ID   A2ANY6_MOUSE            Unreviewed;      5589 AA.
AC   A2ANY6;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 120.
DE   RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN   Name=Mdn1 {ECO:0000313|Ensembl:ENSMUSP00000071569.5,
GN   ECO:0000313|MGI:MGI:1926159};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000071569.5, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:17242355}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000071569.5, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000071569.5,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000071569.5}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000071569.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC       of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC       {ECO:0000256|ARBA:ARBA00004642}.
CC   -!- SIMILARITY: Belongs to the midasin family.
CC       {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_006537539.1; XM_006537476.2.
DR   IntAct; A2ANY6; 2.
DR   iPTMnet; A2ANY6; -.
DR   PhosphoSitePlus; A2ANY6; -.
DR   SwissPalm; A2ANY6; -.
DR   EPD; A2ANY6; -.
DR   jPOST; A2ANY6; -.
DR   MaxQB; A2ANY6; -.
DR   PaxDb; 10090-ENSMUSP00000071569; -.
DR   PeptideAtlas; A2ANY6; -.
DR   ProteomicsDB; 363739; -.
DR   Antibodypedia; 31873; 18 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000071642.11; ENSMUSP00000071569.5; ENSMUSG00000058006.13.
DR   GeneID; 100019; -.
DR   AGR; MGI:1926159; -.
DR   CTD; 23195; -.
DR   MGI; MGI:1926159; Mdn1.
DR   VEuPathDB; HostDB:ENSMUSG00000058006; -.
DR   eggNOG; KOG1808; Eukaryota.
DR   GeneTree; ENSGT00550000074802; -.
DR   HOGENOM; CLU_000050_0_0_1; -.
DR   InParanoid; A2ANY6; -.
DR   OMA; ILEQWHR; -.
DR   OrthoDB; 1221059at2759; -.
DR   PhylomeDB; A2ANY6; -.
DR   TreeFam; TF300488; -.
DR   BioGRID-ORCS; 100019; 29 hits in 80 CRISPR screens.
DR   ChiTaRS; Mdn1; mouse.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; A2ANY6; Protein.
DR   Bgee; ENSMUSG00000058006; Expressed in embryonic post-anal tail and 224 other cell types or tissues.
DR   ExpressionAtlas; A2ANY6; baseline and differential.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0045111; C:intermediate filament cytoskeleton; ISO:MGI.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR   CDD; cd00009; AAA; 2.
DR   CDD; cd01460; vWA_midasin; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR040848; AAA_lid_7.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR029317; KRBA1_rpt.
DR   InterPro; IPR048617; MDN1_AAA_lid_4.
DR   InterPro; IPR012099; Midasin.
DR   InterPro; IPR041190; Midasin_AAA_lid_5.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR   PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR   Pfam; PF07728; AAA_5; 8.
DR   Pfam; PF17865; AAA_lid_5; 1.
DR   Pfam; PF17867; AAA_lid_7; 3.
DR   Pfam; PF21108; MDN1_4th; 1.
DR   PIRSF; PIRSF010340; Midasin; 2.
DR   SMART; SM00382; AAA; 5.
DR   SMART; SM01258; KRBA1; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR010340};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW   Proteomics identification {ECO:0007829|EPD:A2ANY6,
KW   ECO:0007829|MaxQB:A2ANY6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          5377..5576
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          4520..4543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4661..5252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4681..4736
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4751..4770
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4771..4787
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4811..4883
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4897..4911
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4918..4963
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5075..5097
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5098..5147
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5154..5171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5175..5193
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5203..5221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5222..5252
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   5589 AA;  630342 MW;  CE58B46C42EA157A CRC64;
     MEHLSVELVS GPLRLIAAKN EKSSGELNRF LAKSVWTPQD RQCILDSLAQ LLLDKDYTLL
     LGRQLRPILL DLLERNAKAI KTGGQVNHDL HERLSVSMSK LIGSHPDVLP FALRYFKDTY
     PVFQRLFLES SDANPVRYGR RRMKLRDLME AANIFLQHRQ TVFRELWDWS VCVPLLRSHD
     ALVRWHTANC LALVTCMNEE HKLSFLRKIF SSDELVHFRL RLLEEAQLQD LEKALVLANP
     EVSLWHKGEE PQYIQGHLVS ADLSSSVAAV CGVVLPKLSS SPGEQASDRS SSLEQELALK
     SFVLVESVCK NLQLLAVSVA SQNAVLLEGP IGSGKTSLVE HLAAVTGRTK PPQLLKVQLG
     DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATKGYWILL EDIDYAPLDV VSVLIPLLEH
     GELLIPGHGD CLKVAPTFQL FATRRLLSCG GSWYRPMNSH ATMLDKYWTK IHLHNLNKKD
     LNEVLQSKYP SLLAATDHLL DIYIELTGEK HCCPSVAYDK APQEVSEAER ENRRVVLEGR
     ELSLRDLLNW CNRVAHGFDP TSSTALLHIF QEAMDCFTAM LSEQTKKLRM AEVIGSRLNI
     SKKKAEFYCK LYKPEIVINE LDVQVGRVRL LRKQSEVVRI QKEKCTFAAT RPSSVLLEQL
     AVCVSQGEPV LLVGETGTGK TSAVQYLAYA TGQHLRVVNM NQQSDTADLL GGFKPVDHKL
     IWLPLRETFE ELFVQTFSKK QNFTFLGHIQ TCYRQKRWHD LLKLMLHVQK SASTKGGEQS
     QPGLLKEKWE AFGLRLNHAQ QQMKMTENAL LFAFVEGTLA QAIKKGEWIL LDEINLAAPE
     TLECLSGLLE GSSGSLVLLD RGDTEPLVRH PDFRLFACMN PATDVGKRNL PPGIRNRFTE
     LYVEELESKE DLQILIVDYL KGLNVSKNTV QGIVNFYTAL RKESGTKLVD GTGHRPHYSL
     RTLCRALRFA ASNPCGSIQR SLYEGFCLGF LTQLDRASHP VVQKLICQHI ISGNVKSLLK
     QPIPEPKGGR LIQVEGYWIS VGDKEPKIDE TYVLTPSVKL NLRDIARVVS AGTYPVLIQG
     ETSVGKTSLI RWLAAASGNH CVRINNHEHT DIQEYIGCYT SDTSGKLVFN EGVLIDAMRK
     GYWIVLDELN LAPTDVLEAL NRLLDDNREL LITETQEVVR AHPRFMLFAT QNPPGLYGGR
     KVLSRAFRNR FVELHFDELP SSELETILHK RCSLPPSYCS KLVKVMLDLQ SYRRRSSVFA
     GKQGFIALRD LFRWAERYRL AEQTQEDYDW LQHLANDGFM LLAGRVRKQE EADVIQEVLE
     KHFKKKLCPQ SLFSKENVLK LLGKSSTQTT VLESKFSHVV WTESMRRLAV LVGRALEFGE
     PVLLVGDTGC GKTTVCQMFS ALANQKLYSV NCHLNMETSD FLGGLRPVRQ KPNDKDELDT
     RLFEWHDGPL VLAMKEDSFF LLDEISLADD SVLERLNSVL EVEKCLVLAE KGSPESKDNE
     VELLTAGKHF RILATMNPGG DFGKKELSPA LRNRFTEIWC PQSTKREDLI QIINHNLRPG
     LSLAGVGHKG AGVAEVMLAF ITWLTRQEFG RKCVVSIRDI LSWVNFMNSM AEDAAVKRPE
     AISTVTSFVH AACLVYIDGI GSGVTSSGFG TALLAREECL KFLIKKLSKV VRLTQRQKDE
     LKIYDRLRHK EFTSIDDFWG VHPFFIPRGP VLDGHNTGDY ALTAGTTAMN AQRLLRAAKL
     NKPILLEGSP GVGKTSLVAA LAKASGNTLV RINLSEQTDI TDLFGADLPV EGGRGGEFAW
     CDGPLLAALK AGHWVVLDEL NLASQSILEG LNACFDHRGE IYVPELGMSF QVQHEKTRIF
     GCQNPFRQGG GRKGLPKSFL NRFTQVFVDP LTVVDMEFIA STLFPTIDKD IVKKMVAFNN
     HIDHEVTVEK KWGQKGGPWE FNLRDLFRWC QLILVDQSPG CYDPGQHVFL VYGERMRTRE
     DKEKVVAVFK DVFASNSMPY IGTRQFHITP YDIQIGYSVL SRSSYVPHPS RRPLSLLHQS
     FQSLEPIMKC VQMNWMVILV GPASVGKTSL VQLLAHLTGH TLKIMAMNSA MDTTELLGGF
     EQVDIIRPWR LLLEKVERTV RVLLRDSLLI NSVDTEVVLQ AWSHFLLTYK PKCLGEDGKG
     VTIEIVNKLE AVLLLMQRLN NKINSYSKAD FAKLVEDFRS FGVKLLQSAS GRSHGSFEWV
     DSMLVQALKS GDWLLMDNVN FCNPSVLDRL NALLEPGGVL TINERGMVDG STCTVTPNPN
     FRLFLSMDPI HGEISRAMRN RGLEIYISGE EDGSIQDNLD LKVLLHSLGL VGDSVCNILL
     ALHTEIQSLV RGSPASSVST LSHTAILIVQ YLQRGLSLHK AFFEACWEVY VCSQHSAANQ
     KLVQDLLESH TASLQARETW GHSILATGLW PDSVPSALFA TEDSRLSVVR SEGQILAYCL
     NRMSLKTSSW TRSQPLTLQD LENIMQTCSP DDLTFNAVEV DTCWVDEPEV LATAVKLLIE
     RATNQDWMLR VKWLCHLAKN IPQGLESVRV HLEASATALR KFYSTSLSAG VSNVLKILQT
     NITDDFVIPL DPRWNMQALD IIRNSLDFDP QSDQAKQLFA LLESVANKTF IYLDREKRIF
     TEANLVSVGS KKLRSSVLRM SFEFHKDPEN YHSPPHEIVA NLAAFFELID GLILLWVQSP
     QGVVPDAHIN KILGSVQWRD RFWTVADTVT VDASGLALLA LHWHWVSKHL IYQIPQLLVN
     QENKYYKELQ TVSEHIHSCL GSPADSFAGV KKLQAFLGRP FPFKDKLVVD CFLQLQALNR
     ALAIGEQLPV FGECGWQEDI NRLQVVASEW NLKKSLLQAW GLILRANILE DVNLDELKNL
     VSTQCSELKS RGLSRGFLEK AHDASSPSQP DLSSLVHLTR RVQLWPAAEY LAMLWQYRVT
     ADFIAQACLR RSSKHDQMDE EISHHIAFCL KHTPIAPQKL WNLWSLLHIE MLSAQEVSCL
     WSELFTSTFG SSWSSPVTTA PECWLAWSPL PNIQQQEVPR SRWDSTLKGP GSLCRAVFSK
     CCFGVLTNSS RASYWDVSGL PLLSSSHVTL GEWVERAQQL QDISSLLWTN MAVPSVAEFR
     RTDSRLQGLV LCRYLLGLTE LLPAHQRQEY MQNCEHLLLG NTQAFHHVDQ TMGNIGGQEA
     LPKELLCLLL TSLHYFIGEG EGKQNLPEAA RRGRLWVSLG LLQIQTWLPR ARFDPAVKKA
     YKLRYAQDEL RQLQCELKTR NLLSHLQTGR DLEDDIITSH SHPHIKLLPQ RISQLESLVH
     SLSKKQAFRP HLPSYETLVQ EIHHYVTSIA KVTAVQDLLM RLLQALHTDG PKSAQVLQNL
     LKEEASWQQS HHQFRKRLVE EYALYPDTVA PLLASILQLQ HGMRLVASEV HASLHSGVLC
     AENLGALAMA VLAFPSVGPS FPTYHAHADA LCSVNAAEAL RSLGKLMVKR AARKEEAKSQ
     QAYPTREQLL MNALLYLRSH VLCKGELDQR ALLLFRHLCQ EIINEWDEQE RIAQEKAEQE
     SSLYRYRSRS GRTALSEEEE EELELRKLFP LHEKDFADIL MEPTLEEKKK VSDGREEEAA
     PDPTLLCQSS MQAVMLIHQQ LCLSFARSLW YQQAVPPHEA KHYLSLFLSC YQTGASLVTH
     FYPLMGVELN DQLLGSQLLA CTLSSNTLCG EATSDLMMRP DGPYDFYQHP NVAEARQCQP
     VLQGFSEAVS QLLQDWPEHP VLQQLLVVMD RIRGFPLSSP ISKFLNGLEI LLAKAQDWEE
     NASRVLSLRK HLDLVSQMII RWRKLELNCW SMSLDNTMIR HTEKSTKHWF SIYQMLEKHM
     QERTEEQEDD KQMTLMLLVS TLQAFIEGSS LGEFHVRLQM LLVFHCHVLL MPQVEGKDSL
     CSVLWNLYHF YKQFLDPVKA KIMELRSPIE KELKEFVKIS KWNDVSFWSI KQSVEKTHRT
     LFKFMKKFEA VLSEPCQSCL VESDKEEQPD CLPKPTEEAT METSPIQGLN NALRETLLAQ
     PVEWKPSGTE QCQDASPLSV EGELLRRLPR LSKRMRKMCL VFMKESPLPH LVESLDQFTG
     GVISSVSELQ SLKVDPSAEK EKQHSEAKHI LLQKHRALSD LFKHLANIGL SYRKGLAWAR
     SKSPQELLHL HPLDLRSALS IVSSTREADS RLLTEISSLW DGCQKYFYRS LARHTRLTAA
     LATPVKEVSM GTIERCKGFS AHLMKLLIRQ RHSLTTLTEQ WIILRNLLSC VQEIHSRLTG
     PPVYPVAFPP QDSVQQWTER LQHLAMQSQI LLEQFSWLFQ CCPSAEPTVG HRDAQVQEHP
     SASHLENIDF KETIAGVMPD LLSSDLSYPS PVPTSQLPSA CRMRRQDQLW QQSTAGLTEM
     LKTIKTMKAG VDKIRQQSCE TLFHTWEDFE VCSSGLNCLS QVSAHLQGLA SLFILPGIEV
     EQTDSRMALV ESLDYLRGEV SKAIDDFTAW KARLFVAHKQ EGNQMVEESF VEDFSEQVET
     AIRAILCTIQ NLAERNNKKA EDSAVDKRLQ EEDGGKEEEA SFKSLQPGHL TKLLEDDFWA
     SVSTLHVQKI ISSVSELLER LKSCSEDGNT TKHKVFSQSC GLLVRLIPIL CGFSDLVLFF
     LTVSLATHRS TAKLLSVLAQ TFTELSQKGF CLPKELMEDS AGEGATQFHD YEGGGIGDGE
     GMKDVSDRIE NEEQVEDTFQ KGQEKDEEDL DSKPDTKGED NAIEMSEDFD GKMHDGELEQ
     EEDDEKSDSE DGDLDKQMGN LNGEEADKLD ERLWGDDEEE DEDGDGRAEE TGPGVDEEDS
     ELVAKDDSLD AGNLNKNKKH QDEKEDSEPE DVEQGQEKIN EQIDEREYDE NEVDPYHGNQ
     EKLPEPEALD LPDDLKLDSE DKSGGEDTDN EEAEEENPLE IKEKTVDMEE TDHEIEEPGA
     GQDEGESPHE PEEGPSEDKE NMDMDTGADD QDRDTSSHAE EHSLEEEAEE EEEKGEKEED
     KATTDGGGES GVNPVDQGLQ PQKEEEEEGE QSDAEEQVPE ATERKEHATC GQTGVDNVQS
     AQAVELAGAA PEKEQGKEEH GSGAADANQA EGHESNLIAR LSSQQHTNKN TQSFKRRPGQ
     ADNERSVGDY NERVRKRLRT VGTDRETEQE PTQAQVEDAD AFEHVKQGSD AYDAQTYDVA
     SSEQQQTAKA SGQDQEEEEI EDILMDTEEE LMRAEDTEQL KPEAVQSETA ATSGSSEMEV
     DMQTLKTKED QDPRTTTPHQ ETENERPERS RDSTIHTLRQ FLVDSVFQPI LKDISELRQE
     MERQLETWQA HDYGNAEEEK AAAEMWQNYL VLTASLSQQL CEQLRLLLEP TQAAKLRGDY
     RTGKRLNMRK IIPYIASQFR KDRIWLRRTK PSKRQYQICL AIDDSSSMVD NHTKQLAFES
     LAVIGNALTL LEVGQIAVCS FGESVKLLHP FHEQFNDSSG THILRLCTFQ QRKTKIAQFL
     ETVAKMFAAA QKLSQNVSPE TAQLLLIVSD GRGLFLEGKD RVLAAVQAAQ NANIFVIFVV
     LDNPNSRDSI LDIKVPIFKG PGEMPEIRSY MEEFPFPFYI ILRDVNALPE TLSDALRQWF
     ELVTASDHS
//