Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

CD44 antigen

Gene

Cd44

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-2160916. Hyaluronan uptake and degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
CD44 antigenImported
Gene namesi
Name:Cd44Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88338. Cd44.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei406 – 42722HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 498478Sequence analysisPRO_5002642567Add
BLAST

Proteomic databases

PaxDbiA2APM4.

Expressioni

Gene expression databases

BgeeiA2APM4.
ExpressionAtlasiA2APM4. baseline and differential.
GenevisibleiA2APM4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005218.

Structurei

3D structure databases

ProteinModelPortaliA2APM4.
SMRiA2APM4. Positions 25-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 12590LinkInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000231746.
HOVERGENiHBG003850.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR001231. CD44_antigen.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2APM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKFWWHTAW GLCLLQLSLA HPHQQIDLNV TCRYAGVFHV EKNGRYSISR
60 70 80 90 100
TEAADLCQAF NSTLPTMDQM KLALSKGFET CRYGFIEGNV VIPRIHPNAI
110 120 130 140 150
CAANHTGVYI LVTSNTSHYD TYCFNASAPP EEDCTSVTDL PNSFDGPVTI
160 170 180 190 200
TIVNRDGTRY SKKGEYRTHQ EDIDASNIID DDVSSGSTIE KSTPESYILH
210 220 230 240 250
TYLPTEQPTG DQDDSFFIRS TLATNTDSSH STTLQPTAAP NTHLVEDLNR
260 270 280 290 300
TGPLSVTTPQ SHSQNFSTLH GEPEEDENHP TTSILPSSTK SGAKDARRGG
310 320 330 340 350
SLPTDTTTSV EGYTFQYPDT MENGTLFPVT PAKTEVFGET EVTLATDSNV
360 370 380 390 400
NVDGSLPGDR DSSKDSRGSS RTVTHGSELA GHSSANQDSG VTTTSGPMRR
410 420 430 440 450
PQIPEWLIIL ASLLALALIL AVCIAVNSRR RCGQKKKLVI NGGNGTVEDR
460 470 480 490
KPSELNGEAS KSQEMVHLVN KEPSETPDQC MTADETRNLQ SVDMKIGV
Length:498
Mass (Da):54,262
Last modified:February 20, 2007 - v1
Checksum:i4D388DBB9D12F4A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844155 Genomic DNA. No translation available.
RefSeqiNP_001171257.1. NM_001177786.1.
UniGeneiMm.423621.

Genome annotation databases

EnsembliENSMUST00000111191; ENSMUSP00000106822; ENSMUSG00000005087.
GeneIDi12505.
UCSCiuc008lii.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844155 Genomic DNA. No translation available.
RefSeqiNP_001171257.1. NM_001177786.1.
UniGeneiMm.423621.

3D structure databases

ProteinModelPortaliA2APM4.
SMRiA2APM4. Positions 25-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005218.

Proteomic databases

PaxDbiA2APM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111191; ENSMUSP00000106822; ENSMUSG00000005087.
GeneIDi12505.
UCSCiuc008lii.2. mouse.

Organism-specific databases

CTDi960.
MGIiMGI:88338. Cd44.

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000231746.
HOVERGENiHBG003850.

Enzyme and pathway databases

ReactomeiR-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-2160916. Hyaluronan uptake and degradation.

Miscellaneous databases

ChiTaRSiCd44. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiA2APM4.
ExpressionAtlasiA2APM4. baseline and differential.
GenevisibleiA2APM4. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR001231. CD44_antigen.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2APM4_MOUSE
AccessioniPrimary (citable) accession number: A2APM4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.