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Protein
Submitted name:

CD44 antigen

Gene

Cd44

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
CD44 antigenImported
Gene namesi
Name:Cd44Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88338 Cd44

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei688 – 709HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500264273121 – 780Sequence analysisAdd BLAST760

Proteomic databases

MaxQBiA2APM2
PRIDEiA2APM2

Miscellaneous databases

PMAP-CutDBA2APM2

Expressioni

Gene expression databases

BgeeiENSMUSG00000005087
ExpressionAtlasiA2APM2 baseline and differential
GenevisibleiA2APM2 MM

Structurei

3D structure databases

ProteinModelPortaliA2APM2
SMRiA2APM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 125LinkInterPro annotationAdd BLAST90

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IZCP Eukaryota
ENOG4111S6T LUCA
GeneTreeiENSGT00530000063822
HOGENOMiHOG000231746
HOVERGENiHBG003850
KOiK06256
OMAiSHPMGRG
OrthoDBiEOG091G0F98
PhylomeDBiA2APM2
TreeFamiTF334173

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR001231 CD44_antigen
IPR016187 CTDL_fold
IPR000538 Link_dom
PANTHERiPTHR10225:SF6 PTHR10225:SF6, 3 hits
PfamiView protein in Pfam
PF00193 Xlink, 1 hit
PRINTSiPR00658 CD44
PR01265 LINKMODULE
SMARTiView protein in SMART
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2APM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKFWWHTAW GLCLLQLSLA HPHQQIDLNV TCRYAGVFHV EKNGRYSISR
60 70 80 90 100
TEAADLCQAF NSTLPTMDQM KLALSKGFET CRYGFIEGNV VIPRIHPNAI
110 120 130 140 150
CAANHTGVYI LVTSNTSHYD TYCFNASAPP EEDCTSVTDL PNSFDGPVTI
160 170 180 190 200
TIVNRDGTRY SKKGEYRTHQ EDIDASNIID DDVSSGSTIE KSTPESYILH
210 220 230 240 250
TYLPTEQPTG DQDDSFFIRS TLATIASTVH SKSHAAAQKQ NNWIWSWFGN
260 270 280 290 300
SQSTTQTQEP TTSATTALMT TPETPPKRQE AQNWFSWLFQ PSESKSHLHT
310 320 330 340 350
TTKMPGTESN TNPTGWEPNE ENEDETDKYP SFSGSGIDDD EDFISSTIAS
360 370 380 390 400
TPRVSARTED NQDWTQWKPN HSNPEVLLQT TTRMADIDRI STSAHGENWT
410 420 430 440 450
PEPQPPFNNH EYQDEEETPH ATSTTPNSTA EAAATQQETW FQNGWQGKNP
460 470 480 490 500
PTPSEDSHVT EGTTASAHNN HPSQRITTQS QEDVSWTDFF DPISHPMGQG
510 520 530 540 550
HQTESKDTDS SHSTTLQPTA APNTHLVEDL NRTGPLSVTT PQSHSQNFST
560 570 580 590 600
LHGEPEEDEN HPTTSILPSS TKSGAKDARR GGSLPTDTTT SVEGYTFQYP
610 620 630 640 650
DTMENGTLFP VTPAKTEVFG ETEVTLATDS NVNVDGSLPG DRDSSKDSRG
660 670 680 690 700
SSRTVTHGSE LAGHSSANQD SGVTTTSGPM RRPQIPEWLI ILASLLALAL
710 720 730 740 750
ILAVCIAVNS RRRCGQKKKL VINGGNGTVE DRKPSELNGE ASKSQEMVHL
760 770 780
VNKEPSETPD QCMTADETRN LQSVDMKIGV
Length:780
Mass (Da):85,838
Last modified:February 20, 2007 - v1
Checksum:i96A067F59E18CBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844155 Genomic DNA No translation available.
RefSeqiNP_033981.2, NM_009851.2
UniGeneiMm.423621

Genome annotation databases

EnsembliENSMUST00000005218; ENSMUSP00000005218; ENSMUSG00000005087
GeneIDi12505
KEGGimmu:12505
UCSCiuc008lie.2 mouse

Similar proteinsi

Entry informationi

Entry nameiA2APM2_MOUSE
AccessioniPrimary (citable) accession number: A2APM2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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