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Protein
Submitted name:

CD44 antigen

Gene

Cd44

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-2160916. Hyaluronan uptake and degradation.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
CD44 antigenImported
Gene namesi
Name:Cd44Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88338. Cd44.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei565 – 586HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500264232021 – 657Sequence analysisAdd BLAST637

Proteomic databases

MaxQBiA2APM1.
PaxDbiA2APM1.
PeptideAtlasiA2APM1.
PRIDEiA2APM1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005087.
ExpressionAtlasiA2APM1. baseline and differential.
GenevisibleiA2APM1. MM.

Structurei

3D structure databases

ProteinModelPortaliA2APM1.
SMRiA2APM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 125LinkInterPro annotationAdd BLAST90

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
GeneTreeiENSGT00530000063822.
HOVERGENiHBG003850.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016186. C-type_lectin-like/link_sf.
IPR001231. CD44_antigen.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
PANTHERiPTHR10225:SF6. PTHR10225:SF6. 2 hits.
PfamiView protein in Pfam
PF00193. Xlink. 1 hit.
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiView protein in SMART
SM00445. LINK. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A2APM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKFWWHTAW GLCLLQLSLA HPHQQIDLNV TCRYAGVFHV EKNGRYSISR
60 70 80 90 100
TEAADLCQAF NSTLPTMDQM KLALSKGFET CRYGFIEGNV VIPRIHPNAI
110 120 130 140 150
CAANHTGVYI LVTSNTSHYD TYCFNASAPP EEDCTSVTDL PNSFDGPVTI
160 170 180 190 200
TIVNRDGTRY SKKGEYRTHQ EDIDASNIID DDVSSGSTIE KSTPESYILH
210 220 230 240 250
TYLPTEQPTG DQDDSFFIRS TLATIASTPR VSARTEDNQD WTQWKPNHSN
260 270 280 290 300
PEVLLQTTTR MADIDRISTS AHGENWTPEP QPPFNNHEYQ DEEETPHATS
310 320 330 340 350
TTPNSTAEAA ATQQETWFQN GWQGKNPPTP SEDSHVTEGT TASAHNNHPS
360 370 380 390 400
QRITTQSQED VSWTDFFDPI SHPMGQGHQT ESKDTDSSHS TTLQPTAAPN
410 420 430 440 450
THLVEDLNRT GPLSVTTPQS HSQNFSTLHG EPEEDENHPT TSILPSSTKS
460 470 480 490 500
GAKDARRGGS LPTDTTTSVE GYTFQYPDTM ENGTLFPVTP AKTEVFGETE
510 520 530 540 550
VTLATDSNVN VDGSLPGDRD SSKDSRGSSR TVTHGSELAG HSSANQDSGV
560 570 580 590 600
TTTSGPMRRP QIPEWLIILA SLLALALILA VCIAVNSRRR CGQKKKLVIN
610 620 630 640 650
GGNGTVEDRK PSELNGEASK SQEMVHLVNK EPSETPDQCM TADETRNLQS

VDMKIGV
Length:657
Mass (Da):72,088
Last modified:February 20, 2007 - v1
Checksum:iB290E89270F6E01C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844155 Genomic DNA. No translation available.
RefSeqiNP_001171256.1. NM_001177785.1.
UniGeneiMm.423621.

Genome annotation databases

EnsembliENSMUST00000111198; ENSMUSP00000106829; ENSMUSG00000005087.
GeneIDi12505.
UCSCiuc008lih.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiA2APM1_MOUSE
AccessioniPrimary (citable) accession number: A2APM1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 22, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported