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Protein
Submitted name:

CD44 antigen

Gene

Cd44

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-2160916. Hyaluronan uptake and degradation.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
CD44 antigenImported
Gene namesi
Name:Cd44Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88338. Cd44.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei688 – 709HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500264273121 – 780Sequence analysisAdd BLAST760

Proteomic databases

MaxQBiA2APM2.
PaxDbiA2APM2.
PRIDEiA2APM2.

Miscellaneous databases

PMAP-CutDBiA2APM2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005087.
ExpressionAtlasiA2APM2. baseline and differential.
GenevisibleiA2APM2. MM.

Structurei

3D structure databases

ProteinModelPortaliA2APM2.
SMRiA2APM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 125LinkInterPro annotationAdd BLAST90

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000231746.
HOVERGENiHBG003850.
KOiK06256.
OMAiSHPMGRG.
OrthoDBiEOG091G0F98.
PhylomeDBiA2APM2.
TreeFamiTF334173.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016186. C-type_lectin-like/link_sf.
IPR001231. CD44_antigen.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
PANTHERiPTHR10225:SF6. PTHR10225:SF6. 3 hits.
PfamiView protein in Pfam
PF00193. Xlink. 1 hit.
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiView protein in SMART
SM00445. LINK. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A2APM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKFWWHTAW GLCLLQLSLA HPHQQIDLNV TCRYAGVFHV EKNGRYSISR
60 70 80 90 100
TEAADLCQAF NSTLPTMDQM KLALSKGFET CRYGFIEGNV VIPRIHPNAI
110 120 130 140 150
CAANHTGVYI LVTSNTSHYD TYCFNASAPP EEDCTSVTDL PNSFDGPVTI
160 170 180 190 200
TIVNRDGTRY SKKGEYRTHQ EDIDASNIID DDVSSGSTIE KSTPESYILH
210 220 230 240 250
TYLPTEQPTG DQDDSFFIRS TLATIASTVH SKSHAAAQKQ NNWIWSWFGN
260 270 280 290 300
SQSTTQTQEP TTSATTALMT TPETPPKRQE AQNWFSWLFQ PSESKSHLHT
310 320 330 340 350
TTKMPGTESN TNPTGWEPNE ENEDETDKYP SFSGSGIDDD EDFISSTIAS
360 370 380 390 400
TPRVSARTED NQDWTQWKPN HSNPEVLLQT TTRMADIDRI STSAHGENWT
410 420 430 440 450
PEPQPPFNNH EYQDEEETPH ATSTTPNSTA EAAATQQETW FQNGWQGKNP
460 470 480 490 500
PTPSEDSHVT EGTTASAHNN HPSQRITTQS QEDVSWTDFF DPISHPMGQG
510 520 530 540 550
HQTESKDTDS SHSTTLQPTA APNTHLVEDL NRTGPLSVTT PQSHSQNFST
560 570 580 590 600
LHGEPEEDEN HPTTSILPSS TKSGAKDARR GGSLPTDTTT SVEGYTFQYP
610 620 630 640 650
DTMENGTLFP VTPAKTEVFG ETEVTLATDS NVNVDGSLPG DRDSSKDSRG
660 670 680 690 700
SSRTVTHGSE LAGHSSANQD SGVTTTSGPM RRPQIPEWLI ILASLLALAL
710 720 730 740 750
ILAVCIAVNS RRRCGQKKKL VINGGNGTVE DRKPSELNGE ASKSQEMVHL
760 770 780
VNKEPSETPD QCMTADETRN LQSVDMKIGV
Length:780
Mass (Da):85,838
Last modified:February 20, 2007 - v1
Checksum:i96A067F59E18CBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844155 Genomic DNA. No translation available.
RefSeqiNP_033981.2. NM_009851.2.
UniGeneiMm.423621.

Genome annotation databases

EnsembliENSMUST00000005218; ENSMUSP00000005218; ENSMUSG00000005087.
GeneIDi12505.
KEGGimmu:12505.
UCSCiuc008lie.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiA2APM2_MOUSE
AccessioniPrimary (citable) accession number: A2APM2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported