Cd44

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functionⁱ

hyaluronic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1474228 Degradation of the extracellular matrix R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-216083 Integrin cell surface interactions R-MMU-2160916 Hyaluronan uptake and degradation R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-1474228 Degradation of the extracellular matrix
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: CD44 antigenImported
Gene namesⁱ	Name:Cd44Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:88338 Cd44

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	565 – 586	HelicalSequence analysisAdd BLAST		22

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_5002642320	21 – 657	Sequence analysisAdd BLAST		637

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2APM1
PeptideAtlas More...PeptideAtlasⁱ	A2APM1
PRIDEⁱ	A2APM1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000005087
ExpressionAtlasⁱ	A2APM1 baseline and differential
Genevisibleⁱ	A2APM1 MM

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2APM1
SMRⁱ	A2APM1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	36 – 125	LinkInterPro annotationAdd BLAST		90

Keywords - Domainⁱ

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IZCP Eukaryota ENOG4111S6T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063822
HOVERGENⁱ	HBG003850

Family and domain databases

Gene3Dⁱ	3.10.100.101 hit
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR001231 CD44_antigen IPR016187 CTDL_fold IPR000538 Link_dom
PANTHERⁱ	PTHR10225:SF6 PTHR10225:SF6, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00193 Xlink, 1 hit
PRINTSⁱ	PR00658 CD44 PR01265 LINKMODULE
SMARTⁱ	View protein in SMART SM00445 LINK, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS01241 LINK_1, 1 hit PS50963 LINK_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A2APM1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDKFWWHTAW GLCLLQLSLA HPHQQIDLNV TCRYAGVFHV EKNGRYSISR 
        60         70         80         90        100
TEAADLCQAF NSTLPTMDQM KLALSKGFET CRYGFIEGNV VIPRIHPNAI 
       110        120        130        140        150
CAANHTGVYI LVTSNTSHYD TYCFNASAPP EEDCTSVTDL PNSFDGPVTI 
       160        170        180        190        200
TIVNRDGTRY SKKGEYRTHQ EDIDASNIID DDVSSGSTIE KSTPESYILH 
       210        220        230        240        250
TYLPTEQPTG DQDDSFFIRS TLATIASTPR VSARTEDNQD WTQWKPNHSN 
       260        270        280        290        300
PEVLLQTTTR MADIDRISTS AHGENWTPEP QPPFNNHEYQ DEEETPHATS 
       310        320        330        340        350
TTPNSTAEAA ATQQETWFQN GWQGKNPPTP SEDSHVTEGT TASAHNNHPS 
       360        370        380        390        400
QRITTQSQED VSWTDFFDPI SHPMGQGHQT ESKDTDSSHS TTLQPTAAPN 
       410        420        430        440        450
THLVEDLNRT GPLSVTTPQS HSQNFSTLHG EPEEDENHPT TSILPSSTKS 
       460        470        480        490        500
GAKDARRGGS LPTDTTTSVE GYTFQYPDTM ENGTLFPVTP AKTEVFGETE 
       510        520        530        540        550
VTLATDSNVN VDGSLPGDRD SSKDSRGSSR TVTHGSELAG HSSANQDSGV 
       560        570        580        590        600
TTTSGPMRRP QIPEWLIILA SLLALALILA VCIAVNSRRR CGQKKKLVIN 
       610        620        630        640        650
GGNGTVEDRK PSELNGEASK SQEMVHLVNK EPSETPDQCM TADETRNLQS 

VDMKIGV

Length:657

Mass (Da):72,088

Last modified:February 20, 2007 - v1

Checksum:ⁱB290E89270F6E01C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844155 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001171256.1, NM_001177785.1
UniGeneⁱ	Mm.423621

Genome annotation databases

Ensemblⁱ	ENSMUST00000111198; ENSMUSP00000106829; ENSMUSG00000005087
GeneIDⁱ	12505
UCSC genome browser More...UCSCⁱ	uc008lih.2 mouse

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A2APM1	P15379-4 UPI0003D0973A UPI000A317540 UPI000A312AFB	Rattus norvegicus (Rat) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari)	654	UniRef90_P15379-4	Cluster: Isoform 4 of CD44 antigen	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A2APM1	P15379 UPI000A312C99 UPI000A3150AF UPI000A3134E2 UPI000CA05B26 UPI000951D307 UPI000952640D UPI00062BC774 UPI000CEAA554 UPI000043500B +137	Mus musculus (Mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mus caroli (Ryukyu mouse) (Ricefield mouse) Trichechus manatus latirostris (Florida manatee) Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) Orcinus orca (Killer whale) Physeter catodon (Sperm whale) (Physeter macrocephalus) Ursus maritimus (Polar bear) (Thalarctos maritimus) Ailuropoda melanoleuca (Giant panda) Rattus norvegicus (Rat) And more	778	UniRef50_P15379	Cluster: CD44 antigen	148

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844155 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001171256.1, NM_001177785.1
UniGeneⁱ	Mm.423621

3D structure databases

ProteinModelPortalⁱ	A2APM1
SMRⁱ	A2APM1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2APM1
PeptideAtlas More...PeptideAtlasⁱ	A2APM1
PRIDEⁱ	A2APM1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000111198; ENSMUSP00000106829; ENSMUSG00000005087
GeneIDⁱ	12505
UCSC genome browser More...UCSCⁱ	uc008lih.2 mouse

Organism-specific databases

CTDⁱ	960
MGIⁱ	MGI:88338 Cd44

Phylogenomic databases

eggNOGⁱ	ENOG410IZCP Eukaryota ENOG4111S6T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063822
HOVERGENⁱ	HBG003850

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1474228 Degradation of the extracellular matrix R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-216083 Integrin cell surface interactions R-MMU-2160916 Hyaluronan uptake and degradation R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-1474228 Degradation of the extracellular matrix
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	Cd44 mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005087
ExpressionAtlasⁱ	A2APM1 baseline and differential
Genevisibleⁱ	A2APM1 MM

Family and domain databases

Gene3Dⁱ	3.10.100.101 hit
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR001231 CD44_antigen IPR016187 CTDL_fold IPR000538 Link_dom
PANTHERⁱ	PTHR10225:SF6 PTHR10225:SF6, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00193 Xlink, 1 hit
PRINTSⁱ	PR00658 CD44 PR01265 LINKMODULE
SMARTⁱ	View protein in SMART SM00445 LINK, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS01241 LINK_1, 1 hit PS50963 LINK_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A2APM1_MOUSE
Accessionⁱ	A2APM1Primary (citable) accession number: A2APM1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 20, 2007
	Last sequence update:	February 20, 2007
	Last modified:	March 28, 2018
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2APM1 (A2APM1_MOUSE)

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CD44 antigen

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ