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Protein

Amino acid transporter

Gene

Slc1a2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amino acid transporterUniRule annotation
Gene namesi
Name:Slc1a2Imported
ORF Names:mCG_9657Imported, RP23-163L4.1-002Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:101931. Slc1a2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 64HelicalUniRule annotationAdd BLAST23
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 139HelicalUniRule annotationAdd BLAST23
Transmembranei235 – 252HelicalUniRule annotationAdd BLAST18
Transmembranei272 – 297HelicalUniRule annotationAdd BLAST26
Transmembranei309 – 335HelicalUniRule annotationAdd BLAST27
Transmembranei341 – 364HelicalUniRule annotationAdd BLAST24
Transmembranei429 – 453HelicalUniRule annotationAdd BLAST25

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000005089.
ExpressionAtlasiA2APL8. baseline and differential.

Structurei

3D structure databases

SMRiA2APL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiView protein in InterPro
IPR036458. Na-dicarbo_symporter_sf.
IPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
PfamiView protein in Pfam
PF00375. SDF. 1 hit.
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiView protein in PROSITE
PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A2APL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSANNMPKQ VEVRMHDSHL SSDEPKHRNL GMRMCDKLGK NLLLSLTVFG
60 70 80 90 100
VILGAVCGGL LRLASPIHPD VVMLIAFPGD ILMRMLKMLI LPLIISSLIT
110 120 130 140 150
GLSGLDAKAS GRLGTRAMVY YMSTTIIAAV LGVILVLAIH PGNPKLKKQL
160 170 180 190 200
GPGKKNDEVS SLDAFLDLIR NLFPENLVQA CFQQIQTVTK KVLVAPPSEE
210 220 230 240 250
ANTTKAVISM LNETMNEAPE ETKIVIKKGL EFKDGMNVLG LIGFFIAFGI
260 270 280 290 300
AMGKMGEQAK LMVEFFNILN EIVMKLVIMI MWYSPLGIAC LICGKIIAIK
310 320 330 340 350
DLEVVARQLG MYMITVIVGL IIHGGIFLPL IYFVVTRKNP FSFFAGIFQA
360 370 380 390 400
WITALGTASS AGTLPVTFRC LEDNLGIDKR VTRFVLPVGA TINMDGTALY
410 420 430 440 450
EAVAAIFIAQ MNGVILDGGQ IVTVSLTATL ASIGAASIPS AGLVTMLLIL
460 470 480 490 500
TAVGLPTEDI SLLVAVDWLL DRMRTSVNVV GDSFGAGIVY HLSKSELDTI
510 520 530 540 550
DSQHRMQEDI EMTKTQSIYD DKNHRESNSN QCVYAAHNSV VIDECKVTLA
560
ANGKSADCSV EEEPWKREK
Length:569
Mass (Da):61,771
Last modified:February 20, 2007 - v1
Checksum:i930251320261AB8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844605, AL844155 Genomic DNA. Translation: CAM27625.1.
CH466519 Genomic DNA. Translation: EDL27672.1.
RefSeqiNP_001070983.1. NM_001077515.2.
UniGeneiMm.267547.
Mm.371582.
Mm.453107.
Mm.453110.

Genome annotation databases

GeneIDi20511.
UCSCiuc008lib.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiA2APL8_MOUSE
AccessioniPrimary (citable) accession number: A2APL8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)