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Protein
Submitted name:

Z-DNA-binding protein 1

Gene

Zbp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. double-stranded RNA adenosine deaminase activity Source: InterPro
  3. left-handed Z-DNA binding Source: MGI
  4. RNA binding Source: InterPro

GO - Biological processi

  1. positive regulation of type I interferon-mediated signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Z-DNA-binding protein 1Imported
Gene namesi
Name:Zbp1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1927449. Zbp1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiA2APF7.
ExpressionAtlasiA2APF7. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP1Q133632EBI-6115394,EBI-908846From a different organism.
CTBP2P565452EBI-6115394,EBI-741533From a different organism.
PALD1Q9ULE62EBI-6115394,EBI-3957166From a different organism.
PLXDC2Q6UX712EBI-6115394,EBI-6115410From a different organism.
TRAF3Q131142EBI-6115394,EBI-357631From a different organism.

Protein-protein interaction databases

IntActiA2APF7. 9 interactions.

Structurei

3D structure databases

SMRiA2APF7. Positions 13-69, 92-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000002234.
HOVERGENiHBG036279.
KOiK12965.
OMAiKECQVPK.
OrthoDBiEOG70S75W.
TreeFamiTF337658.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR000607. dsRNA_A_deaminase.
IPR025735. RHIM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12721. RHIM. 2 hits.
PF02295. z-alpha. 2 hits.
[Graphical view]
SMARTiSM00550. Zalpha. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2APF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAPVDLST GDNLEQKILQ VLSDDGGPVK IGQLVKKCQV PKKTLNQVLY
60 70 80 90 100
RLKKEDRVSS PEPATWSIGG AASGDGAPAI PENSSAQPSL DERILRFLEA
110 120 130 140 150
NGPHRALHIA KALGMTTAKE VNPLLYSMRN KHLLSYDGQT WKIYHSRQEG
160 170 180 190 200
QDIAHSGVTQ ESPAIICQHN PVNMICQQGA NSHISIANSN AIQIGHGNVI
210 220 230 240 250
VREKACGEPG PRTSHPLPLA WDASAQDMPP VAHGAQYIYM DKSLLQQVQL
260 270 280 290 300
GHHNEMSLVG DAGKHPSYSF SDSPPEVSTT TADPGASFNM QTSEPGPHPE
310 320 330 340 350
GDTVQTVHIK SCFLEDATIG NGNKMTIHLR SKGEVMESGD SEEPKKEDTG
360 370 380 390 400
TSSEATPPRS CQHTPSDSML PTSELRAMAL GDSSPQTTEP VLREHEVQDI
410
ESSQDTGLSK Q
Length:411
Mass (Da):44,271
Last modified:February 19, 2007 - v1
Checksum:i985F7B527F7DA5EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL837509 Genomic DNA. No translation available.
RefSeqiNP_067369.2. NM_021394.2.
UniGeneiMm.116687.

Genome annotation databases

EnsembliENSMUST00000029018; ENSMUSP00000029018; ENSMUSG00000027514.
GeneIDi58203.
KEGGimmu:58203.
UCSCiuc008odo.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL837509 Genomic DNA. No translation available.
RefSeqiNP_067369.2. NM_021394.2.
UniGeneiMm.116687.

3D structure databases

SMRiA2APF7. Positions 13-69, 92-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2APF7. 9 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029018; ENSMUSP00000029018; ENSMUSG00000027514.
GeneIDi58203.
KEGGimmu:58203.
UCSCiuc008odo.3. mouse.

Organism-specific databases

CTDi81030.
MGIiMGI:1927449. Zbp1.

Phylogenomic databases

GeneTreeiENSGT00390000002234.
HOVERGENiHBG036279.
KOiK12965.
OMAiKECQVPK.
OrthoDBiEOG70S75W.
TreeFamiTF337658.

Miscellaneous databases

NextBioi314185.
SOURCEiSearch...

Gene expression databases

BgeeiA2APF7.
ExpressionAtlasiA2APF7. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR000607. dsRNA_A_deaminase.
IPR025735. RHIM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12721. RHIM. 2 hits.
PF02295. z-alpha. 2 hits.
[Graphical view]
SMARTiSM00550. Zalpha. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2APF7_MOUSE
AccessioniPrimary (citable) accession number: A2APF7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 19, 2007
Last sequence update: February 19, 2007
Last modified: March 31, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.