Cd44

Functionⁱ

GO - Molecular functionⁱ

hyaluronic acid binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

cell adhesion Source: InterPro

Complete GO annotation...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1474228. Degradation of the extracellular matrix. R-MMU-202733. Cell surface interactions at the vascular wall. R-MMU-216083. Integrin cell surface interactions. R-MMU-2160916. Hyaluronan uptake and degradation. R-MMU-6798695. Neutrophil degranulation.

Reactomeⁱ

R-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-2160916. Hyaluronan uptake and degradation.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: CD44 antigenImported
Gene namesⁱ	Name:Cd44Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:88338. Cd44.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	565 – 586	HelicalSequence analysisAdd BLAST		22

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_5002642320	21 – 657	Sequence analysisAdd BLAST		637

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2APM1.
PaxDbⁱ	A2APM1.
PeptideAtlas More...PeptideAtlasⁱ	A2APM1.
PRIDEⁱ	A2APM1.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000005087.
ExpressionAtlasⁱ	A2APM1. baseline and differential.
Genevisibleⁱ	A2APM1. MM.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2APM1.
SMRⁱ	A2APM1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	36 – 125	LinkInterPro annotationAdd BLAST		90

Keywords - Domainⁱ

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IZCP. Eukaryota. ENOG4111S6T. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063822.
HOVERGENⁱ	HBG003850.

Family and domain databases

Gene3Dⁱ	3.10.100.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016186. C-type_lectin-like/link. IPR001231. CD44_antigen. IPR016187. CTDL_fold. IPR000538. Link_dom.
PANTHERⁱ	PTHR10225:SF8. PTHR10225:SF8. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00193. Xlink. 1 hit.
PRINTSⁱ	PR00658. CD44. PR01265. LINKMODULE.
SMARTⁱ	View protein in SMART SM00445. LINK. 1 hit.
SUPFAMⁱ	SSF56436. SSF56436. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01241. LINK_1. 1 hit. PS50963. LINK_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A2APM1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDKFWWHTAW GLCLLQLSLA HPHQQIDLNV TCRYAGVFHV EKNGRYSISR 
        60         70         80         90        100
TEAADLCQAF NSTLPTMDQM KLALSKGFET CRYGFIEGNV VIPRIHPNAI 
       110        120        130        140        150
CAANHTGVYI LVTSNTSHYD TYCFNASAPP EEDCTSVTDL PNSFDGPVTI 
       160        170        180        190        200
TIVNRDGTRY SKKGEYRTHQ EDIDASNIID DDVSSGSTIE KSTPESYILH 
       210        220        230        240        250
TYLPTEQPTG DQDDSFFIRS TLATIASTPR VSARTEDNQD WTQWKPNHSN 
       260        270        280        290        300
PEVLLQTTTR MADIDRISTS AHGENWTPEP QPPFNNHEYQ DEEETPHATS 
       310        320        330        340        350
TTPNSTAEAA ATQQETWFQN GWQGKNPPTP SEDSHVTEGT TASAHNNHPS 
       360        370        380        390        400
QRITTQSQED VSWTDFFDPI SHPMGQGHQT ESKDTDSSHS TTLQPTAAPN 
       410        420        430        440        450
THLVEDLNRT GPLSVTTPQS HSQNFSTLHG EPEEDENHPT TSILPSSTKS 
       460        470        480        490        500
GAKDARRGGS LPTDTTTSVE GYTFQYPDTM ENGTLFPVTP AKTEVFGETE 
       510        520        530        540        550
VTLATDSNVN VDGSLPGDRD SSKDSRGSSR TVTHGSELAG HSSANQDSGV 
       560        570        580        590        600
TTTSGPMRRP QIPEWLIILA SLLALALILA VCIAVNSRRR CGQKKKLVIN 
       610        620        630        640        650
GGNGTVEDRK PSELNGEASK SQEMVHLVNK EPSETPDQCM TADETRNLQS 

VDMKIGV

Length:657

Mass (Da):72,088

Last modified:February 20, 2007 - v1

Checksum:ⁱB290E89270F6E01C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844155 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001171256.1. NM_001177785.1.
UniGeneⁱ	Mm.423621.

Genome annotation databases

Ensemblⁱ	ENSMUST00000111198; ENSMUSP00000106829; ENSMUSG00000005087.
GeneIDⁱ	12505.
UCSC genome browser More...UCSCⁱ	uc008lih.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844155 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001171256.1. NM_001177785.1.
UniGeneⁱ	Mm.423621.

3D structure databases

ProteinModelPortalⁱ	A2APM1.
SMRⁱ	A2APM1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2APM1.
PaxDbⁱ	A2APM1.
PeptideAtlas More...PeptideAtlasⁱ	A2APM1.
PRIDEⁱ	A2APM1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000111198; ENSMUSP00000106829; ENSMUSG00000005087.
GeneIDⁱ	12505.
UCSC genome browser More...UCSCⁱ	uc008lih.2. mouse.

Organism-specific databases

CTDⁱ	960.
MGIⁱ	MGI:88338. Cd44.

Phylogenomic databases

eggNOGⁱ	ENOG410IZCP. Eukaryota. ENOG4111S6T. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063822.
HOVERGENⁱ	HBG003850.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1474228. Degradation of the extracellular matrix. R-MMU-202733. Cell surface interactions at the vascular wall. R-MMU-216083. Integrin cell surface interactions. R-MMU-2160916. Hyaluronan uptake and degradation. R-MMU-6798695. Neutrophil degranulation.

Reactomeⁱ

R-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-2160916. Hyaluronan uptake and degradation.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSⁱ	Cd44. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005087.
ExpressionAtlasⁱ	A2APM1. baseline and differential.
Genevisibleⁱ	A2APM1. MM.

Family and domain databases

Gene3Dⁱ	3.10.100.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016186. C-type_lectin-like/link. IPR001231. CD44_antigen. IPR016187. CTDL_fold. IPR000538. Link_dom.
PANTHERⁱ	PTHR10225:SF8. PTHR10225:SF8. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00193. Xlink. 1 hit.
PRINTSⁱ	PR00658. CD44. PR01265. LINKMODULE.
SMARTⁱ	View protein in SMART SM00445. LINK. 1 hit.
SUPFAMⁱ	SSF56436. SSF56436. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01241. LINK_1. 1 hit. PS50963. LINK_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A2APM1_MOUSE
Accessionⁱ	A2APM1Primary (citable) accession number: A2APM1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 20, 2007
	Last sequence update:	February 20, 2007
	Last modified:	July 5, 2017
	This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2APM1 (A2APM1_MOUSE)

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CD44 antigen

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ