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A2AP18

- PLCH2_MOUSE

UniProt

A2AP18 - PLCH2_MOUSE

Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Gene

Plch2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.2 Publications

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

    Cofactori

    Calcium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei415 – 4151PROSITE-ProRule annotation
    Metal bindingi416 – 4161Calcium 1; catalyticBy similarity
    Metal bindingi445 – 4451Calcium 1; catalyticBy similarity
    Metal bindingi447 – 4471Calcium 1; catalyticBy similarity
    Active sitei459 – 4591PROSITE-ProRule annotation
    Metal bindingi494 – 4941Calcium 1; catalyticBy similarity
    Binding sitei543 – 5431SubstrateBy similarity
    Binding sitei545 – 5451SubstrateBy similarity
    Binding sitei734 – 7341SubstrateBy similarity
    Binding sitei761 – 7611SubstrateBy similarity
    Metal bindingi865 – 8651Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi867 – 8671Calcium 2By similarity
    Metal bindingi891 – 8911Calcium 2By similarity
    Metal bindingi920 – 9201Calcium 3By similarity
    Metal bindingi921 – 9211Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi922 – 9221Calcium 3By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi256 – 26712PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    3. phospholipase C activity Source: MGI
    4. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. lipid catabolic process Source: UniProtKB-KW
    3. phosphatidylinositol metabolic process Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Transducer

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196473. Synthesis of IP3 and IP4 in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC:3.1.4.11)
    Alternative name(s):
    Phosphoinositide phospholipase C-eta-2
    Phosphoinositide phospholipase C-like 4
    Short name:
    PLC-L4
    Short name:
    Phospholipase C-like protein 4
    Phospholipase C-eta-2
    Short name:
    PLC-eta2
    Gene namesi
    Name:Plch2
    Synonyms:Plcl4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2443078. Plch2.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication
    Note: Localized predominantly at the plasma membrane.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi415 – 4151H → A: Inhibition of activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150115011-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2PRO_0000308959Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei676 – 6761Phosphoserine1 Publication
    Modified residuei686 – 6861Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiA2AP18.
    PaxDbiA2AP18.
    PRIDEiA2AP18.

    PTM databases

    PhosphoSiteiA2AP18.

    Expressioni

    Tissue specificityi

    Specifically detected in the brain, with higher level in cerebral cortex, olfactory bulb and hippocampus (at protein level). Expressed in the pyramidal cells of the hippocampus, but also in eye and lung.2 Publications

    Developmental stagei

    Expressed at 2 weeks after birth but barely detected 1 week after birth. Increased expression during brain development.1 Publication

    Gene expression databases

    BgeeiA2AP18.
    CleanExiMM_PLCH2.
    GenevestigatoriA2AP18.

    Interactioni

    Protein-protein interaction databases

    IntActiA2AP18. 1 interaction.
    MINTiMINT-4115610.
    STRINGi10090.ENSMUSP00000101256.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AP18.
    SMRiA2AP18. Positions 207-568, 707-964.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini121 – 229109PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini243 – 27836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 31537EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 545146PI-PLC X-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini707 – 821115PI-PLC Y-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini826 – 933108C2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni75 – 229155Necessary for plasma membrane localizationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1227 – 123610Poly-Ser

    Sequence similaritiesi

    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG149692.
    GeneTreeiENSGT00740000114979.
    HOVERGENiHBG107105.
    InParanoidiA2AP18.
    OMAiHPRPPWH.
    OrthoDBiEOG7PGDQ0.
    PhylomeDBiA2AP18.
    TreeFamiTF313216.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028393. PLC-eta2.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF21. PTHR10336:SF21. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view]
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00054. EFh. 2 hits.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2AP18-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGLAWGPSR AAGSSWVNAS GTWEQPLRGF SGLQGGRRRG RGEKGIPEEP     50
    LCQLTPQLGL SLRVPFGLGD YGLDMPGPQP SAASQTTGAV ACLAEVLLWV 100
    GGSVVVSPRW QLSLVVERCM SAMQEGTQMV KLRGSSKGLV RFYYLDEHRS 150
    CLRWRPSRKN EKAKISIDSI QEVSEGRQSE IFQRYPDSSF DPNCCFSIYH 200
    GSHRESLDLV SPSSEEARTW VTGLRYLMAG ISDEDSLARR QRTRDQWLKQ 250
    TFDEADKNGD GSLSISEVLQ LLHKLNVNLP RQRVKQMFRE ADTDDHQGTL 300
    GFEEFCAFYK MMSTRRDLYL LMLTYSNHKD HLDASDLQRF LEVEQKMNGV 350
    TLESCQNIIE QFEPCLENKS KGMLGIDGFT NYTRSPAGDI FNPEHNRVHQ 400
    DMTQPLSHYF ITSSHNTYLV GDQLMSQSRV DMYAWVLQAG CRCVEVDCWD 450
    GPDGEPIVHH GYTLTSKILF KDVIETINKY AFIKNEYPVI LSIENHCSVV 500
    QQKKMAQYLT DILGDKLDLS SVSSEDATML PSPQMLKGKI LVKGKKLPAN 550
    ISEDAEEGEV SDEDSADEME DDCKLLNGDA STNRKRVENI AKKKLDSLIK 600
    ESKIRDCEDP NDFSVSTLSP SGKLGRKAEA KKGQSKVEED VEAGEDSGVS 650
    RQNSRLFMSS FSKRKKKGSK IKKVASVEEG DETLDSPGSQ SRGTARQKKT 700
    MKLSRALSDL VKYTKSVGTH DVEIEVVSSW QVSSFSETKA HQILQQKPTQ 750
    YLRFNQHQLS RIYPSSYRVD SSNYNPQPFW NAGCQMVALN YQSEGRMLQL 800
    NRAKFSANGD CGYVLKPQCM CQGVFNPNSE DPLPGQLKKQ LALRIISGQQ 850
    LPKPRDSVLG DRGEIIDPFV EVEVIGLPVD CSKEQTRVVD DNGFNPMWEE 900
    TLVFTVHMPE IALVRFLVWD HDPIGRDFIG QRTLAFSSIM PGYRHVYLEG 950
    MEEASIFVHV AVSDISGKVK QTLGLKGLFL RGTKPGSLDS HAAGQPLPRP 1000
    SVSQRLLRRT ASAPTKSQKP SRKGFPELAL GTQDAGSEGA ADDVAPSSPN 1050
    PALEAPTQER SGSSSPRDTR LFPLQRPISP LCSLEPIAEE PALGPGLPLQ 1100
    AAAPTGPSQE GSQCPVGLGA KVTSSQQTSL GAFGTLQLRI GGGRENEEPP 1150
    LRPHNGGISS GPREGTSGRQ TDSKSRSRVP GHLPVVRRAK SEGQVLSELS 1200
    PTPAVYSDAT GTDRLWQRLE PGSHRDSVSS SSSMSSNDTV IDLSLPSLGL 1250
    CRSRESIPGV SLGRLTSRPC LASAARPDLP PVTKSKSNPN LRVAGGLPTA 1300
    PDELQPRPLA PRLTGHHPRP PWHHLTLVGL RDCPVSAKSK SLGDLTADDF 1350
    APSFQGSTSS LSCGLGSLGV AHQVLEPGIR RDALTEQLRW LTGFQQAGDI 1400
    TSPTSLGPAG DGSVGGPSFL RRSSSRSQSR VRAIASRARQ AQERQQRLRG 1450
    QDSRGPPEEE RGTPEGACSV GHEGCVDVPM PAKGAPEQVC GAADGQLLLR 1500
    L 1501
    Length:1,501
    Mass (Da):164,297
    Last modified:August 21, 2007 - v2
    Checksum:i6C2CA0E2864B327B
    GO
    Isoform 2 (identifier: A2AP18-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1068-1238: DTRLFPLQRP...SSSSSMSSND → GKAPGGEATE...HSPMFSTVRD
         1239-1501: Missing.

    Show »
    Length:1,238
    Mass (Da):136,321
    Checksum:iF6A095EB915BF370
    GO
    Isoform 3 (identifier: A2AP18-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1068-1252: DTRLFPLQRP...LSLPSLGLCR → GKAPGGEATE...ASHALYTWHA
         1253-1501: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay..

    Show »
    Length:1,252
    Mass (Da):137,734
    Checksum:iD591E6F8D70C95D3
    GO
    Isoform 4 (identifier: A2AP18-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-105: Missing.
         106-116: VSPRWQLSLVV → MDAGAAPQKHM

    Show »
    Length:1,396
    Mass (Da):153,398
    Checksum:iE9DE7ABC3A7F10E7
    GO
    Isoform 5 (identifier: A2AP18-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         40-115: Missing.
         580-675: ASTNRKRVEN...KKGSKIKKVA → VSGSPGSACR...GKWWFTNVKK
         676-1501: Missing.

    Show »
    Length:599
    Mass (Da):67,979
    Checksum:i4388365410ED427F
    GO

    Sequence cautioni

    The sequence BAC32005.1 differs from that shown. Reason: Aberrant splicing.
    The sequence BAC32005.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC37371.1 differs from that shown. Reason: Erroneous termination at position 433. Translated as Tyr.
    The sequence CAO78007.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAO78129.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti340 – 3401F → L in BAC34011. (PubMed:16141072)Curated
    Sequence conflicti664 – 6652RK → HR in AAH40465. (PubMed:15489334)Curated
    Sequence conflicti781 – 7811N → D in BAC32005. (PubMed:16141072)Curated
    Sequence conflicti1258 – 12581P → A in BAC32005. (PubMed:16141072)Curated
    Sequence conflicti1495 – 14951G → S in BAC32005. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 105105Missing in isoform 4. 1 PublicationVSP_029075Add
    BLAST
    Alternative sequencei40 – 11576Missing in isoform 5. 1 PublicationVSP_029076Add
    BLAST
    Alternative sequencei106 – 11611VSPRWQLSLVV → MDAGAAPQKHM in isoform 4. 1 PublicationVSP_029077Add
    BLAST
    Alternative sequencei580 – 67596ASTNR…IKKVA → VSGSPGSACREPGVGPQHPR PILSTKGIYLPQRERGQGVR DKDRRWRVREKGKGTREGAR GICPGGRGDKGLPLDREETD RQTWPIGKWWFTNVKK in isoform 5. 1 PublicationVSP_029078Add
    BLAST
    Alternative sequencei676 – 1501826Missing in isoform 5. 1 PublicationVSP_029079Add
    BLAST
    Alternative sequencei1068 – 1252185DTRLF…LGLCR → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLQREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTGKACRSAASHAL YTWHA in isoform 3. 1 PublicationVSP_029081Add
    BLAST
    Alternative sequencei1068 – 1238171DTRLF…MSSND → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLRREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTVRD in isoform 2. 1 PublicationVSP_029082Add
    BLAST
    Alternative sequencei1239 – 1501263Missing in isoform 2. 1 PublicationVSP_029083Add
    BLAST
    Alternative sequencei1253 – 1501249Missing in isoform 3. 1 PublicationVSP_029084Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ176851 mRNA. Translation: ABA12210.1.
    AL831788, BX004788 Genomic DNA. Translation: CAM16344.2.
    BX004788, AL831788 Genomic DNA. Translation: CAM28037.2.
    AL831788, BX004788 Genomic DNA. Translation: CAO78007.1. Sequence problems.
    BX004788, AL831788 Genomic DNA. Translation: CAO78129.1. Sequence problems.
    AK044619 mRNA. Translation: BAC32005.1. Sequence problems.
    AK049970 mRNA. Translation: BAC34011.1.
    AK078731 mRNA. Translation: BAC37371.1. Sequence problems.
    AY966876 mRNA. Translation: AAY33831.1.
    BC040465 mRNA. Translation: AAH40465.1.
    BC052329 mRNA. Translation: AAH52329.1.
    CCDSiCCDS38990.2. [A2AP18-2]
    CCDS71533.1. [A2AP18-1]
    RefSeqiNP_001106831.1. NM_001113360.2. [A2AP18-1]
    NP_780765.2. NM_175556.4.
    UniGeneiMm.379458.

    Genome annotation databases

    EnsembliENSMUST00000105631; ENSMUSP00000101256; ENSMUSG00000029055. [A2AP18-1]
    ENSMUST00000135665; ENSMUSP00000118292; ENSMUSG00000029055. [A2AP18-4]
    ENSMUST00000145662; ENSMUSP00000119864; ENSMUSG00000029055. [A2AP18-5]
    GeneIDi269615.
    KEGGimmu:269615.
    UCSCiuc008wco.2. mouse. [A2AP18-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ176851 mRNA. Translation: ABA12210.1 .
    AL831788 , BX004788 Genomic DNA. Translation: CAM16344.2 .
    BX004788 , AL831788 Genomic DNA. Translation: CAM28037.2 .
    AL831788 , BX004788 Genomic DNA. Translation: CAO78007.1 . Sequence problems.
    BX004788 , AL831788 Genomic DNA. Translation: CAO78129.1 . Sequence problems.
    AK044619 mRNA. Translation: BAC32005.1 . Sequence problems.
    AK049970 mRNA. Translation: BAC34011.1 .
    AK078731 mRNA. Translation: BAC37371.1 . Sequence problems.
    AY966876 mRNA. Translation: AAY33831.1 .
    BC040465 mRNA. Translation: AAH40465.1 .
    BC052329 mRNA. Translation: AAH52329.1 .
    CCDSi CCDS38990.2. [A2AP18-2 ]
    CCDS71533.1. [A2AP18-1 ]
    RefSeqi NP_001106831.1. NM_001113360.2. [A2AP18-1 ]
    NP_780765.2. NM_175556.4.
    UniGenei Mm.379458.

    3D structure databases

    ProteinModelPortali A2AP18.
    SMRi A2AP18. Positions 207-568, 707-964.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi A2AP18. 1 interaction.
    MINTi MINT-4115610.
    STRINGi 10090.ENSMUSP00000101256.

    PTM databases

    PhosphoSitei A2AP18.

    Proteomic databases

    MaxQBi A2AP18.
    PaxDbi A2AP18.
    PRIDEi A2AP18.

    Protocols and materials databases

    DNASUi 269615.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105631 ; ENSMUSP00000101256 ; ENSMUSG00000029055 . [A2AP18-1 ]
    ENSMUST00000135665 ; ENSMUSP00000118292 ; ENSMUSG00000029055 . [A2AP18-4 ]
    ENSMUST00000145662 ; ENSMUSP00000119864 ; ENSMUSG00000029055 . [A2AP18-5 ]
    GeneIDi 269615.
    KEGGi mmu:269615.
    UCSCi uc008wco.2. mouse. [A2AP18-1 ]

    Organism-specific databases

    CTDi 9651.
    MGIi MGI:2443078. Plch2.

    Phylogenomic databases

    eggNOGi NOG149692.
    GeneTreei ENSGT00740000114979.
    HOVERGENi HBG107105.
    InParanoidi A2AP18.
    OMAi HPRPPWH.
    OrthoDBi EOG7PGDQ0.
    PhylomeDBi A2AP18.
    TreeFami TF313216.

    Enzyme and pathway databases

    Reactomei REACT_196473. Synthesis of IP3 and IP4 in the cytosol.

    Miscellaneous databases

    NextBioi 392931.
    PROi A2AP18.
    SOURCEi Search...

    Gene expression databases

    Bgeei A2AP18.
    CleanExi MM_PLCH2.
    Genevestigatori A2AP18.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028393. PLC-eta2.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF21. PTHR10336:SF21. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view ]
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00054. EFh. 2 hits.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of PLC-eta2."
      Zhou Y., Wing M.R., Sondek J., Harden T.K.
      Biochem. J. 391:667-676(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Strain: C57BL/6J.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-664 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1501 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-246 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Eye, Hippocampus and Retina.
    4. "A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme."
      Nakahara M., Shimozawa M., Nakamura Y., Irino Y., Morita M., Kudo Y., Fukami K.
      J. Biol. Chem. 280:29128-29134(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-1501 (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, REGION, FUNCTION, DEVELOPMENTAL STAGE, MUTAGENESIS OF HIS-415.
      Strain: C57BL/6J x 129.
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 624-1501 (ISOFORM 3).
      Tissue: Eye.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-676 AND SER-686, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    7. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiPLCH2_MOUSE
    AccessioniPrimary (citable) accession number: A2AP18
    Secondary accession number(s): A6PWW5
    , Q3LUA7, Q4QSC7, Q80WP6, Q8BJV1, Q8BWU4, Q8BXN5, Q8CFR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3