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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Gene

Plch2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.2 Publications

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei415PROSITE-ProRule annotation1
Metal bindingi416Calcium 1; catalyticBy similarity1
Metal bindingi445Calcium 1; catalyticBy similarity1
Metal bindingi447Calcium 1; catalyticBy similarity1
Active sitei459PROSITE-ProRule annotation1
Metal bindingi494Calcium 1; catalyticBy similarity1
Binding sitei543SubstrateBy similarity1
Binding sitei545SubstrateBy similarity1
Binding sitei734SubstrateBy similarity1
Binding sitei761SubstrateBy similarity1
Metal bindingi865Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi867Calcium 2By similarity1
Metal bindingi891Calcium 2By similarity1
Metal bindingi920Calcium 3By similarity1
Metal bindingi921Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi922Calcium 3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi256 – 267PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.4.11. 3474.
ReactomeiR-MMU-1855204. Synthesis of IP3 and IP4 in the cytosol.

Chemistry databases

SwissLipidsiSLP:000000943.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-eta-2
Phosphoinositide phospholipase C-like 4
Short name:
PLC-L4
Short name:
Phospholipase C-like protein 4
Phospholipase C-eta-2
Short name:
PLC-eta2
Gene namesi
Name:Plch2
Synonyms:Plcl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2443078. Plch2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi415H → A: Inhibition of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003089591 – 15011-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2Add BLAST1501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei561PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei676PhosphoserineCombined sources1
Modified residuei686PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AP18.
PaxDbiA2AP18.
PRIDEiA2AP18.

PTM databases

iPTMnetiA2AP18.
PhosphoSitePlusiA2AP18.

Expressioni

Tissue specificityi

Specifically detected in the brain, with higher level in cerebral cortex, olfactory bulb and hippocampus (at protein level). Expressed in the pyramidal cells of the hippocampus, but also in eye and lung.2 Publications

Developmental stagei

Expressed at 2 weeks after birth but barely detected 1 week after birth. Increased expression during brain development.1 Publication

Gene expression databases

BgeeiENSMUSG00000029055.
CleanExiMM_PLCH2.
ExpressionAtlasiA2AP18. baseline and differential.
GenevisibleiA2AP18. MM.

Interactioni

Protein-protein interaction databases

IntActiA2AP18. 1 interactor.
MINTiMINT-4115610.
STRINGi10090.ENSMUSP00000101256.

Structurei

3D structure databases

ProteinModelPortaliA2AP18.
SMRiA2AP18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 229PHPROSITE-ProRule annotationAdd BLAST109
Domaini243 – 278EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini279 – 315EF-hand 2PROSITE-ProRule annotationAdd BLAST37
Domaini400 – 545PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST146
Domaini707 – 821PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST115
Domaini826 – 933C2PROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 229Necessary for plasma membrane localizationAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1227 – 1236Poly-Ser10

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOVERGENiHBG107105.
InParanoidiA2AP18.
KOiK19006.
OrthoDBiEOG091G02KH.
PhylomeDBiA2AP18.
TreeFamiTF313216.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028393. PLC-eta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PTHR10336:SF21. PTHR10336:SF21. 2 hits.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF16457. PH_12. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AP18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGLAWGPSR AAGSSWVNAS GTWEQPLRGF SGLQGGRRRG RGEKGIPEEP
60 70 80 90 100
LCQLTPQLGL SLRVPFGLGD YGLDMPGPQP SAASQTTGAV ACLAEVLLWV
110 120 130 140 150
GGSVVVSPRW QLSLVVERCM SAMQEGTQMV KLRGSSKGLV RFYYLDEHRS
160 170 180 190 200
CLRWRPSRKN EKAKISIDSI QEVSEGRQSE IFQRYPDSSF DPNCCFSIYH
210 220 230 240 250
GSHRESLDLV SPSSEEARTW VTGLRYLMAG ISDEDSLARR QRTRDQWLKQ
260 270 280 290 300
TFDEADKNGD GSLSISEVLQ LLHKLNVNLP RQRVKQMFRE ADTDDHQGTL
310 320 330 340 350
GFEEFCAFYK MMSTRRDLYL LMLTYSNHKD HLDASDLQRF LEVEQKMNGV
360 370 380 390 400
TLESCQNIIE QFEPCLENKS KGMLGIDGFT NYTRSPAGDI FNPEHNRVHQ
410 420 430 440 450
DMTQPLSHYF ITSSHNTYLV GDQLMSQSRV DMYAWVLQAG CRCVEVDCWD
460 470 480 490 500
GPDGEPIVHH GYTLTSKILF KDVIETINKY AFIKNEYPVI LSIENHCSVV
510 520 530 540 550
QQKKMAQYLT DILGDKLDLS SVSSEDATML PSPQMLKGKI LVKGKKLPAN
560 570 580 590 600
ISEDAEEGEV SDEDSADEME DDCKLLNGDA STNRKRVENI AKKKLDSLIK
610 620 630 640 650
ESKIRDCEDP NDFSVSTLSP SGKLGRKAEA KKGQSKVEED VEAGEDSGVS
660 670 680 690 700
RQNSRLFMSS FSKRKKKGSK IKKVASVEEG DETLDSPGSQ SRGTARQKKT
710 720 730 740 750
MKLSRALSDL VKYTKSVGTH DVEIEVVSSW QVSSFSETKA HQILQQKPTQ
760 770 780 790 800
YLRFNQHQLS RIYPSSYRVD SSNYNPQPFW NAGCQMVALN YQSEGRMLQL
810 820 830 840 850
NRAKFSANGD CGYVLKPQCM CQGVFNPNSE DPLPGQLKKQ LALRIISGQQ
860 870 880 890 900
LPKPRDSVLG DRGEIIDPFV EVEVIGLPVD CSKEQTRVVD DNGFNPMWEE
910 920 930 940 950
TLVFTVHMPE IALVRFLVWD HDPIGRDFIG QRTLAFSSIM PGYRHVYLEG
960 970 980 990 1000
MEEASIFVHV AVSDISGKVK QTLGLKGLFL RGTKPGSLDS HAAGQPLPRP
1010 1020 1030 1040 1050
SVSQRLLRRT ASAPTKSQKP SRKGFPELAL GTQDAGSEGA ADDVAPSSPN
1060 1070 1080 1090 1100
PALEAPTQER SGSSSPRDTR LFPLQRPISP LCSLEPIAEE PALGPGLPLQ
1110 1120 1130 1140 1150
AAAPTGPSQE GSQCPVGLGA KVTSSQQTSL GAFGTLQLRI GGGRENEEPP
1160 1170 1180 1190 1200
LRPHNGGISS GPREGTSGRQ TDSKSRSRVP GHLPVVRRAK SEGQVLSELS
1210 1220 1230 1240 1250
PTPAVYSDAT GTDRLWQRLE PGSHRDSVSS SSSMSSNDTV IDLSLPSLGL
1260 1270 1280 1290 1300
CRSRESIPGV SLGRLTSRPC LASAARPDLP PVTKSKSNPN LRVAGGLPTA
1310 1320 1330 1340 1350
PDELQPRPLA PRLTGHHPRP PWHHLTLVGL RDCPVSAKSK SLGDLTADDF
1360 1370 1380 1390 1400
APSFQGSTSS LSCGLGSLGV AHQVLEPGIR RDALTEQLRW LTGFQQAGDI
1410 1420 1430 1440 1450
TSPTSLGPAG DGSVGGPSFL RRSSSRSQSR VRAIASRARQ AQERQQRLRG
1460 1470 1480 1490 1500
QDSRGPPEEE RGTPEGACSV GHEGCVDVPM PAKGAPEQVC GAADGQLLLR

L
Length:1,501
Mass (Da):164,297
Last modified:August 21, 2007 - v2
Checksum:i6C2CA0E2864B327B
GO
Isoform 2 (identifier: A2AP18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1068-1238: DTRLFPLQRP...SSSSSMSSND → GKAPGGEATE...HSPMFSTVRD
     1239-1501: Missing.

Show »
Length:1,238
Mass (Da):136,321
Checksum:iF6A095EB915BF370
GO
Isoform 3 (identifier: A2AP18-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1068-1252: DTRLFPLQRP...LSLPSLGLCR → GKAPGGEATE...ASHALYTWHA
     1253-1501: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,252
Mass (Da):137,734
Checksum:iD591E6F8D70C95D3
GO
Isoform 4 (identifier: A2AP18-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     106-116: VSPRWQLSLVV → MDAGAAPQKHM

Show »
Length:1,396
Mass (Da):153,398
Checksum:iE9DE7ABC3A7F10E7
GO
Isoform 5 (identifier: A2AP18-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-115: Missing.
     580-675: ASTNRKRVEN...KKGSKIKKVA → VSGSPGSACR...GKWWFTNVKK
     676-1501: Missing.

Show »
Length:599
Mass (Da):67,979
Checksum:i4388365410ED427F
GO

Sequence cautioni

The sequence BAC32005 differs from that shown. Aberrant splicing.Curated
The sequence BAC32005 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC37371 differs from that shown. Reason: Erroneous termination at position 433. Translated as Tyr.Curated
The sequence CAO78007 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAO78129 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340F → L in BAC34011 (PubMed:16141072).Curated1
Sequence conflicti664 – 665RK → HR in AAH40465 (PubMed:15489334).Curated2
Sequence conflicti781N → D in BAC32005 (PubMed:16141072).Curated1
Sequence conflicti1258P → A in BAC32005 (PubMed:16141072).Curated1
Sequence conflicti1495G → S in BAC32005 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0290751 – 105Missing in isoform 4. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_02907640 – 115Missing in isoform 5. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_029077106 – 116VSPRWQLSLVV → MDAGAAPQKHM in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_029078580 – 675ASTNR…IKKVA → VSGSPGSACREPGVGPQHPR PILSTKGIYLPQRERGQGVR DKDRRWRVREKGKGTREGAR GICPGGRGDKGLPLDREETD RQTWPIGKWWFTNVKK in isoform 5. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_029079676 – 1501Missing in isoform 5. 1 PublicationAdd BLAST826
Alternative sequenceiVSP_0290811068 – 1252DTRLF…LGLCR → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLQREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTGKACRSAASHAL YTWHA in isoform 3. 1 PublicationAdd BLAST185
Alternative sequenceiVSP_0290821068 – 1238DTRLF…MSSND → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLRREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTVRD in isoform 2. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_0290831239 – 1501Missing in isoform 2. 1 PublicationAdd BLAST263
Alternative sequenceiVSP_0290841253 – 1501Missing in isoform 3. 1 PublicationAdd BLAST249

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176851 mRNA. Translation: ABA12210.1.
AL831788, BX004788 Genomic DNA. Translation: CAM16344.2.
BX004788, AL831788 Genomic DNA. Translation: CAM28037.2.
AL831788, BX004788 Genomic DNA. Translation: CAO78007.1. Sequence problems.
BX004788, AL831788 Genomic DNA. Translation: CAO78129.1. Sequence problems.
AK044619 mRNA. Translation: BAC32005.1. Sequence problems.
AK049970 mRNA. Translation: BAC34011.1.
AK078731 mRNA. Translation: BAC37371.1. Sequence problems.
AY966876 mRNA. Translation: AAY33831.1.
BC040465 mRNA. Translation: AAH40465.1.
BC052329 mRNA. Translation: AAH52329.1.
CCDSiCCDS38990.2. [A2AP18-2]
CCDS71533.1. [A2AP18-1]
RefSeqiNP_001106831.1. NM_001113360.2. [A2AP18-1]
NP_780765.2. NM_175556.4.
UniGeneiMm.379458.

Genome annotation databases

EnsembliENSMUST00000105631; ENSMUSP00000101256; ENSMUSG00000029055. [A2AP18-1]
ENSMUST00000135665; ENSMUSP00000118292; ENSMUSG00000029055. [A2AP18-4]
ENSMUST00000145662; ENSMUSP00000119864; ENSMUSG00000029055. [A2AP18-5]
GeneIDi269615.
KEGGimmu:269615.
UCSCiuc008wcq.2. mouse. [A2AP18-5]
uc056zyr.1. mouse. [A2AP18-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ176851 mRNA. Translation: ABA12210.1.
AL831788, BX004788 Genomic DNA. Translation: CAM16344.2.
BX004788, AL831788 Genomic DNA. Translation: CAM28037.2.
AL831788, BX004788 Genomic DNA. Translation: CAO78007.1. Sequence problems.
BX004788, AL831788 Genomic DNA. Translation: CAO78129.1. Sequence problems.
AK044619 mRNA. Translation: BAC32005.1. Sequence problems.
AK049970 mRNA. Translation: BAC34011.1.
AK078731 mRNA. Translation: BAC37371.1. Sequence problems.
AY966876 mRNA. Translation: AAY33831.1.
BC040465 mRNA. Translation: AAH40465.1.
BC052329 mRNA. Translation: AAH52329.1.
CCDSiCCDS38990.2. [A2AP18-2]
CCDS71533.1. [A2AP18-1]
RefSeqiNP_001106831.1. NM_001113360.2. [A2AP18-1]
NP_780765.2. NM_175556.4.
UniGeneiMm.379458.

3D structure databases

ProteinModelPortaliA2AP18.
SMRiA2AP18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AP18. 1 interactor.
MINTiMINT-4115610.
STRINGi10090.ENSMUSP00000101256.

Chemistry databases

SwissLipidsiSLP:000000943.

PTM databases

iPTMnetiA2AP18.
PhosphoSitePlusiA2AP18.

Proteomic databases

MaxQBiA2AP18.
PaxDbiA2AP18.
PRIDEiA2AP18.

Protocols and materials databases

DNASUi269615.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105631; ENSMUSP00000101256; ENSMUSG00000029055. [A2AP18-1]
ENSMUST00000135665; ENSMUSP00000118292; ENSMUSG00000029055. [A2AP18-4]
ENSMUST00000145662; ENSMUSP00000119864; ENSMUSG00000029055. [A2AP18-5]
GeneIDi269615.
KEGGimmu:269615.
UCSCiuc008wcq.2. mouse. [A2AP18-5]
uc056zyr.1. mouse. [A2AP18-1]

Organism-specific databases

CTDi9651.
MGIiMGI:2443078. Plch2.

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOVERGENiHBG107105.
InParanoidiA2AP18.
KOiK19006.
OrthoDBiEOG091G02KH.
PhylomeDBiA2AP18.
TreeFamiTF313216.

Enzyme and pathway databases

BRENDAi3.1.4.11. 3474.
ReactomeiR-MMU-1855204. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

PROiA2AP18.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029055.
CleanExiMM_PLCH2.
ExpressionAtlasiA2AP18. baseline and differential.
GenevisibleiA2AP18. MM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028393. PLC-eta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PTHR10336:SF21. PTHR10336:SF21. 2 hits.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF16457. PH_12. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLCH2_MOUSE
AccessioniPrimary (citable) accession number: A2AP18
Secondary accession number(s): A6PWW5
, Q3LUA7, Q4QSC7, Q80WP6, Q8BJV1, Q8BWU4, Q8BXN5, Q8CFR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 21, 2007
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.