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A2APX6

- A2APX6_MOUSE

UniProt

A2APX6 - A2APX6_MOUSE

Protein

Sodium channel protein

Gene

Scn1a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

    GO - Molecular functioni

    1. voltage-gated sodium channel activity Source: MGI

    GO - Biological processi

    1. action potential Source: MGI
    2. adult walking behavior Source: MGI
    3. membrane depolarization during action potential Source: RefGenome
    4. neuromuscular process controlling posture Source: MGI
    5. neuronal action potential Source: MGI
    6. neuronal action potential propagation Source: MGI
    7. regulation of membrane potential Source: MGI
    8. sodium ion transmembrane transport Source: GOC
    9. sodium ion transport Source: MGI

    Keywords - Molecular functioni

    Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel proteinUniRule annotation
    Gene namesi
    Name:Scn1aImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:98246. Scn1a.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. axon Source: MGI
    2. axon initial segment Source: MGI
    3. intercalated disc Source: MGI
    4. membrane Source: MGI
    5. neuronal cell body Source: MGI
    6. node of Ranvier Source: MGI
    7. sodium channel complex Source: MGI
    8. T-tubule Source: MGI
    9. voltage-gated sodium channel complex Source: InterPro
    10. Z disc Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00560000076721.
    HOGENOMiHOG000231755.
    HOVERGENiHBG053100.
    KOiK04833.
    TreeFamiTF323985.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR008051. Na_channel_a1su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    PR01664. NACHANNEL1.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2APX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK     50
    PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF 100
    RFSATSALYI LTPFNPLRKI AIKILVHSLF SMLIMCTILT NCVFMTMSNP 150
    PDWTKNVEYT FTGIYTFESL IKIIARGFCL EDFTFLRDPW NWLDFTVITF 200
    AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV 250
    MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNITMDY 300
    NGTLVNETVF EFDWKSYIQD SRYHYFLEGV LDALLCGNSS DAGQCPEGYM 350
    CVKAGRNPNY GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM 400
    IFFVLVIFLG SFYLINLILA VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ 450
    LKKQQEAAQQ AAATTASEHS REPSAAGRLS DSSSEASKLS SKSAKERRNR 500
    RKKRKQKEQS GGEEKDDDEF HKSESEDSIR RKGFRFSIEG NRLTYEKRYS 550
    SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED 600
    NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAVFPANGK MHSTVDCNGV 650
    VSLVGGPSVP TSPVGQLLPE GTTTETEMRK RRSSSFHVSM DFLEDPSQRQ 700
    RAMSIASILT NTVEELEESR QKCPPCWYKF SNIFLIWDCS PYWLKVKHIV 750
    NLVVMDPFVD LAITICIVLN TLFMAMEHYP MTEHFNHVLT VGNLVFTGIF 800
    TAEMFLKIIA MDPYYYFQEG WNIFDGFIVT LSLVELGLAN VEGLSVLRSF 850
    RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL 900
    FGKSYKDCVC KIATDCKLPR WHMNDFFHSF LIVFRVLCGE WIETMWDCME 950
    VAGQAMCLTV FMMVMVIGNL VVLNLFLALL LSSFSADNLA ATDDDNEMNN 1000
    LQIAVDRMHK GIAYVKRKIY EFIQQSFVKK QKILDEIKPL DDLNNRKDNC 1050
    ISNHTTEIGK DLDCLKDVNG TTSGIGTGSS VEKYIIDESD YMSFINNPSL 1100
    TVTVPIAVGE SDFENLNTED FSSESDLEES KEKLNESSSS SEGSTVDIGA 1150
    PAEEQPVIEP EETLEPEACF TEGCVQRFKC CQISVEEGRG KQWWNLRRTC 1200
    FRIVEHNWFE TFIVFMILLS SGALAFEDIY IDQRKTIKTM LEYADKVFTY 1250
    IFILEMLLKW VAYGYQTYFT NAWCWLDFLI VDVSLVSLTA NALGYSELGA 1300
    IKSLRTLRAL RPLRALSRFE GMRVVVNALL GAIPSIMNVL LVCLIFWLIF 1350
    SIMGVNLFAG KFYHCVNTTT GDIFEISEVN NHSDCLKLIE RNETARWKNV 1400
    KVNFDNVGFG YLSLLQVATF KGWMDIMYAA VDSRNVELQP KYEESLYMYL 1450
    YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM 1500
    KKLGSKKPQK PIPRPGNKFQ GMVFDFVTRQ VFDISIMILI CLNMVTMMVE 1550
    TDDQSDYVTS ILSRINLVFI VLFTGECVLK LISLRHYYFT IGWNIFDFVV 1600
    VILSIVGMFL AELIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF 1650
    ALMMSLPALF NIGLLLFLVM FIYAIFGMSN FAYVKREVGI DDMFNFETFG 1700
    NSMICLFQIT TSAGWDGLLA PILNSKPPDC DPNKVNPGSS VKGDCGNPSV 1750
    GIFFFVSYII ISFLVVVNMY IAVILENFSV ATEESAEPLS EDDFEMFYEV 1800
    WEKFDPDATQ FMEFEKLSQF AAALEPPLNL PQPNKLQLIA MDLPMVSGDR 1850
    IHCLDILFAF TKRVLGESGE MDALRIQMEE RFMASNPSKV SYQPITTTLK 1900
    RKQEEVSAVI IQRAYRRHLL KRTVKQASFT YNKNKLKGGA NLLVKEDMLI 1950
    DRINENSITE KTDLTMSTAA CPPSYDRVTK PIVEKHEQEG KDEKAKGK 1998
    Length:1,998
    Mass (Da):227,617
    Last modified:February 20, 2007 - v1
    Checksum:i32E3F58EDFE53787
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844526 Genomic DNA. No translation available.
    AL928726 Genomic DNA. No translation available.
    RefSeqiNP_061203.2. NM_018733.2.
    XP_006499091.1. XM_006499028.1.
    UniGeneiMm.439704.
    Mm.455166.

    Genome annotation databases

    EnsembliENSMUST00000077489; ENSMUSP00000076697; ENSMUSG00000064329.
    ENSMUST00000112371; ENSMUSP00000107990; ENSMUSG00000064329.
    GeneIDi20265.
    KEGGimmu:20265.
    UCSCiuc008jwz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844526 Genomic DNA. No translation available.
    AL928726 Genomic DNA. No translation available.
    RefSeqi NP_061203.2. NM_018733.2.
    XP_006499091.1. XM_006499028.1.
    UniGenei Mm.439704.
    Mm.455166.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077489 ; ENSMUSP00000076697 ; ENSMUSG00000064329 .
    ENSMUST00000112371 ; ENSMUSP00000107990 ; ENSMUSG00000064329 .
    GeneIDi 20265.
    KEGGi mmu:20265.
    UCSCi uc008jwz.1. mouse.

    Organism-specific databases

    CTDi 6323.
    MGIi MGI:98246. Scn1a.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00560000076721.
    HOGENOMi HOG000231755.
    HOVERGENi HBG053100.
    KOi K04833.
    TreeFami TF323985.

    Miscellaneous databases

    NextBioi 297935.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR008051. Na_channel_a1su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    PR01664. NACHANNEL1.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2APX6_MOUSE
    AccessioniPrimary (citable) accession number: A2APX6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3