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A2APX6

- A2APX6_MOUSE

UniProt

A2APX6 - A2APX6_MOUSE

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Protein

Sodium channel protein

Gene

Scn1a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: MGI

GO - Biological processi

  1. action potential Source: MGI
  2. adult walking behavior Source: MGI
  3. membrane depolarization during action potential Source: RefGenome
  4. neuromuscular process controlling posture Source: MGI
  5. neuronal action potential Source: MGI
  6. neuronal action potential propagation Source: MGI
  7. regulation of membrane potential Source: MGI
  8. sodium ion transmembrane transport Source: GOC
  9. sodium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:98246. Scn1a.

Subcellular locationi

Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. axon Source: MGI
  2. axon initial segment Source: MGI
  3. intercalated disc Source: MGI
  4. membrane Source: MGI
  5. neuronal cell body Source: MGI
  6. node of Ranvier Source: MGI
  7. sodium channel complex Source: MGI
  8. T-tubule Source: MGI
  9. voltage-gated sodium channel complex Source: InterPro
  10. Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118827.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04833.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01664. NACHANNEL1.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2APX6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF
110 120 130 140 150
RFSATSALYI LTPFNPLRKI AIKILVHSLF SMLIMCTILT NCVFMTMSNP
160 170 180 190 200
PDWTKNVEYT FTGIYTFESL IKIIARGFCL EDFTFLRDPW NWLDFTVITF
210 220 230 240 250
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
260 270 280 290 300
MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNITMDY
310 320 330 340 350
NGTLVNETVF EFDWKSYIQD SRYHYFLEGV LDALLCGNSS DAGQCPEGYM
360 370 380 390 400
CVKAGRNPNY GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM
410 420 430 440 450
IFFVLVIFLG SFYLINLILA VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ
460 470 480 490 500
LKKQQEAAQQ AAATTASEHS REPSAAGRLS DSSSEASKLS SKSAKERRNR
510 520 530 540 550
RKKRKQKEQS GGEEKDDDEF HKSESEDSIR RKGFRFSIEG NRLTYEKRYS
560 570 580 590 600
SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED
610 620 630 640 650
NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAVFPANGK MHSTVDCNGV
660 670 680 690 700
VSLVGGPSVP TSPVGQLLPE GTTTETEMRK RRSSSFHVSM DFLEDPSQRQ
710 720 730 740 750
RAMSIASILT NTVEELEESR QKCPPCWYKF SNIFLIWDCS PYWLKVKHIV
760 770 780 790 800
NLVVMDPFVD LAITICIVLN TLFMAMEHYP MTEHFNHVLT VGNLVFTGIF
810 820 830 840 850
TAEMFLKIIA MDPYYYFQEG WNIFDGFIVT LSLVELGLAN VEGLSVLRSF
860 870 880 890 900
RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL
910 920 930 940 950
FGKSYKDCVC KIATDCKLPR WHMNDFFHSF LIVFRVLCGE WIETMWDCME
960 970 980 990 1000
VAGQAMCLTV FMMVMVIGNL VVLNLFLALL LSSFSADNLA ATDDDNEMNN
1010 1020 1030 1040 1050
LQIAVDRMHK GIAYVKRKIY EFIQQSFVKK QKILDEIKPL DDLNNRKDNC
1060 1070 1080 1090 1100
ISNHTTEIGK DLDCLKDVNG TTSGIGTGSS VEKYIIDESD YMSFINNPSL
1110 1120 1130 1140 1150
TVTVPIAVGE SDFENLNTED FSSESDLEES KEKLNESSSS SEGSTVDIGA
1160 1170 1180 1190 1200
PAEEQPVIEP EETLEPEACF TEGCVQRFKC CQISVEEGRG KQWWNLRRTC
1210 1220 1230 1240 1250
FRIVEHNWFE TFIVFMILLS SGALAFEDIY IDQRKTIKTM LEYADKVFTY
1260 1270 1280 1290 1300
IFILEMLLKW VAYGYQTYFT NAWCWLDFLI VDVSLVSLTA NALGYSELGA
1310 1320 1330 1340 1350
IKSLRTLRAL RPLRALSRFE GMRVVVNALL GAIPSIMNVL LVCLIFWLIF
1360 1370 1380 1390 1400
SIMGVNLFAG KFYHCVNTTT GDIFEISEVN NHSDCLKLIE RNETARWKNV
1410 1420 1430 1440 1450
KVNFDNVGFG YLSLLQVATF KGWMDIMYAA VDSRNVELQP KYEESLYMYL
1460 1470 1480 1490 1500
YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM
1510 1520 1530 1540 1550
KKLGSKKPQK PIPRPGNKFQ GMVFDFVTRQ VFDISIMILI CLNMVTMMVE
1560 1570 1580 1590 1600
TDDQSDYVTS ILSRINLVFI VLFTGECVLK LISLRHYYFT IGWNIFDFVV
1610 1620 1630 1640 1650
VILSIVGMFL AELIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF
1660 1670 1680 1690 1700
ALMMSLPALF NIGLLLFLVM FIYAIFGMSN FAYVKREVGI DDMFNFETFG
1710 1720 1730 1740 1750
NSMICLFQIT TSAGWDGLLA PILNSKPPDC DPNKVNPGSS VKGDCGNPSV
1760 1770 1780 1790 1800
GIFFFVSYII ISFLVVVNMY IAVILENFSV ATEESAEPLS EDDFEMFYEV
1810 1820 1830 1840 1850
WEKFDPDATQ FMEFEKLSQF AAALEPPLNL PQPNKLQLIA MDLPMVSGDR
1860 1870 1880 1890 1900
IHCLDILFAF TKRVLGESGE MDALRIQMEE RFMASNPSKV SYQPITTTLK
1910 1920 1930 1940 1950
RKQEEVSAVI IQRAYRRHLL KRTVKQASFT YNKNKLKGGA NLLVKEDMLI
1960 1970 1980 1990
DRINENSITE KTDLTMSTAA CPPSYDRVTK PIVEKHEQEG KDEKAKGK
Length:1,998
Mass (Da):227,617
Last modified:February 20, 2007 - v1
Checksum:i32E3F58EDFE53787
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844526 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
RefSeqiNP_061203.2. NM_018733.2.
XP_006499091.1. XM_006499028.1.
UniGeneiMm.439704.
Mm.455166.

Genome annotation databases

EnsembliENSMUST00000077489; ENSMUSP00000076697; ENSMUSG00000064329.
ENSMUST00000112371; ENSMUSP00000107990; ENSMUSG00000064329.
GeneIDi20265.
KEGGimmu:20265.
UCSCiuc008jwz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844526 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
RefSeqi NP_061203.2. NM_018733.2.
XP_006499091.1. XM_006499028.1.
UniGenei Mm.439704.
Mm.455166.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077489 ; ENSMUSP00000076697 ; ENSMUSG00000064329 .
ENSMUST00000112371 ; ENSMUSP00000107990 ; ENSMUSG00000064329 .
GeneIDi 20265.
KEGGi mmu:20265.
UCSCi uc008jwz.1. mouse.

Organism-specific databases

CTDi 6323.
MGIi MGI:98246. Scn1a.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118827.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
KOi K04833.
TreeFami TF323985.

Miscellaneous databases

NextBioi 297935.
SOURCEi Search...

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
PR01664. NACHANNEL1.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2APX6_MOUSE
AccessioniPrimary (citable) accession number: A2APX6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3