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Protein

Probable tubulin polyglutamylase TTLL9

Gene

Ttll9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei231ATPBy similarity1
Binding sitei233ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi218 – 221ATP bindingBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8955332 Carboxyterminal post-translational modifications of tubulin

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tubulin polyglutamylase TTLL9 (EC:6.-.-.-)
Alternative name(s):
Tubulin--tyrosine ligase-like protein 9
Gene namesi
Name:Ttll9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913589 Ttll9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245181 – 461Probable tubulin polyglutamylase TTLL9Add BLAST461

Proteomic databases

PaxDbiA2APC3
PRIDEiA2APC3

PTM databases

PhosphoSitePlusiA2APC3

Expressioni

Gene expression databases

BgeeiENSMUSG00000074673
CleanExiMM_TTLL9
ExpressionAtlasiA2APC3 baseline and differential
GenevisibleiA2APC3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099444

Structurei

3D structure databases

ProteinModelPortaliA2APC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 402TTLPROSITE-ProRule annotationAdd BLAST381

Phylogenomic databases

eggNOGiKOG2157 Eukaryota
ENOG410XQDM LUCA
GeneTreeiENSGT00760000118951
HOGENOMiHOG000256695
HOVERGENiHBG066341
InParanoidiA2APC3
KOiK16603
OMAiGFARFCH
OrthoDBiEOG091G082M
PhylomeDBiA2APC3
TreeFamiTF313087

Family and domain databases

InterProiView protein in InterPro
IPR004344 TTL/TTLL_fam
IPR027751 TTLL9
PANTHERiPTHR12241:SF39 PTHR12241:SF39, 1 hit
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2APC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQKNQNSK GHGVSKGKER EQRTLIRFKT TLMNTLMDVL RHRPGWVEVK
60 70 80 90 100
DEGEWDFYWC DVSWLRENFD HTYMDEHVRI SHFRNHYELT RKNYMVKNLK
110 120 130 140 150
RFRKYLERES GKTEAAKCDF FPKTFEMPCE YHLFVEEFRK NPGITWIMKP
160 170 180 190 200
VARSQGKGIF LFRRLKDIMD WRKGTSGKKP TGVETQPARA NMNPSGSHDT
210 220 230 240 250
RSSDDQKDDL PVENYVAQRY VENPYLIGGR KFDLRVYVLV MSYIPLRAWL
260 270 280 290 300
YRDGFARFSN TRFTLNSIDD HYVHLTNVAV QKTSPDYHLK KGCKWMLQRF
310 320 330 340 350
RQYLASKHGP KAVETLFSDM DNIFIKSLQS VQKVIISDKH CFELYGYDIL
360 370 380 390 400
IDQDLKPWLL EVNASPSLTA SSQEDYELKT CLLEDTLHVV DMEARLTGKE
410 420 430 440 450
KRVGGFDLMW NDGPVSREDG PSDLSGMGNF VTNTHLGCVN DRKEQLRQLF
460
RSLQAQRKAP S
Length:461
Mass (Da):54,107
Last modified:March 18, 2008 - v2
Checksum:i6E83E3C9A4788EAD
GO
Isoform 2 (identifier: A2APC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-461: CVNDRKEQLRQLFRSLQAQRKAPS → TLSQTGSEWERNIIGSGGGLGPLGRAV

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):53,947
Checksum:iE44EC1B555455B86
GO

Sequence cautioni

The sequence CAM23684 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM23685 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162F → L in BAB29950 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032261438 – 461CVNDR…RKAPS → TLSQTGSEWERNIIGSGGGL GPLGRAV in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690753 mRNA Translation: CAM84330.1
AK015740 mRNA Translation: BAB29950.1
AL833801, AL928862 Genomic DNA Translation: CAM23682.1
AL833801, AL928862 Genomic DNA Translation: CAM23683.1
AL833801 Genomic DNA Translation: CAM23684.1 Sequence problems.
AL833801 Genomic DNA Translation: CAM23685.1 Sequence problems.
AL928862, AL833801 Genomic DNA Translation: CAM27198.1
AL928862, AL833801 Genomic DNA Translation: CAM27199.1
CCDSiCCDS16903.1 [A2APC3-2]
CCDS38283.1 [A2APC3-1]
RefSeqiNP_001077087.1, NM_001083618.1 [A2APC3-1]
NP_083340.2, NM_029064.2 [A2APC3-2]
UniGeneiMm.44746

Genome annotation databases

EnsembliENSMUST00000099197; ENSMUSP00000096803; ENSMUSG00000074673 [A2APC3-1]
ENSMUST00000103155; ENSMUSP00000099444; ENSMUSG00000074673 [A2APC3-2]
GeneIDi74711
KEGGimmu:74711
UCSCiuc008ngv.1 mouse [A2APC3-2]
uc008ngx.1 mouse [A2APC3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTTLL9_MOUSE
AccessioniPrimary (citable) accession number: A2APC3
Secondary accession number(s): A2APC4
, A2APC5, A2APC6, Q9D570
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 28, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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