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A2APX6 (A2APX6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length1998 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein By similarity RuleBase RU003809.

Sequence similarities

Belongs to the sodium channel family. RuleBase RU003809

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000107990 Ensembl ENSMUSP00000076697

Ontologies

Keywords
   Biological processIon transport
Sodium transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS027359
   LigandSodium
   Molecular functionIon channel
Sodium channel RuleBase RU003809
Voltage-gated channel RuleBase RU003809
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaction potential

Inferred from mutant phenotype PubMed 17928448. Source: MGI

adult walking behavior

Inferred from mutant phenotype PubMed 17537961PubMed 17928448. Source: MGI

neuromuscular process controlling posture

Inferred from mutant phenotype PubMed 16921370PubMed 17928448. Source: MGI

neuronal action potential

Inferred from mutant phenotype PubMed 16921370PubMed 17928448. Source: MGI

neuronal action potential propagation

Inferred from mutant phenotype PubMed 17322896. Source: MGI

regulation of membrane potential

Inferred from mutant phenotype PubMed 17928448. Source: MGI

sodium ion transmembrane transport

Inferred from mutant phenotype PubMed 16921370. Source: GOC

sodium ion transport

Inferred from mutant phenotype PubMed 16921370PubMed 17928448. Source: MGI

   Cellular_componentT-tubule

Inferred from direct assay PubMed 15746173. Source: MGI

Z disc

Inferred from direct assay PubMed 17884088. Source: BHF-UCL

axon

Inferred from direct assay PubMed 17537961PubMed 17928448. Source: MGI

axon initial segment

Inferred from direct assay PubMed 17537961. Source: MGI

intercalated disc

Inferred from direct assay PubMed 15746173. Source: MGI

membrane

Inferred from direct assay PubMed 10827969PubMed 17537961. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 17537961PubMed 17928448. Source: MGI

node of Ranvier

Inferred from direct assay PubMed 17537961. Source: MGI

sodium channel complex

Inferred from physical interaction PubMed 15272007. Source: MGI

voltage-gated sodium channel complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionvoltage-gated sodium channel activity

Inferred from mutant phenotype PubMed 16921370. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A2APX6 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 32E3F58EDFE53787

FASTA1,998227,617
        10         20         30         40         50         60 
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK PNSDLEAGKN 

        70         80         90        100        110        120 
LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF RFSATSALYI LTPFNPLRKI 

       130        140        150        160        170        180 
AIKILVHSLF SMLIMCTILT NCVFMTMSNP PDWTKNVEYT FTGIYTFESL IKIIARGFCL 

       190        200        210        220        230        240 
EDFTFLRDPW NWLDFTVITF AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 

       250        260        270        280        290        300 
IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNITMDY 

       310        320        330        340        350        360 
NGTLVNETVF EFDWKSYIQD SRYHYFLEGV LDALLCGNSS DAGQCPEGYM CVKAGRNPNY 

       370        380        390        400        410        420 
GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM IFFVLVIFLG SFYLINLILA 

       430        440        450        460        470        480 
VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ LKKQQEAAQQ AAATTASEHS REPSAAGRLS 

       490        500        510        520        530        540 
DSSSEASKLS SKSAKERRNR RKKRKQKEQS GGEEKDDDEF HKSESEDSIR RKGFRFSIEG 

       550        560        570        580        590        600 
NRLTYEKRYS SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED 

       610        620        630        640        650        660 
NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAVFPANGK MHSTVDCNGV VSLVGGPSVP 

       670        680        690        700        710        720 
TSPVGQLLPE GTTTETEMRK RRSSSFHVSM DFLEDPSQRQ RAMSIASILT NTVEELEESR 

       730        740        750        760        770        780 
QKCPPCWYKF SNIFLIWDCS PYWLKVKHIV NLVVMDPFVD LAITICIVLN TLFMAMEHYP 

       790        800        810        820        830        840 
MTEHFNHVLT VGNLVFTGIF TAEMFLKIIA MDPYYYFQEG WNIFDGFIVT LSLVELGLAN 

       850        860        870        880        890        900 
VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL 

       910        920        930        940        950        960 
FGKSYKDCVC KIATDCKLPR WHMNDFFHSF LIVFRVLCGE WIETMWDCME VAGQAMCLTV 

       970        980        990       1000       1010       1020 
FMMVMVIGNL VVLNLFLALL LSSFSADNLA ATDDDNEMNN LQIAVDRMHK GIAYVKRKIY 

      1030       1040       1050       1060       1070       1080 
EFIQQSFVKK QKILDEIKPL DDLNNRKDNC ISNHTTEIGK DLDCLKDVNG TTSGIGTGSS 

      1090       1100       1110       1120       1130       1140 
VEKYIIDESD YMSFINNPSL TVTVPIAVGE SDFENLNTED FSSESDLEES KEKLNESSSS 

      1150       1160       1170       1180       1190       1200 
SEGSTVDIGA PAEEQPVIEP EETLEPEACF TEGCVQRFKC CQISVEEGRG KQWWNLRRTC 

      1210       1220       1230       1240       1250       1260 
FRIVEHNWFE TFIVFMILLS SGALAFEDIY IDQRKTIKTM LEYADKVFTY IFILEMLLKW 

      1270       1280       1290       1300       1310       1320 
VAYGYQTYFT NAWCWLDFLI VDVSLVSLTA NALGYSELGA IKSLRTLRAL RPLRALSRFE 

      1330       1340       1350       1360       1370       1380 
GMRVVVNALL GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYHCVNTTT GDIFEISEVN 

      1390       1400       1410       1420       1430       1440 
NHSDCLKLIE RNETARWKNV KVNFDNVGFG YLSLLQVATF KGWMDIMYAA VDSRNVELQP 

      1450       1460       1470       1480       1490       1500 
KYEESLYMYL YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM 

      1510       1520       1530       1540       1550       1560 
KKLGSKKPQK PIPRPGNKFQ GMVFDFVTRQ VFDISIMILI CLNMVTMMVE TDDQSDYVTS 

      1570       1580       1590       1600       1610       1620 
ILSRINLVFI VLFTGECVLK LISLRHYYFT IGWNIFDFVV VILSIVGMFL AELIEKYFVS 

      1630       1640       1650       1660       1670       1680 
PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYAIFGMSN 

      1690       1700       1710       1720       1730       1740 
FAYVKREVGI DDMFNFETFG NSMICLFQIT TSAGWDGLLA PILNSKPPDC DPNKVNPGSS 

      1750       1760       1770       1780       1790       1800 
VKGDCGNPSV GIFFFVSYII ISFLVVVNMY IAVILENFSV ATEESAEPLS EDDFEMFYEV 

      1810       1820       1830       1840       1850       1860 
WEKFDPDATQ FMEFEKLSQF AAALEPPLNL PQPNKLQLIA MDLPMVSGDR IHCLDILFAF 

      1870       1880       1890       1900       1910       1920 
TKRVLGESGE MDALRIQMEE RFMASNPSKV SYQPITTTLK RKQEEVSAVI IQRAYRRHLL 

      1930       1940       1950       1960       1970       1980 
KRTVKQASFT YNKNKLKGGA NLLVKEDMLI DRINENSITE KTDLTMSTAA CPPSYDRVTK 

      1990 
PIVEKHEQEG KDEKAKGK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL844526 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
RefSeqNP_061203.2. NM_018733.2.
XP_006499091.1. XM_006499028.1.
UniGeneMm.439704.
Mm.455166.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000077489; ENSMUSP00000076697; ENSMUSG00000064329.
ENSMUST00000112371; ENSMUSP00000107990; ENSMUSG00000064329.
GeneID20265.
KEGGmmu:20265.
UCSCuc008jwz.1. mouse.

Organism-specific databases

CTD6323.
MGIMGI:98246. Scn1a.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00560000076721.
HOGENOMHOG000231755.
HOVERGENHBG053100.
KOK04833.
TreeFamTF323985.

Family and domain databases

Gene3D1.20.120.350. 4 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PfamPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSPR00170. NACHANNEL.
PR01664. NACHANNEL1.
SMARTSM00015. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297935.
SOURCESearch...

Entry information

Entry nameA2APX6_MOUSE
AccessionPrimary (citable) accession number: A2APX6
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)