha
Sodium channel protein type I subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.1
Gene namesi
Name:Scn1aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98246. Scn1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 123CytoplasmicCuratedAdd BLAST123
Transmembranei124 – 147Helical; Name=S1 of repeat ISequence analysisAdd BLAST24
Topological domaini148 – 155ExtracellularCurated8
Transmembranei156 – 175Helical; Name=S2 of repeat ISequence analysisAdd BLAST20
Topological domaini176 – 188CytoplasmicCuratedAdd BLAST13
Transmembranei189 – 207Helical; Name=S3 of repeat ISequence analysisAdd BLAST19
Topological domaini208 – 213ExtracellularCurated6
Transmembranei214 – 233Helical; Voltage-sensor; Name=S4 of repeat ISequence analysisAdd BLAST20
Topological domaini234 – 249CytoplasmicCuratedAdd BLAST16
Transmembranei250 – 273Helical; Name=S5 of repeat ISequence analysisAdd BLAST24
Topological domaini274 – 399ExtracellularCuratedAdd BLAST126
Transmembranei400 – 425Helical; Name=S6 of repeat ISequence analysisAdd BLAST26
Topological domaini426 – 762CytoplasmicCuratedAdd BLAST337
Transmembranei763 – 787Helical; Name=S1 of repeat IISequence analysisAdd BLAST25
Topological domaini788 – 798ExtracellularCuratedAdd BLAST11
Transmembranei799 – 822Helical; Name=S2 of repeat IISequence analysisAdd BLAST24
Topological domaini823 – 830CytoplasmicCurated8
Transmembranei831 – 850Helical; Name=S3 of repeat IISequence analysisAdd BLAST20
Topological domaini851 – 856ExtracellularCurated6
Transmembranei857 – 876Helical; Voltage-sensor; Name=S4 of repeat IISequence analysisAdd BLAST20
Topological domaini877 – 892CytoplasmicCuratedAdd BLAST16
Transmembranei893 – 913Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini914 – 966ExtracellularCuratedAdd BLAST53
Transmembranei967 – 992Helical; Name=S6 of repeat IISequence analysisAdd BLAST26
Topological domaini993 – 1213CytoplasmicCuratedAdd BLAST221
Transmembranei1214 – 1237Helical; Name=S1 of repeat IIISequence analysisAdd BLAST24
Topological domaini1238 – 1250ExtracellularCuratedAdd BLAST13
Transmembranei1251 – 1276Helical; Name=S2 of repeat IIISequence analysisAdd BLAST26
Topological domaini1277 – 1282CytoplasmicCurated6
Transmembranei1283 – 1304Helical; Name=S3 of repeat IIISequence analysisAdd BLAST22
Topological domaini1305 – 1308ExtracellularCurated4
Transmembranei1309 – 1330Helical; Voltage-sensor; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1331 – 1349CytoplasmicCuratedAdd BLAST19
Transmembranei1350 – 1377Helical; Name=S5 of repeat IIISequence analysisAdd BLAST28
Topological domaini1378 – 1456ExtracellularCuratedAdd BLAST79
Transmembranei1457 – 1483Helical; Name=S6 of repeat IIISequence analysisAdd BLAST27
Topological domaini1484 – 1536CytoplasmicCuratedAdd BLAST53
Transmembranei1537 – 1560Helical; Name=S1 of repeat IVSequence analysisAdd BLAST24
Topological domaini1561 – 1571ExtracellularCuratedAdd BLAST11
Transmembranei1572 – 1595Helical; Name=S2 of repeat IVSequence analysisAdd BLAST24
Topological domaini1596 – 1601CytoplasmicCurated6
Transmembranei1602 – 1625Helical; Name=S3 of repeat IVSequence analysisAdd BLAST24
Topological domaini1626 – 1635ExtracellularCurated10
Transmembranei1636 – 1657Helical; Voltage-sensor; Name=S4 of repeat IVSequence analysisAdd BLAST22
Topological domaini1658 – 1672CytoplasmicCuratedAdd BLAST15
Transmembranei1673 – 1695Helical; Name=S5 of repeat IVSequence analysisAdd BLAST23
Topological domaini1696 – 1761ExtracellularCuratedAdd BLAST66
Transmembranei1762 – 1786Helical; Name=S6 of repeat IVSequence analysisAdd BLAST25
Topological domaini1787 – 2009CytoplasmicCuratedAdd BLAST223

GO - Cellular componenti

  • axon Source: MGI
  • axon initial segment Source: MGI
  • intercalated disc Source: MGI
  • membrane Source: MGI
  • neuronal cell body Source: MGI
  • node of Ranvier Source: MGI
  • sodium channel complex Source: MGI
  • T-tubule Source: MGI
  • voltage-gated sodium channel complex Source: InterPro
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Homozygous mice display severe seizures and premature death on postnatal day 15 (PubMed:16921370). Mice show severe motor deficits, including irregularity of stride length during locomotion, impaired motor reflexes in grasping and mild tremor in limbs when immobile, consistent with cerebellar dysfunction (PubMed:16921370). Heterozygous mice exhibit autistic-like behavior, characterized by hyperactivity, stereotyped behaviors, social interaction deficits and impaired context-dependent spatial memory (PubMed:22914087). Defects are caused by caused by impaired GABAergic neurotransmission (PubMed:22914087). Conditional knockout in forebrain GABAergic neurons leads to premature death caused by generalized tonic-clonic seizures in heterozygous mice (PubMed:22908258).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1648R → H: Homozygous mice display spontaneous generalized seizures and premature death between P16 and P26. Heterozygous mice show infrequent spontaneous seizures, increased susceptibility to chemically and hyperthermia-induced generalized seizures and sleep abnormalities. Heterozygous mice also show deficits in social behavior, spatial memory, cued fear conditioning, pre-pulse inhibition and risk assessment. 2 Publications1

Chemistry databases

ChEMBLiCHEMBL3616352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004375361 – 2009Sodium channel protein type 1 subunit alphaAdd BLAST2009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi301N-linked (GlcNAc...)Sequence analysis1
Glycosylationi306N-linked (GlcNAc...)Sequence analysis1
Glycosylationi338N-linked (GlcNAc...)Sequence analysis1
Modified residuei470PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei525PhosphoserineBy similarity1
Modified residuei550PhosphoserineBy similarity1
Modified residuei551PhosphoserineCombined sources1
Modified residuei607PhosphoserineBy similarity1
Modified residuei730PhosphoserineBy similarity1
Modified residuei1516Phosphoserine; by PKCBy similarity1

Post-translational modificationi

Phosphorylation at Ser-1516 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiA2APX8.
PaxDbiA2APX8.

PTM databases

iPTMnetiA2APX8.
PhosphoSitePlusiA2APX8.

Expressioni

Tissue specificityi

Present in cerebellar Purkinje neurons (at proten level) (PubMed:17928448). Expressed by myelinated, non-C-fiber neurons in sensory ganglia (PubMed:27281198).2 Publications

Gene expression databases

BgeeiENSMUSG00000064329.
ExpressionAtlasiA2APX8. baseline and differential.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and/or beta-3 (SCN4B). Beta-1 (SCN1B) and beta-3 (SCN3B) are non-covalently associated with alpha, while beta-2 (SCN2B) is covalently linked by disulfide bonds. Interacts with FGF13; may regulate SCN1A activity. Interacts with SCN1B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076697.

Structurei

3D structure databases

ProteinModelPortaliA2APX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati110 – 454IBy similarityAdd BLAST345
Repeati750 – 1022IIBy similarityAdd BLAST273
Repeati1200 – 1514IIIBy similarityAdd BLAST315
Repeati1523 – 1821IVBy similarityAdd BLAST299
Domaini1915 – 1944IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1561 – 1571S1-S2 loop of repeat IV1 PublicationAdd BLAST11
Regioni1619 – 1636S3b-S4 loop of repeat IV1 PublicationAdd BLAST18

Domaini

The S3b-S4 and S1-S2 loops of repeat IV are targeted by H.maculata toxins Hm1a and Hm1b, leading to inhibit fast inactivation of Nav1.1/SCN1A. Selectivity for H.maculata toxins Hm1a and Hm1b depends on S1-S2 loops of repeat IV (PubMed:27281198).1 Publication
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiA2APX8.
KOiK04833.
OMAiDNCMSNH.
OrthoDBiEOG091G00FK.
PhylomeDBiA2APX8.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01664. NACHANNEL1.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2APX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF
110 120 130 140 150
RFSATSALYI LTPFNPLRKI AIKILVHSLF SMLIMCTILT NCVFMTMSNP
160 170 180 190 200
PDWTKNVEYT FTGIYTFESL IKIIARGFCL EDFTFLRDPW NWLDFTVITF
210 220 230 240 250
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
260 270 280 290 300
MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNITMDY
310 320 330 340 350
NGTLVNETVF EFDWKSYIQD SRYHYFLEGV LDALLCGNSS DAGQCPEGYM
360 370 380 390 400
CVKAGRNPNY GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM
410 420 430 440 450
IFFVLVIFLG SFYLINLILA VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ
460 470 480 490 500
LKKQQEAAQQ AAATTASEHS REPSAAGRLS DSSSEASKLS SKSAKERRNR
510 520 530 540 550
RKKRKQKEQS GGEEKDDDEF HKSESEDSIR RKGFRFSIEG NRLTYEKRYS
560 570 580 590 600
SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED
610 620 630 640 650
NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAVFPANGK MHSTVDCNGV
660 670 680 690 700
VSLVGGPSVP TSPVGQLLPE VIIDKPATDD NGTTTETEMR KRRSSSFHVS
710 720 730 740 750
MDFLEDPSQR QRAMSIASIL TNTVEELEES RQKCPPCWYK FSNIFLIWDC
760 770 780 790 800
SPYWLKVKHI VNLVVMDPFV DLAITICIVL NTLFMAMEHY PMTEHFNHVL
810 820 830 840 850
TVGNLVFTGI FTAEMFLKII AMDPYYYFQE GWNIFDGFIV TLSLVELGLA
860 870 880 890 900
NVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII
910 920 930 940 950
VFIFAVVGMQ LFGKSYKDCV CKIATDCKLP RWHMNDFFHS FLIVFRVLCG
960 970 980 990 1000
EWIETMWDCM EVAGQAMCLT VFMMVMVIGN LVVLNLFLAL LLSSFSADNL
1010 1020 1030 1040 1050
AATDDDNEMN NLQIAVDRMH KGIAYVKRKI YEFIQQSFVK KQKILDEIKP
1060 1070 1080 1090 1100
LDDLNNRKDN CISNHTTEIG KDLDCLKDVN GTTSGIGTGS SVEKYIIDES
1110 1120 1130 1140 1150
DYMSFINNPS LTVTVPIAVG ESDFENLNTE DFSSESDLEE SKEKLNESSS
1160 1170 1180 1190 1200
SSEGSTVDIG APAEEQPVIE PEETLEPEAC FTEGCVQRFK CCQISVEEGR
1210 1220 1230 1240 1250
GKQWWNLRRT CFRIVEHNWF ETFIVFMILL SSGALAFEDI YIDQRKTIKT
1260 1270 1280 1290 1300
MLEYADKVFT YIFILEMLLK WVAYGYQTYF TNAWCWLDFL IVDVSLVSLT
1310 1320 1330 1340 1350
ANALGYSELG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL LGAIPSIMNV
1360 1370 1380 1390 1400
LLVCLIFWLI FSIMGVNLFA GKFYHCVNTT TGDIFEISEV NNHSDCLKLI
1410 1420 1430 1440 1450
ERNETARWKN VKVNFDNVGF GYLSLLQVAT FKGWMDIMYA AVDSRNVELQ
1460 1470 1480 1490 1500
PKYEESLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM
1510 1520 1530 1540 1550
TEEQKKYYNA MKKLGSKKPQ KPIPRPGNKF QGMVFDFVTR QVFDISIMIL
1560 1570 1580 1590 1600
ICLNMVTMMV ETDDQSDYVT SILSRINLVF IVLFTGECVL KLISLRHYYF
1610 1620 1630 1640 1650
TIGWNIFDFV VVILSIVGMF LAELIEKYFV SPTLFRVIRL ARIGRILRLI
1660 1670 1680 1690 1700
KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKREVG
1710 1720 1730 1740 1750
IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSKPPD CDPNKVNPGS
1760 1770 1780 1790 1800
SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL
1810 1820 1830 1840 1850
SEDDFEMFYE VWEKFDPDAT QFMEFEKLSQ FAAALEPPLN LPQPNKLQLI
1860 1870 1880 1890 1900
AMDLPMVSGD RIHCLDILFA FTKRVLGESG EMDALRIQME ERFMASNPSK
1910 1920 1930 1940 1950
VSYQPITTTL KRKQEEVSAV IIQRAYRRHL LKRTVKQASF TYNKNKLKGG
1960 1970 1980 1990 2000
ANLLVKEDML IDRINENSIT EKTDLTMSTA ACPPSYDRVT KPIVEKHEQE

GKDEKAKGK
Length:2,009
Mass (Da):228,800
Last modified:February 20, 2007 - v1
Checksum:iA373BA0B710C501E
GO
Isoform 2 (identifier: A2APX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     671-681: Missing.

Show »
Length:1,998
Mass (Da):227,617
Checksum:i32E3F58EDFE53787
GO
Isoform 3 (identifier: A2APX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     654-681: Missing.

Show »
Length:1,981
Mass (Da):226,001
Checksum:iC606348B5109703D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058552654 – 681Missing in isoform 3. Add BLAST28
Alternative sequenceiVSP_058553671 – 681Missing in isoform 2. Add BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844526 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
AJ810515 mRNA. Translation: CAH17959.1.
CCDSiCCDS38131.1. [A2APX8-2]
RefSeqiNP_001300926.1. NM_001313997.1. [A2APX8-1]
NP_061203.2. NM_018733.2.
XP_006499090.1. XM_006499027.3.
XP_006499091.1. XM_006499028.3.
UniGeneiMm.439704.
Mm.455166.

Genome annotation databases

EnsembliENSMUST00000077489; ENSMUSP00000076697; ENSMUSG00000064329. [A2APX8-2]
ENSMUST00000094951; ENSMUSP00000092558; ENSMUSG00000064329. [A2APX8-3]
ENSMUST00000112366; ENSMUSP00000107985; ENSMUSG00000064329. [A2APX8-1]
ENSMUST00000112371; ENSMUSP00000107990; ENSMUSG00000064329. [A2APX8-2]
GeneIDi20265.
KEGGimmu:20265.
UCSCiuc033hnf.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844526 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
AJ810515 mRNA. Translation: CAH17959.1.
CCDSiCCDS38131.1. [A2APX8-2]
RefSeqiNP_001300926.1. NM_001313997.1. [A2APX8-1]
NP_061203.2. NM_018733.2.
XP_006499090.1. XM_006499027.3.
XP_006499091.1. XM_006499028.3.
UniGeneiMm.439704.
Mm.455166.

3D structure databases

ProteinModelPortaliA2APX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076697.

Chemistry databases

ChEMBLiCHEMBL3616352.

PTM databases

iPTMnetiA2APX8.
PhosphoSitePlusiA2APX8.

Proteomic databases

MaxQBiA2APX8.
PaxDbiA2APX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077489; ENSMUSP00000076697; ENSMUSG00000064329. [A2APX8-2]
ENSMUST00000094951; ENSMUSP00000092558; ENSMUSG00000064329. [A2APX8-3]
ENSMUST00000112366; ENSMUSP00000107985; ENSMUSG00000064329. [A2APX8-1]
ENSMUST00000112371; ENSMUSP00000107990; ENSMUSG00000064329. [A2APX8-2]
GeneIDi20265.
KEGGimmu:20265.
UCSCiuc033hnf.1. mouse.

Organism-specific databases

CTDi6323.
MGIiMGI:98246. Scn1a.

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiA2APX8.
KOiK04833.
OMAiDNCMSNH.
OrthoDBiEOG091G00FK.
PhylomeDBiA2APX8.
TreeFamiTF323985.

Miscellaneous databases

ChiTaRSiScn1a. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064329.
ExpressionAtlasiA2APX8. baseline and differential.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01664. NACHANNEL1.
ProtoNetiSearch...

Entry informationi

Entry nameiSCN1A_MOUSE
AccessioniPrimary (citable) accession number: A2APX8
Secondary accession number(s): A2APX6, A2APX7, Q68V28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.