A2APX6 (A2APX6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Scn1a Ensembl ENSMUSP00000107990 Ensembl ENSMUSP00000076697

Gene names

Name:

Scn1a Ensembl ENSMUSP00000107990 Ensembl ENSMUSP00000076697 MGI 98246

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000107990

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1998 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003809.
Sequence similarities	Belongs to the sodium channel family. RuleBase RU003809
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000107990 Ensembl ENSMUSP00000076697

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Sodium
Molecular function	Ion channel Sodium channel RuleBase RU003809 Voltage-gated channel RuleBase RU003809
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult walking behavior Inferred from mutant phenotype PubMed 17537961PubMed 17928448. Source: MGI neuromuscular process controlling posture Inferred from mutant phenotype PubMed 16921370PubMed 17928448. Source: MGI neuronal action potential propagation Inferred from mutant phenotype PubMed 17322896. Source: MGI regulation of action potential in neuron Inferred from mutant phenotype PubMed 16921370PubMed 17928448. Source: MGI
Cellular_component	T-tubule Inferred from direct assay PubMed 15746173. Source: MGI Z disc Inferred from direct assay PubMed 17884088. Source: BHF-UCL axon initial segment Inferred from direct assay PubMed 17537961. Source: MGI intercalated disc Inferred from direct assay PubMed 15746173. Source: MGI neuronal cell body Inferred from direct assay PubMed 17537961PubMed 17928448. Source: MGI node of Ranvier Inferred from direct assay PubMed 17537961. Source: MGI sodium channel complex Inferred from physical interaction PubMed 15272007. Source: MGI voltage-gated sodium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	voltage-gated sodium channel activity Inferred from mutant phenotype PubMed 16921370. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2APX6 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 32E3F58EDFE53787	FASTA	1,998	227,617
	10 20 30 40 50 60 MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK PNSDLEAGKN 70 80 90 100 110 120 LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF RFSATSALYI LTPFNPLRKI 130 140 150 160 170 180 AIKILVHSLF SMLIMCTILT NCVFMTMSNP PDWTKNVEYT FTGIYTFESL IKIIARGFCL 190 200 210 220 230 240 EDFTFLRDPW NWLDFTVITF AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 250 260 270 280 290 300 IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNITMDY 310 320 330 340 350 360 NGTLVNETVF EFDWKSYIQD SRYHYFLEGV LDALLCGNSS DAGQCPEGYM CVKAGRNPNY 370 380 390 400 410 420 GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM IFFVLVIFLG SFYLINLILA 430 440 450 460 470 480 VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ LKKQQEAAQQ AAATTASEHS REPSAAGRLS 490 500 510 520 530 540 DSSSEASKLS SKSAKERRNR RKKRKQKEQS GGEEKDDDEF HKSESEDSIR RKGFRFSIEG 550 560 570 580 590 600 NRLTYEKRYS SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED 610 620 630 640 650 660 NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAVFPANGK MHSTVDCNGV VSLVGGPSVP 670 680 690 700 710 720 TSPVGQLLPE GTTTETEMRK RRSSSFHVSM DFLEDPSQRQ RAMSIASILT NTVEELEESR 730 740 750 760 770 780 QKCPPCWYKF SNIFLIWDCS PYWLKVKHIV NLVVMDPFVD LAITICIVLN TLFMAMEHYP 790 800 810 820 830 840 MTEHFNHVLT VGNLVFTGIF TAEMFLKIIA MDPYYYFQEG WNIFDGFIVT LSLVELGLAN 850 860 870 880 890 900 VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL 910 920 930 940 950 960 FGKSYKDCVC KIATDCKLPR WHMNDFFHSF LIVFRVLCGE WIETMWDCME VAGQAMCLTV 970 980 990 1000 1010 1020 FMMVMVIGNL VVLNLFLALL LSSFSADNLA ATDDDNEMNN LQIAVDRMHK GIAYVKRKIY 1030 1040 1050 1060 1070 1080 EFIQQSFVKK QKILDEIKPL DDLNNRKDNC ISNHTTEIGK DLDCLKDVNG TTSGIGTGSS 1090 1100 1110 1120 1130 1140 VEKYIIDESD YMSFINNPSL TVTVPIAVGE SDFENLNTED FSSESDLEES KEKLNESSSS 1150 1160 1170 1180 1190 1200 SEGSTVDIGA PAEEQPVIEP EETLEPEACF TEGCVQRFKC CQISVEEGRG KQWWNLRRTC 1210 1220 1230 1240 1250 1260 FRIVEHNWFE TFIVFMILLS SGALAFEDIY IDQRKTIKTM LEYADKVFTY IFILEMLLKW 1270 1280 1290 1300 1310 1320 VAYGYQTYFT NAWCWLDFLI VDVSLVSLTA NALGYSELGA IKSLRTLRAL RPLRALSRFE 1330 1340 1350 1360 1370 1380 GMRVVVNALL GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYHCVNTTT GDIFEISEVN 1390 1400 1410 1420 1430 1440 NHSDCLKLIE RNETARWKNV KVNFDNVGFG YLSLLQVATF KGWMDIMYAA VDSRNVELQP 1450 1460 1470 1480 1490 1500 KYEESLYMYL YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM 1510 1520 1530 1540 1550 1560 KKLGSKKPQK PIPRPGNKFQ GMVFDFVTRQ VFDISIMILI CLNMVTMMVE TDDQSDYVTS 1570 1580 1590 1600 1610 1620 ILSRINLVFI VLFTGECVLK LISLRHYYFT IGWNIFDFVV VILSIVGMFL AELIEKYFVS 1630 1640 1650 1660 1670 1680 PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYAIFGMSN 1690 1700 1710 1720 1730 1740 FAYVKREVGI DDMFNFETFG NSMICLFQIT TSAGWDGLLA PILNSKPPDC DPNKVNPGSS 1750 1760 1770 1780 1790 1800 VKGDCGNPSV GIFFFVSYII ISFLVVVNMY IAVILENFSV ATEESAEPLS EDDFEMFYEV 1810 1820 1830 1840 1850 1860 WEKFDPDATQ FMEFEKLSQF AAALEPPLNL PQPNKLQLIA MDLPMVSGDR IHCLDILFAF 1870 1880 1890 1900 1910 1920 TKRVLGESGE MDALRIQMEE RFMASNPSKV SYQPITTTLK RKQEEVSAVI IQRAYRRHLL 1930 1940 1950 1960 1970 1980 KRTVKQASFT YNKNKLKGGA NLLVKEDMLI DRINENSITE KTDLTMSTAA CPPSYDRVTK 1990 PIVEKHEQEG KDEKAKGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000107990 Ensembl ENSMUSP00000076697.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000107990 Ensembl ENSMUSP00000076697.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL844526 Genomic DNA. No translation available. AL928726 Genomic DNA. No translation available.
IPI	IPI00661236.
RefSeq	NP_061203.2. NM_018733.2.
UniGene	Mm.439704.
3D structure databases
SMR	A2APX6. Positions 1776-1931.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000077489; ENSMUSP00000076697; ENSMUSG00000064329. ENSMUST00000112371; ENSMUSP00000107990; ENSMUSG00000064329.
GeneID	20265.
KEGG	mmu:20265.
UCSC	uc008jwz.1. mouse.
Organism-specific databases
CTD	6323.
MGI	MGI:98246. Scn1a.
Phylogenomic databases
eggNOG	COG1226.
GeneTree	ENSGT00560000076721.
HOGENOM	HOG000231755.
HOVERGEN	HBG053100.
KO	K04833.
Family and domain databases
InterPro	IPR024583. DUF3451. IPR005821. Ion_trans_dom. IPR000048. IQ_motif_EF-hand-BS. IPR008051. Na_channel_a1su. IPR001696. Na_channel_asu. IPR010526. Na_trans_assoc. [Graphical view]
Pfam	PF11933. DUF3451. 1 hit. PF00520. Ion_trans. 4 hits. PF06512. Na_trans_assoc. 1 hit. [Graphical view]
PRINTS	PR00170. NACHANNEL. PR01664. NACHANNEL1.
SMART	SM00015. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	297935.
SOURCE	Search...

Entry information

Entry name

A2APX6_MOUSE

Accession

Primary (citable) accession number: A2APX6

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)