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A2AP18

- PLCH2_MOUSE

UniProt

A2AP18 - PLCH2_MOUSE

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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Gene

Plch2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.2 Publications

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei415 – 4151PROSITE-ProRule annotation
Metal bindingi416 – 4161Calcium 1; catalyticBy similarity
Metal bindingi445 – 4451Calcium 1; catalyticBy similarity
Metal bindingi447 – 4471Calcium 1; catalyticBy similarity
Active sitei459 – 4591PROSITE-ProRule annotation
Metal bindingi494 – 4941Calcium 1; catalyticBy similarity
Binding sitei543 – 5431SubstrateBy similarity
Binding sitei545 – 5451SubstrateBy similarity
Binding sitei734 – 7341SubstrateBy similarity
Binding sitei761 – 7611SubstrateBy similarity
Metal bindingi865 – 8651Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi867 – 8671Calcium 2By similarity
Metal bindingi891 – 8911Calcium 2By similarity
Metal bindingi920 – 9201Calcium 3By similarity
Metal bindingi921 – 9211Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi922 – 9221Calcium 3By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi256 – 26712PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  3. phospholipase C activity Source: MGI
  4. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. lipid catabolic process Source: UniProtKB-KW
  3. phosphatidylinositol metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196473. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-eta-2
Phosphoinositide phospholipase C-like 4
Short name:
PLC-L4
Short name:
Phospholipase C-like protein 4
Phospholipase C-eta-2
Short name:
PLC-eta2
Gene namesi
Name:Plch2
Synonyms:Plcl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2443078. Plch2.

Subcellular locationi

Cytoplasm 1 Publication. Cell membrane 1 Publication
Note: Localized predominantly at the plasma membrane.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi415 – 4151H → A: Inhibition of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150115011-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2PRO_0000308959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei676 – 6761Phosphoserine1 Publication
Modified residuei686 – 6861Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AP18.
PaxDbiA2AP18.
PRIDEiA2AP18.

PTM databases

PhosphoSiteiA2AP18.

Expressioni

Tissue specificityi

Specifically detected in the brain, with higher level in cerebral cortex, olfactory bulb and hippocampus (at protein level). Expressed in the pyramidal cells of the hippocampus, but also in eye and lung.2 Publications

Developmental stagei

Expressed at 2 weeks after birth but barely detected 1 week after birth. Increased expression during brain development.1 Publication

Gene expression databases

BgeeiA2AP18.
CleanExiMM_PLCH2.
ExpressionAtlasiA2AP18. baseline and differential.
GenevestigatoriA2AP18.

Interactioni

Protein-protein interaction databases

IntActiA2AP18. 1 interaction.
MINTiMINT-4115610.
STRINGi10090.ENSMUSP00000101256.

Structurei

3D structure databases

ProteinModelPortaliA2AP18.
SMRiA2AP18. Positions 207-568, 707-964.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 229109PHPROSITE-ProRule annotationAdd
BLAST
Domaini243 – 27836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini279 – 31537EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini400 – 545146PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST
Domaini707 – 821115PI-PLC Y-boxPROSITE-ProRule annotationAdd
BLAST
Domaini826 – 933108C2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 229155Necessary for plasma membrane localizationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1227 – 123610Poly-Ser

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG149692.
GeneTreeiENSGT00760000118936.
HOVERGENiHBG107105.
InParanoidiA2AP18.
OMAiHPRPPWH.
OrthoDBiEOG7PGDQ0.
PhylomeDBiA2AP18.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028393. PLC-eta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF21. PTHR10336:SF21. 1 hit.
PfamiPF00168. C2. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2AP18-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGLAWGPSR AAGSSWVNAS GTWEQPLRGF SGLQGGRRRG RGEKGIPEEP
60 70 80 90 100
LCQLTPQLGL SLRVPFGLGD YGLDMPGPQP SAASQTTGAV ACLAEVLLWV
110 120 130 140 150
GGSVVVSPRW QLSLVVERCM SAMQEGTQMV KLRGSSKGLV RFYYLDEHRS
160 170 180 190 200
CLRWRPSRKN EKAKISIDSI QEVSEGRQSE IFQRYPDSSF DPNCCFSIYH
210 220 230 240 250
GSHRESLDLV SPSSEEARTW VTGLRYLMAG ISDEDSLARR QRTRDQWLKQ
260 270 280 290 300
TFDEADKNGD GSLSISEVLQ LLHKLNVNLP RQRVKQMFRE ADTDDHQGTL
310 320 330 340 350
GFEEFCAFYK MMSTRRDLYL LMLTYSNHKD HLDASDLQRF LEVEQKMNGV
360 370 380 390 400
TLESCQNIIE QFEPCLENKS KGMLGIDGFT NYTRSPAGDI FNPEHNRVHQ
410 420 430 440 450
DMTQPLSHYF ITSSHNTYLV GDQLMSQSRV DMYAWVLQAG CRCVEVDCWD
460 470 480 490 500
GPDGEPIVHH GYTLTSKILF KDVIETINKY AFIKNEYPVI LSIENHCSVV
510 520 530 540 550
QQKKMAQYLT DILGDKLDLS SVSSEDATML PSPQMLKGKI LVKGKKLPAN
560 570 580 590 600
ISEDAEEGEV SDEDSADEME DDCKLLNGDA STNRKRVENI AKKKLDSLIK
610 620 630 640 650
ESKIRDCEDP NDFSVSTLSP SGKLGRKAEA KKGQSKVEED VEAGEDSGVS
660 670 680 690 700
RQNSRLFMSS FSKRKKKGSK IKKVASVEEG DETLDSPGSQ SRGTARQKKT
710 720 730 740 750
MKLSRALSDL VKYTKSVGTH DVEIEVVSSW QVSSFSETKA HQILQQKPTQ
760 770 780 790 800
YLRFNQHQLS RIYPSSYRVD SSNYNPQPFW NAGCQMVALN YQSEGRMLQL
810 820 830 840 850
NRAKFSANGD CGYVLKPQCM CQGVFNPNSE DPLPGQLKKQ LALRIISGQQ
860 870 880 890 900
LPKPRDSVLG DRGEIIDPFV EVEVIGLPVD CSKEQTRVVD DNGFNPMWEE
910 920 930 940 950
TLVFTVHMPE IALVRFLVWD HDPIGRDFIG QRTLAFSSIM PGYRHVYLEG
960 970 980 990 1000
MEEASIFVHV AVSDISGKVK QTLGLKGLFL RGTKPGSLDS HAAGQPLPRP
1010 1020 1030 1040 1050
SVSQRLLRRT ASAPTKSQKP SRKGFPELAL GTQDAGSEGA ADDVAPSSPN
1060 1070 1080 1090 1100
PALEAPTQER SGSSSPRDTR LFPLQRPISP LCSLEPIAEE PALGPGLPLQ
1110 1120 1130 1140 1150
AAAPTGPSQE GSQCPVGLGA KVTSSQQTSL GAFGTLQLRI GGGRENEEPP
1160 1170 1180 1190 1200
LRPHNGGISS GPREGTSGRQ TDSKSRSRVP GHLPVVRRAK SEGQVLSELS
1210 1220 1230 1240 1250
PTPAVYSDAT GTDRLWQRLE PGSHRDSVSS SSSMSSNDTV IDLSLPSLGL
1260 1270 1280 1290 1300
CRSRESIPGV SLGRLTSRPC LASAARPDLP PVTKSKSNPN LRVAGGLPTA
1310 1320 1330 1340 1350
PDELQPRPLA PRLTGHHPRP PWHHLTLVGL RDCPVSAKSK SLGDLTADDF
1360 1370 1380 1390 1400
APSFQGSTSS LSCGLGSLGV AHQVLEPGIR RDALTEQLRW LTGFQQAGDI
1410 1420 1430 1440 1450
TSPTSLGPAG DGSVGGPSFL RRSSSRSQSR VRAIASRARQ AQERQQRLRG
1460 1470 1480 1490 1500
QDSRGPPEEE RGTPEGACSV GHEGCVDVPM PAKGAPEQVC GAADGQLLLR

L
Length:1,501
Mass (Da):164,297
Last modified:August 21, 2007 - v2
Checksum:i6C2CA0E2864B327B
GO
Isoform 2 (identifier: A2AP18-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1068-1238: DTRLFPLQRP...SSSSSMSSND → GKAPGGEATE...HSPMFSTVRD
     1239-1501: Missing.

Show »
Length:1,238
Mass (Da):136,321
Checksum:iF6A095EB915BF370
GO
Isoform 3 (identifier: A2AP18-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1068-1252: DTRLFPLQRP...LSLPSLGLCR → GKAPGGEATE...ASHALYTWHA
     1253-1501: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay..

Show »
Length:1,252
Mass (Da):137,734
Checksum:iD591E6F8D70C95D3
GO
Isoform 4 (identifier: A2AP18-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     106-116: VSPRWQLSLVV → MDAGAAPQKHM

Show »
Length:1,396
Mass (Da):153,398
Checksum:iE9DE7ABC3A7F10E7
GO
Isoform 5 (identifier: A2AP18-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-115: Missing.
     580-675: ASTNRKRVEN...KKGSKIKKVA → VSGSPGSACR...GKWWFTNVKK
     676-1501: Missing.

Show »
Length:599
Mass (Da):67,979
Checksum:i4388365410ED427F
GO

Sequence cautioni

The sequence BAC32005.1 differs from that shown. Reason: Aberrant splicing.Curated
The sequence BAC32005.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC37371.1 differs from that shown. Reason: Erroneous termination at position 433. Translated as Tyr.Curated
The sequence CAO78007.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAO78129.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401F → L in BAC34011. (PubMed:16141072)Curated
Sequence conflicti664 – 6652RK → HR in AAH40465. (PubMed:15489334)Curated
Sequence conflicti781 – 7811N → D in BAC32005. (PubMed:16141072)Curated
Sequence conflicti1258 – 12581P → A in BAC32005. (PubMed:16141072)Curated
Sequence conflicti1495 – 14951G → S in BAC32005. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 105105Missing in isoform 4. 1 PublicationVSP_029075Add
BLAST
Alternative sequencei40 – 11576Missing in isoform 5. 1 PublicationVSP_029076Add
BLAST
Alternative sequencei106 – 11611VSPRWQLSLVV → MDAGAAPQKHM in isoform 4. 1 PublicationVSP_029077Add
BLAST
Alternative sequencei580 – 67596ASTNR…IKKVA → VSGSPGSACREPGVGPQHPR PILSTKGIYLPQRERGQGVR DKDRRWRVREKGKGTREGAR GICPGGRGDKGLPLDREETD RQTWPIGKWWFTNVKK in isoform 5. 1 PublicationVSP_029078Add
BLAST
Alternative sequencei676 – 1501826Missing in isoform 5. 1 PublicationVSP_029079Add
BLAST
Alternative sequencei1068 – 1252185DTRLF…LGLCR → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLQREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTGKACRSAASHAL YTWHA in isoform 3. 1 PublicationVSP_029081Add
BLAST
Alternative sequencei1068 – 1238171DTRLF…MSSND → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLRREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTVRD in isoform 2. 1 PublicationVSP_029082Add
BLAST
Alternative sequencei1239 – 1501263Missing in isoform 2. 1 PublicationVSP_029083Add
BLAST
Alternative sequencei1253 – 1501249Missing in isoform 3. 1 PublicationVSP_029084Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176851 mRNA. Translation: ABA12210.1.
AL831788, BX004788 Genomic DNA. Translation: CAM16344.2.
BX004788, AL831788 Genomic DNA. Translation: CAM28037.2.
AL831788, BX004788 Genomic DNA. Translation: CAO78007.1. Sequence problems.
BX004788, AL831788 Genomic DNA. Translation: CAO78129.1. Sequence problems.
AK044619 mRNA. Translation: BAC32005.1. Sequence problems.
AK049970 mRNA. Translation: BAC34011.1.
AK078731 mRNA. Translation: BAC37371.1. Sequence problems.
AY966876 mRNA. Translation: AAY33831.1.
BC040465 mRNA. Translation: AAH40465.1.
BC052329 mRNA. Translation: AAH52329.1.
CCDSiCCDS38990.2. [A2AP18-2]
CCDS71533.1. [A2AP18-1]
RefSeqiNP_001106831.1. NM_001113360.2. [A2AP18-1]
NP_780765.2. NM_175556.4.
UniGeneiMm.379458.

Genome annotation databases

EnsembliENSMUST00000105631; ENSMUSP00000101256; ENSMUSG00000029055. [A2AP18-1]
ENSMUST00000135665; ENSMUSP00000118292; ENSMUSG00000029055. [A2AP18-4]
ENSMUST00000145662; ENSMUSP00000119864; ENSMUSG00000029055. [A2AP18-5]
GeneIDi269615.
KEGGimmu:269615.
UCSCiuc008wco.2. mouse. [A2AP18-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176851 mRNA. Translation: ABA12210.1 .
AL831788 , BX004788 Genomic DNA. Translation: CAM16344.2 .
BX004788 , AL831788 Genomic DNA. Translation: CAM28037.2 .
AL831788 , BX004788 Genomic DNA. Translation: CAO78007.1 . Sequence problems.
BX004788 , AL831788 Genomic DNA. Translation: CAO78129.1 . Sequence problems.
AK044619 mRNA. Translation: BAC32005.1 . Sequence problems.
AK049970 mRNA. Translation: BAC34011.1 .
AK078731 mRNA. Translation: BAC37371.1 . Sequence problems.
AY966876 mRNA. Translation: AAY33831.1 .
BC040465 mRNA. Translation: AAH40465.1 .
BC052329 mRNA. Translation: AAH52329.1 .
CCDSi CCDS38990.2. [A2AP18-2 ]
CCDS71533.1. [A2AP18-1 ]
RefSeqi NP_001106831.1. NM_001113360.2. [A2AP18-1 ]
NP_780765.2. NM_175556.4.
UniGenei Mm.379458.

3D structure databases

ProteinModelPortali A2AP18.
SMRi A2AP18. Positions 207-568, 707-964.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi A2AP18. 1 interaction.
MINTi MINT-4115610.
STRINGi 10090.ENSMUSP00000101256.

PTM databases

PhosphoSitei A2AP18.

Proteomic databases

MaxQBi A2AP18.
PaxDbi A2AP18.
PRIDEi A2AP18.

Protocols and materials databases

DNASUi 269615.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105631 ; ENSMUSP00000101256 ; ENSMUSG00000029055 . [A2AP18-1 ]
ENSMUST00000135665 ; ENSMUSP00000118292 ; ENSMUSG00000029055 . [A2AP18-4 ]
ENSMUST00000145662 ; ENSMUSP00000119864 ; ENSMUSG00000029055 . [A2AP18-5 ]
GeneIDi 269615.
KEGGi mmu:269615.
UCSCi uc008wco.2. mouse. [A2AP18-1 ]

Organism-specific databases

CTDi 9651.
MGIi MGI:2443078. Plch2.

Phylogenomic databases

eggNOGi NOG149692.
GeneTreei ENSGT00760000118936.
HOVERGENi HBG107105.
InParanoidi A2AP18.
OMAi HPRPPWH.
OrthoDBi EOG7PGDQ0.
PhylomeDBi A2AP18.
TreeFami TF313216.

Enzyme and pathway databases

Reactomei REACT_196473. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

NextBioi 392931.
PROi A2AP18.
SOURCEi Search...

Gene expression databases

Bgeei A2AP18.
CleanExi MM_PLCH2.
ExpressionAtlasi A2AP18. baseline and differential.
Genevestigatori A2AP18.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028393. PLC-eta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF21. PTHR10336:SF21. 1 hit.
Pfami PF00168. C2. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEi PS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of PLC-eta2."
    Zhou Y., Wing M.R., Sondek J., Harden T.K.
    Biochem. J. 391:667-676(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-664 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1501 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-246 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Eye, Hippocampus and Retina.
  4. "A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme."
    Nakahara M., Shimozawa M., Nakamura Y., Irino Y., Morita M., Kudo Y., Fukami K.
    J. Biol. Chem. 280:29128-29134(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-1501 (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, REGION, FUNCTION, DEVELOPMENTAL STAGE, MUTAGENESIS OF HIS-415.
    Strain: C57BL/6J x 129.
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 624-1501 (ISOFORM 3).
    Tissue: Eye.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-676 AND SER-686, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  7. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiPLCH2_MOUSE
AccessioniPrimary (citable) accession number: A2AP18
Secondary accession number(s): A6PWW5
, Q3LUA7, Q4QSC7, Q80WP6, Q8BJV1, Q8BWU4, Q8BXN5, Q8CFR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3