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Protein
Submitted name:

Protein Scn1a

Gene

Scn1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • voltage-gated sodium channel activity Source: MGI

GO - Biological processi

  • action potential Source: MGI
  • adult walking behavior Source: MGI
  • membrane depolarization during action potential Source: GO_Central
  • neuromuscular process controlling posture Source: MGI
  • neuronal action potential Source: MGI
  • neuronal action potential propagation Source: MGI
  • positive regulation of defense response to virus by host Source: MGI
  • regulation of membrane potential Source: MGI
  • sodium ion transport Source: MGI
  • xenophagy Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Scn1aImported
Gene namesi
Name:Scn1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98246. Scn1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei124 – 14724HelicalSequence analysisAdd
BLAST
Transmembranei192 – 21120HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24422HelicalSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Transmembranei399 – 42628HelicalSequence analysisAdd
BLAST
Transmembranei769 – 78719HelicalSequence analysisAdd
BLAST
Transmembranei799 – 81719HelicalSequence analysisAdd
BLAST
Transmembranei879 – 90729HelicalSequence analysisAdd
BLAST
Transmembranei966 – 99227HelicalSequence analysisAdd
BLAST
Transmembranei1219 – 123719HelicalSequence analysisAdd
BLAST
Transmembranei1258 – 127720HelicalSequence analysisAdd
BLAST
Transmembranei1289 – 131224HelicalSequence analysisAdd
BLAST
Transmembranei1333 – 136129HelicalSequence analysisAdd
BLAST
Transmembranei1459 – 148325HelicalSequence analysisAdd
BLAST
Transmembranei1542 – 156019HelicalSequence analysisAdd
BLAST
Transmembranei1572 – 159019HelicalSequence analysisAdd
BLAST
Transmembranei1602 – 162221HelicalSequence analysisAdd
BLAST
Transmembranei1659 – 168729HelicalSequence analysisAdd
BLAST
Transmembranei1763 – 178624HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: MGI
  • axon initial segment Source: MGI
  • intercalated disc Source: MGI
  • membrane Source: MGI
  • neuronal cell body Source: MGI
  • node of Ranvier Source: MGI
  • sodium channel complex Source: MGI
  • T-tubule Source: MGI
  • voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiA2APX8.
PaxDbiA2APX8.
PRIDEiA2APX8.

PTM databases

iPTMnetiA2APX8.
PhosphoSiteiA2APX8.

Expressioni

Gene expression databases

BgeeiA2APX8.
ExpressionAtlasiA2APX8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076697.

Structurei

3D structure databases

ProteinModelPortaliA2APX8.
SMRiA2APX8. Positions 1787-1939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 433307Ion_transInterPro annotationAdd
BLAST
Domaini505 – 718214Na_trans_cytoplInterPro annotationAdd
BLAST
Domaini769 – 996228Ion_transInterPro annotationAdd
BLAST
Domaini1006 – 1213208Na_trans_assocInterPro annotationAdd
BLAST
Domaini1217 – 1491275Ion_transInterPro annotationAdd
BLAST
Domaini1541 – 1796256Ion_transInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili423 – 46846Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiA2APX8.
KOiK04833.
OMAiITEVNNH.
OrthoDBiEOG7DJSK9.
PhylomeDBiA2APX8.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01664. NACHANNEL1.

Sequencei

Sequence statusi: Complete.

A2APX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF
110 120 130 140 150
RFSATSALYI LTPFNPLRKI AIKILVHSLF SMLIMCTILT NCVFMTMSNP
160 170 180 190 200
PDWTKNVEYT FTGIYTFESL IKIIARGFCL EDFTFLRDPW NWLDFTVITF
210 220 230 240 250
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
260 270 280 290 300
MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNITMDY
310 320 330 340 350
NGTLVNETVF EFDWKSYIQD SRYHYFLEGV LDALLCGNSS DAGQCPEGYM
360 370 380 390 400
CVKAGRNPNY GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM
410 420 430 440 450
IFFVLVIFLG SFYLINLILA VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ
460 470 480 490 500
LKKQQEAAQQ AAATTASEHS REPSAAGRLS DSSSEASKLS SKSAKERRNR
510 520 530 540 550
RKKRKQKEQS GGEEKDDDEF HKSESEDSIR RKGFRFSIEG NRLTYEKRYS
560 570 580 590 600
SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED
610 620 630 640 650
NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAVFPANGK MHSTVDCNGV
660 670 680 690 700
VSLVGGPSVP TSPVGQLLPE VIIDKPATDD NGTTTETEMR KRRSSSFHVS
710 720 730 740 750
MDFLEDPSQR QRAMSIASIL TNTVEELEES RQKCPPCWYK FSNIFLIWDC
760 770 780 790 800
SPYWLKVKHI VNLVVMDPFV DLAITICIVL NTLFMAMEHY PMTEHFNHVL
810 820 830 840 850
TVGNLVFTGI FTAEMFLKII AMDPYYYFQE GWNIFDGFIV TLSLVELGLA
860 870 880 890 900
NVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII
910 920 930 940 950
VFIFAVVGMQ LFGKSYKDCV CKIATDCKLP RWHMNDFFHS FLIVFRVLCG
960 970 980 990 1000
EWIETMWDCM EVAGQAMCLT VFMMVMVIGN LVVLNLFLAL LLSSFSADNL
1010 1020 1030 1040 1050
AATDDDNEMN NLQIAVDRMH KGIAYVKRKI YEFIQQSFVK KQKILDEIKP
1060 1070 1080 1090 1100
LDDLNNRKDN CISNHTTEIG KDLDCLKDVN GTTSGIGTGS SVEKYIIDES
1110 1120 1130 1140 1150
DYMSFINNPS LTVTVPIAVG ESDFENLNTE DFSSESDLEE SKEKLNESSS
1160 1170 1180 1190 1200
SSEGSTVDIG APAEEQPVIE PEETLEPEAC FTEGCVQRFK CCQISVEEGR
1210 1220 1230 1240 1250
GKQWWNLRRT CFRIVEHNWF ETFIVFMILL SSGALAFEDI YIDQRKTIKT
1260 1270 1280 1290 1300
MLEYADKVFT YIFILEMLLK WVAYGYQTYF TNAWCWLDFL IVDVSLVSLT
1310 1320 1330 1340 1350
ANALGYSELG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL LGAIPSIMNV
1360 1370 1380 1390 1400
LLVCLIFWLI FSIMGVNLFA GKFYHCVNTT TGDIFEISEV NNHSDCLKLI
1410 1420 1430 1440 1450
ERNETARWKN VKVNFDNVGF GYLSLLQVAT FKGWMDIMYA AVDSRNVELQ
1460 1470 1480 1490 1500
PKYEESLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM
1510 1520 1530 1540 1550
TEEQKKYYNA MKKLGSKKPQ KPIPRPGNKF QGMVFDFVTR QVFDISIMIL
1560 1570 1580 1590 1600
ICLNMVTMMV ETDDQSDYVT SILSRINLVF IVLFTGECVL KLISLRHYYF
1610 1620 1630 1640 1650
TIGWNIFDFV VVILSIVGMF LAELIEKYFV SPTLFRVIRL ARIGRILRLI
1660 1670 1680 1690 1700
KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKREVG
1710 1720 1730 1740 1750
IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSKPPD CDPNKVNPGS
1760 1770 1780 1790 1800
SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL
1810 1820 1830 1840 1850
SEDDFEMFYE VWEKFDPDAT QFMEFEKLSQ FAAALEPPLN LPQPNKLQLI
1860 1870 1880 1890 1900
AMDLPMVSGD RIHCLDILFA FTKRVLGESG EMDALRIQME ERFMASNPSK
1910 1920 1930 1940 1950
VSYQPITTTL KRKQEEVSAV IIQRAYRRHL LKRTVKQASF TYNKNKLKGG
1960 1970 1980 1990 2000
ANLLVKEDML IDRINENSIT EKTDLTMSTA ACPPSYDRVT KPIVEKHEQE

GKDEKAKGK
Length:2,009
Mass (Da):228,800
Last modified:February 20, 2007 - v1
Checksum:iA373BA0B710C501E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844526 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
RefSeqiNP_001300926.1. NM_001313997.1.
XP_006499090.1. XM_006499027.2.
UniGeneiMm.439704.
Mm.455166.

Genome annotation databases

EnsembliENSMUST00000112366; ENSMUSP00000107985; ENSMUSG00000064329.
GeneIDi20265.
KEGGimmu:20265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844526 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
RefSeqiNP_001300926.1. NM_001313997.1.
XP_006499090.1. XM_006499027.2.
UniGeneiMm.439704.
Mm.455166.

3D structure databases

ProteinModelPortaliA2APX8.
SMRiA2APX8. Positions 1787-1939.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076697.

PTM databases

iPTMnetiA2APX8.
PhosphoSiteiA2APX8.

Proteomic databases

MaxQBiA2APX8.
PaxDbiA2APX8.
PRIDEiA2APX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112366; ENSMUSP00000107985; ENSMUSG00000064329.
GeneIDi20265.
KEGGimmu:20265.

Organism-specific databases

CTDi6323.
MGIiMGI:98246. Scn1a.

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiA2APX8.
KOiK04833.
OMAiITEVNNH.
OrthoDBiEOG7DJSK9.
PhylomeDBiA2APX8.

Miscellaneous databases

ChiTaRSiScn1a. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiA2APX8.
ExpressionAtlasiA2APX8. baseline and differential.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01664. NACHANNEL1.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2APX8_MOUSE
AccessioniPrimary (citable) accession number: A2APX8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.