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A2AP18 (PLCH2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

EC=3.1.4.11
Alternative name(s):
Phosphoinositide phospholipase C-eta-2
Phosphoinositide phospholipase C-like 4
Short name=PLC-L4
Short name=Phospholipase C-like protein 4
Phospholipase C-eta-2
Short name=PLC-eta2
Gene names
Name:Plch2
Synonyms:Plcl4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1501 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. Ref.1 Ref.4

Catalytic activity

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactor

Calcium.

Subcellular location

Cytoplasm. Cell membrane. Note: Localized predominantly at the plasma membrane. Ref.4

Tissue specificity

Specifically detected in the brain, with higher level in cerebral cortex, olfactory bulb and hippocampus (at protein level). Expressed in the pyramidal cells of the hippocampus, but also in eye and lung. Ref.1 Ref.4

Developmental stage

Expressed at 2 weeks after birth but barely detected 1 week after birth. Increased expression during brain development. Ref.4

Sequence similarities

Contains 1 C2 domain.

Contains 2 EF-hand domains.

Contains 1 PH domain.

Contains 1 PI-PLC X-box domain.

Contains 1 PI-PLC Y-box domain.

Sequence caution

The sequence BAC32005.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC32005.1 differs from that shown. Reason: Aberrant splicing.

The sequence BAC37371.1 differs from that shown. Reason: Erroneous termination at position 433. Translated as Tyr.

The sequence CAO78007.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAO78129.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A2AP18-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A2AP18-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1068-1238: DTRLFPLQRP...SSSSSMSSND → GKAPGGEATE...HSPMFSTVRD
     1239-1501: Missing.
Isoform 3 (identifier: A2AP18-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1068-1252: DTRLFPLQRP...LSLPSLGLCR → GKAPGGEATE...ASHALYTWHA
     1253-1501: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay..
Isoform 4 (identifier: A2AP18-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     106-116: VSPRWQLSLVV → MDAGAAPQKHM
Isoform 5 (identifier: A2AP18-5)

The sequence of this isoform differs from the canonical sequence as follows:
     40-115: Missing.
     580-675: ASTNRKRVEN...KKGSKIKKVA → VSGSPGSACR...GKWWFTNVKK
     676-1501: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 150115011-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
PRO_0000308959

Regions

Domain121 – 229109PH
Domain243 – 27836EF-hand 1
Domain279 – 31537EF-hand 2
Domain400 – 545146PI-PLC X-box
Domain707 – 821115PI-PLC Y-box
Domain826 – 933108C2
Calcium binding256 – 26712 Potential
Region75 – 229155Necessary for plasma membrane localization
Compositional bias1227 – 123610Poly-Ser

Sites

Active site4151 By similarity
Active site4591 By similarity
Metal binding4161Calcium 1; catalytic By similarity
Metal binding4451Calcium 1; catalytic By similarity
Metal binding4471Calcium 1; catalytic By similarity
Metal binding4941Calcium 1; catalytic By similarity
Metal binding8651Calcium 2; via carbonyl oxygen By similarity
Metal binding8671Calcium 2 By similarity
Metal binding8911Calcium 2 By similarity
Metal binding9201Calcium 3 By similarity
Metal binding9211Calcium 3; via carbonyl oxygen By similarity
Metal binding9221Calcium 3 By similarity
Binding site5431Substrate By similarity
Binding site5451Substrate By similarity
Binding site7341Substrate By similarity
Binding site7611Substrate By similarity

Amino acid modifications

Modified residue6761Phosphoserine Ref.6
Modified residue6861Phosphoserine Ref.6

Natural variations

Alternative sequence1 – 105105Missing in isoform 4.
VSP_029075
Alternative sequence40 – 11576Missing in isoform 5.
VSP_029076
Alternative sequence106 – 11611VSPRWQLSLVV → MDAGAAPQKHM in isoform 4.
VSP_029077
Alternative sequence580 – 67596ASTNR…IKKVA → VSGSPGSACREPGVGPQHPR PILSTKGIYLPQRERGQGVR DKDRRWRVREKGKGTREGAR GICPGGRGDKGLPLDREETD RQTWPIGKWWFTNVKK in isoform 5.
VSP_029078
Alternative sequence676 – 1501826Missing in isoform 5.
VSP_029079
Alternative sequence1068 – 1252185DTRLF…LGLCR → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLQREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTGKACRSAASHAL YTWHA in isoform 3.
VSP_029081
Alternative sequence1068 – 1238171DTRLF…MSSND → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLRREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTVRD in isoform 2.
VSP_029082
Alternative sequence1239 – 1501263Missing in isoform 2.
VSP_029083
Alternative sequence1253 – 1501249Missing in isoform 3.
VSP_029084

Experimental info

Mutagenesis4151H → A: Inhibition of activity. Ref.4
Sequence conflict3401F → L in BAC34011. Ref.3
Sequence conflict664 – 6652RK → HR in AAH40465. Ref.5
Sequence conflict7811N → D in BAC32005. Ref.3
Sequence conflict12581P → A in BAC32005. Ref.3
Sequence conflict14951G → S in BAC32005. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: 6C2CA0E2864B327B

FASTA1,501164,297
        10         20         30         40         50         60 
MGGLAWGPSR AAGSSWVNAS GTWEQPLRGF SGLQGGRRRG RGEKGIPEEP LCQLTPQLGL 

        70         80         90        100        110        120 
SLRVPFGLGD YGLDMPGPQP SAASQTTGAV ACLAEVLLWV GGSVVVSPRW QLSLVVERCM 

       130        140        150        160        170        180 
SAMQEGTQMV KLRGSSKGLV RFYYLDEHRS CLRWRPSRKN EKAKISIDSI QEVSEGRQSE 

       190        200        210        220        230        240 
IFQRYPDSSF DPNCCFSIYH GSHRESLDLV SPSSEEARTW VTGLRYLMAG ISDEDSLARR 

       250        260        270        280        290        300 
QRTRDQWLKQ TFDEADKNGD GSLSISEVLQ LLHKLNVNLP RQRVKQMFRE ADTDDHQGTL 

       310        320        330        340        350        360 
GFEEFCAFYK MMSTRRDLYL LMLTYSNHKD HLDASDLQRF LEVEQKMNGV TLESCQNIIE 

       370        380        390        400        410        420 
QFEPCLENKS KGMLGIDGFT NYTRSPAGDI FNPEHNRVHQ DMTQPLSHYF ITSSHNTYLV 

       430        440        450        460        470        480 
GDQLMSQSRV DMYAWVLQAG CRCVEVDCWD GPDGEPIVHH GYTLTSKILF KDVIETINKY 

       490        500        510        520        530        540 
AFIKNEYPVI LSIENHCSVV QQKKMAQYLT DILGDKLDLS SVSSEDATML PSPQMLKGKI 

       550        560        570        580        590        600 
LVKGKKLPAN ISEDAEEGEV SDEDSADEME DDCKLLNGDA STNRKRVENI AKKKLDSLIK 

       610        620        630        640        650        660 
ESKIRDCEDP NDFSVSTLSP SGKLGRKAEA KKGQSKVEED VEAGEDSGVS RQNSRLFMSS 

       670        680        690        700        710        720 
FSKRKKKGSK IKKVASVEEG DETLDSPGSQ SRGTARQKKT MKLSRALSDL VKYTKSVGTH 

       730        740        750        760        770        780 
DVEIEVVSSW QVSSFSETKA HQILQQKPTQ YLRFNQHQLS RIYPSSYRVD SSNYNPQPFW 

       790        800        810        820        830        840 
NAGCQMVALN YQSEGRMLQL NRAKFSANGD CGYVLKPQCM CQGVFNPNSE DPLPGQLKKQ 

       850        860        870        880        890        900 
LALRIISGQQ LPKPRDSVLG DRGEIIDPFV EVEVIGLPVD CSKEQTRVVD DNGFNPMWEE 

       910        920        930        940        950        960 
TLVFTVHMPE IALVRFLVWD HDPIGRDFIG QRTLAFSSIM PGYRHVYLEG MEEASIFVHV 

       970        980        990       1000       1010       1020 
AVSDISGKVK QTLGLKGLFL RGTKPGSLDS HAAGQPLPRP SVSQRLLRRT ASAPTKSQKP 

      1030       1040       1050       1060       1070       1080 
SRKGFPELAL GTQDAGSEGA ADDVAPSSPN PALEAPTQER SGSSSPRDTR LFPLQRPISP 

      1090       1100       1110       1120       1130       1140 
LCSLEPIAEE PALGPGLPLQ AAAPTGPSQE GSQCPVGLGA KVTSSQQTSL GAFGTLQLRI 

      1150       1160       1170       1180       1190       1200 
GGGRENEEPP LRPHNGGISS GPREGTSGRQ TDSKSRSRVP GHLPVVRRAK SEGQVLSELS 

      1210       1220       1230       1240       1250       1260 
PTPAVYSDAT GTDRLWQRLE PGSHRDSVSS SSSMSSNDTV IDLSLPSLGL CRSRESIPGV 

      1270       1280       1290       1300       1310       1320 
SLGRLTSRPC LASAARPDLP PVTKSKSNPN LRVAGGLPTA PDELQPRPLA PRLTGHHPRP 

      1330       1340       1350       1360       1370       1380 
PWHHLTLVGL RDCPVSAKSK SLGDLTADDF APSFQGSTSS LSCGLGSLGV AHQVLEPGIR 

      1390       1400       1410       1420       1430       1440 
RDALTEQLRW LTGFQQAGDI TSPTSLGPAG DGSVGGPSFL RRSSSRSQSR VRAIASRARQ 

      1450       1460       1470       1480       1490       1500 
AQERQQRLRG QDSRGPPEEE RGTPEGACSV GHEGCVDVPM PAKGAPEQVC GAADGQLLLR 


L 

« Hide

Isoform 2 [UniParc].

Checksum: F6A095EB915BF370
Show »

FASTA1,238136,321
Isoform 3 [UniParc].

Checksum: D591E6F8D70C95D3
Show »

FASTA1,252137,734
Isoform 4 [UniParc].

Checksum: E9DE7ABC3A7F10E7
Show »

FASTA1,396153,398
Isoform 5 [UniParc].

Checksum: 4388365410ED427F
Show »

FASTA59967,979

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of PLC-eta2."
Zhou Y., Wing M.R., Sondek J., Harden T.K.
Biochem. J. 391:667-676(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
Strain: C57BL/6J.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-664 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1501 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-246 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Eye, Hippocampus and Retina.
[4]"A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme."
Nakahara M., Shimozawa M., Nakamura Y., Irino Y., Morita M., Kudo Y., Fukami K.
J. Biol. Chem. 280:29128-29134(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-1501 (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, REGION, FUNCTION, DEVELOPMENTAL STAGE, MUTAGENESIS OF HIS-415.
Strain: C57BL/6J x 129.
Tissue: Brain.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 624-1501 (ISOFORM 3).
Tissue: Eye.
[6]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-676 AND SER-686, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
[7]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ176851 mRNA. Translation: ABA12210.1.
AL831788, BX004788 Genomic DNA. Translation: CAM16344.2.
BX004788, AL831788 Genomic DNA. Translation: CAM28037.2.
AL831788, BX004788 Genomic DNA. Translation: CAO78007.1. Sequence problems.
BX004788, AL831788 Genomic DNA. Translation: CAO78129.1. Sequence problems.
AK044619 mRNA. Translation: BAC32005.1. Sequence problems.
AK049970 mRNA. Translation: BAC34011.1.
AK078731 mRNA. Translation: BAC37371.1. Sequence problems.
AY966876 mRNA. Translation: AAY33831.1.
BC040465 mRNA. Translation: AAH40465.1.
BC052329 mRNA. Translation: AAH52329.1.
CCDSCCDS38990.2. [A2AP18-2]
CCDS71533.1. [A2AP18-1]
RefSeqNP_001106831.1. NM_001113360.2. [A2AP18-1]
NP_780765.2. NM_175556.4.
UniGeneMm.379458.

3D structure databases

ProteinModelPortalA2AP18.
SMRA2AP18. Positions 207-568, 707-964.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActA2AP18. 1 interaction.
MINTMINT-4115610.
STRING10090.ENSMUSP00000101256.

PTM databases

PhosphoSiteA2AP18.

Proteomic databases

MaxQBA2AP18.
PaxDbA2AP18.
PRIDEA2AP18.

Protocols and materials databases

DNASU269615.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105631; ENSMUSP00000101256; ENSMUSG00000029055. [A2AP18-1]
ENSMUST00000135665; ENSMUSP00000118292; ENSMUSG00000029055. [A2AP18-4]
ENSMUST00000145662; ENSMUSP00000119864; ENSMUSG00000029055. [A2AP18-5]
GeneID269615.
KEGGmmu:269615.
UCSCuc008wco.2. mouse. [A2AP18-1]

Organism-specific databases

CTD9651.
MGIMGI:2443078. Plch2.

Phylogenomic databases

eggNOGNOG149692.
GeneTreeENSGT00740000114979.
HOVERGENHBG107105.
InParanoidA2AP18.
OMAHPRPPWH.
OrthoDBEOG7PGDQ0.
PhylomeDBA2AP18.
TreeFamTF313216.

Gene expression databases

BgeeA2AP18.
CleanExMM_PLCH2.
GenevestigatorA2AP18.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028393. PLC-eta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR001849. Pleckstrin_homology.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF21. PTHR10336:SF21. 1 hit.
PfamPF00168. C2. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSPR00390. PHPHLIPASEC.
SMARTSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio392931.
PROA2AP18.
SOURCESearch...

Entry information

Entry namePLCH2_MOUSE
AccessionPrimary (citable) accession number: A2AP18
Secondary accession number(s): A6PWW5 expand/collapse secondary AC list , Q3LUA7, Q4QSC7, Q80WP6, Q8BJV1, Q8BWU4, Q8BXN5, Q8CFR1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot