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Protein

Probable tubulin polyglutamylase TTLL9

Gene

Ttll9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311ATPBy similarity
Binding sitei233 – 2331ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi218 – 2214ATP bindingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tubulin polyglutamylase TTLL9 (EC:6.-.-.-)
Alternative name(s):
Tubulin--tyrosine ligase-like protein 9
Gene namesi
Name:Ttll9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913589. Ttll9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Probable tubulin polyglutamylase TTLL9PRO_0000324518Add
BLAST

Proteomic databases

PaxDbiA2APC3.
PRIDEiA2APC3.

PTM databases

PhosphoSiteiA2APC3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074673.
CleanExiMM_TTLL9.
ExpressionAtlasiA2APC3. baseline and differential.
GenevisibleiA2APC3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099444.

Structurei

3D structure databases

ProteinModelPortaliA2APC3.
SMRiA2APC3. Positions 45-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 402381TTLPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000256695.
HOVERGENiHBG066341.
InParanoidiA2APC3.
KOiK16603.
OMAiVRICHFR.
OrthoDBiEOG091G082M.
PhylomeDBiA2APC3.
TreeFamiTF313087.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027751. TTLL9.
[Graphical view]
PANTHERiPTHR12241:SF39. PTHR12241:SF39. 2 hits.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2APC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQKNQNSK GHGVSKGKER EQRTLIRFKT TLMNTLMDVL RHRPGWVEVK
60 70 80 90 100
DEGEWDFYWC DVSWLRENFD HTYMDEHVRI SHFRNHYELT RKNYMVKNLK
110 120 130 140 150
RFRKYLERES GKTEAAKCDF FPKTFEMPCE YHLFVEEFRK NPGITWIMKP
160 170 180 190 200
VARSQGKGIF LFRRLKDIMD WRKGTSGKKP TGVETQPARA NMNPSGSHDT
210 220 230 240 250
RSSDDQKDDL PVENYVAQRY VENPYLIGGR KFDLRVYVLV MSYIPLRAWL
260 270 280 290 300
YRDGFARFSN TRFTLNSIDD HYVHLTNVAV QKTSPDYHLK KGCKWMLQRF
310 320 330 340 350
RQYLASKHGP KAVETLFSDM DNIFIKSLQS VQKVIISDKH CFELYGYDIL
360 370 380 390 400
IDQDLKPWLL EVNASPSLTA SSQEDYELKT CLLEDTLHVV DMEARLTGKE
410 420 430 440 450
KRVGGFDLMW NDGPVSREDG PSDLSGMGNF VTNTHLGCVN DRKEQLRQLF
460
RSLQAQRKAP S
Length:461
Mass (Da):54,107
Last modified:March 18, 2008 - v2
Checksum:i6E83E3C9A4788EAD
GO
Isoform 2 (identifier: A2APC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-461: CVNDRKEQLRQLFRSLQAQRKAPS → TLSQTGSEWERNIIGSGGGLGPLGRAV

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):53,947
Checksum:iE44EC1B555455B86
GO

Sequence cautioni

The sequence CAM23684 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM23685 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621F → L in BAB29950 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei438 – 46124CVNDR…RKAPS → TLSQTGSEWERNIIGSGGGL GPLGRAV in isoform 2. 1 PublicationVSP_032261Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690753 mRNA. Translation: CAM84330.1.
AK015740 mRNA. Translation: BAB29950.1.
AL833801, AL928862 Genomic DNA. Translation: CAM23682.1.
AL833801, AL928862 Genomic DNA. Translation: CAM23683.1.
AL833801 Genomic DNA. Translation: CAM23684.1. Sequence problems.
AL833801 Genomic DNA. Translation: CAM23685.1. Sequence problems.
AL928862, AL833801 Genomic DNA. Translation: CAM27198.1.
AL928862, AL833801 Genomic DNA. Translation: CAM27199.1.
CCDSiCCDS16903.1. [A2APC3-2]
CCDS38283.1. [A2APC3-1]
RefSeqiNP_001077087.1. NM_001083618.1. [A2APC3-1]
NP_083340.2. NM_029064.2. [A2APC3-2]
UniGeneiMm.44746.

Genome annotation databases

EnsembliENSMUST00000099197; ENSMUSP00000096803; ENSMUSG00000074673. [A2APC3-1]
ENSMUST00000103155; ENSMUSP00000099444; ENSMUSG00000074673. [A2APC3-2]
GeneIDi74711.
KEGGimmu:74711.
UCSCiuc008ngv.1. mouse. [A2APC3-2]
uc008ngx.1. mouse. [A2APC3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690753 mRNA. Translation: CAM84330.1.
AK015740 mRNA. Translation: BAB29950.1.
AL833801, AL928862 Genomic DNA. Translation: CAM23682.1.
AL833801, AL928862 Genomic DNA. Translation: CAM23683.1.
AL833801 Genomic DNA. Translation: CAM23684.1. Sequence problems.
AL833801 Genomic DNA. Translation: CAM23685.1. Sequence problems.
AL928862, AL833801 Genomic DNA. Translation: CAM27198.1.
AL928862, AL833801 Genomic DNA. Translation: CAM27199.1.
CCDSiCCDS16903.1. [A2APC3-2]
CCDS38283.1. [A2APC3-1]
RefSeqiNP_001077087.1. NM_001083618.1. [A2APC3-1]
NP_083340.2. NM_029064.2. [A2APC3-2]
UniGeneiMm.44746.

3D structure databases

ProteinModelPortaliA2APC3.
SMRiA2APC3. Positions 45-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099444.

PTM databases

PhosphoSiteiA2APC3.

Proteomic databases

PaxDbiA2APC3.
PRIDEiA2APC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099197; ENSMUSP00000096803; ENSMUSG00000074673. [A2APC3-1]
ENSMUST00000103155; ENSMUSP00000099444; ENSMUSG00000074673. [A2APC3-2]
GeneIDi74711.
KEGGimmu:74711.
UCSCiuc008ngv.1. mouse. [A2APC3-2]
uc008ngx.1. mouse. [A2APC3-1]

Organism-specific databases

CTDi164395.
MGIiMGI:1913589. Ttll9.

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000256695.
HOVERGENiHBG066341.
InParanoidiA2APC3.
KOiK16603.
OMAiVRICHFR.
OrthoDBiEOG091G082M.
PhylomeDBiA2APC3.
TreeFamiTF313087.

Miscellaneous databases

PROiA2APC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074673.
CleanExiMM_TTLL9.
ExpressionAtlasiA2APC3. baseline and differential.
GenevisibleiA2APC3. MM.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027751. TTLL9.
[Graphical view]
PANTHERiPTHR12241:SF39. PTHR12241:SF39. 2 hits.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTLL9_MOUSE
AccessioniPrimary (citable) accession number: A2APC3
Secondary accession number(s): A2APC4
, A2APC5, A2APC6, Q9D570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 7, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.